Basic Information:

  VIRBase ID:  

HHID00105230

  Virus:  

SARS-CoV-2

  Host:  

Homo sapiens

  Confidence Score:  

0.9526

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-451a:  MIMAT0001631          IL6R:  NM_001206866     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-451a	IL6R
miRBase Accession/Entrez ID	MIMAT0001631	3570
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	CD126//gp80//HIES5//IL-1Ra//IL-6R//IL-6R-1//IL-6RA//IL6Q//IL6QTL//IL6RA//IL6RQ

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-451a	rs1378754345 chr17:28861413    T/C rs778869519 chr17:28861415    G/A rs746801009 chr17:28861408    AGTAATGGTAACG/A rs747864207 chr17:28861417    A/C rs901867276 chr17:28861419    C/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	IL6R	chr1:154425523(+) A-I      intronic chr1:154425485(+) A-I      intronic chr1:154439146(+) A-I      3'UTR chr1:154421804(+) A-I      intronic chr1:154439145(+) A-I      3'UTR chr1:154439190(+) A-I      3'UTR chr1:154439174(+) A-I      3'UTR chr1:154439153(+) A-I      3'UTR chr1:154425120(+) A-I      intronic chr1:154425119(+) A-I      intronic chr1:154406553(+) A-I      intronic chr1:154425104(+) A-I      intronic chr1:154425079(+) A-I      intronic chr1:154424273(+) A-I      intronic chr1:154406226(+) A-I      intronic chr1:154424217(+) A-I      intronic chr1:154424195(+) A-I      intronic chr1:154424192(+) A-I      intronic chr1:154388897(+) A-I      intronic chr1:154424168(+) A-I      intronic chr1:154424130(+) A-I      intronic chr1:154423901(+) A-I      intronic chr1:154423851(+) A-I      intronic chr1:154423847(+) A-I      intronic chr1:154423832(+) A-I      intronic chr1:154388895(+) A-I      intronic chr1:154423829(+) A-I      intronic chr1:154423823(+) A-I      intronic chr1:154423808(+) A-I      intronic chr1:154423793(+) A-I      intronic chr1:154423792(+) A-I      intronic chr1:154422880(+) A-I      intronic chr1:154422802(+) A-I      intronic chr1:154422701(+) A-I      intronic chr1:154388873(+) A-I      intronic chr1:154422679(+) A-I      intronic chr1:154422666(+) A-I      intronic chr1:154422007(+) A-I      intronic chr1:154421993(+) A-I      intronic chr1:154421985(+) A-I      intronic chr1:154421979(+) A-I      intronic chr1:154421968(+) A-I      intronic chr1:154421766(+) A-I      intronic chr1:154421762(+) A-I      intronic chr1:154421752(+) A-I      intronic chr1:154421729(+) A-I      intronic chr1:154421444(+) A-I      intronic chr1:154421425(+) A-I      intronic chr1:154420373(+) A-I      intronic chr1:154420270(+) A-I      intronic chr1:154420252(+) A-I      intronic chr1:154419840(+) A-I      intronic chr1:154419823(+) A-I      intronic chr1:154419821(+) A-I      intronic chr1:154419792(+) A-I      intronic chr1:154419753(+) A-I      intronic chr1:154419750(+) A-I      intronic chr1:154419719(+) A-I      intronic chr1:154419514(+) A-I      intronic chr1:154388745(+) A-I      intronic chr1:154418431(+) A-I      intronic chr1:154418426(+) A-I      intronic chr1:154418105(+) A-I      intronic chr1:154417977(+) A-I      intronic chr1:154417971(+) A-I      intronic chr1:154388735(+) A-I      intronic chr1:154417349(+) A-I      intronic chr1:154388255(+) A-I      intronic chr1:154417245(+) A-I      intronic chr1:154417217(+) A-I      intronic chr1:154417132(+) A-I      intronic chr1:154417124(+) A-I      intronic chr1:154388193(+) A-I      intronic chr1:154384823(+) A-I      intronic chr1:154416904(+) A-I      intronic chr1:154416884(+) A-I      intronic chr1:154416789(+) A-I      intronic chr1:154416788(+) A-I      intronic chr1:154384810(+) A-I      intronic chr1:154416741(+) A-I      intronic chr1:154415369(+) A-I      intronic chr1:154413419(+) A-I      intronic chr1:154413403(+) A-I      intronic chr1:154413391(+) A-I      intronic chr1:154413312(+) A-I      intronic chr1:154413303(+) A-I      intronic chr1:154384517(+) A-I      intronic chr1:154412562(+) A-I      intronic chr1:154412482(+) A-I      intronic chr1:154412478(+) A-I      intronic chr1:154412459(+) A-I      intronic chr1:154384331(+) A-I      intronic chr1:154412406(+) A-I      intronic chr1:154412038(+) A-I      intronic chr1:154410331(+) A-I      intronic chr1:154410319(+) A-I      intronic chr1:154384328(+) A-I      intronic chr1:154384327(+) A-I      intronic chr1:154429720(+) A-I      intronic chr1:154437314(+) A-I      intronic chr1:154383659(+) A-I      intronic chr1:154437285(+) A-I      intronic chr1:154437220(+) A-I      intronic chr1:154437180(+) A-I      intronic chr1:154436756(+) A-I      intronic chr1:154383639(+) A-I      intronic chr1:154436735(+) A-I      intronic chr1:154383634(+) A-I      intronic chr1:154408875(+) A-I      intronic chr1:154436731(+) A-I      intronic chr1:154381516(+) A-I      intronic chr1:154436692(+) A-I      intronic chr1:154436651(+) A-I      intronic chr1:154436649(+) A-I      intronic chr1:154429786(+) A-I      intronic chr1:154381502(+) A-I      intronic chr1:154429749(+) A-I      intronic chr1:154408804(+) A-I      intronic chr1:154408803(+) A-I      intronic chr1:154429748(+) A-I      intronic chr1:154429731(+) A-I      intronic chr1:154429724(+) A-I      intronic chr1:154429710(+) A-I      intronic chr1:154406689(+) A-I      intronic chr1:154429705(+) A-I      intronic chr1:154429702(+) A-I      intronic chr1:154429679(+) A-I      intronic chr1:154429649(+) A-I      intronic chr1:154429639(+) A-I      intronic chr1:154429638(+) A-I      intronic chr1:154429613(+) A-I      intronic chr1:154429612(+) A-I      intronic chr1:154406554(+) A-I      intronic chr1:154429609(+) A-I      intronic chr1:154429589(+) A-I      intronic chr1:154429570(+) A-I      intronic chr1:154429544(+) A-I      intronic chr1:154428966(+) A-I      intronic chr1:154428957(+) A-I      intronic chr1:154428782(+) A-I      intronic chr1:154428781(+) A-I      intronic chr1:154428046(+) A-I      intronic chr1:154427661(+) A-I      intronic chr1:154427502(+) A-I      intronic chr1:154425638(+) A-I      intronic chr1:154425622(+) A-I      intronic chr1:154425602(+) A-I      intronic chr1:154425593(+) A-I      intronic chr1:154425592(+) A-I      intronic chr1:154425570(+) A-I      intronic chr1:154425502(+) A-I      intronic chr1:154425431(+) A-I      intronic chr1:154425425(+) A-I      intronic chr1:154425160(+) A-I      intronic chr1:154425153(+) A-I      intronic chr1:154429579(+) A-I      intronic chr1:154384237(+) A-I      intronic chr1:154413364(+) A-I      intronic chr1:154409666(+) A-I      intronic chr1:154427580(+) A-I      intronic chr1:154429678(+) A-I      intronic chr1:154425466(+) A-I      intronic chr1:154408940(+) A-I      intronic chr1:154427431(+) A-I      intronic chr1:154406224(+) A-I      intronic chr1:154416858(+) A-I      intronic chr1:154417211(+) A-I      intronic chr1:154417320(+) A-I      intronic chr1:154406402(+) A-I      intronic chr1:154429535(+) A-I      intronic chr1:154417192(+) A-I      intronic chr1:154424152(+) A-I      intronic chr1:154424198(+) A-I      intronic chr1:154415395(+) A-I      intronic chr1:154406291(+) A-I      intronic chr1:154417294(+) A-I      intronic chr1:154420412(+) A-I      intronic chr1:154413338(+) A-I      intronic chr1:154419496(+) A-I      intronic chr1:154409702(+) A-I      intronic chr1:154425465(+) A-I      intronic chr1:154416754(+) A-I      intronic chr1:154422799(+) A-I      intronic chr1:154419713(+) A-I      intronic chr1:154417096(+) A-I      intronic chr1:154437173(+) A-I      intronic chr1:154408807(+) A-I      intronic chr1:154416785(+) A-I      intronic chr1:154409604(+) A-I      intronic chr1:154417116(+) A-I      intronic chr1:154412479(+) A-I      intronic chr1:154417258(+) A-I      intronic chr1:154424212(+) A-I      intronic chr1:154422719(+) A-I      intronic chr1:154412065(+) A-I      intronic chr1:154428278(+) A-I      intronic chr1:154437328(+) A-I      intronic chr1:154406633(+) A-I      intronic chr1:154418115(+) A-I      intronic chr1:154417252(+) A-I      intronic chr1:154419714(+) A-I      intronic chr1:154406477(+) A-I      intronic chr1:154406471(+) A-I      intronic chr1:154429550(+) A-I      intronic chr1:154437398(+) A-I      intronic chr1:154415481(+) A-I      intronic chr1:154421801(+) A-I      intronic chr1:154425528(+) A-I      intronic chr1:154408919(+) A-I      intronic chr1:154428413(+) A-I      intronic chr1:154437202(+) A-I      intronic chr1:154427419(+) A-I      intronic chr1:154428454(+) A-I      intronic chr1:154428430(+) A-I      intronic chr1:154429597(+) A-I      intronic chr1:154429634(+) A-I      intronic chr1:154424274(+) A-I      intronic chr1:154418515(+) A-I      intronic chr1:154425221(+) A-I      intronic chr1:154428482(+) A-I      intronic chr1:154420364(+) A-I      intronic chr1:154420308(+) A-I      intronic chr1:154413351(+) A-I      intronic chr1:154437229(+) A-I      intronic chr1:154406625(+) A-I      intronic chr1:154437344(+) A-I      intronic chr1:154425534(+) A-I      intronic chr1:154412544(+) A-I      intronic chr1:154423739(+) A-I      intronic chr1:154418438(+) A-I      intronic chr1:154425186(+) A-I      intronic chr1:154388226(+) A-I      intronic chr1:154417242(+) A-I      intronic chr1:154409712(+) A-I      intronic chr1:154413290(+) A-I      intronic chr1:154421869(+) A-I      intronic chr1:154437251(+) A-I      intronic chr1:154417321(+) A-I      intronic chr1:154437324(+) A-I      intronic chr1:154419768(+) A-I      intronic chr1:154413390(+) A-I      intronic chr1:154429566(+) A-I      intronic chr1:154421654(+) A-I      intronic chr1:154437188(+) A-I      intronic chr1:154388302(+) A-I      intronic chr1:154422862(+) A-I      intronic chr1:154425558(+) A-I      intronic chr1:154410216(+) A-I      intronic chr1:154427483(+) A-I      intronic chr1:154419555(+) A-I      intronic chr1:154415376(+) A-I      intronic chr1:154428422(+) A-I      intronic chr1:154437284(+) A-I      intronic chr1:154408800(+) A-I      intronic chr1:154415434(+) A-I      intronic chr1:154413309(+) A-I      intronic chr1:154398444(+) A-I      intronic chr1:154416764(+) A-I      intronic chr1:154427556(+) A-I      intronic chr1:154425521(+) A-I      intronic chr1:154427999(+) A-I      intronic chr1:154428110(+) A-I      intronic chr1:154408944(+) A-I      intronic chr1:154428412(+) A-I      intronic chr1:154427607(+) A-I      intronic chr1:154428380(+) A-I      intronic chr1:154437179(+) A-I      intronic chr1:154421450(+) A-I      intronic chr1:154421842(+) A-I      intronic chr1:154408834(+) A-I      intronic chr1:154415289(+) A-I      intronic chr1:154425192(+) A-I      intronic chr1:154383615(+) A-I      intronic chr1:154421805(+) A-I      intronic chr1:154428371(+) A-I      intronic chr1:154409959(+) A-I      intronic chr1:154415294(+) A-I      intronic chr1:154408797(+) A-I      intronic chr1:154420292(+) A-I      intronic chr1:154429552(+) A-I      intronic chr1:154437350(+) A-I      intronic chr1:154437361(+) A-I      intronic chr1:154417232(+) A-I      intronic chr1:154429637(+) A-I      intronic chr1:154415307(+) A-I      intronic chr1:154408906(+) A-I      intronic chr1:154428799(+) A-I      intronic chr1:154408833(+) A-I      intronic chr1:154428483(+) A-I      intronic chr1:154417328(+) A-I      intronic chr1:154416957(+) A-I      intronic chr1:154386499(+) A-I      intronic chr1:154418151(+) A-I      intronic chr1:154417980(+) A-I      intronic chr1:154428113(+) A-I      intronic chr1:154415332(+) A-I      intronic chr1:154428439(+) A-I      intronic chr1:154425531(+) A-I      intronic chr1:154423744(+) A-I      intronic chr1:154429530(+) A-I      intronic chr1:154422874(+) A-I      intronic chr1:154384833(+) A-I      intronic chr1:154384269(+) A-I      intronic chr1:154425520(+) A-I      intronic chr1:154437391(+) A-I      intronic chr1:154427663(+) A-I      intronic chr1:154425053(+) A-I      intronic chr1:154435449(+) A-I      intronic chr1:154418424(+) A-I      intronic chr1:154412553(+) A-I      intronic chr1:154417288(+) A-I      intronic chr1:154413232(+) A-I      intronic chr1:154406407(+) A-I      intronic chr1:154429640(+) A-I      intronic chr1:154436687(+) A-I      intronic chr1:154406292(+) A-I      intronic chr1:154437279(+) A-I      intronic chr1:154420447(+) A-I      intronic chr1:154425525(+) A-I      intronic chr1:154419646(+) A-I      intronic chr1:154383635(+) A-I      intronic chr1:154428857(+) A-I      intronic chr1:154420247(+) A-I      intronic chr1:154417191(+) A-I      intronic chr1:154428373(+) A-I      intronic chr1:154428372(+) A-I      intronic chr1:154412518(+) A-I      intronic chr1:154429598(+) A-I      intronic chr1:154388200(+) A-I      intronic chr1:154427555(+) A-I      intronic chr1:154412569(+) A-I      intronic chr1:154424286(+) A-I      intronic chr1:154425522(+) A-I      intronic chr1:154417972(+) A-I      intronic chr1:154417299(+) A-I      intronic chr1:154417965(+) A-I      intronic chr1:154388393(+) A-I      intronic chr1:154416867(+) A-I      intronic chr1:154420291(+) A-I      intronic chr1:154413329(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	IL6R	chr1:154383615(+) A-G intron -    22484847 chr1:154383635(+) A-G intron -    22484847 chr1:154384237(+) A-G intron -    22484847 chr1:154384269(+) A-G intron -    22484847 chr1:154388200(+) A-G intron -    22484847 chr1:154388226(+) A-G intron -    22484847 chr1:154388302(+) A-G intron -    22484847 chr1:154406224(+) A-G intron -    22484847 chr1:154406291(+) A-G intron -    22484847 chr1:154406292(+) A-G intron -    22484847 chr1:154406402(+) A-G intron -    22484847 chr1:154406407(+) A-G intron -    22484847 chr1:154406625(+) A-G intron -    22484847 chr1:154408800(+) A-G intron -    22484847 chr1:154408833(+) A-G intron -    22484847 chr1:154408834(+) A-G intron -    22484847 chr1:154413149(+) G-T intron -    22484847 chr1:154413150(+) A-T intron -    22484847 chr1:154413232(+) A-G intron -    22484847 chr1:154413309(+) A-G intron -    22484847 chr1:154415307(+) A-G intron -    22484847 chr1:154416754(+) A-G intron -    22484847 chr1:154416785(+) A-G intron -    22484847 chr1:154416858(+) A-G intron -    22484847 chr1:154416867(+) A-G intron -    22484847 chr1:154417094(+) T-C intron -    22484847 chr1:154417096(+) A-G intron -    22484847 chr1:154417258(+) A-G intron -    22484847 chr1:154417294(+) A-G intron -    22484847 chr1:154417320(+) A-G intron -    22484847 chr1:154417328(+) A-G intron -    22484847 chr1:154417965(+) A-G intron -    22484847 chr1:154418424(+) A-G intron -    22484847 chr1:154418438(+) A-G intron -    22484847 chr1:154419555(+) A-G intron -    22484847 chr1:154419646(+) A-G intron -    22484847 chr1:154419713(+) A-G intron -    22484847 chr1:154420247(+) A-G intron -    22484847 chr1:154420292(+) A-G intron -    22484847 chr1:154420308(+) A-G intron -    22484847 chr1:154420364(+) A-G intron -    22484847 chr1:154420412(+) A-G intron -    22484847 chr1:154421869(+) A-G intron -    22484847 chr1:154422799(+) A-G intron -    22484847 chr1:154423739(+) A-G intron -    22484847 chr1:154423744(+) A-G intron -    22484847 chr1:154424132(+) C-T intron -    22484847 chr1:154424152(+) A-G intron -    22484847 chr1:154424198(+) A-G intron -    22484847 chr1:154424274(+) A-G intron -    22484847 chr1:154425186(+) A-G intron -    22484847 chr1:154425192(+) A-G intron -    22484847 chr1:154425465(+) A-G intron -    22484847 chr1:154425525(+) A-G intron -    22484847 chr1:154425558(+) A-G intron -    22484847 chr1:154427419(+) A-G intron -    22484847 chr1:154427431(+) A-G intron -    22484847 chr1:154428371(+) A-G intron -    22484847 chr1:154428372(+) A-G intron -    22484847 chr1:154428373(+) A-G intron -    22484847 chr1:154428412(+) A-G intron -    22484847 chr1:154429550(+) A-G intron -    22484847 chr1:154436642(+) A-T intron -    22484847 chr1:154437179(+) A-G intron -    22484847 chr1:154437251(+) A-G intron -    22484847 chr1:154437324(+) A-G intron -    22484847 chr1:154437328(+) A-G intron -    22484847 chr1:154437398(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	IL6R	chr1:154377841-154377842(+) m6A 5'UTR       24981863 chr1:154377937-154377938(+) m6A 5'UTR       24981863 chr1:154437652-154437653(+) m6A 3'UTR//CDS//exon       24284625 chr1:154437803-154437804(+) m6A 3'UTR//CDS       24284625//24209618//24981863//22608085 chr1:154437836-154437837(+) m6A 3'UTR//CDS       24284625//24981863//22608085 chr1:154437882-154437883(+) m6A 3'UTR       24284625//25456834//24981863//22608085 chr1:154437899-154437900(+) m6A 3'UTR       24284625//25456834//24981863//22608085 chr1:154438051-154438052(+) m6A 3'UTR       24284625//25456834//24981863//22575960//22608085 chr1:154438092-154438093(+) m6A 3'UTR       24284625//25456834//24981863//22575960//22608085 chr1:154438113-154438114(+) m6A 3'UTR       24284625//25456834//24981863//22575960//22608085 chr1:154438124-154438125(+) m6A 3'UTR       24284625//25456834//24981863//22575960//22608085 chr1:154438133-154438134(+) m6A 3'UTR       24284625//25456834//24981863//22575960//22608085 chr1:154438145-154438146(+) m6A 3'UTR       24284625//25456834//24981863//22575960//22608085 chr1:154438321-154438322(+) m6A 3'UTR       24284625//25456834//24981863 chr1:154438330-154438331(+) m6A 3'UTR       24284625//25456834//24981863 chr1:154438386-154438387(+) m6A 3'UTR       24284625//24981863 chr1:154438442-154438443(+) m6A 3'UTR       24284625//24981863 chr1:154438600-154438601(+) m6A 3'UTR       -

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-451a	Exosome Primary T lymphocytes     24356509 Exosome Plasma     29130611 Exosome Peripheral blood|Portal vein blood     30561106 Exosome Serum     18589210 Exosome Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901 Exosome Breast cancer cell line (MCF-7)     20976003 Exosome B cell line (Raji)|Jurkat-derived T cell line (J77cl20)     21505438 Exosome Renal cancer cells     21670082 Exosome HCC cell line (Hep3B|HepG2|PLC/PRF/5)     21721029 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Human mast cell line (HMC-1)     24009880 Exosome Plasma     24130905 Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326 Exosome Blood|B lymphoblastoid cells|Endothelial cells|Lymphoma tissue|Mast cells     - Extracellular Vesicle Liposarcoma cell lines (Lipo224B|Lipo246|Lipo863|LPS141)|Preadipocytes     28588009 Extracellular vesicle HEK-293T cells     22849433 Extracellular vesicle Colon cancer cell line (LIM1863)     25330373 Microvesicle Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901 Microvesicle Liver resident stem cells|Mesenchymal stem cells     20668554 Microvesicle Plasma     23077538 Microvesicle Blood|Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     -
	IL6R	Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleus HCC cell line (HepG2)     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-451a
Interactor2: IL6R

Evidence Support:

Strong-Evidence	Dual luciferase reporter assay//qRT-PCR//Western blot
Support Database	ViRBase

References:

PMID	33675361	Target region	None
Source	ViRBase	Interactor1 expression	Downregulation
Tissue or cell line	Hela cells//RKO cells	Interactor2 expression	Downregulation
Description	In the current study, available miRNAs that regulate drug targets for treating COVID-19 in clinical trials are summarized in Table 2. miRNAs regulate the clinical targets of SARS-CoV-2 in TTD.