ncRNADetailInformation

Detail Information
Functional analysis

miRNA name

pre-miRNA

family

pre-miRNA Sequence

mature-miRNA

mature sequence

pre-miRNA description

miR-24

MI0000080	MIPF0000041	CUCCGGUGCCUACUGAGCUGAUAUCAGUUCUCAUUUUACACACUGGCUCAGUUCAGCAGGAACAGGAG	MIMAT0000079 hsa-miR-24-1-5p	UGCCUACUGAGCUGAUAUCAGU
MI0000081	MIPF0000041	CUCUGCCUCCCGUGCCUACUGAGCUGAAACACAGUUGGUUUGUGUACACUGGCUCAGUUCAGCAGGAACAGGG	MIMAT0000080 hsa-miR-24-3p	UGGCUCAGUUCAGCAGGAACAG	mir-24-2 was identified independently by two groups. This sequence wasnamed miR-24 precursor-19 in reference .
MI0000081	MIPF0000041	CUCUGCCUCCCGUGCCUACUGAGCUGAAACACAGUUGGUUUGUGUACACUGGCUCAGUUCAGCAGGAACAGGG	MIMAT0004497 hsa-miR-24-2-5p	UGCCUACUGAGCUGAAACACAG	mir-24-2 was identified independently by two groups. This sequence wasnamed miR-24 precursor-19 in reference .
MI0000081	MIPF0000041	CUCUGCCUCCCGUGCCUACUGAGCUGAAACACAGUUGGUUUGUGUACACUGGCUCAGUUCAGCAGGAACAGGG	MIMAT0000080 hsa-miR-24-3p	UGGCUCAGUUCAGCAGGAACAG	mir-24-2 was identified independently by two groups. This sequence wasnamed miR-24 precursor-19 in reference .
MI0000080	MIPF0000041	CUCCGGUGCCUACUGAGCUGAUAUCAGUUCUCAUUUUACACACUGGCUCAGUUCAGCAGGAACAGGAG	MIMAT0000079 hsa-miR-24-1-5p	UGCCUACUGAGCUGAUAUCAGU
MI0000081	MIPF0000041	CUCUGCCUCCCGUGCCUACUGAGCUGAAACACAGUUGGUUUGUGUACACUGGCUCAGUUCAGCAGGAACAGGG	MIMAT0004497 hsa-miR-24-2-5p	UGCCUACUGAGCUGAAACACAG	mir-24-2 was identified independently by two groups. This sequence wasnamed miR-24 precursor-19 in reference .
MI0000081	MIPF0000041	CUCUGCCUCCCGUGCCUACUGAGCUGAAACACAGUUGGUUUGUGUACACUGGCUCAGUUCAGCAGGAACAGGG	MIMAT0000080 hsa-miR-24-3p	UGGCUCAGUUCAGCAGGAACAG	mir-24-2 was identified independently by two groups. This sequence wasnamed miR-24 precursor-19 in reference .
MI0000080	MIPF0000041	CUCCGGUGCCUACUGAGCUGAUAUCAGUUCUCAUUUUACACACUGGCUCAGUUCAGCAGGAACAGGAG	MIMAT0000079 hsa-miR-24-1-5p	UGCCUACUGAGCUGAUAUCAGU
MI0000081	MIPF0000041	CUCUGCCUCCCGUGCCUACUGAGCUGAAACACAGUUGGUUUGUGUACACUGGCUCAGUUCAGCAGGAACAGGG	MIMAT0000080 hsa-miR-24-3p	UGGCUCAGUUCAGCAGGAACAG	mir-24-2 was identified independently by two groups. This sequence wasnamed miR-24 precursor-19 in reference .
MI0000081	MIPF0000041	CUCUGCCUCCCGUGCCUACUGAGCUGAAACACAGUUGGUUUGUGUACACUGGCUCAGUUCAGCAGGAACAGGG	MIMAT0004497 hsa-miR-24-2-5p	UGCCUACUGAGCUGAAACACAG	mir-24-2 was identified independently by two groups. This sequence wasnamed miR-24 precursor-19 in reference .

link to database

TargetScanS 6.2 | MicroCosm | microRNA.org | miRNAMap 2.0

Interacted genes from RAID,miRTarBase

VGLL3,SLC7A1,UBE3A,TNPO3,MED24,GTF3C2,BEX1,EIF4H,LAPTM4B,SLC35B2,DCAF4,ACD,FEN1,PTPN9,POLR2D
more » VGLL3,SLC7A1,UBE3A,TNPO3,MED24,GTF3C2,BEX1,EIF4H,LAPTM4B,SLC35B2,DCAF4,ACD,FEN1,PTPN9,POLR2D,SNX12,ATP5B,NFAT5,MED22,PDLIM7,TAF15,KLHDC3,CDK4,SUMO3,RALA,MAGI1,VRK1,LAMTOR3,STRADB,CTDSP2,UBD,BCL2L12,MCM10,TUBGCP2,SCML2,FKBP1B,DND1,CCL2,HIC2,DHCR24,MYC,MRPL40,PACSIN3,GORASP2,C1orf135,CDKN2A,SLITRK1,NUBPL,CCNA2,ACVR1B,NARF,DEPDC1,SLC5A6,SCML1,DDX5,ITFG3,APAF1,HSF2,BTBD3,OGFR,CDCA7,C1orf106,GTF2E1,CTLA4,IQCB1,EXOSC1,ANPEP,DARS2,GCLM,ARHGEF7,NUP54,MRPS22,AMPD2,RAP2C,TMED7,ACACA,RNF11,GYG2,MATR3,DCP2,TMEM194A,FZD4,PTPLAD1,PDXK,EIF4G3,WRB,ADD3,AK3,SNTB1,DCAF10,EIF2S3,PSME3,FAF1,ARHGAP19,EXOSC8,R3HDM4,GMFB,CTCF,ZBED1,SPIN4,TOMM22,KPNA6,TMTC4,TBPL1,MIDN,POLD1,VPS35,RNF2,SNRPB2,KIAA0020,C15orf57,MLEC,GFOD1,RHOT2,NETO2,C22orf13,UBE2C,CCNB1,RPS16,CASP9,NKD1,ZNF217,NEDD4L,LLGL1,GNPAT,PPP3R1,CCDC58,RNF144A,CHFR,MMS19,CHD8,GLYR1,CDKN1B,ZCCHC14,C15orf39,H2AFX,IKBKAP,FURIN,KHSRP,MAPK14,BCL2L2,AKAP7,RRM2,PAF1,MTF2,ACTL6A,CMTM3,SRRT,BCL2,FBXO34,ABCE1,SLC2A3,C6orf130,NFKBIA,YOD1,GBAS,KHNYN,CCNG1,ALG5,NCBP2,MBD6,RPL7L1,CARD10,KLHL23,DHFRP1,HDAC1,PHOSPHO2,HNF4A,KIAA0100,RANBP1,AAMP,USP10,DEDD,FOXQ1,S100P,E2F3,CIRBP,RPS7,RRP12,MIS18A,LSM12,AK4,UBC,OXSR1,UQCC,GLUL,MCM4,ARL1,MARCKSL1,SESN1,NR0B2,GPR172A,SH3PXD2A,TM9SF3,PRKRIR,CTDSP1,LBR,URM1,C8orf33,DSC2,SLC29A4,NOP14,E2F1,FNTB,RCE1,PA2G4,METAP2,KIAA1967,PRIM1,MRPL27,CCDC59,LIMD1,VPS25,PHF16,BCL2L11,ALG1,FOXP3,CSTF3,CNDP2,PLIN3,NOP56,BRD8,ERBB3,PIM2,FZD5,ABCB10,STK35,VHL,COPS7A,DTL,TYW3,C7orf30,PSTPIP2,ZNF813,PCGF6,C8orf42,ALDH5A1,PROSER1,TNIP2,RIF1,SULT2A1,TOP1,TGFB1,RFWD2,ADD1,XIAP,PSMD1,NEK6,E2F2,KCNJ14,TOMM34,PTPRF,CSK,NAE1,SLC25A15,ZNF264,PDPK1,BCL7A,TNFAIP3,DUS1L,TRIB3,HMGB2,THOP1,PCNA,DDHD2,CCAR1,BRCA1,STX16,CDK1,RPRD2,CHEK1,TCEA3,CD34,C18orf56,SLC7A2,PER2,KIAA0195,CORO1A,DNAJB12,CYP20A1,CMTM4,GGA2,CWC27,PCK2,FAH,PPM1F,ZMYND19,AURKB,MAK16,ADPGK,SLC11A2,MED16,AGPAT3,PAK4,EEF1A1,COMMD9,MRPS24,NOTCH1,NET1,HBQ1,UNG,JARID2,UGDH,AGFG1,SNRPD3,PTGFRN,SERGEF,NRIP1,ARHGEF18,TMEM209,PLAGL2,ST7L,TSPAN14,MUDENG,ADRM1,ZNF317,ATAD3A,NOTUM,NASP

KEGG pathways enriched for interacted genes

pathway name

pathway description

target genes enrich in pathway

p-value

hsa04110	Cell cycle	MCM4,E2F1,CCNA2,CHEK1,CDKN2A,CDK4,CDKN1B,E2F3,E2F2,CDK1,TGFB1,HDAC1,CCNB1,PCNA,MYC,	2.80E-7
hsa04115	p53 signaling pathway	CASP9,RFWD2,APAF1,CHEK1,CDKN2A,RRM2,SESN1,CDK4,CCNB1,CCNG1,CDK1,	1.27E-6
hsa05220	Chronic myeloid leukemia	TGFB1,E2F1,ACVR1B,HDAC1,CDKN2A,CDK4,CDKN1B,NFKBIA,E2F3,MYC,E2F2,	3.21E-6
hsa05222	Small cell lung cancer	CASP9,E2F1,BCL2,APAF1,CDK4,CDKN1B,XIAP,NFKBIA,E2F3,MYC,E2F2,	9.12E-6
hsa05212	Pancreatic cancer	CASP9,TGFB1,E2F1,RALA,ACVR1B,CDKN2A,CDK4,E2F3,E2F2,	1.23E-4

hsa05200	Pathways in cancer	CASP9,FZD5,E2F1,BCL2,RALA,ACVR1B,CDKN2A,VHL,CDK4,XIAP,CDKN1B,E2F3,E2F2,TGFB1,FZD4,HDAC1,NFKBIA,MYC,	4.75E-4
hsa05223	Non-small cell lung cancer	CASP9,E2F1,CDKN2A,PDPK1,CDK4,E2F3,E2F2,	9.00E-4
hsa05219	Bladder cancer	E2F1,CDKN2A,CDK4,E2F3,MYC,E2F2,	1.79E-2
hsa05215	Prostate cancer	CASP9,E2F1,BCL2,PDPK1,CDKN1B,NFKBIA,E2F3,E2F2,	2.64E-2
hsa03030	DNA replication	MCM4,FEN1,POLD1,PRIM1,PCNA,	6.71E-2
hsa05210	Colorectal cancer	CASP9,FZD5,TGFB1,FZD4,BCL2,ACVR1B,MYC,	8.48E-2
hsa05014	Amyotrophic lateral sclerosis (ALS)	CASP9,BCL2,MAPK14,APAF1,PPP3R1,	2.54E-1
hsa04660	T cell receptor signaling pathway	PAK4,MAPK14,NFAT5,CDK4,NFKBIA,PPP3R1,CTLA4,	2.66E-1
hsa04210	Apoptosis	CASP9,BCL2,APAF1,XIAP,NFKBIA,PPP3R1,	3.68E-1
hsa03410	Base excision repair	FEN1,POLD1,UNG,PCNA,	3.72E-1
hsa04621	NOD-like receptor signaling pathway	MAPK14,TNFAIP3,CCL2,XIAP,NFKBIA,	4.19E-1
hsa05214	Glioma	E2F1,CDKN2A,CDK4,E2F3,E2F2,	4.40E-1
hsa05218	Melanoma	E2F1,CDKN2A,CDK4,E2F3,E2F2,	6.32E-1
hsa04120	Ubiquitin mediated proteolysis	RFWD2,UBE2C,BRCA1,NEDD4L,VHL,XIAP,UBE3A,	7.02E-1

Gene ontology terms enriched for interacted genes

GO terms

GO terms description

target genes enrich in GO term

p-value

GO:0012501	programmed cell death	PPM1F,CASP9,CCAR1,NAE1,E2F1,APAF1,CDKN2A,CDKN1B,XIAP,BCL2L12,KIAA1967,PPP3R1,DEDD,ARHGEF18,NET1,PSME3,BCL2L11,RHOT2,TRIB3,PIM2,ERBB3,BCL2,BCL2L2,BRCA1,TOP1,UBC,E2F2,SLC11A2,DHCR24,TNFAIP3,FAF1,NFKBIA,NEK6,MYC,	3.89E-8
GO:0051726	regulation of cell cycle	E2F1,NAE1,BCL2,CCNA2,UBE2C,MAPK14,BRCA1,CHEK1,CDKN2A,CDK4,CHFR,CDKN1B,H2AFX,RANBP1,E2F2,CDK1,TGFB1,CTCF,HNF4A,HDAC1,CCNB1,CCNG1,NEK6,MYC,	6.39E-8
GO:0042981	regulation of apoptosis	CASP9,STRADB,NAE1,CARD10,APAF1,NOTCH1,CDKN2A,FURIN,CCL2,CDKN1B,XIAP,CDK1,PPP3R1,DEDD,ARHGEF18,TGFB1,NET1,PSME3,PLAGL2,BCL2L11,BCL2,ERBB3,PIM2,BCL2L2,BRCA1,PTPRF,GCLM,ACVR1B,ARHGEF7,VHL,UBC,DHCR24,SLC11A2,CHD8,TNFAIP3,HDAC1,FAF1,NFKBIA,MYC,	1.12E-7
GO:0007049	cell cycle	CCAR1,STRADB,KLHDC3,NAE1,E2F1,CDKN2A,RIF1,CHFR,CDKN1B,CDK1,TGFB1,RNF2,PSME3,NASP,MIS18A,BCL2,PIM2,UBE2C,CCNA2,POLD1,BRCA1,PSMD1,ACVR1B,CHEK1,SESN1,UBC,CDK4,H2AFX,PA2G4,RANBP1,E2F3,E2F2,DHCR24,AURKB,CCNB1,CCNG1,NEK6,MYC,	1.34E-7
GO:0043067	regulation of programmed cell death	CASP9,STRADB,NAE1,CARD10,APAF1,NOTCH1,CDKN2A,FURIN,CCL2,CDKN1B,XIAP,CDK1,PPP3R1,DEDD,ARHGEF18,TGFB1,NET1,PSME3,PLAGL2,BCL2L11,BCL2,ERBB3,PIM2,BCL2L2,BRCA1,PTPRF,GCLM,ACVR1B,ARHGEF7,VHL,UBC,DHCR24,SLC11A2,CHD8,TNFAIP3,HDAC1,FAF1,NFKBIA,MYC,	1.44E-7

GO:0010941	regulation of cell death	CASP9,STRADB,NAE1,CARD10,APAF1,NOTCH1,CDKN2A,FURIN,CCL2,CDKN1B,XIAP,CDK1,PPP3R1,DEDD,ARHGEF18,TGFB1,NET1,PSME3,PLAGL2,BCL2L11,BCL2,ERBB3,PIM2,BCL2L2,BRCA1,PTPRF,GCLM,ACVR1B,ARHGEF7,VHL,UBC,DHCR24,SLC11A2,CHD8,TNFAIP3,HDAC1,FAF1,NFKBIA,MYC,	1.59E-7
GO:0006915	apoptosis	PPM1F,CASP9,CCAR1,E2F1,NAE1,APAF1,CDKN2A,XIAP,BCL2L12,KIAA1967,PPP3R1,DEDD,ARHGEF18,NET1,PSME3,BCL2L11,RHOT2,TRIB3,PIM2,ERBB3,BCL2,BCL2L2,BRCA1,UBC,E2F2,SLC11A2,DHCR24,TNFAIP3,FAF1,NFKBIA,NEK6,MYC,	3.01E-7
GO:0008219	cell death	CCAR1,PPM1F,CASP9,NAE1,E2F1,APAF1,CDKN2A,CDKN1B,XIAP,BCL2L12,KIAA1967,PPP3R1,DEDD,ARHGEF18,TGFB1,NET1,PSME3,BCL2L11,RHOT2,TRIB3,PIM2,ERBB3,BCL2,BCL2L2,BRCA1,TOP1,UBC,E2F2,SLC11A2,DHCR24,TNFAIP3,FAF1,NFKBIA,NEK6,MYC,	5.58E-7
GO:0016265	death	CCAR1,PPM1F,CASP9,NAE1,E2F1,APAF1,CDKN2A,CDKN1B,XIAP,BCL2L12,KIAA1967,PPP3R1,DEDD,ARHGEF18,TGFB1,NET1,PSME3,BCL2L11,RHOT2,TRIB3,PIM2,ERBB3,BCL2,BCL2L2,BRCA1,TOP1,UBC,E2F2,SLC11A2,DHCR24,TNFAIP3,FAF1,NFKBIA,NEK6,MYC,	6.48E-7
GO:0022402	cell cycle process	KLHDC3,E2F1,CDKN2A,CHFR,CDKN1B,CDK1,TGFB1,PSME3,MIS18A,BCL2,PIM2,CCNA2,UBE2C,POLD1,BRCA1,PSMD1,ACVR1B,CHEK1,SESN1,UBC,CDK4,H2AFX,RANBP1,PA2G4,DHCR24,AURKB,CCNB1,CCNG1,NEK6,MYC,	8.01E-7
GO:0009057	macromolecule catabolic process	NAE1,APAF1,CDKN2A,YOD1,CHFR,XIAP,CDK1,RNF2,TGFB1,USP10,PSME3,SUMO3,NEDD4L,RNF11,URM1,DTL,UBE2C,UBD,FBXO34,BRCA1,PSMD1,VHL,DCP2,UBC,UBE3A,RNF144A,ABCE1,DHCR24,RFWD2,FEN1,NCBP2,TNFAIP3,CCNB1,FAF1,MYC,	3.56E-6
GO:0044265	cellular macromolecule catabolic process	NAE1,APAF1,CDKN2A,YOD1,CHFR,XIAP,CDK1,RNF2,USP10,PSME3,SUMO3,NEDD4L,RNF11,URM1,DTL,UBE2C,UBD,FBXO34,BRCA1,PSMD1,VHL,DCP2,UBC,UBE3A,RNF144A,ABCE1,RFWD2,FEN1,NCBP2,TNFAIP3,CCNB1,FAF1,MYC,	5.37E-6
GO:0000278	mitotic cell cycle	E2F1,BCL2,UBE2C,CCNA2,POLD1,ACVR1B,PSMD1,CHEK1,CDKN2A,UBC,CDK4,CHFR,CDKN1B,CDK1,RNF2,AURKB,PSME3,CCNB1,CCNG1,NEK6,MIS18A,	2.13E-5
GO:0032446	protein modification by small protein conjugation	PAF1,RNF2,NAE1,UBE2C,BRCA1,SUMO3,NEDD4L,VHL,UBC,CHFR,RNF11,UBE3A,	3.71E-5
GO:0000075	cell cycle checkpoint	TGFB1,NAE1,CCNA2,MAPK14,BRCA1,CHEK1,CDKN2A,CHFR,H2AFX,CDK1,	5.00E-5
GO:0006260	DNA replication	MCM4,NAE1,HMGB2,POLD1,BRCA1,TOP1,PRIM1,CHEK1,RRM2,MCM10,FEN1,NASP,PCNA,DTL,	5.93E-5
GO:0043632	modification-dependent macromolecule catabolic process	NAE1,YOD1,XIAP,CHFR,CDK1,RNF2,USP10,PSME3,SUMO3,NEDD4L,RNF11,URM1,DTL,UBE2C,UBD,BRCA1,FBXO34,PSMD1,VHL,UBC,UBE3A,RNF144A,RFWD2,TNFAIP3,CCNB1,FAF1,	7.60E-5
GO:0019941	modification-dependent protein catabolic process	NAE1,YOD1,XIAP,CHFR,CDK1,RNF2,USP10,PSME3,SUMO3,NEDD4L,RNF11,URM1,DTL,UBE2C,UBD,BRCA1,FBXO34,PSMD1,VHL,UBC,UBE3A,RNF144A,RFWD2,TNFAIP3,CCNB1,FAF1,	7.60E-5
GO:0022403	cell cycle phase	E2F1,PIM2,KLHDC3,BCL2,UBE2C,CCNA2,POLD1,ACVR1B,CHEK1,CDKN2A,CDK4,CHFR,CDKN1B,H2AFX,RANBP1,CDK1,AURKB,CCNB1,CCNG1,NEK6,MIS18A,	1.02E-4
GO:0043066	negative regulation of apoptosis	STRADB,PIM2,BCL2,ERBB3,BCL2L2,GCLM,NOTCH1,VHL,FURIN,UBC,CCL2,XIAP,CDK1,DHCR24,CHD8,TNFAIP3,HDAC1,NFKBIA,MYC,	1.21E-4
GO:0007346	regulation of mitotic cell cycle	TGFB1,HNF4A,BCL2,NAE1,CCNA2,UBE2C,CDKN2A,CHFR,NEK6,RANBP1,MYC,CDK1,	1.33E-4
GO:0006916	anti-apoptosis	STRADB,BCL2,PIM2,BCL2L2,VHL,CCL2,UBC,XIAP,CDK1,DHCR24,TNFAIP3,HDAC1,NFKBIA,MYC,	1.34E-4
GO:0043069	negative regulation of programmed cell death	STRADB,PIM2,BCL2,ERBB3,BCL2L2,GCLM,NOTCH1,VHL,FURIN,UBC,CCL2,XIAP,CDK1,DHCR24,CHD8,TNFAIP3,HDAC1,NFKBIA,MYC,	1.44E-4
GO:0060548	negative regulation of cell death	STRADB,PIM2,BCL2,ERBB3,BCL2L2,GCLM,NOTCH1,VHL,FURIN,UBC,CCL2,XIAP,CDK1,DHCR24,CHD8,TNFAIP3,HDAC1,NFKBIA,MYC,	1.50E-4
GO:0051603	proteolysis involved in cellular protein catabolic process	NAE1,YOD1,XIAP,CHFR,CDK1,RNF2,USP10,PSME3,SUMO3,NEDD4L,RNF11,URM1,DTL,UBE2C,UBD,BRCA1,FBXO34,PSMD1,VHL,UBC,UBE3A,RNF144A,RFWD2,TNFAIP3,CCNB1,FAF1,	1.53E-4
GO:0044257	cellular protein catabolic process	NAE1,YOD1,XIAP,CHFR,CDK1,RNF2,USP10,PSME3,SUMO3,NEDD4L,RNF11,URM1,DTL,UBE2C,UBD,BRCA1,FBXO34,PSMD1,VHL,UBC,UBE3A,RNF144A,RFWD2,TNFAIP3,CCNB1,FAF1,	1.64E-4
GO:0070647	protein modification by small protein conjugation or removal	PAF1,RNF2,NAE1,UBE2C,BRCA1,SUMO3,NEDD4L,VHL,UBC,CHFR,RNF11,UBE3A,	2.10E-4
GO:0006259	DNA metabolic process	MCM4,NAE1,KLHDC3,HMGB2,POLD1,BRCA1,APAF1,TOP1,CHEK1,PRIM1,CDKN2A,RRM2,H2AFX,MCM10,CTCF,FEN1,MMS19,UNG,NASP,ACD,PCNA,MYC,DTL,	2.15E-4
GO:0006974	response to DNA damage stimulus	CASP9,NAE1,HMGB2,CCNA2,MAPK14,POLD1,BRCA1,CHEK1,SESN1,RIF1,XIAP,H2AFX,CDK1,FEN1,MMS19,UNG,ACD,PCNA,DTL,	2.31E-4
GO:0000077	DNA damage checkpoint	NAE1,CCNA2,MAPK14,BRCA1,CHEK1,H2AFX,CDK1,	2.56E-4
GO:0030163	protein catabolic process	NAE1,YOD1,XIAP,CHFR,CDK1,RNF2,USP10,PSME3,SUMO3,NEDD4L,RNF11,URM1,DTL,UBE2C,UBD,BRCA1,FBXO34,PSMD1,VHL,UBC,UBE3A,RNF144A,RFWD2,TNFAIP3,CCNB1,FAF1,	2.64E-4
GO:0010604	positive regulation of macromolecule metabolic process	E2F1,HMGB2,MAPK14,NOTCH1,FURIN,NRIP1,CDK1,TGFB1,HNF4A,MMS19,PSME3,PLAGL2,FOXP3,BCL2,PACSIN3,UBE2C,CCNA2,BRCA1,PSMD1,VHL,UBC,CDK4,H2AFX,E2F3,CHD8,CTCF,DDX5,NFAT5,HDAC1,CCNB1,NFKBIA,MYC,	3.14E-4
GO:0016567	protein ubiquitination	PAF1,RNF2,UBE2C,BRCA1,NEDD4L,VHL,UBC,CHFR,RNF11,UBE3A,	3.92E-4
GO:0031570	DNA integrity checkpoint	NAE1,CCNA2,MAPK14,BRCA1,CHEK1,H2AFX,CDK1,	3.99E-4
GO:0032270	positive regulation of cellular protein metabolic process	BCL2,UBE2C,PACSIN3,BRCA1,PSMD1,FURIN,CDK4,UBC,CDK1,TGFB1,PSME3,CCNB1,NFKBIA,FOXP3,	4.47E-4
GO:0032774	RNA biosynthetic process	PRIM1,CDKN2A,ZNF217,MED24,HSF2,E2F3,E2F2,MED16,GTF3C2,GTF2E1,NFAT5,TCEA3,POLR2D,ADRM1,MYC,TBPL1,	4.63E-4
GO:0043029	T cell homeostasis	TGFB1,BCL2,CORO1A,BCL2L11,FOXP3,	5.56E-4
GO:0010605	negative regulation of macromolecule metabolic process	PCGF6,SRRT,E2F1,HMGB2,JARID2,CDKN2A,FURIN,CDKN1B,NRIP1,DEDD,RNF2,TGFB1,HNF4A,HIC2,PSME3,ACD,BCL7A,FOXP3,UBE2C,BRCA1,PSMD1,VHL,UBC,PA2G4,CTCF,HDAC1,NR0B2,MYC,	5.98E-4
GO:0032268	regulation of cellular protein metabolic process	BCL2,UBE2C,PACSIN3,BRCA1,PTPLAD1,PSMD1,CDKN2A,FURIN,UBC,CDK4,EIF4G3,PA2G4,CDK1,TGFB1,HNF4A,NCBP2,PSME3,EIF4H,CCNB1,NFKBIA,FOXP3,	6.10E-4
GO:0051247	positive regulation of protein metabolic process	BCL2,UBE2C,PACSIN3,BRCA1,PSMD1,FURIN,CDK4,UBC,CDK1,TGFB1,PSME3,CCNB1,NFKBIA,FOXP3,	6.65E-4
GO:0051329	interphase of mitotic cell cycle	E2F1,BCL2,POLD1,ACVR1B,CHEK1,CDKN2A,CDK4,CCNB1,CDKN1B,	6.89E-4
GO:0051340	regulation of ligase activity	UBE2C,GCLM,PSME3,PSMD1,CDKN2A,UBC,CCNB1,CDK1,	7.88E-4
GO:0034470	ncRNA processing	TYW3,RPS7,SRRT,EXOSC8,NOP56,EXOSC1,RPS16,CDKN2A,DUS1L,URM1,PA2G4,NOP14,	7.91E-4
GO:0042127	regulation of cell proliferation	CORO1A,JARID2,NOTCH1,CDKN2A,CCL2,CDKN1B,CDCA7,PRKRIR,TGFB1,HNF4A,FNTB,FOXP3,CSK,BCL2,ERBB3,CCNA2,PTPRF,BRCA1,CHEK1,SESN1,VHL,CDK4,E2F3,DHCR24,HDAC1,NFKBIA,MYC,MARCKSL1,CTLA4,	8.05E-4
GO:0051325	interphase	E2F1,BCL2,POLD1,ACVR1B,CHEK1,CDKN2A,CDK4,CCNB1,CDKN1B,	8.33E-4
GO:0006352	transcription initiation	MED16,GTF2E1,POLR2D,MED24,E2F3,MYC,E2F2,TBPL1,	9.12E-4
GO:0033554	cellular response to stress	STRADB,CASP9,NAE1,BCL2,HMGB2,CCNA2,MAPK14,POLD1,BRCA1,PTPLAD1,CHEK1,SESN1,RIF1,XIAP,H2AFX,CDK1,SLC11A2,FEN1,MMS19,UNG,ACD,PCNA,DTL,	9.66E-4
GO:0051051	negative regulation of transport	TGFB1,HNF4A,BCL2,ERBB3,SERGEF,PACSIN3,NEDD4L,FAF1,NFKBIA,FOXP3,	9.79E-4
GO:0007249	I-kappaB kinase/NF-kappaB cascade	CARD10,IKBKAP,PTPLAD1,TMED7,FAF1,NFKBIA,TNIP2,	1.12E-2
GO:0006351	transcription, DNA-dependent	CDKN2A,ZNF217,MED24,HSF2,E2F3,E2F2,MED16,GTF3C2,GTF2E1,TCEA3,NFAT5,POLR2D,ADRM1,MYC,TBPL1,	1.21E-2
GO:0043065	positive regulation of apoptosis	CASP9,BCL2,BRCA1,PTPRF,ACVR1B,NOTCH1,ARHGEF7,CDKN2A,UBC,CDKN1B,PPP3R1,DEDD,ARHGEF18,TGFB1,NET1,PLAGL2,FAF1,BCL2L11,MYC,	1.23E-2
GO:0043068	positive regulation of programmed cell death	CASP9,BCL2,BRCA1,PTPRF,ACVR1B,NOTCH1,ARHGEF7,CDKN2A,UBC,CDKN1B,PPP3R1,DEDD,ARHGEF18,TGFB1,NET1,PLAGL2,FAF1,BCL2L11,MYC,	1.32E-2
GO:0010942	positive regulation of cell death	CASP9,BCL2,BRCA1,PTPRF,ACVR1B,NOTCH1,ARHGEF7,CDKN2A,UBC,CDKN1B,PPP3R1,DEDD,ARHGEF18,TGFB1,NET1,PLAGL2,FAF1,BCL2L11,MYC,	1.40E-2
GO:0006364	rRNA processing	RPS7,EXOSC8,NOP56,EXOSC1,RPS16,CDKN2A,PA2G4,NOP14,	1.67E-2
GO:0006367	transcription initiation from RNA polymerase II promoter	MED16,GTF2E1,POLR2D,MED24,E2F3,E2F2,TBPL1,	1.67E-2
GO:0002260	lymphocyte homeostasis	TGFB1,BCL2,CORO1A,BCL2L11,FOXP3,	1.71E-2
GO:0032386	regulation of intracellular transport	TGFB1,HNF4A,FKBP1B,NCBP2,CDKN2A,FAF1,NFKBIA,	2.09E-2
GO:0045941	positive regulation of transcription	E2F1,HMGB2,CCNA2,MAPK14,BRCA1,NOTCH1,VHL,UBC,E2F3,NRIP1,TGFB1,CHD8,CTCF,HNF4A,MMS19,DDX5,NFAT5,HDAC1,PLAGL2,NFKBIA,MYC,FOXP3,	2.13E-2
GO:0016072	rRNA metabolic process	RPS7,EXOSC8,NOP56,EXOSC1,RPS16,CDKN2A,PA2G4,NOP14,	2.13E-2
GO:0006508	proteolysis	CASP9,NAE1,CNDP2,RCE1,FURIN,YOD1,CHFR,XIAP,CDK1,RNF2,THOP1,USP10,PSME3,SUMO3,NEDD4L,RNF11,URM1,DTL,UBE2C,UBD,FBXO34,BRCA1,PSMD1,VHL,UBC,ANPEP,METAP2,UBE3A,RNF144A,DHCR24,RFWD2,TNFAIP3,CCNB1,FAF1,	2.37E-2
GO:0051351	positive regulation of ligase activity	UBE2C,GCLM,PSME3,PSMD1,UBC,CCNB1,CDK1,	2.41E-2
GO:0031396	regulation of protein ubiquitination	UBE2C,BRCA1,PSME3,PSMD1,CDKN2A,UBC,CCNB1,CDK1,	2.69E-2
GO:0010629	negative regulation of gene expression	PCGF6,SRRT,E2F1,HMGB2,JARID2,BRCA1,VHL,CDKN1B,NRIP1,PA2G4,DEDD,RNF2,TGFB1,CTCF,HIC2,NR0B2,HDAC1,BCL7A,MYC,FOXP3,	2.98E-2
GO:0010628	positive regulation of gene expression	E2F1,HMGB2,CCNA2,MAPK14,BRCA1,NOTCH1,VHL,UBC,E2F3,NRIP1,TGFB1,CHD8,CTCF,HNF4A,MMS19,DDX5,NFAT5,HDAC1,PLAGL2,NFKBIA,MYC,FOXP3,	3.01E-2
GO:0045935	positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	E2F1,HMGB2,CCNA2,MAPK14,BRCA1,NOTCH1,VHL,UBC,H2AFX,E2F3,NRIP1,TGFB1,CHD8,CTCF,HNF4A,MMS19,DDX5,NFAT5,HDAC1,PLAGL2,NFKBIA,MYC,FOXP3,	3.26E-2
GO:0008285	negative regulation of cell proliferation	CSK,BCL2,JARID2,PTPRF,CHEK1,CDKN2A,SESN1,VHL,CDKN1B,PRKRIR,DHCR24,TGFB1,HNF4A,FNTB,FOXP3,CTLA4,	3.31E-2
GO:0051438	regulation of ubiquitin-protein ligase activity	UBE2C,PSME3,PSMD1,CDKN2A,UBC,CCNB1,CDK1,	3.36E-2
GO:0006468	protein amino acid phosphorylation	STRADB,CSK,PIM2,ERBB3,BCL2,MAPK14,IKBKAP,STK35,PTPLAD1,ACVR1B,CHEK1,PDPK1,CDK4,CCL2,GMFB,VRK1,CDK1,PAK4,AURKB,TGFB1,LAMTOR3,OXSR1,NEK6,TRIB3,	3.45E-2
GO:0043933	macromolecular complex subunit organization	LLGL1,HMGB2,CARD10,IKBKAP,SNRPD3,RRM2,MED24,MAGI1,TGFB1,NASP,TOMM22,TUBGCP2,VHL,H2AFX,E2F3,E2F2,ALDH5A1,MED16,CTCF,NCBP2,GTF2E1,POLR2D,ADRM1,MYC,TBPL1,	3.62E-2
GO:0007242	intracellular signaling cascade	STRADB,RAP2C,NAE1,HMGB2,MAPK14,IKBKAP,CARD10,PTPLAD1,MED24,CCL2,NRIP1,CDK1,LAMTOR3,THOP1,NET1,PCNA,RHOT2,CSK,ERBB3,CCNA2,UBE2C,RALA,BRCA1,TMED7,ARHGEF7,CHEK1,PDPK1,H2AFX,TNIP2,DHCR24,MED16,FEN1,ARL1,OXSR1,FAF1,NFKBIA,AKAP7,DEPDC1,	3.65E-2
GO:0042770	DNA damage response, signal transduction	NAE1,CCNA2,MAPK14,BRCA1,CHEK1,H2AFX,CDK1,	3.81E-2
GO:0034660	ncRNA metabolic process	DARS2,TYW3,RPS7,EXOSC8,NOP56,EXOSC1,RPS16,CDKN2A,DUS1L,URM1,PA2G4,NOP14,	4.05E-2
GO:0010552	positive regulation of specific transcription from RNA polymerase II promoter	HNF4A,HMGB2,NOTCH1,HDAC1,NFKBIA,FOXP3,	4.17E-2
GO:0043085	positive regulation of catalytic activity	STRADB,CASP9,BCL2,UBE2C,CARD10,GCLM,PTPLAD1,APAF1,PSMD1,CDKN2A,PDPK1,UBC,CDK1,SLC11A2,TGFB1,LAMTOR3,PSME3,ACD,CCNB1,MYC,	4.18E-2
GO:0016310	phosphorylation	STRADB,IKBKAP,MAPK14,PTPLAD1,CCL2,GMFB,CDK1,PAK4,TGFB1,LAMTOR3,TRIB3,ATP5B,CSK,ERBB3,BCL2,PIM2,STK35,TOP1,ACVR1B,CHEK1,PDPK1,CDK4,VRK1,AURKB,OXSR1,AK3,NEK6,	4.23E-2
GO:0052548	regulation of endopeptidase activity	CASP9,DHCR24,SLC11A2,APAF1,CDKN2A,FURIN,MYC,	4.31E-2
GO:0001776	leukocyte homeostasis	TGFB1,BCL2,CORO1A,BCL2L11,FOXP3,	4.39E-2
GO:0006261	DNA-dependent DNA replication	MCM4,HMGB2,FEN1,POLD1,TOP1,PRIM1,	4.49E-2
GO:0046822	regulation of nucleocytoplasmic transport	TGFB1,HNF4A,NCBP2,CDKN2A,FAF1,NFKBIA,	4.49E-2
GO:0051173	positive regulation of nitrogen compound metabolic process	E2F1,HMGB2,CCNA2,MAPK14,BRCA1,NOTCH1,VHL,UBC,H2AFX,E2F3,NRIP1,TGFB1,CHD8,CTCF,HNF4A,MMS19,DDX5,NFAT5,HDAC1,PLAGL2,NFKBIA,MYC,FOXP3,	4.76E-2
GO:0031398	positive regulation of protein ubiquitination	UBE2C,BRCA1,PSME3,PSMD1,UBC,CCNB1,CDK1,	4.85E-2
GO:0052547	regulation of peptidase activity	CASP9,DHCR24,SLC11A2,APAF1,CDKN2A,FURIN,MYC,	5.44E-2
GO:0032844	regulation of homeostatic process	TGFB1,FKBP1B,BCL2,MAPK14,GCLM,ACVR1B,ACD,MYC,	5.55E-2
GO:0010557	positive regulation of macromolecule biosynthetic process	E2F1,HMGB2,CCNA2,MAPK14,BRCA1,NOTCH1,VHL,UBC,CDK4,E2F3,NRIP1,TGFB1,CHD8,CTCF,HNF4A,MMS19,DDX5,NFAT5,HDAC1,PLAGL2,NFKBIA,MYC,FOXP3,	5.70E-2
GO:0016481	negative regulation of transcription	PCGF6,E2F1,HMGB2,JARID2,BRCA1,VHL,CDKN1B,NRIP1,PA2G4,DEDD,RNF2,TGFB1,CTCF,HIC2,NR0B2,HDAC1,BCL7A,FOXP3,	5.75E-2
GO:0051224	negative regulation of protein transport	HNF4A,SERGEF,FAF1,NFKBIA,FOXP3,	6.43E-2
GO:0070271	protein complex biogenesis	TOMM22,LLGL1,TUBGCP2,CARD10,IKBKAP,RRM2,VHL,MED24,E2F3,E2F2,MAGI1,ALDH5A1,MED16,TGFB1,GTF2E1,POLR2D,ADRM1,MYC,TBPL1,	6.76E-2
GO:0006461	protein complex assembly	TOMM22,LLGL1,TUBGCP2,CARD10,IKBKAP,RRM2,VHL,MED24,E2F3,E2F2,MAGI1,ALDH5A1,MED16,TGFB1,GTF2E1,POLR2D,ADRM1,MYC,TBPL1,	6.76E-2
GO:0043523	regulation of neuron apoptosis	CASP9,DHCR24,BCL2,ERBB3,PTPRF,GCLM,FURIN,	6.78E-2
GO:0022613	ribonucleoprotein complex biogenesis	RPS7,EXOSC8,NOP56,NCBP2,EXOSC1,SNRPD3,RPS16,CDKN2A,PA2G4,NOP14,	6.78E-2
GO:0065003	macromolecular complex assembly	TOMM22,LLGL1,TUBGCP2,HMGB2,CARD10,IKBKAP,SNRPD3,RRM2,VHL,MED24,H2AFX,E2F3,E2F2,MAGI1,ALDH5A1,MED16,TGFB1,NCBP2,GTF2E1,POLR2D,ADRM1,MYC,TBPL1,	6.83E-2
GO:0031400	negative regulation of protein modification process	TGFB1,HNF4A,UBE2C,PSME3,PSMD1,CDKN2A,UBC,FOXP3,	6.99E-2
GO:0044093	positive regulation of molecular function	STRADB,CASP9,BCL2,UBE2C,CARD10,GCLM,PTPLAD1,APAF1,PSMD1,CDKN2A,PDPK1,UBC,ADD1,CDK1,SLC11A2,TGFB1,LAMTOR3,PSME3,ACD,CCNB1,MYC,	7.04E-2
GO:0006396	RNA processing	TYW3,CCAR1,EXOSC8,SRRT,SNRPB2,CSTF3,NOP56,KHSRP,EXOSC1,SNRPD3,RPS16,CDKN2A,DUS1L,PA2G4,NOP14,RPS7,NCBP2,DDX5,POLR2D,URM1,	7.10E-2
GO:0031145	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process	UBE2C,PSME3,PSMD1,UBC,CCNB1,CDK1,	7.29E-2
GO:0007276	gamete generation	BCL2,BCL2L2,HMGB2,NOTCH1,DND1,CHEK1,SPIN4,H2AFX,HSF2,NRIP1,DEDD,TGFB1,CCNB1,BCL2L11,AGFG1,TBPL1,	7.38E-2
GO:0008633	activation of pro-apoptotic gene products	BCL2,BCL2L11,MYC,PPP3R1,	7.65E-2
GO:0045934	negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	PCGF6,E2F1,HMGB2,JARID2,BRCA1,VHL,CDKN1B,NRIP1,PA2G4,DEDD,RNF2,TGFB1,CTCF,HIC2,NR0B2,HDAC1,ACD,BCL7A,FOXP3,	7.76E-2
GO:0042254	ribosome biogenesis	RPS7,EXOSC8,NOP56,EXOSC1,RPS16,CDKN2A,PA2G4,NOP14,	7.98E-2
GO:0007093	mitotic cell cycle checkpoint	TGFB1,NAE1,CCNA2,CHFR,CDK1,	8.32E-2
GO:0045893	positive regulation of transcription, DNA-dependent	E2F1,HMGB2,MAPK14,BRCA1,NOTCH1,E2F3,NRIP1,TGFB1,CHD8,HNF4A,CTCF,MMS19,NFAT5,HDAC1,PLAGL2,NFKBIA,MYC,FOXP3,	8.35E-2
GO:0006796	phosphate metabolic process	STRADB,PPM1F,MAPK14,IKBKAP,PTPN9,PTPLAD1,CCL2,GMFB,CDK1,PAK4,TGFB1,LAMTOR3,TRIB3,ATP5B,CSK,ERBB3,BCL2,PIM2,PTPRF,STK35,TOP1,ACVR1B,CHEK1,PDPK1,CDK4,VRK1,AURKB,OXSR1,AK3,NEK6,	8.52E-2
GO:0006793	phosphorus metabolic process	STRADB,PPM1F,MAPK14,IKBKAP,PTPN9,PTPLAD1,CCL2,GMFB,CDK1,PAK4,TGFB1,LAMTOR3,TRIB3,ATP5B,CSK,ERBB3,BCL2,PIM2,PTPRF,STK35,TOP1,ACVR1B,CHEK1,PDPK1,CDK4,VRK1,AURKB,OXSR1,AK3,NEK6,	8.52E-2
GO:0031401	positive regulation of protein modification process	TGFB1,BCL2,UBE2C,BRCA1,PSME3,PSMD1,UBC,CCNB1,CDK1,FOXP3,	8.63E-2
GO:0051437	positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle	UBE2C,PSME3,PSMD1,UBC,CCNB1,CDK1,	8.80E-2
GO:0051172	negative regulation of nitrogen compound metabolic process	PCGF6,E2F1,HMGB2,JARID2,BRCA1,VHL,CDKN1B,NRIP1,PA2G4,DEDD,RNF2,TGFB1,CTCF,HIC2,NR0B2,HDAC1,ACD,BCL7A,FOXP3,	8.87E-2
GO:0000279	M phase	KLHDC3,PIM2,UBE2C,CCNA2,CHEK1,CHFR,H2AFX,RANBP1,CDK1,AURKB,CCNB1,CCNG1,NEK6,MIS18A,	9.10E-2
GO:0051254	positive regulation of RNA metabolic process	E2F1,HMGB2,MAPK14,BRCA1,NOTCH1,E2F3,NRIP1,TGFB1,CHD8,HNF4A,CTCF,MMS19,NFAT5,HDAC1,PLAGL2,NFKBIA,MYC,FOXP3,	9.17E-2
GO:0031099	regeneration	TGFB1,BCL2,CCNA2,NOTCH1,CCNB1,CCL2,	9.34E-2
GO:0006357	regulation of transcription from RNA polymerase II promoter	E2F1,HMGB2,MAPK14,IKBKAP,JARID2,BRCA1,NOTCH1,MED22,VHL,NRIP1,RNF2,CHD8,MED16,TGFB1,HNF4A,NFAT5,NR0B2,HDAC1,TCEA3,PLAGL2,NFKBIA,BRD8,MYC,FOXP3,	9.50E-2
GO:0031328	positive regulation of cellular biosynthetic process	E2F1,HMGB2,CCNA2,MAPK14,BRCA1,NOTCH1,VHL,UBC,CDK4,E2F3,NRIP1,TGFB1,CHD8,CTCF,HNF4A,MMS19,DDX5,NFAT5,HDAC1,PLAGL2,NFKBIA,MYC,FOXP3,	9.55E-2
GO:0051301	cell division	UBE2C,CCNA2,NOTCH1,TOP1,CDKN2A,CDK4,CHFR,CDK1,AURKB,CCNB1,CCNG1,NEK6,MIS18A,	9.64E-2
GO:0031399	regulation of protein modification process	BCL2,UBE2C,BRCA1,PSMD1,PTPLAD1,CDKN2A,UBC,CDK1,TGFB1,HNF4A,PSME3,CCNB1,FOXP3,	9.64E-2
GO:0051443	positive regulation of ubiquitin-protein ligase activity	UBE2C,PSME3,PSMD1,UBC,CCNB1,CDK1,	9.91E-2

KEGG pathways and Gene Ontology terms enriched for the interacted genes of ncRNA from RAID and miRTarBase.

disease name	related genes	p-value