Detail Information

Basic Information:


  VIRBase ID:  

HHID00026589

  Virus:  

Hepatitis B virus (HBV)

  Host:  

Homo sapiens

  Confidence Score:  

0.8808

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-let-7e-5p:           CASP3:      

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Interactor Information:


Interactor1 Interactor2
Symbol hsa-let-7e-5p CASP3
miRBase
Accession/Entrez ID		 MIMAT0000066 836
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - CPP32//CPP32B//SCA-1

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-let-7e-5p
rs1189776118 chr19:51692814    T/C

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR CASP3
chr4:185563395(-) A-I      intronic
chr4:185563394(-) A-I      intronic
chr4:185563384(-) A-I      intronic
chr4:185563373(-) A-I      intronic
chr4:185563404(-) A-I      intronic
chr4:185563238(-) A-I      intronic
chr4:185563248(-) A-I      intronic
chr4:185563256(-) A-I      intronic
chr4:185563258(-) A-I      intronic
chr4:185563263(-) A-I      intronic
chr4:185563366(-) A-I      intronic
chr4:185563267(-) A-I      intronic
chr4:185563281(-) A-I      intronic
chr4:185563282(-) A-I      intronic
chr4:185563287(-) A-I      intronic
chr4:185558634(-) A-I      intronic
chr4:185558588(-) A-I      intronic
chr4:185558356(-) A-I      intronic
chr4:185564752(-) A-I      intronic
chr4:185564777(-) A-I      intronic
chr4:185564768(-) A-I      intronic
chr4:185564626(-) A-I      intronic
chr4:185563358(-) A-I      intronic
chr4:185557396(-) A-I      intronic
chr4:185563253(-) A-I      intronic
chr4:185557349(-) A-I      intronic
chr4:185558689(-) A-I      intronic
chr4:185558232(-) A-I      intronic
chr4:185558615(-) A-I      intronic
chr4:185551739(-) A-I      intronic
chr4:185558568(-) A-I      intronic
chr4:185563319(-) A-I      intronic
chr4:185566909(-) A-I      intronic
chr4:185566948(-) A-I      intronic
chr4:185558311(-) A-I      intronic
chr4:185558258(-) A-I      intronic
chr4:185558672(-) A-I      intronic
chr4:185560238(-) A-I      intronic
chr4:185560360(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED CASP3
chr4:185570553(-) A-I exon 5'UTR    19478186
chr4:185558311(-) A-G intron -    22484847
chr4:185558672(-) A-G intron -    22484847
chr4:185563358(-) A-G intron -    22484847
chr4:185566794(-) G-A intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase CASP3
chr4:185549472-185549473(-) m6A 3'UTR       24981863
chr4:185556524-185556525(-) m6A CDS       -
chr4:185556542-185556543(-) m6A CDS       -
chr4:185559556-185559557(-) m6A CDS       24981863
chr4:185559590-185559591(-) m6A CDS       24981863//27773535
chr4:185559599-185559600(-) m6A CDS       24981863//27773535
chr4:185565779-185565780(-) m6A 5'UTR//intron       24981863

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-let-7e-5p
Apoptotic body Human umbilical vein endothelial cells     19996457
Cytoplasm Nasopharyngeal carcinoma cells     20498841
Cytoplasm Cell line (HeLa)     21695135
Cytoplasm HeLa cells     22058130
Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Exosome Primary ovarian tumor cells|Serum     18589210
Exosome Hetastatic gastric cancer cell line (AZ-P7a)     20949044
Exosome Breast cancer cell line (MCF-7)     20976003
Exosome Primary dendritic cells     21505438
Exosome Breast milk     22211110
Exosome Epidermal melanocytes (HEMa-LP)     23056502
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome K562 cells     24460325
Exosome Breast cancer cell lines (MCF-7|MDA-MB-231)     24468161
Exosome Endothelial cells|Epithelial cells|Mast cells|Seminal fluid     -
Extracellular vesicle HEK-293T cells     22849433
Microvesicle Plasma     23077538
Microvesicle Seminal plasma     23539611
Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     -
Mitochondrion Skeletal muscle myoblasts     21637849
Mitochondrion Cell line (HEK-293|HeLa)     22984580
Nucleolus Myoblasts     19628621
Nucleolus Breast adenocarcinoma cells (MCF-7)     24918059
Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Nucleus Nasopharyngeal carcinoma cells     20498841
Nucleus HeLa cells     22058130
CASP3
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Nucleoplasm K562 cells     -
Nucleus HCC cell line (HepG2)|K562 cells     -
Ribosome HEK-293 cells     22199352

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-let-7e-5p
Alvocidib 5287969 Drug resistant
ethyl, methoxy, prodigisine - Drug resistant
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-let-7e-5p
Thymidine-5'-phosphate 9700 Drug interaction    RC00000291
Hyaluronidase 91820602 Drug interaction    RC00000301
Formaldehyde 712 Drug interaction    RC00000283
Gemcitabine 60750 Drug interaction    RC00000295
Vincristine 5978 Drug interaction    RC00000290
Estradiol 5757 Drug interaction    RC00000289
Eloxatine 5310940 Drug interaction    RC00000299
Imatinib 5291 Drug interaction    RC00000288
Docosahexaenoic acid 445580 Drug interaction    RC00000298
Etoposide 36462 Drug interaction    RC00000294
Paclitaxel 36314 Drug interaction    RC00000293
5-Fluorouracil 3385 Drug interaction    RC00000287
Doxorubicin 31703 Drug interaction    RC00000292
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00000286
Verapamil 2520 Drug interaction    RC00000285
N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719 Drug interaction    RC00000300
Bicalutamide 2375 Drug interaction    RC00000284
Gefitinib 123631 Drug interaction    RC00000297
Ginsenoside Rh2 119307 Drug interaction    RC00000296
Hydroxamic acid HDACi LAQ824 - Drug interaction    RC00000302
Marine fungal metabolite 1386A - Drug interaction    RC00000303
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-let-7e-5p
Cisplatin 5702198       25356050
Doxorubicin 31703       24759738
N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719       26456124
Methyl (9R,10S,11S,12R,19R)-11-acetyloxy-12-ethyl-4-[(13S,15R,17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-8-formyl-10-hydroxy-5-methoxy-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate 134755071       24759738

Interaction Network (The top 100 interactions):


Interactor1: hsa-let-7e-5p
Interactor2: CASP3

Evidence Support:


Strong-Evidence Luciferase reporter assay//RT-PCR
Support Database VIRmiRNA

References:


PMID 21565290 Target region 3'UTR
Source VIRmiRNA Interactor1 expression None
Tissue or cell line B-lymphocyte cells Interactor2 expression None
Description We listed the cellular functions of these relevant miRNAs in liver disease and their biological properties associated with HBV or HBV-related HCC in Table 1. We also summarized the known changes of miRNAs involved in multiple steps of chronic hepatitis B, from hepatitis to cirrhosis and finally to HCC (Fig. 3).

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