ncRDeathDB2.0 database: an all-inclusive information resource on ncRNAs in cell deaths

Programmed cell death (PCD), which is a critical biological process with many important functions, consists of apoptosis, autophagy and programmed necrosis. Apoptosis is the most extensively investigated cell death subroutine. After decades of studies, the molecular features and signal pathways modulating apoptosis have been resolved in great details. Autophagy constitutes a stress adaptation that avoids cell death while induces an alternative pathway to cellular demise that is called autophagic cell death. Previously, necrosis was thought as an uncontrolled type of cell death, nevertheless, its programmed nature and the genetic components are continually identified recently.
Non-coding RNAs (ncRNAs) are a class of functional RNA molecules including miRNAs, lncRNAs and snoRNAs, which do not translate into proteins but play an essential role in regulating the expression of coding genes. In the past few years, increasing evidences suggested that aberrant expression of ncRNAs regulate different subroutines of PCD. Therefore, a knowledge depository, which integrates information for both ncRNAs and their interacted genes in PCD network, will be of great help. Hence, we developed ncRDeathDB 2.0 (, which allows users to browse, search and analyze the PCD associated ncRNAs. Compared with its first release (miRDeathDB,, ncRDeathDB not only enriches ncRNA types by including lncRNA and snoRNA with update annotations, but also integrates a variety of useful tools to analyze the predicated binding sites and network visualization. Such a systems biology analysis will provide a global picture of the ncRNA-mediated cell death network and support the users to investigate on the the intra- and inter-modular connectivity of different subroutines of PCD.

How to Cite:
Deng Wu , Yan Huang , Juanjuan Kang , ... Dong Wang, ncRDeathDB: a comprehensive bioinformatics resource for deciphering network organization of the ncRNA-mediated cell death system. Autophagy. 2015 Oct 3;11(10):1917-26.

Connect the dots: a systems level approach for analyzing the miRNA-mediated cell death network.Autophagy. 2013, Mar, 9(3):436-9.