ncRNADetailInformation

Detail Information
Functional analysis

miRNA name

pre-miRNA

family

pre-miRNA Sequence

mature-miRNA

mature sequence

pre-miRNA description

miR-7

MI0000265	MIPF0000022	AGAUUAGAGUGGCUGUGGUCUAGUGCUGUGUGGAAGACUAGUGAUUUUGUUGUUCUGAUGUACUACGACAACAAGUCACAGCCGGCCUCAUAGCGCAGACUCCCUUCGAC	MIMAT0000252 hsa-miR-7-5p	UGGAAGACUAGUGAUUUUGUUGU
MI0000263	MIPF0000022	UUGGAUGUUGGCCUAGUUCUGUGUGGAAGACUAGUGAUUUUGUUGUUUUUAGAUAACUAAAUCGACAACAAAUCACAGUCUGCCAUAUGGCACAGGCCAUGCCUCUACAG	MIMAT0004553 hsa-miR-7-1-3p	CAACAAAUCACAGUCUGCCAUA	This human miRNA was predicted by computational methods using conservationwith mouse and Fugu rubripes sequences . Expression of the excised miRhas been validated in zebrafish, and the 5' end mapped by PCR. Landgrafet al. confirm expression in human . The mature sequence shown hererepresents the most commonly cloned form from large-scale cloning studies.
MI0000264	MIPF0000022	CUGGAUACAGAGUGGACCGGCUGGCCCCAUCUGGAAGACUAGUGAUUUUGUUGUUGUCUUACUGCGCUCAACAACAAAUCCCAGUCUACCUAAUGGUGCCAGCCAUCGCA	MIMAT0004554 hsa-miR-7-2-3p	CAACAAAUCCCAGUCUACCUAA	This human miRNA was predicted by computational methods using conservationwith mouse and Fugu rubripes sequences . Expression of the excised miRhas been validated in zebrafish, and the 5' end mapped by PCR. Landgrafet al. confirm expression in human . The mature sequence shown hererepresents the most commonly cloned form from large-scale cloning studies.
MI0000265	MIPF0000022	AGAUUAGAGUGGCUGUGGUCUAGUGCUGUGUGGAAGACUAGUGAUUUUGUUGUUCUGAUGUACUACGACAACAAGUCACAGCCGGCCUCAUAGCGCAGACUCCCUUCGAC	MIMAT0000252 hsa-miR-7-5p	UGGAAGACUAGUGAUUUUGUUGU
MI0000263	MIPF0000022	UUGGAUGUUGGCCUAGUUCUGUGUGGAAGACUAGUGAUUUUGUUGUUUUUAGAUAACUAAAUCGACAACAAAUCACAGUCUGCCAUAUGGCACAGGCCAUGCCUCUACAG	MIMAT0004553 hsa-miR-7-1-3p	CAACAAAUCACAGUCUGCCAUA	This human miRNA was predicted by computational methods using conservationwith mouse and Fugu rubripes sequences . Expression of the excised miRhas been validated in zebrafish, and the 5' end mapped by PCR. Landgrafet al. confirm expression in human . The mature sequence shown hererepresents the most commonly cloned form from large-scale cloning studies.
MI0000264	MIPF0000022	CUGGAUACAGAGUGGACCGGCUGGCCCCAUCUGGAAGACUAGUGAUUUUGUUGUUGUCUUACUGCGCUCAACAACAAAUCCCAGUCUACCUAAUGGUGCCAGCCAUCGCA	MIMAT0004554 hsa-miR-7-2-3p	CAACAAAUCCCAGUCUACCUAA	This human miRNA was predicted by computational methods using conservationwith mouse and Fugu rubripes sequences . Expression of the excised miRhas been validated in zebrafish, and the 5' end mapped by PCR. Landgrafet al. confirm expression in human . The mature sequence shown hererepresents the most commonly cloned form from large-scale cloning studies.
MI0000265	MIPF0000022	AGAUUAGAGUGGCUGUGGUCUAGUGCUGUGUGGAAGACUAGUGAUUUUGUUGUUCUGAUGUACUACGACAACAAGUCACAGCCGGCCUCAUAGCGCAGACUCCCUUCGAC	MIMAT0000252 hsa-miR-7-5p	UGGAAGACUAGUGAUUUUGUUGU
MI0000263	MIPF0000022	UUGGAUGUUGGCCUAGUUCUGUGUGGAAGACUAGUGAUUUUGUUGUUUUUAGAUAACUAAAUCGACAACAAAUCACAGUCUGCCAUAUGGCACAGGCCAUGCCUCUACAG	MIMAT0004553 hsa-miR-7-1-3p	CAACAAAUCACAGUCUGCCAUA	This human miRNA was predicted by computational methods using conservationwith mouse and Fugu rubripes sequences . Expression of the excised miRhas been validated in zebrafish, and the 5' end mapped by PCR. Landgrafet al. confirm expression in human . The mature sequence shown hererepresents the most commonly cloned form from large-scale cloning studies.
MI0000264	MIPF0000022	CUGGAUACAGAGUGGACCGGCUGGCCCCAUCUGGAAGACUAGUGAUUUUGUUGUUGUCUUACUGCGCUCAACAACAAAUCCCAGUCUACCUAAUGGUGCCAGCCAUCGCA	MIMAT0004554 hsa-miR-7-2-3p	CAACAAAUCCCAGUCUACCUAA	This human miRNA was predicted by computational methods using conservationwith mouse and Fugu rubripes sequences . Expression of the excised miRhas been validated in zebrafish, and the 5' end mapped by PCR. Landgrafet al. confirm expression in human . The mature sequence shown hererepresents the most commonly cloned form from large-scale cloning studies.
MI0000265	MIPF0000022	AGAUUAGAGUGGCUGUGGUCUAGUGCUGUGUGGAAGACUAGUGAUUUUGUUGUUCUGAUGUACUACGACAACAAGUCACAGCCGGCCUCAUAGCGCAGACUCCCUUCGAC	MIMAT0000252 hsa-miR-7-5p	UGGAAGACUAGUGAUUUUGUUGU

link to database

TargetScanS 6.2 | MicroCosm | microRNA.org | miRNAMap 2.0

Interacted genes from RAID,miRTarBase

MRPL10,TGOLN2,TBC1D2B,SHISA5,ANXA11,CHRNA2,WNT8B,EXOC3,GRINA,HPCAL1,ZNF365,MGLL,RELA,SAMSN1,CNN3
more » MRPL10,TGOLN2,TBC1D2B,SHISA5,ANXA11,CHRNA2,WNT8B,EXOC3,GRINA,HPCAL1,ZNF365,MGLL,RELA,SAMSN1,CNN3,GJC1,WFS1,HOXA3,MFSD5,DCAF7,IFNE,DUSP23,POLE4,CNOT8,MS4A4A,TGM2,WDR45,TSN,FLNA,RALA,CACNG5,TRAM2,PFN2,SNX29,USP31,GALNT2,PTP4A2,TMEM69,PPIF,AKT1,IDE,SLC6A9,BMPR2,GLDN,TMEM38B,TAF4,NRSN2,PNISR,SLC25A37,RNF41,DNAJC11,LYPD3,MMP2,EXOSC2,EHD1,TMEM48,NBL1,RAF1,PDE4D,ACVR1B,SERP1,CAMK2D,TMEM134,EFHD2,NDFIP2,ALDH3B2,RNF128,PDGFC,FADD,RYK,MPP5,C10orf105,GPAA1,HNRNPU,JPH1,MINA,CXCL5,VPS4A,LAMC2,CALM3,FAM89B,PAX6,ZNF805,PIGH,ARG1,UBQLN4,GLO1,BCKDK,ARL15,XPR1,RPS6KB2,RFFL,KIF24,AGPAT1,ZYX,SERTAD4,RDH16,TRIM47,IGFBP4,TNP1,SQSTM1,GFRA1,MATR3,ZNF655,PTAR1,SOCS2,TMEM97,KRT7,IL21R,CAPN2,TTLL12,LYPLA2,EIF5A2,CALU,FAM126B,ZP3,C5orf22,SLC26A3,EIF2S3,GDNF,PSME3,SNAPIN,NUDCD3,POLE3,CDC37,CHD9,PLEKHB1,GLS,NFYA,KIAA0247,CCDC76,ALDH3A2,PAK1,EIF2AK1,ZDHHC3,ATP1B3,PLEKHH1,BTG2,FGF1,CLK3,ZNF436,SLC25A39,CLEC4G,LITAF,PIK3CB,RPS3A,ASB2,SETD1B,CASP9,DDI2,VPS13D,EIF4EBP2,ADO,NAV1,UHRF1,TMED2,PHF10,SIGMAR1,PLEC,TCOF1,RWDD1,GIT1,APLP2,MEPCE,SOLH,ERF,KRTAP11-1,GTF3C5,ILF3,PTK2,PRDX1,MPDU1,TRIM14,HPS6,OR1A1,TRIM8,ROR1,SPATA2,TAF1,CAPZA1,BCL2,C17orf78,EGFR,PPAP2B,SMARCD1,WASF2,GBF1,ZNF460,IGSF8,CANT1,KCNK13,CAGE1,NR1H2,HOXC12,OAS2,COLEC12,CDC42EP4,AP1M1,LRRC59,IL12RB2,ARF4,ZFYVE20,SSU72,NXT2,CRTC3,ARMC10,RSPRY1,TNFAIP2,SP7,LUC7L2,EIF3L,IRS1,AGK,RUSC1,DAZAP2,STK40,C1orf144,RNF38,RPS6KB1,SGPL1,ZFAND4,CPNE2,PPRC1,EIF4E,KRT80,MARCKSL1,KCNH2,ALG3,HTRA4,CLN3,PAPPA,LRP6,CKAP4,PITPNC1,GPR19,GPR172A,BCCIP,PRKRIR,SERTAD3,RHBDF2,TAPBP,CTDSP1,ZNF507,ERI2,PRDM8,VPS26A,KRTAP4-7,CHAMP1,DSC2,VAMP8,PPP2R1B,FRS2,DTYMK,DNAJC5,DEFA5,PHF16,AKR7A2,MAP2K2,XRCC5,HSPBP1,C1orf21,CORO6,RPS19BP1,ADCY9,RSU1,SNCA,HELLS,LANCL1,ZNF625,HOXB5,TMEM81,LCE1E,SCAMP2,TAGLN,TNK2,TFPI,ST3GAL5,RPL15,TPGS2,TMUB2,SH3BP4,MTOR,AUP1,FNDC4,MAPK1,SSX1,RAB11FIP5,TOP2A,UNC119,SETD8,BCL9L,ZNF555,XIAP,CCDC65,ATF5,ALDH1A3,SUPT4H1,E2F2,KCNJ14,SLC39A11,C11orf24,MAPK9,MAS1L,HDLBP,SCARB2,OSBPL11,ATF7IP2,AP3M1,IRS2,SLC25A15,TNRC6B,SDHC,ZNF264,PDIA3,RCC2,CRTAP,MYEOV,DUS1L,KEAP1,SRM,HECTD3,DCAF12,MICALL1,SLC3A2,KIF16B,TSKU,C3orf38,IGF1R,ABCC1,POLR2E,TSC22D4,RNF114,KRTAP4-2,SRSF1,ANKRD31,PTK7,PRRT3,MMP9,HIATL1,MIF4GD,KPNB1,GRAMD1A,SNAP29,PARP11,CDC25B,TMED10,DNAJC27,NDUFA4,CFLAR,TCL1B,UBE2R2,IGSF3,DCTD,GLT8D2,SERTAD2,PMEPA1,YY1,MOCS3,PMP2,SLC25A44,PHC2,ACOT4,TMEM43,HMGN4,CRLS1,DBNL,SLC35A5,SEPP1,LGALS3BP,RBM17,SRGAP2,CYBASC3,ENTPD6,SIRT2,TSEN34,TIMM50,FAM113B,CAV1,COMMD7,NCEH1,UBE3C,TUSC2,TRPA1,DOCK5,SULT1C2,ACTN2,MFSD10,EHD3,C19orf12,DCAF17,RRAS2,GINS1,MAP1B,MAPK3,ADAMTS17,GRB2,OSBPL8

KEGG pathways enriched for interacted genes

pathway name

pathway description

target genes enrich in pathway

p-value

hsa04012	ErbB signaling pathway	MAPK9,PTK2,MAP2K2,RAF1,EGFR,CAMK2D,PAK1,AKT1,MTOR,PIK3CB,RPS6KB1,RPS6KB2,GRB2,MAPK3,MAPK1,	3.40E-8
hsa05215	Prostate cancer	CASP9,BCL2,MAP2K2,RAF1,EGFR,RELA,PDGFC,AKT1,E2F2,MTOR,PIK3CB,IGF1R,GRB2,MAPK3,MAPK1,	4.60E-8
hsa05214	Glioma	MAP2K2,RAF1,CAMK2D,EGFR,AKT1,MTOR,E2F2,PIK3CB,IGF1R,GRB2,MAPK3,CALM3,MAPK1,	4.89E-8
hsa04510	Focal adhesion	MAPK9,CAPN2,PTK2,BCL2,RAF1,EGFR,FLNA,PDGFC,ZYX,PAK1,CAV1,XIAP,AKT1,LAMC2,IGF1R,PIK3CB,GRB2,MAPK3,ACTN2,MAPK1,	7.53E-7
hsa04910	Insulin signaling pathway	MAPK9,MAP2K2,RAF1,IRS2,AKT1,MTOR,PIK3CB,SOCS2,RPS6KB1,RPS6KB2,GRB2,EIF4E,MAPK3,IRS1,CALM3,MAPK1,	1.60E-6

hsa05221	Acute myeloid leukemia	PIK3CB,RPS6KB1,RPS6KB2,MAP2K2,GRB2,RAF1,RELA,MAPK3,AKT1,MTOR,MAPK1,	1.78E-6
hsa05212	Pancreatic cancer	MAPK9,CASP9,PIK3CB,RALA,RAF1,EGFR,RELA,ACVR1B,MAPK3,AKT1,E2F2,MAPK1,	1.86E-6
hsa05200	Pathways in cancer	CASP9,RAF1,EGFR,RELA,WNT8B,XIAP,MTOR,IGF1R,FADD,FGF1,MAPK9,MMP2,PTK2,BCL2,MAP2K2,RALA,MMP9,ACVR1B,AKT1,E2F2,LAMC2,PIK3CB,GRB2,MAPK3,MAPK1,	2.60E-6
hsa04722	Neurotrophin signaling pathway	MAPK9,FRS2,BCL2,MAP2K2,RAF1,CAMK2D,RELA,IRS2,AKT1,PIK3CB,GRB2,MAPK3,IRS1,CALM3,MAPK1,	3.02E-6
hsa05223	Non-small cell lung cancer	CASP9,PIK3CB,MAP2K2,GRB2,RAF1,EGFR,MAPK3,AKT1,E2F2,MAPK1,	8.05E-6
hsa05210	Colorectal cancer	MAPK9,IGF1R,CASP9,PIK3CB,BCL2,GRB2,RAF1,EGFR,ACVR1B,MAPK3,AKT1,MAPK1,	8.78E-6
hsa05218	Melanoma	IGF1R,PIK3CB,MAP2K2,FGF1,RAF1,EGFR,MAPK3,PDGFC,AKT1,E2F2,MAPK1,	1.18E-5
hsa05213	Endometrial cancer	CASP9,PIK3CB,MAP2K2,GRB2,RAF1,EGFR,MAPK3,AKT1,MAPK1,	4.79E-5
hsa05219	Bladder cancer	MMP2,MAP2K2,MMP9,RAF1,EGFR,MAPK3,E2F2,MAPK1,	8.56E-5
hsa05220	Chronic myeloid leukemia	PIK3CB,MAP2K2,GRB2,RAF1,RELA,ACVR1B,MAPK3,AKT1,E2F2,MAPK1,	1.19E-4
hsa04666	Fc gamma R-mediated phagocytosis	PIK3CB,WASF2,RPS6KB1,RPS6KB2,RAF1,MAPK3,PAK1,PPAP2B,AKT1,MAPK1,MARCKSL1,	1.53E-4
hsa04930	Type II diabetes mellitus	MAPK9,PIK3CB,SOCS2,MAPK3,IRS1,IRS2,MTOR,MAPK1,	1.79E-4
hsa04912	GnRH signaling pathway	MAPK9,MMP2,ADCY9,MAP2K2,GRB2,RAF1,CAMK2D,EGFR,MAPK3,CALM3,MAPK1,	1.98E-4
hsa04150	mTOR signaling pathway	PIK3CB,RPS6KB1,RPS6KB2,MAPK3,EIF4E,AKT1,MTOR,MAPK1,	3.42E-4
hsa04810	Regulation of actin cytoskeleton	PTK2,WASF2,MAP2K2,RAF1,EGFR,PDGFC,PAK1,GIT1,PIK3CB,FGF1,MAPK3,RRAS2,ACTN2,MAPK1,PFN2,	1.24E-2
hsa05222	Small cell lung cancer	CASP9,LAMC2,PIK3CB,PTK2,BCL2,RELA,XIAP,AKT1,E2F2,	1.38E-2
hsa04914	Progesterone-mediated oocyte maturation	MAPK9,IGF1R,PIK3CB,CDC25B,ADCY9,RAF1,MAPK3,AKT1,MAPK1,	1.61E-2
hsa04210	Apoptosis	CAPN2,CASP9,PIK3CB,BCL2,FADD,CFLAR,RELA,XIAP,AKT1,	1.73E-2
hsa04660	T cell receptor signaling pathway	MAPK9,PIK3CB,MAP2K2,GRB2,RAF1,RELA,MAPK3,PAK1,AKT1,MAPK1,	1.81E-2
hsa05211	Renal cell carcinoma	PIK3CB,MAP2K2,GRB2,RAF1,MAPK3,PAK1,AKT1,MAPK1,	2.08E-2
hsa04662	B cell receptor signaling pathway	PIK3CB,MAP2K2,GRB2,RAF1,RELA,MAPK3,AKT1,MAPK1,	3.09E-2
hsa04370	VEGF signaling pathway	CASP9,PIK3CB,PTK2,MAP2K2,RAF1,MAPK3,AKT1,MAPK1,	3.09E-2
hsa04010	MAPK signaling pathway	MAPK9,CACNG5,MAP2K2,RAF1,EGFR,ACVR1B,RELA,FLNA,PAK1,AKT1,CDC25B,FGF1,GRB2,MAPK3,RRAS2,MAPK1,	3.59E-2
hsa04664	Fc epsilon RI signaling pathway	MAPK9,PIK3CB,MAP2K2,GRB2,RAF1,MAPK3,AKT1,MAPK1,	3.86E-2
hsa04960	Aldosterone-regulated sodium reabsorption	PIK3CB,ATP1B3,MAPK3,IRS1,IRS2,MAPK1,	3.86E-2
hsa04540	Gap junction	ADCY9,MAP2K2,GRB2,RAF1,EGFR,MAPK3,PDGFC,MAPK1,	7.96E-2
hsa04916	Melanogenesis	ADCY9,MAP2K2,RAF1,CAMK2D,MAPK3,CALM3,WNT8B,MAPK1,	1.39E-1
hsa04520	Adherens junction	IGF1R,WASF2,EGFR,ACVR1B,MAPK3,ACTN2,MAPK1,	1.43E-1
hsa04620	Toll-like receptor signaling pathway	MAPK9,PIK3CB,FADD,MAP2K2,RELA,MAPK3,AKT1,MAPK1,	1.54E-1
hsa04062	Chemokine signaling pathway	PIK3CB,PTK2,ADCY9,GRB2,RAF1,CXCL5,RELA,MAPK3,PAK1,AKT1,MAPK1,	2.27E-1
hsa04350	TGF-beta signaling pathway	BMPR2,RPS6KB1,RPS6KB2,ACVR1B,MAPK3,PPP2R1B,MAPK1,	2.48E-1
hsa05010	Alzheimer's disease	CAPN2,CASP9,FADD,SNCA,NDUFA4,SDHC,MAPK3,CALM3,IDE,MAPK1,	2.51E-1
hsa04320	Dorso-ventral axis formation	GRB2,EGFR,MAPK3,MAPK1,	2.59E-1
hsa00561	Glycerolipid metabolism	ALDH3A2,AGPAT1,AGK,PPAP2B,MGLL,	2.84E-1
hsa04920	Adipocytokine signaling pathway	MAPK9,RELA,IRS1,IRS2,AKT1,MTOR,	2.92E-1
hsa04720	Long-term potentiation	MAP2K2,RAF1,CAMK2D,MAPK3,CALM3,MAPK1,	3.09E-1
hsa04730	Long-term depression	IGF1R,MAP2K2,RAF1,MAPK3,PPP2R1B,MAPK1,	3.26E-1
hsa00240	Pyrimidine metabolism	DTYMK,POLR2E,ENTPD6,POLE4,DCTD,POLE3,CANT1,	3.61E-1
hsa04144	Endocytosis	IGF1R,RAB11FIP5,ZFYVE20,EHD1,EGFR,ACVR1B,VPS4A,RNF41,GIT1,EHD3,	4.87E-1
hsa04114	Oocyte meiosis	IGF1R,ADCY9,CAMK2D,MAPK3,CALM3,PPP2R1B,MAPK1,	6.53E-1
hsa04621	NOD-like receptor signaling pathway	MAPK9,RELA,MAPK3,XIAP,MAPK1,	7.63E-1
hsa05120	Epithelial cell signaling in Helicobacter pylori infection	MAPK9,EGFR,RELA,PAK1,GIT1,	9.92E-1

Gene ontology terms enriched for interacted genes

GO terms

GO terms description

target genes enrich in GO term

p-value

GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	BMPR2,FRS2,PTK2,RAF1,EGFR,FLNA,PDGFC,IRS2,AKT1,ARF4,IGF1R,SOCS2,FGF1,GRB2,IRS1,ROR1,EIF4EBP2,SGPL1,	1.09E-5
GO:0046777	protein amino acid autophosphorylation	IGF1R,CLK3,PTK2,CAMK2D,EGFR,EIF2AK1,ACVR1B,PAK1,TAF1,AKT1,MTOR,	1.83E-5
GO:0007265	Ras protein signal transduction	CDC42EP4,WASF2,MAP2K2,GRB2,RALA,RAF1,MAPK3,RRAS2,DBNL,RSU1,MAPK1,	1.14E-4
GO:0032268	regulation of cellular protein metabolic process	EGFR,PDGFC,TAF1,MTOR,PSME3,EIF4E,IDE,EIF4EBP2,NR1H2,TNRC6B,BMPR2,BCL2,SNCA,NDFIP2,PAK1,CAV1,KRT7,DBNL,AKT1,EIF2AK1,CLN3,EIF5A2,TNK2,MIF4GD,MAPK1,	1.57E-4
GO:0043434	response to peptide hormone stimulus	BCL2,BTG2,RELA,IRS2,AKT1,MTOR,IGF1R,SOCS2,RPS6KB1,GRB2,IRS1,EIF4EBP2,MAP1B,	1.69E-4

GO:0043066	negative regulation of apoptosis	BCL2,BTG2,SNCA,EGFR,RELA,WFS1,XIAP,AKT1,GLO1,HELLS,IGF1R,GDNF,SOCS2,TGM2,CFLAR,CLN3,DNAJC5,SQSTM1,XRCC5,ATF5,	3.70E-4
GO:0006468	protein amino acid phosphorylation	PTK7,FRS2,CLK3,RAF1,EGFR,TAF1,BCKDK,MTOR,IGF1R,RYK,MAPK9,BMPR2,PTK2,BCL2,IL12RB2,MAP2K2,CAMK2D,ACVR1B,PAK1,DBNL,AKT1,PIK3CB,RPS6KB1,RPS6KB2,EIF2AK1,ROR1,MAPK3,TNK2,STK40,MAPK1,	4.35E-4
GO:0043069	negative regulation of programmed cell death	BCL2,BTG2,SNCA,EGFR,RELA,WFS1,XIAP,AKT1,GLO1,HELLS,IGF1R,GDNF,SOCS2,TGM2,CFLAR,CLN3,DNAJC5,SQSTM1,XRCC5,ATF5,	4.36E-4
GO:0060548	negative regulation of cell death	BCL2,BTG2,SNCA,EGFR,RELA,WFS1,XIAP,AKT1,GLO1,HELLS,IGF1R,GDNF,SOCS2,TGM2,CFLAR,CLN3,DNAJC5,SQSTM1,XRCC5,ATF5,	4.56E-4
GO:0010627	regulation of protein kinase cascade	NDFIP2,RELA,FLNA,CANT1,PAK1,CAV1,PRDX1,AKT1,DBNL,MTOR,FADD,TGM2,CFLAR,SQSTM1,SHISA5,LITAF,	4.67E-4
GO:0042981	regulation of apoptosis	CASP9,EGFR,RELA,RPS3A,XIAP,HELLS,IGF1R,SOCS2,FADD,CFLAR,DNAJC5,PSME3,SQSTM1,XRCC5,ATF5,MAPK9,ALDH1A3,BCL2,PDIA3,BTG2,SNCA,MMP9,ACVR1B,TOP2A,WFS1,PRDX1,AKT1,GLO1,PPIF,GDNF,TGM2,CLN3,ACTN2,MAPK1,	4.99E-4
GO:0016192	vesicle-mediated transport	TMED10,SCAMP2,LRP6,SH3BP4,SNAP29,COLEC12,FLNA,VPS4A,TAPBP,SNAPIN,VAMP8,TMED2,SQSTM1,AP1M1,ZFYVE20,WASF2,SNCA,CAV1,DBNL,GBF1,ARF4,VPS26A,EHD1,CLN3,EXOC3,MARCKSL1,AP3M1,	5.01E-4
GO:0031998	regulation of fatty acid beta-oxidation	IRS1,IRS2,AKT1,MTOR,	5.62E-4
GO:0043067	regulation of programmed cell death	CASP9,EGFR,RELA,RPS3A,XIAP,HELLS,IGF1R,SOCS2,FADD,CFLAR,DNAJC5,PSME3,SQSTM1,XRCC5,ATF5,MAPK9,ALDH1A3,BCL2,PDIA3,BTG2,SNCA,MMP9,ACVR1B,TOP2A,WFS1,PRDX1,AKT1,GLO1,PPIF,GDNF,TGM2,CLN3,ACTN2,MAPK1,	5.90E-4
GO:0010941	regulation of cell death	CASP9,EGFR,RELA,RPS3A,XIAP,HELLS,IGF1R,SOCS2,FADD,CFLAR,DNAJC5,PSME3,SQSTM1,XRCC5,ATF5,MAPK9,ALDH1A3,BCL2,PDIA3,BTG2,SNCA,MMP9,ACVR1B,TOP2A,WFS1,PRDX1,AKT1,GLO1,PPIF,GDNF,TGM2,CLN3,ACTN2,MAPK1,	6.27E-4
GO:0043122	regulation of I-kappaB kinase/NF-kappaB cascade	FADD,TGM2,CFLAR,NDFIP2,RELA,SQSTM1,FLNA,SHISA5,CANT1,LITAF,	6.31E-4
GO:0007167	enzyme linked receptor protein signaling pathway	BMPR2,FRS2,PTK2,RAF1,EGFR,ACVR1B,FLNA,PDGFC,IRS2,AKT1,ARF4,IGF1R,SOCS2,FGF1,GRB2,IRS1,ROR1,EIF4EBP2,SGPL1,	6.56E-4
GO:0006916	anti-apoptosis	BCL2,SNCA,RELA,XIAP,AKT1,GLO1,HELLS,IGF1R,GDNF,SOCS2,TGM2,CFLAR,SQSTM1,ATF5,	7.17E-4
GO:0019217	regulation of fatty acid metabolic process	SNCA,IRS1,NR1H2,CAV1,IRS2,AKT1,MTOR,	7.21E-4
GO:0030335	positive regulation of cell migration	IGF1R,RPS6KB1,BCL2,MMP9,EGFR,IRS1,RRAS2,IRS2,MAPK1,	8.11E-4
GO:0043491	protein kinase B signaling cascade	RPS6KB1,RPS6KB2,IRS1,AKT1,	8.29E-4
GO:0010608	posttranscriptional regulation of gene expression	BCL2,FLNA,KRT7,AKT1,MTOR,GDNF,EIF2AK1,EIF5A2,EIF4E,HNRNPU,EIF4EBP2,MIF4GD,TNRC6B,MAPK1,	8.90E-4
GO:0016310	phosphorylation	PTK7,FRS2,CLK3,NDUFA4,RAF1,EGFR,TAF1,BCKDK,MTOR,IGF1R,RYK,BMPR2,MAPK9,PTK2,IL12RB2,BCL2,SNCA,MAP2K2,CAMK2D,ACVR1B,PAK1,DBNL,AGK,AKT1,PIK3CB,RPS6KB1,RPS6KB2,EIF2AK1,ROR1,MAPK3,TNK2,STK40,MAPK1,	9.25E-4
GO:0006793	phosphorus metabolic process	PTK7,FRS2,NCEH1,CLK3,NDUFA4,RAF1,EGFR,TAF1,BCKDK,PTP4A2,MTOR,IGF1R,RYK,DUSP23,BMPR2,MAPK9,PTK2,IL12RB2,BCL2,SNCA,MAP2K2,CAMK2D,ACVR1B,PAK1,DBNL,AGK,AKT1,PIK3CB,RPS6KB1,CDC25B,RPS6KB2,EIF2AK1,MAPK3,ROR1,TIMM50,TNK2,STK40,MAPK1,	9.50E-4
GO:0006796	phosphate metabolic process	PTK7,FRS2,NCEH1,CLK3,NDUFA4,RAF1,EGFR,TAF1,BCKDK,PTP4A2,MTOR,IGF1R,RYK,DUSP23,BMPR2,MAPK9,PTK2,IL12RB2,BCL2,SNCA,MAP2K2,CAMK2D,ACVR1B,PAK1,DBNL,AGK,AKT1,PIK3CB,RPS6KB1,CDC25B,RPS6KB2,EIF2AK1,MAPK3,ROR1,TIMM50,TNK2,STK40,MAPK1,	9.50E-4
GO:0008284	positive regulation of cell proliferation	BCL2,IL12RB2,EGFR,CAMK2D,RELA,PDGFC,IRS2,PAX6,MTOR,IGF1R,RPS6KB1,CDC25B,TGM2,FGF1,AGPAT1,CXCL5,EIF5A2,IRS1,HOXA3,MAPK1,MARCKSL1,	9.88E-4
GO:0018210	peptidyl-threonine modification	BCL2,ACVR1B,TAF1,GALNT2,MTOR,	1.06E-2
GO:0008286	insulin receptor signaling pathway	IGF1R,GRB2,IRS1,EIF4EBP2,IRS2,AKT1,	1.28E-2
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB cascade	FADD,TGM2,CFLAR,NDFIP2,RELA,FLNA,SHISA5,CANT1,LITAF,	1.42E-2
GO:0040017	positive regulation of locomotion	IGF1R,RPS6KB1,BCL2,MMP9,EGFR,IRS1,RRAS2,IRS2,MAPK1,	1.52E-2
GO:0051272	positive regulation of cell motion	IGF1R,RPS6KB1,BCL2,MMP9,EGFR,IRS1,RRAS2,IRS2,MAPK1,	1.52E-2
GO:0010565	regulation of cellular ketone metabolic process	SNCA,IRS1,NR1H2,CAV1,IRS2,AKT1,MTOR,	1.61E-2
GO:0032868	response to insulin stimulus	IGF1R,RPS6KB1,GRB2,RELA,IRS1,EIF4EBP2,IRS2,AKT1,MTOR,	1.73E-2
GO:0016044	membrane organization	WASF2,LRP6,BCL2,SH3BP4,SNCA,SNAP29,COLEC12,EGFR,SERP1,CAV1,DBNL,VAMP8,PPIF,GBF1,GDNF,EHD1,CLN3,AP1M1,TIMM50,	2.22E-2
GO:0006081	cellular aldehyde metabolic process	ALDH1A3,ALDH3B2,ALDH3A2,AKR7A2,GLO1,	3.22E-2
GO:0032885	regulation of polysaccharide biosynthetic process	IRS1,IRS2,AKT1,MTOR,	3.30E-2
GO:0010962	regulation of glucan biosynthetic process	IRS1,IRS2,AKT1,MTOR,	3.30E-2
GO:0005979	regulation of glycogen biosynthetic process	IRS1,IRS2,AKT1,MTOR,	3.30E-2
GO:0006417	regulation of translation	EIF2AK1,EIF5A2,EIF4E,EIF4EBP2,KRT7,MIF4GD,AKT1,TNRC6B,MTOR,MAPK1,	3.54E-2
GO:0040012	regulation of locomotion	IGF1R,RPS6KB1,BCL2,SNCA,MMP9,EGFR,IRS1,RRAS2,IRS2,PAX6,AKT1,MAPK1,	3.83E-2
GO:0032881	regulation of polysaccharide metabolic process	IRS1,IRS2,AKT1,MTOR,	4.06E-2
GO:0070271	protein complex biogenesis	POLR2E,PTK2,KPNB1,CAPZA1,COLEC12,FLNA,PDGFC,GPAA1,TAF4,TAPBP,CAV1,TAF1,E2F2,VAMP8,IGF1R,TGM2,FADD,GRB2,IRS1,IDE,ACTN2,TMEM48,	4.51E-2
GO:0006461	protein complex assembly	POLR2E,PTK2,KPNB1,CAPZA1,COLEC12,FLNA,PDGFC,GPAA1,TAF4,TAPBP,CAV1,TAF1,E2F2,VAMP8,IGF1R,TGM2,FADD,GRB2,IRS1,IDE,ACTN2,TMEM48,	4.51E-2
GO:0030334	regulation of cell migration	IGF1R,RPS6KB1,BCL2,MMP9,EGFR,IRS1,RRAS2,IRS2,PAX6,AKT1,MAPK1,	4.56E-2
GO:0022612	gland morphogenesis	BCL2,EGFR,CAV1,PAX6,	4.92E-2
GO:0043524	negative regulation of neuron apoptosis	GDNF,BCL2,SNCA,DNAJC5,CLN3,WFS1,	5.36E-2
GO:0009894	regulation of catabolic process	RELA,CLN3,FLNA,IRS1,IRS2,TAF1,AKT1,MTOR,	5.55E-2
GO:0018107	peptidyl-threonine phosphorylation	BCL2,ACVR1B,TAF1,MTOR,	6.94E-2
GO:0010647	positive regulation of cell communication	SNCA,NDFIP2,EGFR,ACVR1B,RELA,FLNA,CANT1,CAV1,MTOR,FADD,TGM2,CFLAR,AGPAT1,IRS1,SHISA5,LITAF,	6.95E-2
GO:0008104	protein localization	SCAMP2,TMED10,SNAP29,EGFR,SERP1,FLNA,VPS4A,PAX6,SNAPIN,TMED2,TRAM2,VPS13D,SQSTM1,AP1M1,RAB11FIP5,ZFYVE20,PDIA3,KPNB1,NXT2,CDC37,GPAA1,CAV1,AKT1,ARF4,VPS26A,EIF5A2,RFFL,TIMM50,EXOC3,MAPK1,TMEM48,AP3M1,	7.71E-2
GO:0009612	response to mechanical stimulus	TRPA1,RPS6KB1,BTG2,RELA,CAV1,MAP1B,	7.97E-2
GO:0042325	regulation of phosphorylation	BMPR2,FRS2,BCL2,ADCY9,EGFR,CDC37,PDGFC,SIRT2,PAK1,CAV1,AGK,AKT1,DBNL,APLP2,MTOR,PIK3CB,CDC25B,BCCIP,IRS1,TNK2,	8.28E-2
GO:0051247	positive regulation of protein metabolic process	BMPR2,BCL2,NDFIP2,TAF1,WFS1,CAV1,AKT1,MTOR,PSME3,EIF5A2,TNK2,NR1H2,MAPK1,	8.32E-2
GO:0007243	protein kinase cascade	MAPK9,FRS2,EGFR,PAK1,CAV1,AKT1,DBNL,PIK3CB,IGF1R,SOCS2,RPS6KB1,RPS6KB2,FGF1,AGPAT1,GRB2,IRS1,MAPK1,	8.83E-2
GO:0009895	negative regulation of catabolic process	RELA,CLN3,FLNA,AKT1,MTOR,	8.90E-2
GO:0016197	endosome transport	ZFYVE20,VPS26A,EHD1,SQSTM1,FLNA,VPS4A,	9.23E-2
GO:0051325	interphase	BCL2,CAMK2D,EGFR,ACVR1B,ZNF655,TAF1,KRT7,AKT1,	9.41E-2
GO:0032870	cellular response to hormone stimulus	IGF1R,SOCS2,RPS6KB1,ADCY9,GRB2,IRS1,EIF4EBP2,IRS2,AKT1,	9.75E-2

KEGG pathways and Gene Ontology terms enriched for the interacted genes of ncRNA from RAID and miRTarBase.

disease name	related genes	p-value