Detail

RLID: RLID00027501
RNA Symbol: hsa-let-7c
RNA Category: miRNA
Organism: Homo sapiens
Aliase: hsa-let-7cL
Sequence:
Homology: aae-let-7 (Aedes aegypti), bta-let-7a-5p (Bos taurus)
Subcellular Localization:
Localization Tissue Validated Method PMID
Circulating Plasma Next-generation sequencing 25415674
Description: To determine the effects of CAD on the levels of circulating miRNAs, we performed miRNA profile analysis by deep sequencing using RNA isolated from 20 patients with CAD and 20 healthy controls. Two hundred ninety-six miRNAs were detected in the plasma of healthy individuals and 196 in patients with CAD. Among all the miRNAs detected, 173 miRNAs were found in both groups, only 123 miRNAs were detected in healthy individuals, while only 23 miRNAs were detected in patients with CAD. The levels of circulating miRNA profoundly differed between patients and healthy controls, as demonstrated in the scatter (Figure ?(Figure1).1). There were 53 miRNAs that showed more than 2-fold differential expression between groups. Detailed information of these miRNAs is listed in supplementary Table 2.

Other Subcellular Localization:

RLID Localization Tissue Validated Method PMID
RLID00027498 Cytoplasm HeLa cell Next-generation sequencing 22058130
RLID00027499 Microvesicle Hepatoma cell qRT-PCR|Microarray 23771658
RLID00027500 Nucleus HeLa cell Next-generation sequencing 22058130
RLID00027502 Nucleolus HeLa|MCF7 Microarray 24918059
RLID00027503 Exosome Serum Next-generation sequencing 24683445
RLID00027504 Exosome Plasma Next-generation sequencing 24683445
RLID00027505 Exosome Saliva Next-generation sequencing 23302638
RLID00027506 Cytoplasm HeLa|MCF7 Microarray 24918059
RLID00027507 Exosome Mast cell Microarray 24009880