The Detail page: representing the detail information for virus-host related ncRNA interaction;
The Binding page: representing the predicted binding sites.
The Network page: representing the interaction sub-network of interacting ncRNA/Interactor.
- Detail
- Binding
- Network
Detail: | |
Vhid: | HVID00011766 |
---|---|
Virus: | Adeno-associated virus(AAV) |
Host Species: | Homo sapiens |
ncRNA Source: | Host |
ncRNA Category: | miRNA |
ncRNA Symbol: | hsa-mir-214 |
Tissue: | Saos-2 cells |
Expression Direction of ncRNA: | - |
Interactor in Virus or Host: | Virus |
Interactor Category: | Protein |
Interactor Symbol: | E1A |
Expression Direction of Interactor: | Downregulation |
Validated Method: | Luciferase reporter. |
PMID: | 22982546 |
Detailed Description: | The activity from the same reporter was unchanged in HeLa cells, which display low-level miR-214 expression. Finally, we confirmed that the knockdown of the miR-214 upregulated the productive efficiency of the virus. These findings indicate that cellular miR-214 is capable of inhibiting adenovirus replication by regulating the translation of E1A protein. |
The 'First Node' or 'Second Node' option represents the sub-network of interacting ncRNA/Interactor with the first or second interaction node,
the 'Both the Nodes' option represents the sub-network of interacting ncRNA/Interactor with both of interaction nodes.
The 'First Neighbour' represents the sub-network of direct interacting with the center node,
the 'Second Neighbour' represents the sub-network of direct or second step interacting with the center node.
Interaction sub-network based on the two nodes of this interaction may help the researchers represents all interacting partners immediately.