Basic Information
RNALocate ID: RLID:01001231
RNA Symbol: hsa-let-7e-5p
Localization: Cytoplasm
RNA Information
RNA Name: hsa-let-7e
RNA ID: miRBase:MIMAT0000066
RNA Category: miRNA
Species: Homo sapiens
Sequence:
Localization Information
PubMed ID: 21695135
Tissue/Cell Line: Cell line (HeLa)
Method: Microarray

Heatmap showing the 57 miRNAs differentially expressed in HeLa cells from mitochondrial and cytosolic RNA. Three independent microarray profiling experiments (microarray n1, n2 and n3) are shown and reproducibly revealed 13 miRNAs enriched in mitochondrial RNA.

Originally published in PLoS One. Bandiera S, et al, 2011. Reproduced under the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/)
Description: While 44 miRNAs showed a greater enrichment in the cytosolic Hy3-labeled RNA fraction, 13 miRNAs were significantly and reproducibly enriched in the mitochondrial Hy5-labeled RNA sample (ranging from 1.5- to 56-fold), namely hsa-miR-1973, hsa-miR-1275, hsa-miR-494, hsa-miR-513a-5p, hsa-miR-1246, hsa-miR-328, hsa-miR-1908, hsa-miR-1972, hsa-miR-1974, hsa-miR-1977, hsa-miR-638, hsa-miR-1978 and hsa-miR-1201 (Figure 5A). Data are collected from Figure 5.
Other Subcellular Localization
RNALocate ID Localization Tissue/Cell line PubMed ID
RLID:01001230 Cytoplasm Nasopharyngeal carcinoma cells 20498841
RLID:01001232 Cytoplasm HeLa cells 22058130
RLID:01001233 Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa) 24918059
RLID:01001234 Mitochondrion Skeletal muscle myoblasts 21637849
RLID:01001235 Mitochondrion Cell line (HEK-293|HeLa) 22984580
RLID:01001236 Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa) 24918059
RLID:01001237 Nucleolus Myoblasts 19628621
RLID:01001238 Nucleolus Breast adenocarcinoma cells (MCF-7) 24918059
RLID:01001239 Nucleus Nasopharyngeal carcinoma cells 20498841
RLID:01001240 Nucleus HeLa cells 22058130
RLID:11000626 Apoptotic body Human umbilical vein endothelial cells 19996457
RLID:11000627 Exosome Primary ovarian tumor cells|Serum 18589210
RLID:11000628 Exosome Hetastatic gastric cancer cell line (AZ-P7a) 20949044
RLID:11000629 Exosome Breast cancer cell line (MCF-7) 20976003
RLID:11000630 Exosome Primary dendritic cells 21505438
RLID:11000631 Exosome Breast milk 22211110
RLID:11000632 Exosome Epidermal melanocytes (HEMa-LP) 23056502
RLID:11000633 Exosome Brain tissue 23382797
RLID:11000634 Exosome Plasma 23663360
RLID:11000635 Exosome K562 cells 24460325
RLID:11000636 Exosome Breast cancer cell lines (MCF-7|MDA-MB-231) 24468161
RLID:11000637 Extracellular vesicle HEK-293T cells 22849433
RLID:11000638 Microvesicle Plasma 23077538
RLID:11000639 Microvesicle Seminal plasma 23539611
RLID-D:11000005 Exosome Endothelial cells|Epithelial cells|Mast cells|Seminal fluid
RLID-D:11000265 Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine
ncRNA Disease Information
Resource RNA Symbol Disease Link
MNDR hsa-let-7e-5p Diffuse large b cell lymphoma MNDR-E-MI-01439
MNDR hsa-let-7e-5p Splenic marginal zone lymphoma MNDR-E-MI-01440
MNDR hsa-let-7e-5p Colorectal adenoma MNDR-E-MI-01441
MNDR hsa-let-7e-5p Oral squamous cell carcinoma MNDR-E-MI-01442
MNDR hsa-let-7e-5p Lymphoma non-hodgkin MNDR-E-MI-01443
MNDR hsa-let-7e-5p Estrogen-receptor positive breast cancer MNDR-E-MI-01444
MNDR hsa-let-7e-5p Estrogen-receptor negative breast cancer MNDR-E-MI-01445
MNDR hsa-let-7e-5p Progesterone-receptor positive breast cancer MNDR-E-MI-01446
MNDR hsa-let-7e-5p Progesterone-receptor negative breast cancer MNDR-E-MI-01447
MNDR hsa-let-7e-5p Breast cancer luminal MNDR-E-MI-01448
MNDR hsa-let-7e-5p Prostate cancer MNDR-E-MI-01449
MNDR hsa-let-7e-5p Gastric cancer MNDR-E-MI-01450
MNDR hsa-let-7e-5p Gastric lymphoma MNDR-E-MI-01451
MNDR hsa-let-7e-5p Alzheimer disease MNDR-E-MI-01452
MNDR hsa-let-7e-5p Dysautonomia familial MNDR-E-MI-01453
MNDR hsa-let-7e-5p Head and neck cancer MNDR-E-MI-01454
MNDR hsa-let-7e-5p Leukemia MNDR-E-MI-01455
MNDR hsa-let-7e-5p Cardiovascular disease MNDR-E-MI-01456
MNDR hsa-let-7e-5p Lung cancer MNDR-E-MI-01457
MNDR hsa-let-7e-5p Metabolic syndrome x MNDR-E-MI-01458
MNDR hsa-let-7e-5p Parkinson disease MNDR-E-MI-01459
MNDR hsa-let-7e-5p Colonic adenomas MNDR-E-MI-01460
MNDR hsa-let-7e-5p Basal-like breast cancer MNDR-E-MI-01461
MNDR hsa-let-7e-5p Thyroid cancer MNDR-E-MI-01462
MNDR hsa-let-7e-5p Pancreatic cancer MNDR-E-MI-01463
MNDR hsa-let-7e-5p Melanoma MNDR-E-MI-01464
MNDR hsa-let-7e-5p Nephroblastoma MNDR-E-MI-01465
MNDR hsa-let-7e-5p Colon cancer MNDR-E-MI-01466
MNDR hsa-let-7e-5p Ischemic attack transient MNDR-E-MI-01467
MNDR hsa-let-7e-5p Colon adenocarcinoma MNDR-E-MI-01468
MNDR hsa-let-7e-5p Familial ovarian cancer MNDR-E-MI-01469
MNDR hsa-let-7e-5p Prostate adenocarcinoma MNDR-E-MI-01470
MNDR hsa-let-7e-5p Carcinoma ductal breast MNDR-E-MI-01471
MNDR hsa-let-7e-5p Glioblastoma MNDR-E-MI-01472
MNDR hsa-let-7e-5p Malignant glioma MNDR-E-MI-01473
MNDR hsa-let-7e-5p Chordoma MNDR-E-MI-01474
MNDR hsa-let-7e-5p Amyotrophic lateral sclerosis MNDR-E-MI-01475
MNDR hsa-let-7e-5p Temporal lobe epilepsy MNDR-E-MI-01476
MNDR hsa-let-7e-5p Osteosarcoma MNDR-E-MI-01477
MNDR hsa-let-7e-5p Liver cancer MNDR-E-MI-01478
MNDR hsa-let-7e-5p Uterine cancer MNDR-E-MI-01479
MNDR hsa-let-7e-5p Cervical adenocarcinoma MNDR-E-MI-01480
MNDR hsa-let-7e-5p Gastric adenocarcinoma MNDR-E-MI-01481
MNDR hsa-let-7e-5p Lung squamous cell carcinoma MNDR-E-MI-01482
MNDR hsa-let-7e-5p Lung adenocarcinoma MNDR-E-MI-01483
MNDR hsa-let-7e-5p Adrenocortical cancer MNDR-E-MI-01484
MNDR hsa-let-7e-5p Thyroid carcinoma MNDR-E-MI-01485
MNDR hsa-let-7e-5p Pancreatic adenocarcinoma MNDR-E-MI-01486
MNDR hsa-let-7e-5p Kidney renal clear cell carcinoma MNDR-E-MI-01487
MNDR hsa-let-7e-5p Kidney renal papillary cell carcinoma MNDR-E-MI-01488
MNDR hsa-let-7e-5p Renal clear cell carcinoma MNDR-E-MI-01489
MNDR hsa-let-7e-5p Biliary tract cancer MNDR-E-MI-01490
MNDR hsa-let-7e-5p Cholangiocarcinoma MNDR-E-MI-01491
MNDR hsa-let-7e-5p Esophageal cancer MNDR-E-MI-01492
MNDR hsa-let-7e-5p Liver cirrhosis MNDR-E-MI-01493
MNDR hsa-let-7e-5p Synovial sarcoma MNDR-E-MI-01494
MNDR hsa-let-7e-5p Head and neck squamous cell carcinoma MNDR-E-MI-01495
MNDR hsa-let-7e-5p Adenoma MNDR-E-MI-01496
MNDR hsa-let-7e-5p Breast invasive carcinoma MNDR-E-MI-01497
MNDR hsa-let-7e-5p Early hepatocellular carcinoma MNDR-E-MI-01498
MNDR hsa-let-7e-5p Familiar ovarian carcinoma MNDR-E-MI-01499
MNDR hsa-let-7e-5p B-cell lymphoma MNDR-E-MI-01500
MNDR hsa-let-7e-5p Rheumatoid arthritis MNDR-E-MI-01501
MNDR hsa-let-7e-5p T-cell leukemia MNDR-E-MI-01502
MNDR hsa-let-7e-5p Retinoblastoma MNDR-E-MI-01503
MNDR hsa-let-7e-5p Neuroblastoma MNDR-E-MI-01504
MNDR hsa-let-7e-5p Hodgkin lymphoma MNDR-E-MI-01505
MNDR hsa-let-7e-5p Burkitt lymphoma MNDR-E-MI-01506
MNDR hsa-let-7e-5p Tonsil cancer MNDR-E-MI-01507
MNDR hsa-let-7e-5p Neuromyelitis optica MNDR-E-MI-01508
MNDR hsa-let-7e-5p Acute myelogenous leukemia MNDR-E-MI-01509
MNDR hsa-let-7e-5p Colorectal cancer MNDR-E-MI-01510
MNDR hsa-let-7e-5p Nasopharynx carcinoma MNDR-E-MI-01511
MNDR hsa-let-7e-5p Multiple myeloma MNDR-E-MI-01512
MNDR hsa-let-7e-5p Nasopharyngeal cancer MNDR-E-MI-01513
MNDR hsa-let-7e-5p Prostatic neoplasms MNDR-E-MI-01514
MNDR hsa-let-7e-5p Epstein-barr virus infections MNDR-E-MI-01515
MNDR hsa-let-7e-5p Cerebral hemorrhage traumatic MNDR-E-MI-01516
MNDR hsa-let-7e-5p Intracranial hemorrhage hypertensive MNDR-E-MI-01517
MNDR hsa-let-7e-5p Stroke MNDR-E-MI-01518
MNDR hsa-let-7e-5p Stroke lacunar MNDR-E-MI-01519
MNDR hsa-let-7e-5p Duke C MNDR-E-MI-01520
MNDR hsa-let-7e-5p Low grade dysplastic nodule MNDR-E-MI-01521
MNDR hsa-let-7e-5p Solid-pseudopapillary neoplasm of pancreas MNDR-E-MI-01522
RNA Interaction Information
Resource RNA Symbol Species Link RNALocate ID
RNAInter ACVR1B Homo sapiens RR00038913
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