Basic Information
RNALocate ID: | RLID:11002822 |
RNA Symbol: | hsa-miR-451a |
Localization: | Exosome |
RNA Information
RNA Name: | hsa-miR-451 |
RNA ID: | miRBase:MIMAT0001631 |
RNA Category: | miRNA |
Species: | Homo sapiens |
Localization Information
PubMed ID: | 20615901 |
Tissue/Cell Line: | Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549) |
Method: | Microarray|RT-PCR |
Originally published in Nucleic Acids Res. Wang K, et al, 2010. Reproduced under the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) |
|
Description: | These observations of miRNA distribution demonstrate that the miRNA export system in the cells must somehow be able to target specific miRNAs to specific extracellular structures, but does not exclusively channel specific miRNAs to a given fraction. There are, however, some miRNAs that are found in the supernatant almost to the exclusion of all other fractions (miR-219 in A549 culture medium, Figure 4b, for example). Another significant observation from this data is that even though we showed that the two cell lines studied here export a similar spectrum of miRNAs (Figure 1b) the distributions of miRNAs from the two cell lines demonstrate clear differences, as shown in Figure 4b and c. For example, miR-145 is present at very low levels in HepG2 derived microvesicles (Figure 4c), while the same miRNA is present at significant levels in both A549 derived microvesicles and exosomes (Figure 4b). On the other hand, there are some miRNAs, notably those that are almost uniformly distributed among the fractions, with the same distribution no matter which cell-line is the source. These observations certainly indicate the degree of complexity of this export system that will bear further investigation. Data are collected from Figure 4. |
Other Subcellular Localization
RNALocate ID | Localization | Tissue/Cell line | PubMed ID |
RLID:11002818 | Exosome | Primary T lymphocytes | 24356509 |
RLID:11002819 | Exosome | Plasma | 29130611 |
RLID:11002820 | Exosome | Peripheral blood|Portal vein blood | 30561106 |
RLID:11002821 | Exosome | Serum | 18589210 |
RLID:11002823 | Exosome | Breast cancer cell line (MCF-7) | 20976003 |
RLID:11002824 | Exosome | B cell line (Raji)|Jurkat-derived T cell line (J77cl20) | 21505438 |
RLID:11002825 | Exosome | Renal cancer cells | 21670082 |
RLID:11002826 | Exosome | HCC cell line (Hep3B|HepG2|PLC/PRF/5) | 21721029 |
RLID:11002827 | Exosome | Brain tissue | 23382797 |
RLID:11002828 | Exosome | Plasma | 23663360 |
RLID:11002829 | Exosome | Human mast cell line (HMC-1) | 24009880 |
RLID:11002830 | Exosome | Plasma | 24130905 |
RLID:11002831 | Exosome | B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells | 25242326 |
RLID:11002832 | Extracellular Vesicle | Liposarcoma cell lines (Lipo224B|Lipo246|Lipo863|LPS141)|Preadipocytes | 28588009 |
RLID:11002833 | Extracellular vesicle | HEK-293T cells | 22849433 |
RLID:11002834 | Extracellular vesicle | Colon cancer cell line (LIM1863) | 25330373 |
RLID:11002835 | Microvesicle | Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549) | 20615901 |
RLID:11002836 | Microvesicle | Liver resident stem cells|Mesenchymal stem cells | 20668554 |
RLID:11002837 | Microvesicle | Plasma | 23077538 |
RLID-D:11000144 | Exosome | Blood|B lymphoblastoid cells|Endothelial cells|Lymphoma tissue|Mast cells | |
RLID-D:11000461 | Microvesicle | Blood|Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine |
ncRNA Disease Information
Resource | RNA Symbol | Disease | Link |
MNDR | hsa-mir-451a | Pterygium | MNDR-E-MI-51116 |
MNDR | hsa-mir-451a | Adult T cell leukemia | MNDR-E-MI-51117 |
MNDR | hsa-miR-451a | Large cell neuroendocrine cancer | MNDR-E-MI-51118 |
MNDR | hsa-miR-451a | Follicular lymphoma | MNDR-E-MI-51119 |
MNDR | hsa-miR-451a | Medulloblastoma | MNDR-E-MI-51120 |
MNDR | hsa-miR-451a | High-grade serous ovarian carcinoma | MNDR-E-MI-51121 |
MNDR | hsa-miR-451a | Ovarian clear cell carcinoma | MNDR-E-MI-51122 |
MNDR | hsa-miR-451a | Uterine corpus endometrial carcinoma | MNDR-E-MI-51123 |
MNDR | hsa-miR-451a | Lymphoma | MNDR-E-MI-51124 |
MNDR | hsa-miR-451a | Estrogen-receptor positive breast cancer | MNDR-E-MI-51125 |
MNDR | hsa-miR-451a | Estrogen-receptor negative breast cancer | MNDR-E-MI-51126 |
MNDR | hsa-miR-451a | Progesterone-receptor positive breast cancer | MNDR-E-MI-51127 |
MNDR | hsa-miR-451a | Progesterone-receptor negative breast cancer | MNDR-E-MI-51128 |
MNDR | hsa-miR-451a | Her2-receptor positive breast cancer | MNDR-E-MI-51129 |
MNDR | hsa-miR-451a | Breast cancer luminal | MNDR-E-MI-51130 |
MNDR | hsa-miR-451a | Anencephaly | MNDR-E-MI-51131 |
MNDR | hsa-miR-451a | Precursor cell lymphoblastic leukemia-lymphoma | MNDR-E-MI-51132 |
MNDR | hsa-mir-451a | Colorectal carcinoma | MNDR-E-MI-51133 |
MNDR | hsa-miR-451a | Fatty liver non-alcoholic | MNDR-E-MI-51134 |
MNDR | hsa-mir-451a | Fatty liver non-alcoholic | MNDR-E-MI-51135 |
MNDR | hsa-mir-451a | Acth-independent macronodular adrenal hyperplasia; aimah | MNDR-E-MI-51136 |
MNDR | hsa-miR-451a | Prostate cancer | MNDR-E-MI-51137 |
MNDR | hsa-mir-451a | Early-stage gastric carcinoma | MNDR-E-MI-51138 |
MNDR | hsa-miR-451a | Gastric cancer | MNDR-E-MI-51139 |
MNDR | hsa-miR-451a | Alzheimer disease | MNDR-E-MI-51140 |
MNDR | hsa-miR-451a | Sickle cell anemia | MNDR-E-MI-51141 |
MNDR | hsa-mir-451a | Sickle cell diseases | MNDR-E-MI-51142 |
MNDR | hsa-miR-451a | Intracranial aneurysm | MNDR-E-MI-51143 |
MNDR | hsa-mir-451a | Bladder cancer | MNDR-E-MI-51144 |
MNDR | hsa-miR-451a | Esophageal carcinoma | MNDR-E-MI-51145 |
MNDR | hsa-mir-451a | Esophageal carcinoma | MNDR-E-MI-51146 |
MNDR | hsa-miR-451a | Sarcoma | MNDR-E-MI-51147 |
MNDR | hsa-miR-451a | Dysautonomia familial | MNDR-E-MI-51148 |
MNDR | hsa-miR-451a | Seizures | MNDR-E-MI-51149 |
MNDR | hsa-miR-451a | Head and neck cancer | MNDR-E-MI-51150 |
MNDR | hsa-miR-451a | Hypertrophic cardiomyopathy | MNDR-E-MI-51151 |
MNDR | hsa-miR-451a | Primary biliary cirrhosis | MNDR-E-MI-51152 |
MNDR | hsa-miR-451a | Malaria | MNDR-E-MI-51153 |
MNDR | hsa-mir-451a | Malaria | MNDR-E-MI-51154 |
MNDR | hsa-miR-451a | Leukemia | MNDR-E-MI-51155 |
MNDR | hsa-mir-451a | Leiomyoma | MNDR-E-MI-51156 |
MNDR | hsa-miR-451a | Huntington disease | MNDR-E-MI-51157 |
MNDR | hsa-miR-451a | Chorea | MNDR-E-MI-51158 |
MNDR | hsa-miR-451a | Cardiovascular disease | MNDR-E-MI-51159 |
MNDR | hsa-mir-451a | Dilated cardiomyopathy | MNDR-E-MI-51160 |
MNDR | hsa-miR-451a | Moyamoya disease | MNDR-E-MI-51161 |
MNDR | hsa-miR-451a | Brain cancer | MNDR-E-MI-51162 |
MNDR | hsa-miR-451a | Uterine fibroid | MNDR-E-MI-51163 |
MNDR | hsa-mir-451a | Lung cancer | MNDR-E-MI-51164 |
MNDR | hsa-miR-451a | Lung cancer | MNDR-E-MI-51165 |
MNDR | hsa-miR-451a | Down syndrome | MNDR-E-MI-51166 |
MNDR | hsa-miR-451a | Parkinson disease | MNDR-E-MI-51167 |
MNDR | hsa-miR-451a | Major depressive disorder | MNDR-E-MI-51168 |
MNDR | hsa-miR-451a | Basal-like breast cancer | MNDR-E-MI-51169 |
MNDR | hsa-mir-451a | Breast cancer | MNDR-E-MI-51170 |
MNDR | hsa-mir-451a | Neoplasms | MNDR-E-MI-51171 |
MNDR | hsa-mir-451a | Squamous cell carcinoma | MNDR-E-MI-51172 |
MNDR | hsa-miR-451a | Thyroid cancer | MNDR-E-MI-51173 |
MNDR | hsa-miR-451a | Pituitary neoplasms | MNDR-E-MI-51174 |
MNDR | hsa-mir-451a | Pancreatic cancer | MNDR-E-MI-51175 |
MNDR | hsa-miR-451a | Pancreatic cancer | MNDR-E-MI-51176 |
MNDR | hsa-mir-451a | Supravalvar aortic stenosis | MNDR-E-MI-51177 |
MNDR | hsa-miR-451a | Rectum adenocarcinoma | MNDR-E-MI-51178 |
MNDR | hsa-miR-451a | Nephroblastoma | MNDR-E-MI-51179 |
MNDR | hsa-miR-451a | Colon cancer | MNDR-E-MI-51180 |
MNDR | hsa-mir-451a | Colon cancer | MNDR-E-MI-51181 |
MNDR | hsa-miR-451a | Ischemic attack transient | MNDR-E-MI-51182 |
MNDR | hsa-miR-451a | Colon adenocarcinoma | MNDR-E-MI-51183 |
MNDR | hsa-miR-451a | Multiple sclerosis relapsing-remitting | MNDR-E-MI-51184 |
MNDR | hsa-miR-451a | Familial ovarian cancer | MNDR-E-MI-51185 |
MNDR | hsa-mir-451a | Ovarian cancer | MNDR-E-MI-51186 |
MNDR | hsa-mir-451a | Basal cell carcinoma | MNDR-E-MI-51187 |
MNDR | hsa-miR-451a | Prostate adenocarcinoma | MNDR-E-MI-51188 |
MNDR | hsa-miR-451a | Thyroid adenomas | MNDR-E-MI-51189 |
MNDR | hsa-mir-451a | Pulmonary tuberculosis | MNDR-E-MI-51190 |
MNDR | hsa-miR-451a | Carcinoma ductal breast | MNDR-E-MI-51191 |
MNDR | hsa-miR-451a | Glioblastoma | MNDR-E-MI-51192 |
MNDR | hsa-mir-451a | Glioblastoma | MNDR-E-MI-51193 |
MNDR | hsa-mir-451a | Glioblastoma multiforme somatic | MNDR-E-MI-51194 |
MNDR | hsa-miR-451a | Glioma | MNDR-E-MI-51195 |
MNDR | hsa-mir-451a | Glioma | MNDR-E-MI-51196 |
MNDR | hsa-miR-451a | Chronic obstructive pulmonary disease | MNDR-E-MI-51197 |
MNDR | hsa-mir-451a | Gastrointestinal neoplasms | MNDR-E-MI-51198 |
MNDR | hsa-miR-451a | Amyotrophic lateral sclerosis | MNDR-E-MI-51199 |
MNDR | hsa-miR-451a | Epilepsy temporal lobe | MNDR-E-MI-51200 |
MNDR | hsa-miR-451a | Osteosarcoma | MNDR-E-MI-51201 |
MNDR | hsa-mir-451a | Osteosarcoma | MNDR-E-MI-51202 |
MNDR | hsa-miR-451a | Liposarcoma | MNDR-E-MI-51203 |
MNDR | hsa-mir-451a | Liposarcoma | MNDR-E-MI-51204 |
MNDR | hsa-miR-451a | Breast carcinoma | MNDR-E-MI-51205 |
MNDR | hsa-miR-451a | Meningioma | MNDR-E-MI-51206 |
MNDR | hsa-miR-451a | Liver cancer | MNDR-E-MI-51207 |
MNDR | hsa-mir-451a | Mucinous cystadenocarcinoma | MNDR-E-MI-51208 |
MNDR | hsa-miR-451a | Cervical adenocarcinoma | MNDR-E-MI-51209 |
MNDR | hsa-miR-451a | Gastric adenocarcinoma | MNDR-E-MI-51210 |
MNDR | hsa-miR-451a | Cervical squamous cell carcinoma | MNDR-E-MI-51211 |
MNDR | hsa-miR-451a | Pituitary adenoma | MNDR-E-MI-51212 |
MNDR | hsa-miR-451a | Lung squamous cell carcinoma | MNDR-E-MI-51213 |
MNDR | hsa-mir-451a | Carcinoma lung non-small-cell | MNDR-E-MI-51214 |
MNDR | hsa-miR-451a | Non-small cell lung cancer | MNDR-E-MI-51215 |
MNDR | hsa-miR-451a | Lung adenocarcinoma | MNDR-E-MI-51216 |
MNDR | hsa-mir-451a | Lung adenocarcinoma | MNDR-E-MI-51217 |
MNDR | hsa-miR-451a | Thyroid carcinoma | MNDR-E-MI-51218 |
MNDR | hsa-mir-451a | Papillary thyroid carcinoma | MNDR-E-MI-51219 |
MNDR | hsa-miR-451a | Ovarian carcinoma | MNDR-E-MI-51220 |
MNDR | hsa-miR-451a | Bladder urothelial carcinoma | MNDR-E-MI-51221 |
MNDR | hsa-miR-451a | Pancreatic adenocarcinoma | MNDR-E-MI-51222 |
MNDR | hsa-mir-451a | Cervical cancer | MNDR-E-MI-51223 |
MNDR | hsa-miR-451a | Myasthenia gravis autoimmune experimental | MNDR-E-MI-51224 |
MNDR | hsa-miR-451a | Carcinoma renal cell | MNDR-E-MI-51225 |
MNDR | hsa-mir-451a | Renal cell carcinoma | MNDR-E-MI-51226 |
MNDR | hsa-miR-451a | Kidney renal papillary cell carcinoma | MNDR-E-MI-51227 |
MNDR | hsa-miR-451a | Renal clear cell carcinoma | MNDR-E-MI-51228 |
MNDR | hsa-miR-451a | Large cell carcinoma | MNDR-E-MI-51229 |
MNDR | hsa-miR-451a | Biliary tract cancer | MNDR-E-MI-51230 |
MNDR | hsa-miR-451a | Intrahepatic cholangiocarcinoma | MNDR-E-MI-51231 |
MNDR | hsa-miR-451a | Cholangiocarcinoma | MNDR-E-MI-51232 |
MNDR | hsa-mir-451a | Esophageal cancer | MNDR-E-MI-51233 |
MNDR | hsa-miR-451a | Esophageal cancer | MNDR-E-MI-51234 |
MNDR | hsa-miR-451a | Liver cirrhosis | MNDR-E-MI-51235 |
MNDR | hsa-miR-451a | Prolactinoma | MNDR-E-MI-51236 |
MNDR | hsa-miR-451a | Lung small cell carcinoma | MNDR-E-MI-51237 |
MNDR | hsa-miR-451a | Head and neck squamous cell carcinoma | MNDR-E-MI-51238 |
MNDR | hsa-mir-451a | Head and neck squamous cell carcinoma | MNDR-E-MI-51239 |
MNDR | hsa-mir-451a | Myocardial infarction | MNDR-E-MI-51240 |
MNDR | hsa-miR-451a | Fibromyalgia | MNDR-E-MI-51241 |
MNDR | hsa-mir-451a | Pulmonary hypertension | MNDR-E-MI-51242 |
MNDR | hsa-miR-451a | Adenoma | MNDR-E-MI-51243 |
MNDR | hsa-miR-451a | Breast invasive carcinoma | MNDR-E-MI-51244 |
MNDR | hsa-mir-451a | Carcinoma hepatocellular | MNDR-E-MI-51245 |
MNDR | hsa-miR-451a | Early hepatocellular carcinoma | MNDR-E-MI-51246 |
MNDR | hsa-miR-451a | Embryonal cancer | MNDR-E-MI-51247 |
MNDR | hsa-miR-451a | Familiar ovarian carcinoma | MNDR-E-MI-51248 |
MNDR | hsa-mir-451a | Precursor b-cell lymphoblastic leukemia-lymphoma | MNDR-E-MI-51249 |
MNDR | hsa-miR-451a | B-cell lymphoma | MNDR-E-MI-51250 |
MNDR | hsa-mir-451a | Rheumatoid arthritis | MNDR-E-MI-51251 |
MNDR | hsa-miR-451a | Rheumatoid arthritis | MNDR-E-MI-51252 |
MNDR | hsa-mir-451a | Hypopharyngeal cancer | MNDR-E-MI-51253 |
MNDR | hsa-mir-451a | Gastroesphageal reflux | MNDR-E-MI-51254 |
MNDR | hsa-miR-451a | Chronic myelogenous leukemia | MNDR-E-MI-51255 |
MNDR | hsa-mir-451a | Chronic myelogenous leukemia | MNDR-E-MI-51256 |
MNDR | hsa-miR-451a | Neuromyelitis optica | MNDR-E-MI-51257 |
MNDR | hsa-mir-451a | Polycythemia vera | MNDR-E-MI-51258 |
MNDR | hsa-miR-451a | Acute myelocytic leukemia | MNDR-E-MI-51259 |
MNDR | hsa-mir-451a | Acute myeloid leukemia | MNDR-E-MI-51260 |
MNDR | hsa-miR-451a | Colorectal cancer | MNDR-E-MI-51261 |
MNDR | hsa-mir-451a | Colorectal cancer | MNDR-E-MI-51262 |
MNDR | hsa-mir-451a | Carcinoma nasopharyngeal | MNDR-E-MI-51263 |
MNDR | hsa-mir-451a | Nasopharynx carcinoma | MNDR-E-MI-51264 |
MNDR | hsa-miR-451a | Tyrosinemias | MNDR-E-MI-51265 |
MNDR | hsa-miR-451a | Leukemia lymphoblastic acute | MNDR-E-MI-51266 |
MNDR | hsa-mir-451a | Diabetic nephropathies | MNDR-E-MI-51267 |
MNDR | hsa-miR-451a | Ependymoma | MNDR-E-MI-51268 |
MNDR | hsa-mir-451a | Erythropoiesis | MNDR-E-MI-51269 |
MNDR | hsa-miR-451a | Hearing loss noise-induced | MNDR-E-MI-51270 |
MNDR | hsa-miR-451a | Cardiomegaly | MNDR-E-MI-51271 |
MNDR | hsa-mir-451a | Infection | MNDR-E-MI-51272 |
MNDR | hsa-miR-451a | Nasopharyngeal cancer | MNDR-E-MI-51273 |
MNDR | hsa-mir-451a | Trophoblasts | MNDR-E-MI-51274 |
MNDR | hsa-mir-451a | Retinal neovascularization | MNDR-E-MI-51275 |
MNDR | hsa-mir-451a | Ischemic heart disease | MNDR-E-MI-51276 |
MNDR | hsa-miR-451a | Subarachnoid hemorrhage traumatic | MNDR-E-MI-51277 |
MNDR | hsa-miR-451a | Stroke lacunar | MNDR-E-MI-51278 |
MNDR | hsa-mir-451a | Non-alcoholic fatty liver disease | MNDR-E-MI-51279 |
MNDR | hsa-miR-451a | Breast cancer her3+ negative | MNDR-E-MI-51280 |
MNDR | hsa-miR-451a | High grade dysplastic nodule | MNDR-E-MI-51281 |
MNDR | hsa-mir-451a | Hypopharyngeal squamous cell carcinoma | MNDR-E-MI-51282 |
MNDR | hsa-mir-451a | Stroke susceptibility | MNDR-E-MI-51283 |
RNA Interaction Information
Resource | RNA Symbol | Species | Link | RNALocate ID |
RNAInter | ABCB1 | Homo sapiens | RR00022787 |
TOP