Detail Information

Basic Information:


  VIRBase ID:  

HHID00039839

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-let-7e-5p:           ADRB2:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-let-7e-5p ADRB2
miRBase
Accession/Entrez ID		 MIMAT0000066 154
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - ADRB2R//ADRBR//B2AR//BAR//BETA2AR

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-let-7e-5p
rs1189776118 chr19:51692814    T/C

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase ADRB2
chr5:148206691-148206692(+) m6A CDS       24284625//24981863//22608085
chr5:148206721-148206722(+) m6A CDS       24284625//24981863//22608085
chr5:148206760-148206761(+) m6A CDS       24284625//24981863//22608085
chr5:148206958-148206959(+) m6A CDS       24284625//22608085
chr5:148206980-148206981(+) m6A CDS       24284625//22608085
chr5:148207124-148207125(+) m6A CDS       24284625//25456834//24981863//22608085
chr5:148207164-148207165(+) m6A CDS       24284625//24209618//25456834//24981863//22608085
chr5:148207500-148207501(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085
chr5:148207518-148207519(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085
chr5:148207532-148207533(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085
chr5:148207550-148207551(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085
chr5:148207658-148207659(+) m6A 3'UTR       24284625//24209618//24981863//22575960//22608085
chr5:148207676-148207677(+) m6A 3'UTR       24284625//24981863//22608085
chr5:148207683-148207684(+) m6A 3'UTR       24284625//24981863//22608085
chr5:148207710-148207711(+) m6A 3'UTR       24981863//22608085
chr5:148208019-148208020(+) m6A 3'UTR       24284625//24981863//22608085
chr5:148208043-148208044(+) m6A 3'UTR       24284625//24981863//22608085
chr5:148208058-148208059(+) m6A 3'UTR       24284625//24981863//22608085
chr5:148208064-148208065(+) m6A 3'UTR       24284625//24981863//22608085

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-let-7e-5p
Apoptotic body Human umbilical vein endothelial cells     19996457
Cytoplasm Nasopharyngeal carcinoma cells     20498841
Cytoplasm Cell line (HeLa)     21695135
Cytoplasm HeLa cells     22058130
Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Exosome Primary ovarian tumor cells|Serum     18589210
Exosome Hetastatic gastric cancer cell line (AZ-P7a)     20949044
Exosome Breast cancer cell line (MCF-7)     20976003
Exosome Primary dendritic cells     21505438
Exosome Breast milk     22211110
Exosome Epidermal melanocytes (HEMa-LP)     23056502
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome K562 cells     24460325
Exosome Breast cancer cell lines (MCF-7|MDA-MB-231)     24468161
Exosome Endothelial cells|Epithelial cells|Mast cells|Seminal fluid     -
Extracellular vesicle HEK-293T cells     22849433
Microvesicle Plasma     23077538
Microvesicle Seminal plasma     23539611
Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     -
Mitochondrion Skeletal muscle myoblasts     21637849
Mitochondrion Cell line (HEK-293|HeLa)     22984580
Nucleolus Myoblasts     19628621
Nucleolus Breast adenocarcinoma cells (MCF-7)     24918059
Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Nucleus Nasopharyngeal carcinoma cells     20498841
Nucleus HeLa cells     22058130
ADRB2
Exosome Blood     -
Nucleus Nasopharyngeal carcinoma cells     20498841

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-let-7e-5p
Alvocidib 5287969 Drug resistant
ethyl, methoxy, prodigisine - Drug resistant
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-let-7e-5p
Thymidine-5'-phosphate 9700 Drug interaction    RC00000291
Hyaluronidase 91820602 Drug interaction    RC00000301
Formaldehyde 712 Drug interaction    RC00000283
Gemcitabine 60750 Drug interaction    RC00000295
Vincristine 5978 Drug interaction    RC00000290
Estradiol 5757 Drug interaction    RC00000289
Eloxatine 5310940 Drug interaction    RC00000299
Imatinib 5291 Drug interaction    RC00000288
Docosahexaenoic acid 445580 Drug interaction    RC00000298
Etoposide 36462 Drug interaction    RC00000294
Paclitaxel 36314 Drug interaction    RC00000293
5-Fluorouracil 3385 Drug interaction    RC00000287
Doxorubicin 31703 Drug interaction    RC00000292
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00000286
Verapamil 2520 Drug interaction    RC00000285
N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719 Drug interaction    RC00000300
Bicalutamide 2375 Drug interaction    RC00000284
Gefitinib 123631 Drug interaction    RC00000297
Ginsenoside Rh2 119307 Drug interaction    RC00000296
Hydroxamic acid HDACi LAQ824 - Drug interaction    RC00000302
Marine fungal metabolite 1386A - Drug interaction    RC00000303
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-let-7e-5p
Cisplatin 5702198       25356050
Doxorubicin 31703       24759738
N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719       26456124
Methyl (9R,10S,11S,12R,19R)-11-acetyloxy-12-ethyl-4-[(13S,15R,17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-8-formyl-10-hydroxy-5-methoxy-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate 134755071       24759738

Interaction Network (The top 100 interactions):


Interactor1: hsa-let-7e-5p
Interactor2: ADRB2

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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