Basic Information
RNALocate ID: RLID:11001666
RNA Symbol: hsa-miR-15b-5p
Localization: Microvesicle
RNA Information
RNA Name: hsa-miR-15b
RNA ID: miRBase:MIMAT0000417
RNA Category: miRNA
Species: Homo sapiens
Sequence:
Localization Information
PubMed ID: 20615901
Tissue/Cell Line: Lung epithelial carcinoma cell line (A549)
Method: Microarray|RT-PCR

Originally published in Nucleic Acids Res. Wang K, et al, 2010. Reproduced under the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/)
Description: These observations of miRNA distribution demonstrate that the miRNA export system in the cells must somehow be able to target specific miRNAs to specific extracellular structures, but does not exclusively channel specific miRNAs to a given fraction. There are, however, some miRNAs that are found in the supernatant almost to the exclusion of all other fractions (miR-219 in A549 culture medium, Figure 4b, for example). Another significant observation from this data is that even though we showed that the two cell lines studied here export a similar spectrum of miRNAs (Figure 1b) the distributions of miRNAs from the two cell lines demonstrate clear differences, as shown in Figure 4b and c. For example, miR-145 is present at very low levels in HepG2 derived microvesicles (Figure 4c), while the same miRNA is present at significant levels in both A549 derived microvesicles and exosomes (Figure 4b). On the other hand, there are some miRNAs, notably those that are almost uniformly distributed among the fractions, with the same distribution no matter which cell-line is the source. These observations certainly indicate the degree of complexity of this export system that will bear further investigation. Data are collected from Figure 4.
Other Subcellular Localization
RNALocate ID Localization Tissue/Cell line PubMed ID
RLID:01001717 Cytoplasm Neural progenitor cells 21363885
RLID:01001718 Cytoplasm Cell line (HeLa) 21695135
RLID:01001719 Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa) 24918059
RLID:01001720 Mitochondrion Skeletal muscle myoblasts 21637849
RLID:01001721 Mitochondrion Cell line (HEK-293|HeLa) 22984580
RLID:01001722 Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa) 24918059
RLID:01001723 Nucleolus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa) 24918059
RLID:01001724 Nucleus Colon adenocarcinoma cells 20864815
RLID:11001654 Exosome Glioblastoma cells 19011622
RLID:11001655 Exosome Lung adenocarcinoma epithelial cell line (A549) 20615901
RLID:11001656 Exosome Breast cancer cell line (MCF-7) 20976003
RLID:11001657 Exosome Primary dendritic cells|T cell line (J77) 21505438
RLID:11001658 Exosome Renal cancer cells 21670082
RLID:11001659 Exosome Breast milk 22211110
RLID:11001660 Exosome Brain tissue 23382797
RLID:11001661 Exosome Plasma 23663360
RLID:11001662 Exosome Human mast cell line (HMC-1) 24009880
RLID:11001663 Exosome Breast cancer cell lines (MCF-7|MDA-MB-231) 24468161
RLID:11001664 Extracellular vesicle HEK-293T cells 22849433
RLID:11001665 Microvesicle Glioblastoma cells 19011622
RLID:11001667 Microvesicle Plasma 23077538
RLID:11001668 Microvesicle Seminal plasma 23539611
RLID-D:11000070 Exosome Endothelial cells|Epithelial cells
RLID-D:11000345 Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine
ncRNA Disease Information
Resource RNA Symbol Disease Link
MNDR hsa-miR-15b-5p Splenic marginal zone lymphoma MNDR-E-MI-18279
MNDR hsa-miR-15b-5p Multiple sclerosis chronic progressive MNDR-E-MI-18280
MNDR hsa-miR-15b-5p Tongue squamous cell carcinoma MNDR-E-MI-18281
MNDR hsa-miR-15b-5p Oral squamous cell carcinoma MNDR-E-MI-18282
MNDR hsa-miR-15b-5p High-grade serous ovarian carcinoma MNDR-E-MI-18283
MNDR hsa-miR-15b-5p Uterine corpus endometrial carcinoma MNDR-E-MI-18284
MNDR hsa-miR-15b-5p Lymphoma MNDR-E-MI-18285
MNDR hsa-miR-15b-5p Lymphoma non-hodgkin MNDR-E-MI-18286
MNDR hsa-miR-15b-5p Estrogen-receptor positive breast cancer MNDR-E-MI-18287
MNDR hsa-miR-15b-5p Estrogen-receptor negative breast cancer MNDR-E-MI-18288
MNDR hsa-miR-15b-5p Progesterone-receptor positive breast cancer MNDR-E-MI-18289
MNDR hsa-miR-15b-5p Progesterone-receptor negative breast cancer MNDR-E-MI-18290
MNDR hsa-miR-15b-5p Her2-receptor positive breast cancer MNDR-E-MI-18291
MNDR hsa-miR-15b-5p Acute promyelocytic leukemia MNDR-E-MI-18292
MNDR hsa-miR-15b-5p Breast cancer luminal MNDR-E-MI-18293
MNDR hsa-miR-15b-5p Niemann-pick disease type c MNDR-E-MI-18294
MNDR hsa-miR-15b-5p Lupus nephritis MNDR-E-MI-18295
MNDR hsa-miR-15b-5p Prostate cancer MNDR-E-MI-18296
MNDR hsa-miR-15b-5p Gastric cancer MNDR-E-MI-18297
MNDR hsa-miR-15b-5p Gastric lymphoma MNDR-E-MI-18298
MNDR hsa-miR-15b-5p Alzheimer disease MNDR-E-MI-18299
MNDR hsa-miR-15b-5p Encephalitis japanese MNDR-E-MI-18300
MNDR hsa-miR-15b-5p Intracranial aneurysm MNDR-E-MI-18301
MNDR hsa-miR-15b-5p Esophageal carcinoma MNDR-E-MI-18302
MNDR hsa-miR-15b-5p Dysautonomia familial MNDR-E-MI-18303
MNDR hsa-miR-15b-5p Seizures MNDR-E-MI-18304
MNDR hsa-miR-15b-5p Leukemia MNDR-E-MI-18305
MNDR hsa-miR-15b-5p Huntington disease MNDR-E-MI-18306
MNDR hsa-miR-15b-5p Chorea MNDR-E-MI-18307
MNDR hsa-miR-15b-5p Cardiovascular disease MNDR-E-MI-18308
MNDR hsa-miR-15b-5p Carotid stenosis MNDR-E-MI-18309
MNDR hsa-miR-15b-5p Moyamoya disease MNDR-E-MI-18310
MNDR hsa-miR-15b-5p Lung cancer MNDR-E-MI-18311
MNDR hsa-miR-15b-5p Fragile x syndrome MNDR-E-MI-18312
MNDR hsa-miR-15b-5p Parkinson disease MNDR-E-MI-18313
MNDR hsa-miR-15b-5p Niemann-pick disease MNDR-E-MI-18314
MNDR hsa-miR-15b-5p Basal-like breast cancer MNDR-E-MI-18315
MNDR hsa-miR-15b-5p Thyroid cancer MNDR-E-MI-18316
MNDR hsa-miR-15b-5p Pituitary neoplasms MNDR-E-MI-18317
MNDR hsa-miR-15b-5p Pancreatic cancer MNDR-E-MI-18318
MNDR hsa-miR-15b-5p Malignant melanoma MNDR-E-MI-18319
MNDR hsa-miR-15b-5p Gaucher disease MNDR-E-MI-18320
MNDR hsa-miR-15b-5p Rectum adenocarcinoma MNDR-E-MI-18321
MNDR hsa-miR-15b-5p Nephroblastoma MNDR-E-MI-18322
MNDR hsa-miR-15b-5p Colon cancer MNDR-E-MI-18323
MNDR hsa-miR-15b-5p Colon adenocarcinoma MNDR-E-MI-18324
MNDR hsa-miR-15b-5p Multiple sclerosis relapsing-remitting MNDR-E-MI-18325
MNDR hsa-miR-15b-5p Familial ovarian cancer MNDR-E-MI-18326
MNDR hsa-miR-15b-5p Acromegaly MNDR-E-MI-18327
MNDR hsa-miR-15b-5p Prostate adenocarcinoma MNDR-E-MI-18328
MNDR hsa-miR-15b-5p Carcinoma ductal breast MNDR-E-MI-18329
MNDR hsa-miR-15b-5p Glioblastoma MNDR-E-MI-18330
MNDR hsa-miR-15b-5p Astrocytoma MNDR-E-MI-18331
MNDR hsa-miR-15b-5p Glioma MNDR-E-MI-18332
MNDR hsa-miR-15b-5p Oligodendroglioma MNDR-E-MI-18333
MNDR hsa-miR-15b-5p Neurilemmoma MNDR-E-MI-18334
MNDR hsa-miR-15b-5p Chordoma MNDR-E-MI-18335
MNDR hsa-miR-15b-5p Amyotrophic lateral sclerosis MNDR-E-MI-18336
MNDR hsa-miR-15b-5p Osteosarcoma MNDR-E-MI-18337
MNDR hsa-miR-15b-5p Liposarcoma MNDR-E-MI-18338
MNDR hsa-miR-15b-5p Liver cancer MNDR-E-MI-18339
MNDR hsa-miR-15b-5p Cervical adenocarcinoma MNDR-E-MI-18340
MNDR hsa-miR-15b-5p Gastric adenocarcinoma MNDR-E-MI-18341
MNDR hsa-miR-15b-5p Cervical squamous cell carcinoma MNDR-E-MI-18342
MNDR hsa-miR-15b-5p Pituitary adenoma MNDR-E-MI-18343
MNDR hsa-miR-15b-5p Lung squamous cell carcinoma MNDR-E-MI-18344
MNDR hsa-miR-15b-5p Carcinoma lung non-small-cell MNDR-E-MI-18345
MNDR hsa-miR-15b-5p Lung adenocarcinoma MNDR-E-MI-18346
MNDR hsa-miR-15b-5p Adrenocortical cancer MNDR-E-MI-18347
MNDR hsa-miR-15b-5p Ovarian carcinoma MNDR-E-MI-18348
MNDR hsa-miR-15b-5p Bladder urothelial carcinoma MNDR-E-MI-18349
MNDR hsa-miR-15b-5p Pancreatic adenocarcinoma MNDR-E-MI-18350
MNDR hsa-miR-15b-5p Myasthenia gravis autoimmune experimental MNDR-E-MI-18351
MNDR hsa-miR-15b-5p Carcinoma renal cell MNDR-E-MI-18352
MNDR hsa-miR-15b-5p Kidney renal papillary cell carcinoma MNDR-E-MI-18353
MNDR hsa-miR-15b-5p Clear cell renal cell carcinoma MNDR-E-MI-18354
MNDR hsa-miR-15b-5p Cholangiocarcinoma MNDR-E-MI-18355
MNDR hsa-miR-15b-5p Esophageal cancer MNDR-E-MI-18356
MNDR hsa-miR-15b-5p Oncocytoma MNDR-E-MI-18357
MNDR hsa-miR-15b-5p Lung small cell carcinoma MNDR-E-MI-18358
MNDR hsa-miR-15b-5p Head and neck squamous cell carcinoma MNDR-E-MI-18359
MNDR hsa-miR-15b-5p Heart failure MNDR-E-MI-18360
MNDR hsa-miR-15b-5p Growth hormone-secreting pituitary adenoma MNDR-E-MI-18361
MNDR hsa-miR-15b-5p Breast invasive carcinoma MNDR-E-MI-18362
MNDR hsa-miR-15b-5p Hepatocellular carcinoma MNDR-E-MI-18363
MNDR hsa-miR-15b-5p Familiar ovarian carcinoma MNDR-E-MI-18364
MNDR hsa-miR-15b-5p B-cell lymphoma MNDR-E-MI-18365
MNDR hsa-miR-15b-5p Rheumatoid arthritis MNDR-E-MI-18366
MNDR hsa-miR-15b-5p Retinoblastoma MNDR-E-MI-18367
MNDR hsa-miR-15b-5p Barrett's adenocarcinoma MNDR-E-MI-18368
MNDR hsa-miR-15b-5p Hodgkin disease MNDR-E-MI-18369
MNDR hsa-miR-15b-5p Burkitt lymphoma MNDR-E-MI-18370
MNDR hsa-miR-15b-5p Mouth neoplasms MNDR-E-MI-18371
MNDR hsa-miR-15b-5p Psoriasis MNDR-E-MI-18372
MNDR hsa-miR-15b-5p Acute myelogenous leukemia MNDR-E-MI-18373
MNDR hsa-miR-15b-5p Colorectal cancer MNDR-E-MI-18374
MNDR hsa-miR-15b-5p Nasopharynx carcinoma MNDR-E-MI-18375
MNDR hsa-miR-15b-5p Type 2 diabetes mellitus MNDR-E-MI-18376
MNDR hsa-miR-15b-5p Multiple myeloma MNDR-E-MI-18377
MNDR hsa-miR-15b-5p Uterine cervical neoplasms MNDR-E-MI-18378
MNDR hsa-miR-15b-5p Ependymoma MNDR-E-MI-18379
MNDR hsa-miR-15b-5p Cardiac hypertrophy MNDR-E-MI-18380
MNDR hsa-miR-15b-5p Nasopharyngeal cancer MNDR-E-MI-18381
MNDR hsa-miR-15b-5p Cerebral hemorrhage traumatic MNDR-E-MI-18382
MNDR hsa-miR-15b-5p Stroke lacunar MNDR-E-MI-18383
MNDR hsa-miR-15b-5p Barrett's carcinogenesis MNDR-E-MI-18384
MNDR hsa-miR-15b-5p Breast cancer her3+ negative MNDR-E-MI-18385
RNA Interaction Information
Resource RNA Symbol Species Link RNALocate ID
RNAInter AGO2 Homo sapiens RR00055677
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