Detail Information

Basic Information:


  VIRBase ID:  

HHID00058605

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-451a:           LIN9:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-451a LIN9
miRBase
Accession/Entrez ID		 MIMAT0001631 286826
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - BARA//BARPsv//Lin-9//TGS//TGS1//TGS2

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-451a
rs1378754345 chr17:28861413    T/C
rs778869519 chr17:28861415    G/A
rs746801009 chr17:28861408    AGTAATGGTAACG/A
rs747864207 chr17:28861417    A/C
rs901867276 chr17:28861419    C/T

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR LIN9
chr1:226446884(-) A-I      intronic
chr1:226486440(-) A-I      intronic
chr1:226446898(-) A-I      intronic
chr1:226469572(-) A-I      intronic
chr1:226469574(-) A-I      intronic
chr1:226469577(-) A-I      intronic
chr1:226446933(-) A-I      intronic
chr1:226445945(-) A-I      intronic
chr1:226446874(-) A-I      intronic
chr1:226469588(-) A-I      intronic
chr1:226446045(-) A-I      intronic
chr1:226472325(-) A-I      intronic
chr1:226446916(-) A-I      intronic
chr1:226482094(-) A-I      intronic
chr1:226446911(-) A-I      intronic
chr1:226445984(-) A-I      intronic
chr1:226488470(-) A-I      intronic
chr1:226476789(-) A-I      intronic
chr1:226470753(-) A-I      intronic
chr1:226429392(-) A-I      intronic
chr1:226481869(-) A-I      intronic
chr1:226482622(-) A-I      intronic
chr1:226467077(-) A-I      intronic
chr1:226467076(-) A-I      intronic
chr1:226482624(-) A-I      intronic
chr1:226486317(-) A-I      intronic
chr1:226487736(-) A-I      intronic
chr1:226488007(-) A-I      intronic
chr1:226487777(-) A-I      intronic
chr1:226466048(-) A-I      intronic
chr1:226481529(-) A-I      intronic
chr1:226476873(-) A-I      intronic
chr1:226476788(-) A-I      intronic
chr1:226490132(-) A-I      intronic
chr1:226481447(-) A-I      intronic
chr1:226481528(-) A-I      intronic
chr1:226476774(-) A-I      intronic
chr1:226429415(-) A-I      intronic
chr1:226476771(-) A-I      intronic
chr1:226481507(-) A-I      intronic
chr1:226481460(-) A-I      intronic
chr1:226432051(-) A-I      intronic
chr1:226490055(-) A-I      intronic
chr1:226475952(-) A-I      intronic
chr1:226490050(-) A-I      intronic
chr1:226434239(-) A-I      intronic
chr1:226471106(-) A-I      intronic
chr1:226471094(-) A-I      intronic
chr1:226434302(-) A-I      intronic
chr1:226471015(-) A-I      intronic
chr1:226435367(-) A-I      intronic
chr1:226439040(-) A-I      intronic
chr1:226439305(-) A-I      intronic
chr1:226441110(-) A-I      intronic
chr1:226470980(-) A-I      intronic
chr1:226481486(-) A-I      intronic
chr1:226488511(-) A-I      intronic
chr1:226470863(-) A-I      intronic
chr1:226441198(-) A-I      intronic
chr1:226470866(-) A-I      intronic
chr1:226441295(-) A-I      intronic
chr1:226441507(-) A-I      intronic
chr1:226475940(-) A-I      intronic
chr1:226486319(-) A-I      intronic
chr1:226488408(-) A-I      intronic
chr1:226442512(-) A-I      intronic
chr1:226442560(-) A-I      intronic
chr1:226446019(-) A-I      intronic
chr1:226466078(-) A-I      intronic
chr1:226446080(-) A-I      intronic
chr1:226470772(-) A-I      intronic
chr1:226446086(-) A-I      intronic
chr1:226451522(-) A-I      intronic
chr1:226486318(-) A-I      intronic
chr1:226488391(-) A-I      intronic
chr1:226488353(-) A-I      intronic
chr1:226466047(-) A-I      intronic
chr1:226486396(-) A-I      intronic
chr1:226441133(-) A-I      intronic
chr1:226488008(-) A-I      intronic
chr1:226471483(-) A-I      intronic
chr1:226435411(-) A-I      intronic
chr1:226491582(-) A-I      intronic
chr1:226435654(-) A-I      intronic
chr1:226435438(-) A-I      intronic
chr1:226486344(-) A-I      intronic
chr1:226435648(-) A-I      intronic
chr1:226435656(-) A-I      intronic
chr1:226431872(-) A-I      intronic
chr1:226481877(-) A-I      intronic
chr1:226435666(-) A-I      intronic
chr1:226482221(-) A-I      intronic
chr1:226486069(-) A-I      intronic
chr1:226458404(-) A-I      intronic
chr1:226483114(-) A-I      intronic
chr1:226438307(-) A-I      intronic
chr1:226435511(-) A-I      intronic
chr1:226435501(-) A-I      intronic
chr1:226428254(-) A-I      intronic
chr1:226441494(-) A-I      intronic
chr1:226458423(-) A-I      intronic
chr1:226435664(-) A-I      intronic
chr1:226470973(-) A-I      intronic
chr1:226482995(-) A-I      intronic
chr1:226464841(-) A-I      intronic
chr1:226435620(-) A-I      intronic
chr1:226446799(-) A-I      intronic
chr1:226432089(-) A-I      intronic
chr1:226458436(-) A-I      intronic
chr1:226431850(-) A-I      intronic
chr1:226476853(-) A-I      intronic
chr1:226476814(-) A-I      intronic
chr1:226446893(-) A-I      intronic
chr1:226463489(-) A-I      intronic
chr1:226471542(-) A-I      intronic
chr1:226445958(-) A-I      intronic
chr1:226486151(-) A-I      intronic
chr1:226445825(-) A-I      intronic
chr1:226477161(-) A-I      intronic
chr1:226470925(-) A-I      intronic
chr1:226469668(-) A-I      intronic
chr1:226431649(-) A-I      intronic
chr1:226470508(-) A-I      intronic
chr1:226470778(-) A-I      intronic
chr1:226439734(-) A-I      intronic
chr1:226472342(-) A-I      intronic
chr1:226464827(-) A-I      intronic
chr1:226486073(-) A-I      intronic
chr1:226469492(-) A-I      intronic
chr1:226440556(-) A-I      intronic
chr1:226481426(-) A-I      intronic
chr1:226433192(-) A-I      intronic
chr1:226486474(-) A-I      intronic
chr1:226439930(-) A-I      intronic
chr1:226459918(-) A-I      intronic
chr1:226481407(-) A-I      intronic
chr1:226432131(-) A-I      intronic
chr1:226488400(-) A-I      intronic
chr1:226433184(-) A-I      intronic
chr1:226466130(-) A-I      intronic
chr1:226428524(-) A-I      intronic
chr1:226482734(-) A-I      intronic
chr1:226446402(-) A-I      intronic
chr1:226486047(-) A-I      intronic
chr1:226435441(-) A-I      intronic
chr1:226481496(-) A-I      intronic
chr1:226426261(-) A-I      intronic
chr1:226471073(-) A-I      intronic
chr1:226439865(-) A-I      intronic
chr1:226434418(-) A-I      intronic
chr1:226458432(-) A-I      intronic
chr1:226435510(-) A-I      intronic
chr1:226431727(-) A-I      intronic
chr1:226446030(-) A-I      intronic
chr1:226435517(-) A-I      intronic
chr1:226487780(-) A-I      intronic
chr1:226435594(-) A-I      intronic
chr1:226446865(-) A-I      intronic
chr1:226433323(-) A-I      intronic
chr1:226425077(-) A-I      intronic
chr1:226441451(-) A-I      intronic
chr1:226441191(-) A-I      intronic
chr1:226471386(-) A-I      intronic
chr1:226471537(-) A-I      intronic
chr1:226434227(-) A-I      intronic
chr1:226483103(-) A-I      intronic
chr1:226425177(-) A-I      intronic
chr1:226482747(-) A-I      intronic
chr1:226458469(-) A-I      intronic
chr1:226477228(-) A-I      intronic
chr1:226427345(-) A-I      intronic
chr1:226471486(-) A-I      intronic
chr1:226475758(-) A-I      intronic
chr1:226433472(-) A-I      intronic
chr1:226435570(-) A-I      intronic
chr1:226469666(-) A-I      intronic
chr1:226476879(-) A-I      intronic
chr1:226491353(-) A-I      intronic
chr1:226446810(-) A-I      intronic
chr1:226433395(-) A-I      intronic
chr1:226482190(-) A-I      intronic
chr1:226441213(-) A-I      intronic
chr1:226470749(-) A-I      intronic
chr1:226492686(-) A-I      intronic
chr1:226445957(-) A-I      intronic
chr1:226486046(-) A-I      intronic
chr1:226433474(-) A-I      intronic
chr1:226441936(-) A-I      intronic
chr1:226435569(-) A-I      intronic
chr1:226427344(-) A-I      intronic
chr1:226435578(-) A-I      intronic
chr1:226445942(-) A-I      intronic
chr1:226443873(-) A-I      intronic
chr1:226491374(-) A-I      intronic
chr1:226482616(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED LIN9
chr1:226435569(-) A-I intron -    15258596   //22028664
chr1:226435570(-) A-I intron -    15258596   //22028664
chr1:226435578(-) A-I intron -    15258596   //22028664
chr1:226435594(-) A-I intron -    15258596   //22028664   //22327324
chr1:226445764(-) A-I intron -    22327324
chr1:226446720(-) A-I intron -    22327324
chr1:226446935(-) A-I intron -    22327324
chr1:226435411(-) A-I intron -    22028664
chr1:226435438(-) A-I intron -    22028664
chr1:226435445(-) A-I intron -    22028664
chr1:226435501(-) A-I intron -    22028664
chr1:226435510(-) A-I intron -    22028664
chr1:226435511(-) A-I intron -    22028664
chr1:226435517(-) A-I intron -    22028664
chr1:226435648(-) A-I intron -    22028664
chr1:226435654(-) A-I intron -    22028664
chr1:226435656(-) A-I intron -    22028664
chr1:226435664(-) A-I intron -    22028664
chr1:226435666(-) A-I intron -    22028664
chr1:226431727(-) A-G intron -    22484847
chr1:226432131(-) A-G intron -    22484847
chr1:226434418(-) A-G intron -    22484847
chr1:226435594(-) A-G intron -    22484847
chr1:226441191(-) A-G intron -    22484847
chr1:226441936(-) A-G intron -    22484847
chr1:226443822(-) T-C intron -    22484847
chr1:226445627(-) T-C intron -    22484847
chr1:226445726(-) T-C intron -    22484847
chr1:226445730(-) T-C intron -    22484847
chr1:226445764(-) T-C intron -    22484847
chr1:226445804(-) T-C intron -    22484847
chr1:226445947(-) T-C intron -    22484847
chr1:226446030(-) A-G intron -    22484847
chr1:226446059(-) T-C intron -    22484847
chr1:226446081(-) T-C intron -    22484847
chr1:226446082(-) T-C intron -    22484847
chr1:226446402(-) A-G intron -    22484847
chr1:226446547(-) T-C intron -    22484847
chr1:226446720(-) T-C intron -    22484847
chr1:226446762(-) T-C intron -    22484847
chr1:226446799(-) A-G intron -    22484847
chr1:226446810(-) A-G intron -    22484847
chr1:226446823(-) T-C intron -    22484847
chr1:226446858(-) T-C intron -    22484847
chr1:226446865(-) A-G intron -    22484847
chr1:226446935(-) T-C intron -    22484847
chr1:226458432(-) A-G intron -    22484847
chr1:226459897(-) T-C intron -    22484847
chr1:226469666(-) A-G intron -    22484847
chr1:226469668(-) A-G intron -    22484847
chr1:226470508(-) A-G intron -    22484847
chr1:226475758(-) A-G intron -    22484847
chr1:226476879(-) A-G intron -    22484847
chr1:226481407(-) A-G intron -    22484847
chr1:226481496(-) A-G intron -    22484847
chr1:226481877(-) A-G intron -    22484847
chr1:226482221(-) A-G intron -    22484847
chr1:226482734(-) A-G intron -    22484847
chr1:226482747(-) A-G intron -    22484847
chr1:226482995(-) A-G intron -    22484847
chr1:226483114(-) A-G intron -    22484847
chr1:226486046(-) A-G intron -    22484847
chr1:226486047(-) A-G intron -    22484847
chr1:226486069(-) A-G intron -    22484847
chr1:226486073(-) A-G intron -    22484847
chr1:226486151(-) A-G intron -    22484847
chr1:226486344(-) A-G intron -    22484847
chr1:226487780(-) A-G intron -    22484847
chr1:226488008(-) A-G intron -    22484847
chr1:226488400(-) A-G intron -    22484847
chr1:226491582(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase LIN9
chr1:226419563-226419564(-) m6A 3'UTR       27773535
chr1:226419662-226419663(-) m6A 3'UTR       27773535
chr1:226419690-226419691(-) m6A 3'UTR       27773535
chr1:226419828-226419829(-) m6A 3'UTR       27773535
chr1:226419857-226419858(-) m6A 3'UTR       27773535
chr1:226419931-226419932(-) m6A 3'UTR       27773535//22608085
chr1:226419945-226419946(-) m6A 3'UTR       27773535//22608085
chr1:226420018-226420019(-) Y 3'UTR       26075521
chr1:226420045-226420046(-) m6A 3'UTR       24284625//24981863//27773535//22608085
chr1:226420062-226420063(-) m6A 3'UTR       24284625//24981863//27773535//22608085
chr1:226420102-226420103(-) m6A 3'UTR       24284625//24981863//27773535//22608085
chr1:226420170-226420171(-) m6A 3'UTR       24284625//24981863//27773535//22608085
chr1:226420205-226420206(-) m6A CDS       24284625//24981863//27773535//22608085
chr1:226420241-226420242(-) m6A CDS       24284625//24981863//27773535//22608085
chr1:226438558-226438559(-) m6A CDS       27773535
chr1:226438584-226438585(-) m6A CDS       27773535
chr1:226453314-226453315(-) m6A CDS       24981863
chr1:226496585-226496586(-) m6A 5'UTR//intron       22608085
chr1:226496904-226496905(-) m6A 5'UTR//intron       22608085
chr1:226496919-226496920(-) m6A 5'UTR//intron       22608085
chr1:226497153-226497154(-) m6A 5'UTR//intron       24209618
chr1:226497182-226497183(-) m6A 5'UTR//intron       24209618
chr1:226497225-226497226(-) m6A 5'UTR//intron       24209618
chr1:226497427-226497428(-) m6A 5'UTR//CDS       22608085
chr1:226497553-226497554(-) m6A CDS       24284625//22608085
chr1:226497566-226497567(-) m6A CDS       24284625//22608085

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-451a
Exosome Primary T lymphocytes     24356509
Exosome Plasma     29130611
Exosome Peripheral blood|Portal vein blood     30561106
Exosome Serum     18589210
Exosome Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901
Exosome Breast cancer cell line (MCF-7)     20976003
Exosome B cell line (Raji)|Jurkat-derived T cell line (J77cl20)     21505438
Exosome Renal cancer cells     21670082
Exosome HCC cell line (Hep3B|HepG2|PLC/PRF/5)     21721029
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Human mast cell line (HMC-1)     24009880
Exosome Plasma     24130905
Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326
Exosome Blood|B lymphoblastoid cells|Endothelial cells|Lymphoma tissue|Mast cells     -
Extracellular Vesicle Liposarcoma cell lines (Lipo224B|Lipo246|Lipo863|LPS141)|Preadipocytes     28588009
Extracellular vesicle HEK-293T cells     22849433
Extracellular vesicle Colon cancer cell line (LIM1863)     25330373
Microvesicle Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901
Microvesicle Liver resident stem cells|Mesenchymal stem cells     20668554
Microvesicle Plasma     23077538
Microvesicle Blood|Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     -
LIN9
Chromatin K562 cells     -
Cytosol HCC cell line (HepG2)|K562 cells     -
Exosome Blood     -
Membrane K562 cells     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus HeLa-S3 cells     -

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-451a
Interactor2: LIN9

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region CDS
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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