Basic Information:

  VIRBase ID:  

HHID00050042

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5725

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-15b-5p:  MIMAT0000417          VEGFA:  NM_001171622     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-15b-5p	VEGFA
miRBase Accession/Entrez ID	MIMAT0000417	7422
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	MVCD1//VEGF//VPF

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-15b-5p	rs752662639 chr3:160404619    A/T rs767416190 chr3:160404617    T/A

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	VEGFA	chr6:43738036-43738037(+) m6A 5'UTR//exon       24981863 chr6:43738048-43738049(+) m6A 5'UTR//exon       24981863 chr6:43738124-43738125(+) m6A 5'UTR//exon       24981863 chr6:43738139-43738140(+) m6A 5'UTR//exon       24284625 chr6:43738249-43738250(+) m6A 5'UTR//exon       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085 chr6:43738450-43738451(+) m6A CDS//exon       24284625//24209618//25456834//24981863//27371828//27773536//22575960//22608085 chr6:43738458-43738459(+) m6A CDS//exon       24284625//24209618//25456834//24981863//27371828//27773536//22575960//22608085 chr6:43738509-43738510(+) m6A CDS//exon       24284625//24209618//25456834//24981863//27371828//27773536//22575960//22608085 chr6:43738601-43738602(+) m6A 5'UTR//CDS//exon       24284625//24209618//25456834//24981863//27371828//27773536//22575960//22608085 chr6:43738738-43738739(+) m1A 5'UTR//CDS//exon       26863196//26863410 chr6:43738825-43738826(+) m6A 5'UTR//CDS//exon       24284625//24209618//25456834//24981863//27371828//27773536//22575960//22608085 chr6:43738980-43738981(+) m6A 5'UTR//CDS//exon       24284625//24209618//25456834//24981863//27371828//27773536//22575960 chr6:43738987-43738988(+) m6A CDS//exon       24284625//24209618//25456834//24981863//27371828//27773536//22575960 chr6:43741786-43741787(+) m6A exon//intron       - chr6:43745461-43745462(+) m6A exon//intron       27773535 chr6:43745833-43745834(+) m6A exon//intron       - chr6:43745926-43745927(+) m6A exon//intron       - chr6:43746210-43746211(+) m6A CDS//exon//intron       24284625//24209618 chr6:43746477-43746478(+) m6A exon//intron       24981863 chr6:43746646-43746647(+) m6A CDS//exon//intron       24981863 chr6:43746762-43746763(+) m6A exon//intron       24981863 chr6:43747745-43747746(+) m6A exon//intron       - chr6:43748323-43748324(+) m6A exon//intron       - chr6:43749769-43749770(+) m6A CDS//exon//intron       24284625 chr6:43749775-43749776(+) m6A CDS//exon//intron       24284625 chr6:43752338-43752339(+) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr6:43752360-43752361(+) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085 chr6:43752386-43752387(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085 chr6:43752423-43752424(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085 chr6:43752441-43752442(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr6:43752463-43752464(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr6:43752498-43752499(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr6:43752632-43752633(+) m6A 3'UTR//exon       24284625//24209618//24981863//22608085 chr6:43752790-43752791(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr6:43752852-43752853(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr6:43752961-43752962(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr6:43752971-43752972(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr6:43753013-43753014(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr6:43753021-43753022(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr6:43753022-43753023(+) Cm 3'UTR//exon       - chr6:43753046-43753047(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr6:43753082-43753083(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr6:43753211-43753212(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr6:43753243-43753244(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr6:43753288-43753289(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr6:43753339-43753340(+) m6A 3'UTR//exon       24284625//24209618//24981863//22575960//22608085 chr6:43753362-43753363(+) m6A 3'UTR//exon       24284625//24209618//24981863//22575960//22608085 chr6:43753387-43753388(+) m6A 3'UTR//exon       24284625//24209618//24981863//22575960//22608085 chr6:43753464-43753465(+) m6A 3'UTR//exon       24284625//24209618//22575960 chr6:43753562-43753563(+) m6A 3'UTR//exon       24284625

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-15b-5p	Cytoplasm Neural progenitor cells     21363885 Cytoplasm Cell line (HeLa)     21695135 Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Exosome Glioblastoma cells     19011622 Exosome Lung adenocarcinoma epithelial cell line (A549)     20615901 Exosome Breast cancer cell line (MCF-7)     20976003 Exosome Primary dendritic cells|T cell line (J77)     21505438 Exosome Renal cancer cells     21670082 Exosome Breast milk     22211110 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Human mast cell line (HMC-1)     24009880 Exosome Breast cancer cell lines (MCF-7|MDA-MB-231)     24468161 Exosome Endothelial cells|Epithelial cells     - Extracellular vesicle HEK-293T cells     22849433 Microvesicle Glioblastoma cells     19011622 Microvesicle Lung epithelial carcinoma cell line (A549)     20615901 Microvesicle Plasma     23077538 Microvesicle Seminal plasma     23539611 Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     - Mitochondrion Skeletal muscle myoblasts     21637849 Mitochondrion Cell line (HEK-293|HeLa)     22984580 Nucleolus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Nucleus Colon adenocarcinoma cells     20864815
	VEGFA	Chromatin K562 cells     - Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Endoplasmic reticulum Human fibrosarcoma cells (HT1080)     25753659 Exosome Blood     - Insoluble cytoplasm HCC cell line (HepG2)     - Membrane K562 cells     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus Colon cancer cells     24393600 Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     - Ribosome HeLa cells     25063809

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function
ncDR	hsa-miR-15b-5p	[[4-(3-Aminophenyl)-2-pyridyl]methyleneamino]thiourea 9556427 Drug sensitive 1,9-Pyrazoloanthrone 8515 Drug resistant 1,5-Methano-11H-furo(3,2-g)pyrano(3,2-b)xanthene-3a(4H)-crotonaldehyde, 1,2,5,7-tetrahydro-8-hydroxy-alpha,2,2,11,11-pentamethyl-13-(3-methyl-2-butenyl)-4,7-dioxo-, trans- 78358492 Drug sensitive Acnistin F 6712173 Drug sensitive Piriqualone 6015423 Drug sensitive trans-1,2-Bis(propylsulfonyl)ethylene 5904452 Drug sensitive Artelasticin 5471311 Drug sensitive 5,10-Dimethoxybenzo[g]quinolin-2(1H)-one 54612875 Drug resistant Withacnistin 54606507 Drug sensitive Antineoplastic-651590 54604785 Drug sensitive Aspiculamycin hcl 54600418 Drug resistant Pyrethrosin 5281496 Drug sensitive Benzamide riboside 458027 Drug sensitive S-(Dimethylarsino)-3-mercapto-1,2-propyl diacetate 406479 Drug sensitive Ethanone, 1-[3-(bromomethyl)-1,4-dioxido-2-quinoxalinyl]- 404859 Drug sensitive 2-[(Phenylamino)methyl]benzene-1,4-diol 403336 Drug sensitive 11H-Benzo[a]carbazole-1,4-dione, 7,11-dimethyl- 371271 Drug sensitive Helenin 327378 Drug sensitive 1H-Benzo[a]carbazole-1,4(11H)-dione, 11-methyl- 261066 Drug sensitive (S)-2-Amino-3-(hydroxy(nitroso)amino)propanoic acid 136096147 Drug resistant 12-Iminodaunorubicin hcl 135539784 Drug sensitive p-Toluquinone 11122 Drug sensitive 2,3-dihydro-1,2-syn-3-[phenylseleno]brefeldin a - Drug resistant (1s,2e,4r,7e,11e)-4-hydroxy-2,7,11-cembratrien-6-one - Drug sensitive (2r,3r)-(+)-methyl 3-phenyloxirane-carboxylate - Drug sensitive 1,2-naphthoquinone, 3,7-dimethyl- - Drug sensitive 1h-benzo[a]carbazole-1,4(11h)-dione, 11-phenyl- - Drug sensitive 2,2',5,5'-tetrahydroxy-4,4'-dimethylbiphenyl - Drug sensitive 2-bromo-5,8-dihydroxy-3-methyl-1,4-naphthoquinone - Drug sensitive benzofurazan, 4-nitro-7-(2-pyridinylthio)-, n-oxide - Drug sensitive benzofurazan, 5-nitro-6-(1-piperidinyl)-, 1-oxide - Drug sensitive c4, carbonyl, ethyl prodigiosine - Drug sensitive cyclopentanone, 2,5-bis[(trimethylamino)methyl]-, iodide - Drug sensitive ethanone, 1-(2-pyrimidinyl)-, (2-benzoxazolyl)hydrazone - Drug sensitive 4-carbo-1-thiazolidine-3-o-gluconyl-.gamma.-lactone - Drug sensitive cyclo [n-naphthoyl-d-lys-asn-gln-trp-ala-val-d-ala-his-leu] - Drug sensitive

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-15b-5p	Curcumin 969516 Drug interaction    RC00002458 Formaldehyde 712 Drug interaction    RC00002438 Bisphenol A 6623 Drug interaction    RC00002448 Aniline 6115 Drug interaction    RC00002447 Gemcitabine 60750 Drug interaction    RC00002454 Testosterone 6013 Drug interaction    RC00002446 Vincristine 5978 Drug interaction    RC00002445 Dehydroepiandrosterone 5881 Drug interaction    RC00002444 Estradiol 5757 Drug interaction    RC00002443 Eloxatine 5310940 Drug interaction    RC00002461 Imatinib 5291 Drug interaction    RC00002442 Morphine 5288826 Drug interaction    RC00002460 Cholecalciferol 5280795 Drug interaction    RC00002459 Diethylstilbestrol 448537 Drug interaction    RC00002457 Tretinoin 444795 Drug interaction    RC00002456 Etoposide 36462 Drug interaction    RC00002453 Paclitaxel 36314 Drug interaction    RC00002452 5-Fluorouracil 3385 Drug interaction    RC00002441 Doxorubicin 31703 Drug interaction    RC00002451 cis-Diaminedichloroplatinum 2767 Drug interaction    RC00002440 Verapamil 2520 Drug interaction    RC00002439 Vinblastine 13342 Drug interaction    RC00002450 O,P'-Ddt 13089 Drug interaction    RC00002449 Ginsenoside Rh2 119307 Drug interaction    RC00002455 TRAIL therapy - Drug interaction    RC00002462 Glucocorticoid - Drug interaction    RC00002463 Marine fungal metabolite 1386A - Drug interaction    RC00002464 Chemotherapy - Drug interaction    RC00008841

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-15b-5p	5-Fluorouracil 3385       28646148

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-15b-5p
Interactor2: VEGFA

Evidence Support:

Weak-Evidence	HITS-CLIP//PAR-CLIP
Support Database	ViRBase

References:

PMID	22473208	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	Jijoye cells	Interactor2 expression	None
Description	Our HITS-CLIP data yield 1185 human 3'UTRs targeted by members of the miR-17~92 cluster in Jijoye cells. Comparison to the 1664 3'UTRs targeted by EBV miRNAs reveals 740 shared genes (44% of EBV targets and 62% of miR-17~92 targets; Figure 6B and Supplementary Table 7). Thus, EBV miRNAs co-target a majority of miR-17~92 regulated mRNAs, which are assigned to a variety of pathways, most notably regulating transcription, apoptosis, and the cell cycle (Figure 6C). Similarly, other abundant immunologically relevant miRNAs, 142-3p and miR-155, co-target with EBV miRNAs a large fraction of their Ago-bound 3'UTRs, representing ~60% of the targets for each of these host miRNAs (Supplementary Figure 5).