ncRNADetailInformation

Detail Information
Functional analysis

miRNA name

pre-miRNA

family

pre-miRNA Sequence

mature-miRNA

mature sequence

pre-miRNA description

miR-449

MI0001648	MIPF0000133	CUGUGUGUGAUGAGCUGGCAGUGUAUUGUUAGCUGGUUGAAUAUGUGAAUGGCAUCGGCUAACAUGCAACUGCUGUCUUAUUGCAUAUACA	MIMAT0001541 hsa-miR-449a	UGGCAGUGUAUUGUUAGCUGGU
MI0003823	MIPF0000133	GCUGGGAUGUGUCAGGUAGGCAGUGUAUUGCUAGCGGCUGUUAAUGAUUUUAACAGUUGCUAGUUGCACUCCUCUCUGUUGCAUUCAGAAGC	MIMAT0010251 hsa-miR-449c-5p	UAGGCAGUGUAUUGCUAGCGGCUGU	This sequence was identified as a miRNA candidate by Berezikov et al.using the RAKE techniques . Expression was later confirmed by Wyman etal. .
MI0003823	MIPF0000133	GCUGGGAUGUGUCAGGUAGGCAGUGUAUUGCUAGCGGCUGUUAAUGAUUUUAACAGUUGCUAGUUGCACUCCUCUCUGUUGCAUUCAGAAGC	MIMAT0013771 hsa-miR-449c-3p	UUGCUAGUUGCACUCCUCUCUGU	This sequence was identified as a miRNA candidate by Berezikov et al.using the RAKE techniques . Expression was later confirmed by Wyman etal. .
MI0003673	MIPF0000133	UGACCUGAAUCAGGUAGGCAGUGUAUUGUUAGCUGGCUGCUUGGGUCAAGUCAGCAGCCACAACUACCCUGCCACUUGCUUCUGGAUAAAUUCUUCU	MIMAT0003327 hsa-miR-449b-5p	AGGCAGUGUAUUGUUAGCUGGC
MI0003673	MIPF0000133	UGACCUGAAUCAGGUAGGCAGUGUAUUGUUAGCUGGCUGCUUGGGUCAAGUCAGCAGCCACAACUACCCUGCCACUUGCUUCUGGAUAAAUUCUUCU	MIMAT0009203 hsa-miR-449b-3p	CAGCCACAACUACCCUGCCACU
MI0001648	MIPF0000133	CUGUGUGUGAUGAGCUGGCAGUGUAUUGUUAGCUGGUUGAAUAUGUGAAUGGCAUCGGCUAACAUGCAACUGCUGUCUUAUUGCAUAUACA	MIMAT0001541 hsa-miR-449a	UGGCAGUGUAUUGUUAGCUGGU
MI0003823	MIPF0000133	GCUGGGAUGUGUCAGGUAGGCAGUGUAUUGCUAGCGGCUGUUAAUGAUUUUAACAGUUGCUAGUUGCACUCCUCUCUGUUGCAUUCAGAAGC	MIMAT0010251 hsa-miR-449c-5p	UAGGCAGUGUAUUGCUAGCGGCUGU	This sequence was identified as a miRNA candidate by Berezikov et al.using the RAKE techniques . Expression was later confirmed by Wyman etal. .
MI0003823	MIPF0000133	GCUGGGAUGUGUCAGGUAGGCAGUGUAUUGCUAGCGGCUGUUAAUGAUUUUAACAGUUGCUAGUUGCACUCCUCUCUGUUGCAUUCAGAAGC	MIMAT0013771 hsa-miR-449c-3p	UUGCUAGUUGCACUCCUCUCUGU	This sequence was identified as a miRNA candidate by Berezikov et al.using the RAKE techniques . Expression was later confirmed by Wyman etal. .
MI0003673	MIPF0000133	UGACCUGAAUCAGGUAGGCAGUGUAUUGUUAGCUGGCUGCUUGGGUCAAGUCAGCAGCCACAACUACCCUGCCACUUGCUUCUGGAUAAAUUCUUCU	MIMAT0003327 hsa-miR-449b-5p	AGGCAGUGUAUUGUUAGCUGGC
MI0003673	MIPF0000133	UGACCUGAAUCAGGUAGGCAGUGUAUUGUUAGCUGGCUGCUUGGGUCAAGUCAGCAGCCACAACUACCCUGCCACUUGCUUCUGGAUAAAUUCUUCU	MIMAT0009203 hsa-miR-449b-3p	CAGCCACAACUACCCUGCCACU
MI0001648	MIPF0000133	CUGUGUGUGAUGAGCUGGCAGUGUAUUGUUAGCUGGUUGAAUAUGUGAAUGGCAUCGGCUAACAUGCAACUGCUGUCUUAUUGCAUAUACA	MIMAT0001541 hsa-miR-449a	UGGCAGUGUAUUGUUAGCUGGU
MI0003823	MIPF0000133	GCUGGGAUGUGUCAGGUAGGCAGUGUAUUGCUAGCGGCUGUUAAUGAUUUUAACAGUUGCUAGUUGCACUCCUCUCUGUUGCAUUCAGAAGC	MIMAT0010251 hsa-miR-449c-5p	UAGGCAGUGUAUUGCUAGCGGCUGU	This sequence was identified as a miRNA candidate by Berezikov et al.using the RAKE techniques . Expression was later confirmed by Wyman etal. .
MI0003823	MIPF0000133	GCUGGGAUGUGUCAGGUAGGCAGUGUAUUGCUAGCGGCUGUUAAUGAUUUUAACAGUUGCUAGUUGCACUCCUCUCUGUUGCAUUCAGAAGC	MIMAT0013771 hsa-miR-449c-3p	UUGCUAGUUGCACUCCUCUCUGU	This sequence was identified as a miRNA candidate by Berezikov et al.using the RAKE techniques . Expression was later confirmed by Wyman etal. .
MI0003673	MIPF0000133	UGACCUGAAUCAGGUAGGCAGUGUAUUGUUAGCUGGCUGCUUGGGUCAAGUCAGCAGCCACAACUACCCUGCCACUUGCUUCUGGAUAAAUUCUUCU	MIMAT0003327 hsa-miR-449b-5p	AGGCAGUGUAUUGUUAGCUGGC
MI0003673	MIPF0000133	UGACCUGAAUCAGGUAGGCAGUGUAUUGUUAGCUGGCUGCUUGGGUCAAGUCAGCAGCCACAACUACCCUGCCACUUGCUUCUGGAUAAAUUCUUCU	MIMAT0009203 hsa-miR-449b-3p	CAGCCACAACUACCCUGCCACU
MI0001648	MIPF0000133	CUGUGUGUGAUGAGCUGGCAGUGUAUUGUUAGCUGGUUGAAUAUGUGAAUGGCAUCGGCUAACAUGCAACUGCUGUCUUAUUGCAUAUACA	MIMAT0001541 hsa-miR-449a	UGGCAGUGUAUUGUUAGCUGGU
MI0003823	MIPF0000133	GCUGGGAUGUGUCAGGUAGGCAGUGUAUUGCUAGCGGCUGUUAAUGAUUUUAACAGUUGCUAGUUGCACUCCUCUCUGUUGCAUUCAGAAGC	MIMAT0010251 hsa-miR-449c-5p	UAGGCAGUGUAUUGCUAGCGGCUGU	This sequence was identified as a miRNA candidate by Berezikov et al.using the RAKE techniques . Expression was later confirmed by Wyman etal. .
MI0003823	MIPF0000133	GCUGGGAUGUGUCAGGUAGGCAGUGUAUUGCUAGCGGCUGUUAAUGAUUUUAACAGUUGCUAGUUGCACUCCUCUCUGUUGCAUUCAGAAGC	MIMAT0013771 hsa-miR-449c-3p	UUGCUAGUUGCACUCCUCUCUGU	This sequence was identified as a miRNA candidate by Berezikov et al.using the RAKE techniques . Expression was later confirmed by Wyman etal. .
MI0003673	MIPF0000133	UGACCUGAAUCAGGUAGGCAGUGUAUUGUUAGCUGGCUGCUUGGGUCAAGUCAGCAGCCACAACUACCCUGCCACUUGCUUCUGGAUAAAUUCUUCU	MIMAT0003327 hsa-miR-449b-5p	AGGCAGUGUAUUGUUAGCUGGC
MI0003673	MIPF0000133	UGACCUGAAUCAGGUAGGCAGUGUAUUGUUAGCUGGCUGCUUGGGUCAAGUCAGCAGCCACAACUACCCUGCCACUUGCUUCUGGAUAAAUUCUUCU	MIMAT0009203 hsa-miR-449b-3p	CAGCCACAACUACCCUGCCACU

link to database

TargetScanS 6.2 | MicroCosm | microRNA.org | miRNAMap 2.0

Interacted genes from RAID,miRTarBase

KCND3,HDAC1,HNF4A,CDK4,MYC,WISP2,C2orf69,CCNE2,CDK6,CDC25A,CCND1,GMNN,SIRT1,PLA2G4A,NOTCH1
more » KCND3,HDAC1,HNF4A,CDK4,MYC,WISP2,C2orf69,CCNE2,CDK6,CDC25A,CCND1,GMNN,SIRT1,PLA2G4A,NOTCH1,HDAC8,BCL2

KEGG pathways enriched for interacted genes

pathway name

pathway description

target genes enrich in pathway

p-value

hsa04110	Cell cycle	CCND1,CDK6,CCNE2,CDC25A,HDAC1,CDK4,MYC,	8.17E-8
hsa05222	Small cell lung cancer	CCND1,CDK6,CCNE2,BCL2,CDK4,MYC,	4.66E-7
hsa05200	Pathways in cancer	CCND1,CDK6,CCNE2,BCL2,HDAC1,CDK4,MET,MYC,	1.14E-6
hsa05220	Chronic myeloid leukemia	CCND1,CDK6,HDAC1,CDK4,MYC,	1.33E-5
hsa04115	p53 signaling pathway	CCND1,CDK6,CCNE2,CDK4,	3.49E-4

Gene ontology terms enriched for interacted genes

GO terms

GO terms description

target genes enrich in GO term

p-value

GO:0051726	regulation of cell cycle	CCND1,CDK6,CCNE2,HNF4A,BCL2,CDC25A,HDAC1,CDK4,GMNN,MYC,	2.77E-11
GO:0042127	regulation of cell proliferation	CCND1,CDK6,HNF4A,BCL2,PLA2G4A,WISP2,NOTCH1,HDAC1,CDK4,SIRT1,MYC,	2.44E-9
GO:0008284	positive regulation of cell proliferation	CCND1,CDK6,BCL2,PLA2G4A,NOTCH1,HDAC1,CDK4,MYC,	2.15E-7
GO:0045786	negative regulation of cell cycle	CDK6,HNF4A,BCL2,HDAC1,GMNN,	2.05E-6
GO:0051329	interphase of mitotic cell cycle	CCND1,CDK6,BCL2,CDC25A,CDK4,	5.37E-6

GO:0051325	interphase	CCND1,CDK6,BCL2,CDC25A,CDK4,	6.02E-6
GO:0007049	cell cycle	CCND1,CDK6,CCNE2,BCL2,CDC25A,CDK4,GMNN,MYC,	1.44E-5
GO:0051301	cell division	CCND1,CDK6,CCNE2,CDC25A,NOTCH1,CDK4,	1.70E-5
GO:0000082	G1/S transition of mitotic cell cycle	CCND1,BCL2,CDC25A,CDK4,	3.62E-5
GO:0045596	negative regulation of cell differentiation	CCND1,CDK6,NOTCH1,HDAC1,SIRT1,	9.89E-5
GO:0042325	regulation of phosphorylation	CCND1,CCNE2,HNF4A,BCL2,CDC25A,MET,	1.51E-4
GO:0010551	regulation of specific transcription from RNA polymerase II promoter	HNF4A,NOTCH1,HDAC1,SIRT1,	1.70E-4
GO:0016575	histone deacetylation	HDAC1,SIRT1,HDAC8,	1.76E-4
GO:0051174	regulation of phosphorus metabolic process	CCND1,CCNE2,HNF4A,BCL2,CDC25A,MET,	1.82E-4
GO:0019220	regulation of phosphate metabolic process	CCND1,CCNE2,HNF4A,BCL2,CDC25A,MET,	1.82E-4
GO:0008406	gonad development	CCND1,BCL2,PLA2G4A,SIRT1,	2.85E-4
GO:0010604	positive regulation of macromolecule metabolic process	CCND1,HNF4A,BCL2,NOTCH1,HDAC1,CDK4,MYC,	2.93E-4
GO:0006476	protein amino acid deacetylation	HDAC1,SIRT1,HDAC8,	2.98E-4
GO:0032844	regulation of homeostatic process	CDK6,BCL2,PLA2G4A,MYC,	3.01E-4
GO:0022402	cell cycle process	CCND1,CDK6,BCL2,CDC25A,CDK4,MYC,	3.71E-4
GO:0048742	regulation of skeletal muscle fiber development	BCL2,NOTCH1,HDAC1,	3.87E-4
GO:0048608	reproductive structure development	CCND1,BCL2,PLA2G4A,SIRT1,	4.04E-4
GO:0045137	development of primary sexual characteristics	CCND1,BCL2,PLA2G4A,SIRT1,	4.13E-4
GO:0048511	rhythmic process	BCL2,PLA2G4A,CDK4,SIRT1,	4.23E-4
GO:0032583	regulation of gene-specific transcription	HNF4A,NOTCH1,HDAC1,SIRT1,	4.84E-4
GO:0048641	regulation of skeletal muscle tissue development	BCL2,NOTCH1,HDAC1,	5.22E-4
GO:0051153	regulation of striated muscle cell differentiation	BCL2,NOTCH1,HDAC1,	6.37E-4
GO:0007548	sex differentiation	CCND1,BCL2,PLA2G4A,SIRT1,	6.86E-4
GO:0007346	regulation of mitotic cell cycle	CCND1,HNF4A,BCL2,MYC,	6.99E-4
GO:0000278	mitotic cell cycle	CCND1,CDK6,BCL2,CDC25A,CDK4,	7.71E-4
GO:0031328	positive regulation of cellular biosynthetic process	HNF4A,PLA2G4A,NOTCH1,HDAC1,CDK4,MYC,	8.98E-4
GO:0051147	regulation of muscle cell differentiation	BCL2,NOTCH1,HDAC1,	9.47E-4
GO:0009891	positive regulation of biosynthetic process	HNF4A,PLA2G4A,NOTCH1,HDAC1,CDK4,MYC,	9.59E-4
GO:0022403	cell cycle phase	CCND1,CDK6,BCL2,CDC25A,CDK4,	1.17E-2
GO:0006357	regulation of transcription from RNA polymerase II promoter	HNF4A,NOTCH1,HDAC1,SIRT1,HDAC8,MYC,	1.17E-2
GO:0010605	negative regulation of macromolecule metabolic process	HNF4A,HDAC1,GMNN,SIRT1,HDAC8,MYC,	1.22E-2
GO:0031667	response to nutrient levels	CCND1,BCL2,PLA2G4A,SIRT1,	1.48E-2
GO:0016202	regulation of striated muscle tissue development	BCL2,NOTCH1,HDAC1,	1.55E-2
GO:0048634	regulation of muscle development	BCL2,NOTCH1,HDAC1,	1.61E-2
GO:0000079	regulation of cyclin-dependent protein kinase activity	CCND1,CCNE2,CDC25A,	1.81E-2
GO:0042981	regulation of apoptosis	BCL2,PLA2G4A,NOTCH1,HDAC1,SIRT1,MYC,	1.84E-2
GO:0043067	regulation of programmed cell death	BCL2,PLA2G4A,NOTCH1,HDAC1,SIRT1,MYC,	1.92E-2
GO:0010941	regulation of cell death	BCL2,PLA2G4A,NOTCH1,HDAC1,SIRT1,MYC,	1.95E-2
GO:0010552	positive regulation of specific transcription from RNA polymerase II promoter	HNF4A,NOTCH1,HDAC1,	2.01E-2
GO:0009991	response to extracellular stimulus	CCND1,BCL2,PLA2G4A,SIRT1,	2.03E-2
GO:0048609	reproductive process in a multicellular organism	BCL2,PLA2G4A,NOTCH1,MET,SIRT1,	2.13E-2
GO:0032504	multicellular organism reproduction	BCL2,PLA2G4A,NOTCH1,MET,SIRT1,	2.13E-2
GO:0022602	ovulation cycle process	BCL2,PLA2G4A,SIRT1,	2.37E-2
GO:0008585	female gonad development	BCL2,PLA2G4A,SIRT1,	2.53E-2
GO:0007292	female gamete generation	BCL2,PLA2G4A,SIRT1,	2.61E-2
GO:0033273	response to vitamin	CCND1,BCL2,PLA2G4A,	2.69E-2
GO:0042698	ovulation cycle	BCL2,PLA2G4A,SIRT1,	2.77E-2
GO:0031099	regeneration	CCND1,BCL2,NOTCH1,	2.93E-2
GO:0046660	female sex differentiation	BCL2,PLA2G4A,SIRT1,	2.93E-2
GO:0046545	development of primary female sexual characteristics	BCL2,PLA2G4A,SIRT1,	2.93E-2
GO:0003006	reproductive developmental process	CCND1,BCL2,PLA2G4A,SIRT1,	3.33E-2
GO:0030278	regulation of ossification	CDK6,BCL2,PLA2G4A,	3.73E-2
GO:0051384	response to glucocorticoid stimulus	CCND1,BCL2,PLA2G4A,	3.73E-2
GO:0006796	phosphate metabolic process	CCND1,CDK6,BCL2,CDC25A,CDK4,MET,	4.26E-2
GO:0006793	phosphorus metabolic process	CCND1,CDK6,BCL2,CDC25A,CDK4,MET,	4.26E-2
GO:0031960	response to corticosteroid stimulus	CCND1,BCL2,PLA2G4A,	4.42E-2
GO:0043193	positive regulation of gene-specific transcription	HNF4A,NOTCH1,HDAC1,	4.62E-2
GO:0010557	positive regulation of macromolecule biosynthetic process	HNF4A,NOTCH1,HDAC1,CDK4,MYC,	6.18E-2
GO:0006468	protein amino acid phosphorylation	CCND1,CDK6,BCL2,CDK4,MET,	6.62E-2
GO:0045859	regulation of protein kinase activity	CCND1,CCNE2,CDC25A,MET,	7.19E-2
GO:0007568	aging	BCL2,PLA2G4A,SIRT1,	7.29E-2
GO:0043066	negative regulation of apoptosis	BCL2,NOTCH1,HDAC1,MYC,	7.72E-2
GO:0043549	regulation of kinase activity	CCND1,CCNE2,CDC25A,MET,	7.90E-2
GO:0043069	negative regulation of programmed cell death	BCL2,NOTCH1,HDAC1,MYC,	8.02E-2
GO:0060548	negative regulation of cell death	BCL2,NOTCH1,HDAC1,MYC,	8.08E-2
GO:0008285	negative regulation of cell proliferation	CDK6,HNF4A,BCL2,WISP2,	8.15E-2
GO:0009628	response to abiotic stimulus	CCND1,BCL2,PLA2G4A,MYC,	8.59E-2
GO:0010033	response to organic substance	CCND1,HNF4A,BCL2,PLA2G4A,MYC,	8.70E-2
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	HNF4A,NOTCH1,HDAC1,MYC,	8.78E-2
GO:0051338	regulation of transferase activity	CCND1,CCNE2,CDC25A,MET,	8.84E-2
GO:0016570	histone modification	HDAC1,SIRT1,HDAC8,	8.91E-2
GO:0016569	covalent chromatin modification	HDAC1,SIRT1,HDAC8,	9.48E-2
GO:0010038	response to metal ion	CCND1,BCL2,PLA2G4A,	9.92E-2

KEGG pathways and Gene Ontology terms enriched for the interacted genes of ncRNA from RAID and miRTarBase.

disease name	related genes	p-value