Basic Information
| RNALocate ID: | RLID:11001656 |
| RNA Symbol: | hsa-miR-15b-5p |
| Localization: | Exosome |
RNA Information
| RNA Name: | hsa-miR-15b |
| RNA ID: | miRBase:MIMAT0000417 |
| RNA Category: | miRNA |
| Species: | Homo sapiens |
Localization Information
| PubMed ID: | 20976003 |
| Tissue/Cell Line: | Breast cancer cell line (MCF-7) |
| Method: | Microarray |
| Description: | Because of the suggested roles of extracellular miRNAs in signaling and diagnosis, we investigated whether the intracellular and extracellular miRNA composition are the same. To answer this question, we performed microRNA microarray analyses of MCF7 cellular (c) and extracellular (x) RNAs (Figure 2A), and found that about 66% of the released miRNAs are at an abundance that closely reflects the cellular miRNA abundance (Figures 2B and 2C). This finding is in agreement with a model wherein most, but not all miRNAs are released passively by mass action. Data are collected from Figure 2. |
Other Subcellular Localization
| RNALocate ID | Localization | Tissue/Cell line | PubMed ID |
| RLID:01001717 | Cytoplasm | Neural progenitor cells | 21363885 |
| RLID:01001718 | Cytoplasm | Cell line (HeLa) | 21695135 |
| RLID:01001719 | Cytoplasm | Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa) | 24918059 |
| RLID:01001720 | Mitochondrion | Skeletal muscle myoblasts | 21637849 |
| RLID:01001721 | Mitochondrion | Cell line (HEK-293|HeLa) | 22984580 |
| RLID:01001722 | Nucleus | Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa) | 24918059 |
| RLID:01001723 | Nucleolus | Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa) | 24918059 |
| RLID:01001724 | Nucleus | Colon adenocarcinoma cells | 20864815 |
| RLID:11001654 | Exosome | Glioblastoma cells | 19011622 |
| RLID:11001655 | Exosome | Lung adenocarcinoma epithelial cell line (A549) | 20615901 |
| RLID:11001657 | Exosome | Primary dendritic cells|T cell line (J77) | 21505438 |
| RLID:11001658 | Exosome | Renal cancer cells | 21670082 |
| RLID:11001659 | Exosome | Breast milk | 22211110 |
| RLID:11001660 | Exosome | Brain tissue | 23382797 |
| RLID:11001661 | Exosome | Plasma | 23663360 |
| RLID:11001662 | Exosome | Human mast cell line (HMC-1) | 24009880 |
| RLID:11001663 | Exosome | Breast cancer cell lines (MCF-7|MDA-MB-231) | 24468161 |
| RLID:11001664 | Extracellular vesicle | HEK-293T cells | 22849433 |
| RLID:11001665 | Microvesicle | Glioblastoma cells | 19011622 |
| RLID:11001666 | Microvesicle | Lung epithelial carcinoma cell line (A549) | 20615901 |
| RLID:11001667 | Microvesicle | Plasma | 23077538 |
| RLID:11001668 | Microvesicle | Seminal plasma | 23539611 |
| RLID-D:11000070 | Exosome | Endothelial cells|Epithelial cells | |
| RLID-D:11000345 | Microvesicle | Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine |
ncRNA Disease Information
| Resource | RNA Symbol | Disease | Link |
| MNDR | hsa-miR-15b-5p | Splenic marginal zone lymphoma | MNDR-E-MI-18279 |
| MNDR | hsa-miR-15b-5p | Multiple sclerosis chronic progressive | MNDR-E-MI-18280 |
| MNDR | hsa-miR-15b-5p | Tongue squamous cell carcinoma | MNDR-E-MI-18281 |
| MNDR | hsa-miR-15b-5p | Oral squamous cell carcinoma | MNDR-E-MI-18282 |
| MNDR | hsa-miR-15b-5p | High-grade serous ovarian carcinoma | MNDR-E-MI-18283 |
| MNDR | hsa-miR-15b-5p | Uterine corpus endometrial carcinoma | MNDR-E-MI-18284 |
| MNDR | hsa-miR-15b-5p | Lymphoma | MNDR-E-MI-18285 |
| MNDR | hsa-miR-15b-5p | Lymphoma non-hodgkin | MNDR-E-MI-18286 |
| MNDR | hsa-miR-15b-5p | Estrogen-receptor positive breast cancer | MNDR-E-MI-18287 |
| MNDR | hsa-miR-15b-5p | Estrogen-receptor negative breast cancer | MNDR-E-MI-18288 |
| MNDR | hsa-miR-15b-5p | Progesterone-receptor positive breast cancer | MNDR-E-MI-18289 |
| MNDR | hsa-miR-15b-5p | Progesterone-receptor negative breast cancer | MNDR-E-MI-18290 |
| MNDR | hsa-miR-15b-5p | Her2-receptor positive breast cancer | MNDR-E-MI-18291 |
| MNDR | hsa-miR-15b-5p | Acute promyelocytic leukemia | MNDR-E-MI-18292 |
| MNDR | hsa-miR-15b-5p | Breast cancer luminal | MNDR-E-MI-18293 |
| MNDR | hsa-miR-15b-5p | Niemann-pick disease type c | MNDR-E-MI-18294 |
| MNDR | hsa-miR-15b-5p | Lupus nephritis | MNDR-E-MI-18295 |
| MNDR | hsa-miR-15b-5p | Prostate cancer | MNDR-E-MI-18296 |
| MNDR | hsa-miR-15b-5p | Gastric cancer | MNDR-E-MI-18297 |
| MNDR | hsa-miR-15b-5p | Gastric lymphoma | MNDR-E-MI-18298 |
| MNDR | hsa-miR-15b-5p | Alzheimer disease | MNDR-E-MI-18299 |
| MNDR | hsa-miR-15b-5p | Encephalitis japanese | MNDR-E-MI-18300 |
| MNDR | hsa-miR-15b-5p | Intracranial aneurysm | MNDR-E-MI-18301 |
| MNDR | hsa-miR-15b-5p | Esophageal carcinoma | MNDR-E-MI-18302 |
| MNDR | hsa-miR-15b-5p | Dysautonomia familial | MNDR-E-MI-18303 |
| MNDR | hsa-miR-15b-5p | Seizures | MNDR-E-MI-18304 |
| MNDR | hsa-miR-15b-5p | Leukemia | MNDR-E-MI-18305 |
| MNDR | hsa-miR-15b-5p | Huntington disease | MNDR-E-MI-18306 |
| MNDR | hsa-miR-15b-5p | Chorea | MNDR-E-MI-18307 |
| MNDR | hsa-miR-15b-5p | Cardiovascular disease | MNDR-E-MI-18308 |
| MNDR | hsa-miR-15b-5p | Carotid stenosis | MNDR-E-MI-18309 |
| MNDR | hsa-miR-15b-5p | Moyamoya disease | MNDR-E-MI-18310 |
| MNDR | hsa-miR-15b-5p | Lung cancer | MNDR-E-MI-18311 |
| MNDR | hsa-miR-15b-5p | Fragile x syndrome | MNDR-E-MI-18312 |
| MNDR | hsa-miR-15b-5p | Parkinson disease | MNDR-E-MI-18313 |
| MNDR | hsa-miR-15b-5p | Niemann-pick disease | MNDR-E-MI-18314 |
| MNDR | hsa-miR-15b-5p | Basal-like breast cancer | MNDR-E-MI-18315 |
| MNDR | hsa-miR-15b-5p | Thyroid cancer | MNDR-E-MI-18316 |
| MNDR | hsa-miR-15b-5p | Pituitary neoplasms | MNDR-E-MI-18317 |
| MNDR | hsa-miR-15b-5p | Pancreatic cancer | MNDR-E-MI-18318 |
| MNDR | hsa-miR-15b-5p | Malignant melanoma | MNDR-E-MI-18319 |
| MNDR | hsa-miR-15b-5p | Gaucher disease | MNDR-E-MI-18320 |
| MNDR | hsa-miR-15b-5p | Rectum adenocarcinoma | MNDR-E-MI-18321 |
| MNDR | hsa-miR-15b-5p | Nephroblastoma | MNDR-E-MI-18322 |
| MNDR | hsa-miR-15b-5p | Colon cancer | MNDR-E-MI-18323 |
| MNDR | hsa-miR-15b-5p | Colon adenocarcinoma | MNDR-E-MI-18324 |
| MNDR | hsa-miR-15b-5p | Multiple sclerosis relapsing-remitting | MNDR-E-MI-18325 |
| MNDR | hsa-miR-15b-5p | Familial ovarian cancer | MNDR-E-MI-18326 |
| MNDR | hsa-miR-15b-5p | Acromegaly | MNDR-E-MI-18327 |
| MNDR | hsa-miR-15b-5p | Prostate adenocarcinoma | MNDR-E-MI-18328 |
| MNDR | hsa-miR-15b-5p | Carcinoma ductal breast | MNDR-E-MI-18329 |
| MNDR | hsa-miR-15b-5p | Glioblastoma | MNDR-E-MI-18330 |
| MNDR | hsa-miR-15b-5p | Astrocytoma | MNDR-E-MI-18331 |
| MNDR | hsa-miR-15b-5p | Glioma | MNDR-E-MI-18332 |
| MNDR | hsa-miR-15b-5p | Oligodendroglioma | MNDR-E-MI-18333 |
| MNDR | hsa-miR-15b-5p | Neurilemmoma | MNDR-E-MI-18334 |
| MNDR | hsa-miR-15b-5p | Chordoma | MNDR-E-MI-18335 |
| MNDR | hsa-miR-15b-5p | Amyotrophic lateral sclerosis | MNDR-E-MI-18336 |
| MNDR | hsa-miR-15b-5p | Osteosarcoma | MNDR-E-MI-18337 |
| MNDR | hsa-miR-15b-5p | Liposarcoma | MNDR-E-MI-18338 |
| MNDR | hsa-miR-15b-5p | Liver cancer | MNDR-E-MI-18339 |
| MNDR | hsa-miR-15b-5p | Cervical adenocarcinoma | MNDR-E-MI-18340 |
| MNDR | hsa-miR-15b-5p | Gastric adenocarcinoma | MNDR-E-MI-18341 |
| MNDR | hsa-miR-15b-5p | Cervical squamous cell carcinoma | MNDR-E-MI-18342 |
| MNDR | hsa-miR-15b-5p | Pituitary adenoma | MNDR-E-MI-18343 |
| MNDR | hsa-miR-15b-5p | Lung squamous cell carcinoma | MNDR-E-MI-18344 |
| MNDR | hsa-miR-15b-5p | Carcinoma lung non-small-cell | MNDR-E-MI-18345 |
| MNDR | hsa-miR-15b-5p | Lung adenocarcinoma | MNDR-E-MI-18346 |
| MNDR | hsa-miR-15b-5p | Adrenocortical cancer | MNDR-E-MI-18347 |
| MNDR | hsa-miR-15b-5p | Ovarian carcinoma | MNDR-E-MI-18348 |
| MNDR | hsa-miR-15b-5p | Bladder urothelial carcinoma | MNDR-E-MI-18349 |
| MNDR | hsa-miR-15b-5p | Pancreatic adenocarcinoma | MNDR-E-MI-18350 |
| MNDR | hsa-miR-15b-5p | Myasthenia gravis autoimmune experimental | MNDR-E-MI-18351 |
| MNDR | hsa-miR-15b-5p | Carcinoma renal cell | MNDR-E-MI-18352 |
| MNDR | hsa-miR-15b-5p | Kidney renal papillary cell carcinoma | MNDR-E-MI-18353 |
| MNDR | hsa-miR-15b-5p | Clear cell renal cell carcinoma | MNDR-E-MI-18354 |
| MNDR | hsa-miR-15b-5p | Cholangiocarcinoma | MNDR-E-MI-18355 |
| MNDR | hsa-miR-15b-5p | Esophageal cancer | MNDR-E-MI-18356 |
| MNDR | hsa-miR-15b-5p | Oncocytoma | MNDR-E-MI-18357 |
| MNDR | hsa-miR-15b-5p | Lung small cell carcinoma | MNDR-E-MI-18358 |
| MNDR | hsa-miR-15b-5p | Head and neck squamous cell carcinoma | MNDR-E-MI-18359 |
| MNDR | hsa-miR-15b-5p | Heart failure | MNDR-E-MI-18360 |
| MNDR | hsa-miR-15b-5p | Growth hormone-secreting pituitary adenoma | MNDR-E-MI-18361 |
| MNDR | hsa-miR-15b-5p | Breast invasive carcinoma | MNDR-E-MI-18362 |
| MNDR | hsa-miR-15b-5p | Hepatocellular carcinoma | MNDR-E-MI-18363 |
| MNDR | hsa-miR-15b-5p | Familiar ovarian carcinoma | MNDR-E-MI-18364 |
| MNDR | hsa-miR-15b-5p | B-cell lymphoma | MNDR-E-MI-18365 |
| MNDR | hsa-miR-15b-5p | Rheumatoid arthritis | MNDR-E-MI-18366 |
| MNDR | hsa-miR-15b-5p | Retinoblastoma | MNDR-E-MI-18367 |
| MNDR | hsa-miR-15b-5p | Barrett's adenocarcinoma | MNDR-E-MI-18368 |
| MNDR | hsa-miR-15b-5p | Hodgkin disease | MNDR-E-MI-18369 |
| MNDR | hsa-miR-15b-5p | Burkitt lymphoma | MNDR-E-MI-18370 |
| MNDR | hsa-miR-15b-5p | Mouth neoplasms | MNDR-E-MI-18371 |
| MNDR | hsa-miR-15b-5p | Psoriasis | MNDR-E-MI-18372 |
| MNDR | hsa-miR-15b-5p | Acute myelogenous leukemia | MNDR-E-MI-18373 |
| MNDR | hsa-miR-15b-5p | Colorectal cancer | MNDR-E-MI-18374 |
| MNDR | hsa-miR-15b-5p | Nasopharynx carcinoma | MNDR-E-MI-18375 |
| MNDR | hsa-miR-15b-5p | Type 2 diabetes mellitus | MNDR-E-MI-18376 |
| MNDR | hsa-miR-15b-5p | Multiple myeloma | MNDR-E-MI-18377 |
| MNDR | hsa-miR-15b-5p | Uterine cervical neoplasms | MNDR-E-MI-18378 |
| MNDR | hsa-miR-15b-5p | Ependymoma | MNDR-E-MI-18379 |
| MNDR | hsa-miR-15b-5p | Cardiac hypertrophy | MNDR-E-MI-18380 |
| MNDR | hsa-miR-15b-5p | Nasopharyngeal cancer | MNDR-E-MI-18381 |
| MNDR | hsa-miR-15b-5p | Cerebral hemorrhage traumatic | MNDR-E-MI-18382 |
| MNDR | hsa-miR-15b-5p | Stroke lacunar | MNDR-E-MI-18383 |
| MNDR | hsa-miR-15b-5p | Barrett's carcinogenesis | MNDR-E-MI-18384 |
| MNDR | hsa-miR-15b-5p | Breast cancer her3+ negative | MNDR-E-MI-18385 |
RNA Interaction Information
| Resource | RNA Symbol | Species | Link | RNALocate ID |
| RNAInter | AGO2 | Homo sapiens | RR00055677 |
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