Detail Information

Basic Information:


  VIRBase ID:  

HHID00105148

  Virus:  

SARS-CoV-2

  Host:  

Homo sapiens

  Confidence Score:  

0.2494

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-15b-5p:           TLR3:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-15b-5p TLR3
miRBase
Accession/Entrez ID		 MIMAT0000417 7098
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - CD283//IIAE2

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-15b-5p
rs752662639 chr3:160404619    A/T
rs767416190 chr3:160404617    T/A

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR TLR3
chr4:187001863(+) A-I      intronic
chr4:187003336(+) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase TLR3
chr4:186990367-186990368(+) m6A 5'UTR       24981863
chr4:186997778-186997779(+) m6A CDS       24981863
chr4:187003525-187003526(+) m6A 5'UTR//CDS//exon       24981863
chr4:187003579-187003580(+) m6A 5'UTR//CDS//exon       24981863
chr4:187003649-187003650(+) m6A 5'UTR//CDS//exon       24981863
chr4:187003659-187003660(+) m6A 5'UTR//CDS//exon       24981863
chr4:187003978-187003979(+) m6A CDS//exon       24981863
chr4:187004022-187004023(+) m6A CDS//exon       24284625//24981863
chr4:187004037-187004038(+) m6A CDS//exon       24284625//24981863
chr4:187004177-187004178(+) m6A CDS//exon       24209618//24981863
chr4:187004260-187004261(+) m6A CDS//exon       24284625//24209618//24981863
chr4:187004635-187004636(+) m6A CDS//exon       24981863
chr4:187004686-187004687(+) m6A CDS//exon       24981863
chr4:187004746-187004747(+) m6A CDS//exon       24981863
chr4:187004829-187004830(+) m6A CDS//exon       24284625//24209618//24981863
chr4:187004906-187004907(+) m6A CDS//exon       24284625//24209618//24981863
chr4:187004932-187004933(+) m6A CDS//exon       24284625//24209618//24981863
chr4:187004948-187004949(+) m6A CDS//exon       24284625//24209618//24981863
chr4:187005082-187005083(+) m6A CDS//exon       24284625//24981863
chr4:187005090-187005091(+) m6A CDS//exon       24284625//24981863
chr4:187005095-187005096(+) m6A CDS//exon       24284625//24981863
chr4:187005155-187005156(+) m6A CDS//exon       24284625//24981863
chr4:187005181-187005182(+) m6A CDS//exon       24284625//25456834//24981863
chr4:187005214-187005215(+) m6A CDS//exon       25456834//24981863
chr4:187005236-187005237(+) m6A CDS//exon       25456834//24981863
chr4:187005310-187005311(+) m6A CDS//exon       24981863
chr4:187005888-187005889(+) m6A CDS//exon       24981863
chr4:187005893-187005894(+) m6A CDS//exon       24981863
chr4:187005944-187005945(+) m6A CDS//exon       24981863
chr4:187006013-187006014(+) m6A CDS//exon       24981863

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-15b-5p
Cytoplasm Neural progenitor cells     21363885
Cytoplasm Cell line (HeLa)     21695135
Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Exosome Glioblastoma cells     19011622
Exosome Lung adenocarcinoma epithelial cell line (A549)     20615901
Exosome Breast cancer cell line (MCF-7)     20976003
Exosome Primary dendritic cells|T cell line (J77)     21505438
Exosome Renal cancer cells     21670082
Exosome Breast milk     22211110
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Human mast cell line (HMC-1)     24009880
Exosome Breast cancer cell lines (MCF-7|MDA-MB-231)     24468161
Exosome Endothelial cells|Epithelial cells     -
Extracellular vesicle HEK-293T cells     22849433
Microvesicle Glioblastoma cells     19011622
Microvesicle Lung epithelial carcinoma cell line (A549)     20615901
Microvesicle Plasma     23077538
Microvesicle Seminal plasma     23539611
Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     -
Mitochondrion Skeletal muscle myoblasts     21637849
Mitochondrion Cell line (HEK-293|HeLa)     22984580
Nucleolus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Nucleus Colon adenocarcinoma cells     20864815
TLR3
Exosome Blood     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-15b-5p
[[4-(3-Aminophenyl)-2-pyridyl]methyleneamino]thiourea 9556427 Drug sensitive
1,9-Pyrazoloanthrone 8515 Drug resistant
1,5-Methano-11H-furo(3,2-g)pyrano(3,2-b)xanthene-3a(4H)-crotonaldehyde, 1,2,5,7-tetrahydro-8-hydroxy-alpha,2,2,11,11-pentamethyl-13-(3-methyl-2-butenyl)-4,7-dioxo-, trans- 78358492 Drug sensitive
Acnistin F 6712173 Drug sensitive
Piriqualone 6015423 Drug sensitive
trans-1,2-Bis(propylsulfonyl)ethylene 5904452 Drug sensitive
Artelasticin 5471311 Drug sensitive
5,10-Dimethoxybenzo[g]quinolin-2(1H)-one 54612875 Drug resistant
Withacnistin 54606507 Drug sensitive
Antineoplastic-651590 54604785 Drug sensitive
Aspiculamycin hcl 54600418 Drug resistant
Pyrethrosin 5281496 Drug sensitive
Benzamide riboside 458027 Drug sensitive
S-(Dimethylarsino)-3-mercapto-1,2-propyl diacetate 406479 Drug sensitive
Ethanone, 1-[3-(bromomethyl)-1,4-dioxido-2-quinoxalinyl]- 404859 Drug sensitive
2-[(Phenylamino)methyl]benzene-1,4-diol 403336 Drug sensitive
11H-Benzo[a]carbazole-1,4-dione, 7,11-dimethyl- 371271 Drug sensitive
Helenin 327378 Drug sensitive
1H-Benzo[a]carbazole-1,4(11H)-dione, 11-methyl- 261066 Drug sensitive
(S)-2-Amino-3-(hydroxy(nitroso)amino)propanoic acid 136096147 Drug resistant
12-Iminodaunorubicin hcl 135539784 Drug sensitive
p-Toluquinone 11122 Drug sensitive
2,3-dihydro-1,2-syn-3-[phenylseleno]brefeldin a - Drug resistant
(1s,2e,4r,7e,11e)-4-hydroxy-2,7,11-cembratrien-6-one - Drug sensitive
(2r,3r)-(+)-methyl 3-phenyloxirane-carboxylate - Drug sensitive
1,2-naphthoquinone, 3,7-dimethyl- - Drug sensitive
1h-benzo[a]carbazole-1,4(11h)-dione, 11-phenyl- - Drug sensitive
2,2',5,5'-tetrahydroxy-4,4'-dimethylbiphenyl - Drug sensitive
2-bromo-5,8-dihydroxy-3-methyl-1,4-naphthoquinone - Drug sensitive
benzofurazan, 4-nitro-7-(2-pyridinylthio)-, n-oxide - Drug sensitive
benzofurazan, 5-nitro-6-(1-piperidinyl)-, 1-oxide - Drug sensitive
c4, carbonyl, ethyl prodigiosine - Drug sensitive
cyclopentanone, 2,5-bis[(trimethylamino)methyl]-, iodide - Drug sensitive
ethanone, 1-(2-pyrimidinyl)-, (2-benzoxazolyl)hydrazone - Drug sensitive
4-carbo-1-thiazolidine-3-o-gluconyl-.gamma.-lactone - Drug sensitive
cyclo [n-naphthoyl-d-lys-asn-gln-trp-ala-val-d-ala-his-leu] - Drug sensitive
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-15b-5p
Curcumin 969516 Drug interaction    RC00002458
Formaldehyde 712 Drug interaction    RC00002438
Bisphenol A 6623 Drug interaction    RC00002448
Aniline 6115 Drug interaction    RC00002447
Gemcitabine 60750 Drug interaction    RC00002454
Testosterone 6013 Drug interaction    RC00002446
Vincristine 5978 Drug interaction    RC00002445
Dehydroepiandrosterone 5881 Drug interaction    RC00002444
Estradiol 5757 Drug interaction    RC00002443
Eloxatine 5310940 Drug interaction    RC00002461
Imatinib 5291 Drug interaction    RC00002442
Morphine 5288826 Drug interaction    RC00002460
Cholecalciferol 5280795 Drug interaction    RC00002459
Diethylstilbestrol 448537 Drug interaction    RC00002457
Tretinoin 444795 Drug interaction    RC00002456
Etoposide 36462 Drug interaction    RC00002453
Paclitaxel 36314 Drug interaction    RC00002452
5-Fluorouracil 3385 Drug interaction    RC00002441
Doxorubicin 31703 Drug interaction    RC00002451
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00002440
Verapamil 2520 Drug interaction    RC00002439
Vinblastine 13342 Drug interaction    RC00002450
O,P'-Ddt 13089 Drug interaction    RC00002449
Ginsenoside Rh2 119307 Drug interaction    RC00002455
TRAIL therapy - Drug interaction    RC00002462
Glucocorticoid - Drug interaction    RC00002463
Marine fungal metabolite 1386A - Drug interaction    RC00002464
Chemotherapy - Drug interaction    RC00008841
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-15b-5p
5-Fluorouracil 3385       28646148

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-15b-5p
Interactor2: TLR3

Evidence Support:


Prediction-Evidence microT//miRanda//miRMap//PicTar//PITA//Targetscan
Support Database ViRBase

References:


PMID 33428154 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line None Interactor2 expression None
Description To explore the regulatory relationship between the 5 key genes, 3 coronavirus-related genes (ACE2, TMPRSS2, BSG), and their target miRNA, we used 6 miRNA target prediction databases to predict the target miRNA of these genes.

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