Basic Information
RNALocate ID: RLID:11002835
RNA Symbol: hsa-miR-451a
Localization: Microvesicle
RNA Information
RNA Name: hsa-miR-451
RNA ID: miRBase:MIMAT0001631
RNA Category: miRNA
Species: Homo sapiens
Sequence:
Localization Information
PubMed ID: 20615901
Tissue/Cell Line: Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)
Method: Microarray|RT-PCR

Originally published in Nucleic Acids Res. Wang K, et al, 2010. Reproduced under the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/)
Description: These observations of miRNA distribution demonstrate that the miRNA export system in the cells must somehow be able to target specific miRNAs to specific extracellular structures, but does not exclusively channel specific miRNAs to a given fraction. There are, however, some miRNAs that are found in the supernatant almost to the exclusion of all other fractions (miR-219 in A549 culture medium, Figure 4b, for example). Another significant observation from this data is that even though we showed that the two cell lines studied here export a similar spectrum of miRNAs (Figure 1b) the distributions of miRNAs from the two cell lines demonstrate clear differences, as shown in Figure 4b and c. For example, miR-145 is present at very low levels in HepG2 derived microvesicles (Figure 4c), while the same miRNA is present at significant levels in both A549 derived microvesicles and exosomes (Figure 4b). On the other hand, there are some miRNAs, notably those that are almost uniformly distributed among the fractions, with the same distribution no matter which cell-line is the source. These observations certainly indicate the degree of complexity of this export system that will bear further investigation. Data are collected from Figure 4.
Other Subcellular Localization
RNALocate ID Localization Tissue/Cell line PubMed ID
RLID:11002818 Exosome Primary T lymphocytes 24356509
RLID:11002819 Exosome Plasma 29130611
RLID:11002820 Exosome Peripheral blood|Portal vein blood 30561106
RLID:11002821 Exosome Serum 18589210
RLID:11002822 Exosome Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549) 20615901
RLID:11002823 Exosome Breast cancer cell line (MCF-7) 20976003
RLID:11002824 Exosome B cell line (Raji)|Jurkat-derived T cell line (J77cl20) 21505438
RLID:11002825 Exosome Renal cancer cells 21670082
RLID:11002826 Exosome HCC cell line (Hep3B|HepG2|PLC/PRF/5) 21721029
RLID:11002827 Exosome Brain tissue 23382797
RLID:11002828 Exosome Plasma 23663360
RLID:11002829 Exosome Human mast cell line (HMC-1) 24009880
RLID:11002830 Exosome Plasma 24130905
RLID:11002831 Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells 25242326
RLID:11002832 Extracellular Vesicle Liposarcoma cell lines (Lipo224B|Lipo246|Lipo863|LPS141)|Preadipocytes 28588009
RLID:11002833 Extracellular vesicle HEK-293T cells 22849433
RLID:11002834 Extracellular vesicle Colon cancer cell line (LIM1863) 25330373
RLID:11002836 Microvesicle Liver resident stem cells|Mesenchymal stem cells 20668554
RLID:11002837 Microvesicle Plasma 23077538
RLID-D:11000144 Exosome Blood|B lymphoblastoid cells|Endothelial cells|Lymphoma tissue|Mast cells
RLID-D:11000461 Microvesicle Blood|Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine
ncRNA Disease Information
Resource RNA Symbol Disease Link
MNDR hsa-mir-451a Pterygium MNDR-E-MI-51116
MNDR hsa-mir-451a Adult T cell leukemia MNDR-E-MI-51117
MNDR hsa-miR-451a Large cell neuroendocrine cancer MNDR-E-MI-51118
MNDR hsa-miR-451a Follicular lymphoma MNDR-E-MI-51119
MNDR hsa-miR-451a Medulloblastoma MNDR-E-MI-51120
MNDR hsa-miR-451a High-grade serous ovarian carcinoma MNDR-E-MI-51121
MNDR hsa-miR-451a Ovarian clear cell carcinoma MNDR-E-MI-51122
MNDR hsa-miR-451a Uterine corpus endometrial carcinoma MNDR-E-MI-51123
MNDR hsa-miR-451a Lymphoma MNDR-E-MI-51124
MNDR hsa-miR-451a Estrogen-receptor positive breast cancer MNDR-E-MI-51125
MNDR hsa-miR-451a Estrogen-receptor negative breast cancer MNDR-E-MI-51126
MNDR hsa-miR-451a Progesterone-receptor positive breast cancer MNDR-E-MI-51127
MNDR hsa-miR-451a Progesterone-receptor negative breast cancer MNDR-E-MI-51128
MNDR hsa-miR-451a Her2-receptor positive breast cancer MNDR-E-MI-51129
MNDR hsa-miR-451a Breast cancer luminal MNDR-E-MI-51130
MNDR hsa-miR-451a Anencephaly MNDR-E-MI-51131
MNDR hsa-miR-451a Precursor cell lymphoblastic leukemia-lymphoma MNDR-E-MI-51132
MNDR hsa-mir-451a Colorectal carcinoma MNDR-E-MI-51133
MNDR hsa-miR-451a Fatty liver non-alcoholic MNDR-E-MI-51134
MNDR hsa-mir-451a Fatty liver non-alcoholic MNDR-E-MI-51135
MNDR hsa-mir-451a Acth-independent macronodular adrenal hyperplasia; aimah MNDR-E-MI-51136
MNDR hsa-miR-451a Prostate cancer MNDR-E-MI-51137
MNDR hsa-mir-451a Early-stage gastric carcinoma MNDR-E-MI-51138
MNDR hsa-miR-451a Gastric cancer MNDR-E-MI-51139
MNDR hsa-miR-451a Alzheimer disease MNDR-E-MI-51140
MNDR hsa-miR-451a Sickle cell anemia MNDR-E-MI-51141
MNDR hsa-mir-451a Sickle cell diseases MNDR-E-MI-51142
MNDR hsa-miR-451a Intracranial aneurysm MNDR-E-MI-51143
MNDR hsa-mir-451a Bladder cancer MNDR-E-MI-51144
MNDR hsa-miR-451a Esophageal carcinoma MNDR-E-MI-51145
MNDR hsa-mir-451a Esophageal carcinoma MNDR-E-MI-51146
MNDR hsa-miR-451a Sarcoma MNDR-E-MI-51147
MNDR hsa-miR-451a Dysautonomia familial MNDR-E-MI-51148
MNDR hsa-miR-451a Seizures MNDR-E-MI-51149
MNDR hsa-miR-451a Head and neck cancer MNDR-E-MI-51150
MNDR hsa-miR-451a Hypertrophic cardiomyopathy MNDR-E-MI-51151
MNDR hsa-miR-451a Primary biliary cirrhosis MNDR-E-MI-51152
MNDR hsa-miR-451a Malaria MNDR-E-MI-51153
MNDR hsa-mir-451a Malaria MNDR-E-MI-51154
MNDR hsa-miR-451a Leukemia MNDR-E-MI-51155
MNDR hsa-mir-451a Leiomyoma MNDR-E-MI-51156
MNDR hsa-miR-451a Huntington disease MNDR-E-MI-51157
MNDR hsa-miR-451a Chorea MNDR-E-MI-51158
MNDR hsa-miR-451a Cardiovascular disease MNDR-E-MI-51159
MNDR hsa-mir-451a Dilated cardiomyopathy MNDR-E-MI-51160
MNDR hsa-miR-451a Moyamoya disease MNDR-E-MI-51161
MNDR hsa-miR-451a Brain cancer MNDR-E-MI-51162
MNDR hsa-miR-451a Uterine fibroid MNDR-E-MI-51163
MNDR hsa-mir-451a Lung cancer MNDR-E-MI-51164
MNDR hsa-miR-451a Lung cancer MNDR-E-MI-51165
MNDR hsa-miR-451a Down syndrome MNDR-E-MI-51166
MNDR hsa-miR-451a Parkinson disease MNDR-E-MI-51167
MNDR hsa-miR-451a Major depressive disorder MNDR-E-MI-51168
MNDR hsa-miR-451a Basal-like breast cancer MNDR-E-MI-51169
MNDR hsa-mir-451a Breast cancer MNDR-E-MI-51170
MNDR hsa-mir-451a Neoplasms MNDR-E-MI-51171
MNDR hsa-mir-451a Squamous cell carcinoma MNDR-E-MI-51172
MNDR hsa-miR-451a Thyroid cancer MNDR-E-MI-51173
MNDR hsa-miR-451a Pituitary neoplasms MNDR-E-MI-51174
MNDR hsa-mir-451a Pancreatic cancer MNDR-E-MI-51175
MNDR hsa-miR-451a Pancreatic cancer MNDR-E-MI-51176
MNDR hsa-mir-451a Supravalvar aortic stenosis MNDR-E-MI-51177
MNDR hsa-miR-451a Rectum adenocarcinoma MNDR-E-MI-51178
MNDR hsa-miR-451a Nephroblastoma MNDR-E-MI-51179
MNDR hsa-miR-451a Colon cancer MNDR-E-MI-51180
MNDR hsa-mir-451a Colon cancer MNDR-E-MI-51181
MNDR hsa-miR-451a Ischemic attack transient MNDR-E-MI-51182
MNDR hsa-miR-451a Colon adenocarcinoma MNDR-E-MI-51183
MNDR hsa-miR-451a Multiple sclerosis relapsing-remitting MNDR-E-MI-51184
MNDR hsa-miR-451a Familial ovarian cancer MNDR-E-MI-51185
MNDR hsa-mir-451a Ovarian cancer MNDR-E-MI-51186
MNDR hsa-mir-451a Basal cell carcinoma MNDR-E-MI-51187
MNDR hsa-miR-451a Prostate adenocarcinoma MNDR-E-MI-51188
MNDR hsa-miR-451a Thyroid adenomas MNDR-E-MI-51189
MNDR hsa-mir-451a Pulmonary tuberculosis MNDR-E-MI-51190
MNDR hsa-miR-451a Carcinoma ductal breast MNDR-E-MI-51191
MNDR hsa-miR-451a Glioblastoma MNDR-E-MI-51192
MNDR hsa-mir-451a Glioblastoma MNDR-E-MI-51193
MNDR hsa-mir-451a Glioblastoma multiforme somatic MNDR-E-MI-51194
MNDR hsa-miR-451a Glioma MNDR-E-MI-51195
MNDR hsa-mir-451a Glioma MNDR-E-MI-51196
MNDR hsa-miR-451a Chronic obstructive pulmonary disease MNDR-E-MI-51197
MNDR hsa-mir-451a Gastrointestinal neoplasms MNDR-E-MI-51198
MNDR hsa-miR-451a Amyotrophic lateral sclerosis MNDR-E-MI-51199
MNDR hsa-miR-451a Epilepsy temporal lobe MNDR-E-MI-51200
MNDR hsa-miR-451a Osteosarcoma MNDR-E-MI-51201
MNDR hsa-mir-451a Osteosarcoma MNDR-E-MI-51202
MNDR hsa-miR-451a Liposarcoma MNDR-E-MI-51203
MNDR hsa-mir-451a Liposarcoma MNDR-E-MI-51204
MNDR hsa-miR-451a Breast carcinoma MNDR-E-MI-51205
MNDR hsa-miR-451a Meningioma MNDR-E-MI-51206
MNDR hsa-miR-451a Liver cancer MNDR-E-MI-51207
MNDR hsa-mir-451a Mucinous cystadenocarcinoma MNDR-E-MI-51208
MNDR hsa-miR-451a Cervical adenocarcinoma MNDR-E-MI-51209
MNDR hsa-miR-451a Gastric adenocarcinoma MNDR-E-MI-51210
MNDR hsa-miR-451a Cervical squamous cell carcinoma MNDR-E-MI-51211
MNDR hsa-miR-451a Pituitary adenoma MNDR-E-MI-51212
MNDR hsa-miR-451a Lung squamous cell carcinoma MNDR-E-MI-51213
MNDR hsa-mir-451a Carcinoma lung non-small-cell MNDR-E-MI-51214
MNDR hsa-miR-451a Non-small cell lung cancer MNDR-E-MI-51215
MNDR hsa-miR-451a Lung adenocarcinoma MNDR-E-MI-51216
MNDR hsa-mir-451a Lung adenocarcinoma MNDR-E-MI-51217
MNDR hsa-miR-451a Thyroid carcinoma MNDR-E-MI-51218
MNDR hsa-mir-451a Papillary thyroid carcinoma MNDR-E-MI-51219
MNDR hsa-miR-451a Ovarian carcinoma MNDR-E-MI-51220
MNDR hsa-miR-451a Bladder urothelial carcinoma MNDR-E-MI-51221
MNDR hsa-miR-451a Pancreatic adenocarcinoma MNDR-E-MI-51222
MNDR hsa-mir-451a Cervical cancer MNDR-E-MI-51223
MNDR hsa-miR-451a Myasthenia gravis autoimmune experimental MNDR-E-MI-51224
MNDR hsa-miR-451a Carcinoma renal cell MNDR-E-MI-51225
MNDR hsa-mir-451a Renal cell carcinoma MNDR-E-MI-51226
MNDR hsa-miR-451a Kidney renal papillary cell carcinoma MNDR-E-MI-51227
MNDR hsa-miR-451a Renal clear cell carcinoma MNDR-E-MI-51228
MNDR hsa-miR-451a Large cell carcinoma MNDR-E-MI-51229
MNDR hsa-miR-451a Biliary tract cancer MNDR-E-MI-51230
MNDR hsa-miR-451a Intrahepatic cholangiocarcinoma MNDR-E-MI-51231
MNDR hsa-miR-451a Cholangiocarcinoma MNDR-E-MI-51232
MNDR hsa-mir-451a Esophageal cancer MNDR-E-MI-51233
MNDR hsa-miR-451a Esophageal cancer MNDR-E-MI-51234
MNDR hsa-miR-451a Liver cirrhosis MNDR-E-MI-51235
MNDR hsa-miR-451a Prolactinoma MNDR-E-MI-51236
MNDR hsa-miR-451a Lung small cell carcinoma MNDR-E-MI-51237
MNDR hsa-miR-451a Head and neck squamous cell carcinoma MNDR-E-MI-51238
MNDR hsa-mir-451a Head and neck squamous cell carcinoma MNDR-E-MI-51239
MNDR hsa-mir-451a Myocardial infarction MNDR-E-MI-51240
MNDR hsa-miR-451a Fibromyalgia MNDR-E-MI-51241
MNDR hsa-mir-451a Pulmonary hypertension MNDR-E-MI-51242
MNDR hsa-miR-451a Adenoma MNDR-E-MI-51243
MNDR hsa-miR-451a Breast invasive carcinoma MNDR-E-MI-51244
MNDR hsa-mir-451a Carcinoma hepatocellular MNDR-E-MI-51245
MNDR hsa-miR-451a Early hepatocellular carcinoma MNDR-E-MI-51246
MNDR hsa-miR-451a Embryonal cancer MNDR-E-MI-51247
MNDR hsa-miR-451a Familiar ovarian carcinoma MNDR-E-MI-51248
MNDR hsa-mir-451a Precursor b-cell lymphoblastic leukemia-lymphoma MNDR-E-MI-51249
MNDR hsa-miR-451a B-cell lymphoma MNDR-E-MI-51250
MNDR hsa-mir-451a Rheumatoid arthritis MNDR-E-MI-51251
MNDR hsa-miR-451a Rheumatoid arthritis MNDR-E-MI-51252
MNDR hsa-mir-451a Hypopharyngeal cancer MNDR-E-MI-51253
MNDR hsa-mir-451a Gastroesphageal reflux MNDR-E-MI-51254
MNDR hsa-miR-451a Chronic myelogenous leukemia MNDR-E-MI-51255
MNDR hsa-mir-451a Chronic myelogenous leukemia MNDR-E-MI-51256
MNDR hsa-miR-451a Neuromyelitis optica MNDR-E-MI-51257
MNDR hsa-mir-451a Polycythemia vera MNDR-E-MI-51258
MNDR hsa-miR-451a Acute myelocytic leukemia MNDR-E-MI-51259
MNDR hsa-mir-451a Acute myeloid leukemia MNDR-E-MI-51260
MNDR hsa-miR-451a Colorectal cancer MNDR-E-MI-51261
MNDR hsa-mir-451a Colorectal cancer MNDR-E-MI-51262
MNDR hsa-mir-451a Carcinoma nasopharyngeal MNDR-E-MI-51263
MNDR hsa-mir-451a Nasopharynx carcinoma MNDR-E-MI-51264
MNDR hsa-miR-451a Tyrosinemias MNDR-E-MI-51265
MNDR hsa-miR-451a Leukemia lymphoblastic acute MNDR-E-MI-51266
MNDR hsa-mir-451a Diabetic nephropathies MNDR-E-MI-51267
MNDR hsa-miR-451a Ependymoma MNDR-E-MI-51268
MNDR hsa-mir-451a Erythropoiesis MNDR-E-MI-51269
MNDR hsa-miR-451a Hearing loss noise-induced MNDR-E-MI-51270
MNDR hsa-miR-451a Cardiomegaly MNDR-E-MI-51271
MNDR hsa-mir-451a Infection MNDR-E-MI-51272
MNDR hsa-miR-451a Nasopharyngeal cancer MNDR-E-MI-51273
MNDR hsa-mir-451a Trophoblasts MNDR-E-MI-51274
MNDR hsa-mir-451a Retinal neovascularization MNDR-E-MI-51275
MNDR hsa-mir-451a Ischemic heart disease MNDR-E-MI-51276
MNDR hsa-miR-451a Subarachnoid hemorrhage traumatic MNDR-E-MI-51277
MNDR hsa-miR-451a Stroke lacunar MNDR-E-MI-51278
MNDR hsa-mir-451a Non-alcoholic fatty liver disease MNDR-E-MI-51279
MNDR hsa-miR-451a Breast cancer her3+ negative MNDR-E-MI-51280
MNDR hsa-miR-451a High grade dysplastic nodule MNDR-E-MI-51281
MNDR hsa-mir-451a Hypopharyngeal squamous cell carcinoma MNDR-E-MI-51282
MNDR hsa-mir-451a Stroke susceptibility MNDR-E-MI-51283
RNA Interaction Information
Resource RNA Symbol Species Link RNALocate ID
RNAInter ABCB1 Homo sapiens RR00022787
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