ncRNADetailInformation

Detail Information
Functional analysis

miRNA name

pre-miRNA

family

pre-miRNA Sequence

mature-miRNA

mature sequence

pre-miRNA description

miR-200a

MI0000737	MIPF0000019	CCGGGCCCCUGUGAGCAUCUUACCGGACAGUGCUGGAUUUCCCAGCUUGACUCUAACACUGUCUGGUAACGAUGUUCAAAGGUGACCCGC	MIMAT0000682 hsa-miR-200a-3p	UAACACUGUCUGGUAACGAUGU	miR-200a was cloned from mouse kidney tissue , and expression laterconfirmed by cloning in human .
MI0000737	MIPF0000019	CCGGGCCCCUGUGAGCAUCUUACCGGACAGUGCUGGAUUUCCCAGCUUGACUCUAACACUGUCUGGUAACGAUGUUCAAAGGUGACCCGC	MIMAT0001620 hsa-miR-200a-5p	CAUCUUACCGGACAGUGCUGGA	miR-200a was cloned from mouse kidney tissue , and expression laterconfirmed by cloning in human .
MI0000737	MIPF0000019	CCGGGCCCCUGUGAGCAUCUUACCGGACAGUGCUGGAUUUCCCAGCUUGACUCUAACACUGUCUGGUAACGAUGUUCAAAGGUGACCCGC	MIMAT0000682 hsa-miR-200a-3p	UAACACUGUCUGGUAACGAUGU	miR-200a was cloned from mouse kidney tissue , and expression laterconfirmed by cloning in human .
MI0000737	MIPF0000019	CCGGGCCCCUGUGAGCAUCUUACCGGACAGUGCUGGAUUUCCCAGCUUGACUCUAACACUGUCUGGUAACGAUGUUCAAAGGUGACCCGC	MIMAT0001620 hsa-miR-200a-5p	CAUCUUACCGGACAGUGCUGGA	miR-200a was cloned from mouse kidney tissue , and expression laterconfirmed by cloning in human .

link to database

TargetScanS 6.2 | MicroCosm | microRNA.org | miRNAMap 2.0

Interacted genes from RAID,miRTarBase

SMAD2,PDCD4,GEMIN2,G3BP2,RAB30,PSMD2,DACT2,CTNNB1,TCF7L1,KLF11,GDAP1,PCDH8,THBS1,TRAPPC2P1,HDAC4
more » SMAD2,PDCD4,GEMIN2,G3BP2,RAB30,PSMD2,DACT2,CTNNB1,TCF7L1,KLF11,GDAP1,PCDH8,THBS1,TRAPPC2P1,HDAC4,DACT3,HOXB5,ZEB1,YAP1,VCAM1,CCNE2,KLHL20,BAD,DACT1,WDR37,RASSF2,KEAP1,VAC14,SIRT1,SMAD3,TFRC,ELMO2,PTPRD,BAP1,SHC1,DLX5,ZEB2,WASF3,MAPK14,GATA6,BCL2,SEPT7,ERBB2IP,RIN2

KEGG pathways enriched for interacted genes

pathway name

pathway description

target genes enrich in pathway

p-value

hsa05210	Colorectal cancer	BCL2,TCF7L1,SMAD3,BAD,CTNNB1,SMAD2,	2.87E-6
hsa04520	Adherens junction	TCF7L1,SMAD3,WASF3,CTNNB1,SMAD2,	5.84E-5
hsa05215	Prostate cancer	CCNE2,BCL2,TCF7L1,BAD,CTNNB1,	1.03E-4
hsa05200	Pathways in cancer	CCNE2,BCL2,TCF7L1,SMAD3,BAD,CTNNB1,SMAD2,	2.09E-4
hsa04510	Focal adhesion	BCL2,SHC1,BAD,THBS1,CTNNB1,	2.29E-2

Gene ontology terms enriched for interacted genes

GO terms

GO terms description

target genes enrich in GO term

p-value

GO:0010604	positive regulation of macromolecule metabolic process	YAP1,BCL2,PSMD2,TCF7L1,MAPK14,SHC1,HDAC4,GATA6,CTNNB1,SMAD3,ZFPM2,THBS1,ZEB1,SMAD2,	5.86E-7
GO:0016481	negative regulation of transcription	KLF11,TCF7L1,SMAD3,HDAC4,ZFPM2,PDCD4,ZEB2,SIRT1,ZEB1,CTNNB1,SMAD2,	6.22E-7
GO:0010605	negative regulation of macromolecule metabolic process	PSMD2,TCF7L1,HDAC4,ZEB2,PDCD4,CTNNB1,KLF11,SMAD3,ZFPM2,THBS1,ZEB1,SIRT1,SMAD2,	8.14E-7
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	YAP1,MAPK14,TCF7L1,SMAD3,HDAC4,GATA6,ZFPM2,ZEB1,CTNNB1,SMAD2,	1.02E-6
GO:0051094	positive regulation of developmental process	BCL2,MAPK14,SMAD3,DLX5,BAD,GATA6,THBS1,CTNNB1,SMAD2,	1.25E-6

GO:0010629	negative regulation of gene expression	KLF11,TCF7L1,SMAD3,HDAC4,ZFPM2,PDCD4,ZEB2,SIRT1,ZEB1,CTNNB1,SMAD2,	1.45E-6
GO:0045934	negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	KLF11,TCF7L1,SMAD3,HDAC4,ZFPM2,PDCD4,ZEB2,SIRT1,ZEB1,CTNNB1,SMAD2,	1.68E-6
GO:0042127	regulation of cell proliferation	BCL2,SHC1,HDAC4,DLX5,CTNNB1,VCAM1,BAP1,KLF11,SMAD3,THBS1,ZEB1,SIRT1,SMAD2,	1.70E-6
GO:0051172	negative regulation of nitrogen compound metabolic process	KLF11,TCF7L1,SMAD3,HDAC4,ZFPM2,PDCD4,ZEB2,SIRT1,ZEB1,CTNNB1,SMAD2,	1.90E-6
GO:0010557	positive regulation of macromolecule biosynthetic process	YAP1,MAPK14,TCF7L1,SHC1,SMAD3,HDAC4,GATA6,ZFPM2,ZEB1,THBS1,CTNNB1,SMAD2,	1.98E-6
GO:0010558	negative regulation of macromolecule biosynthetic process	KLF11,TCF7L1,SMAD3,HDAC4,ZFPM2,PDCD4,ZEB2,SIRT1,ZEB1,CTNNB1,SMAD2,	3.04E-6
GO:0031328	positive regulation of cellular biosynthetic process	YAP1,MAPK14,TCF7L1,SHC1,SMAD3,HDAC4,GATA6,ZFPM2,ZEB1,THBS1,CTNNB1,SMAD2,	3.11E-6
GO:0001501	skeletal system development	BCL2,MAPK14,HOXB5,SMAD3,HDAC4,DLX5,TRAPPC2P1,ZEB1,CTNNB1,	3.48E-6
GO:0009891	positive regulation of biosynthetic process	YAP1,MAPK14,TCF7L1,SHC1,SMAD3,HDAC4,GATA6,ZFPM2,ZEB1,THBS1,CTNNB1,SMAD2,	3.57E-6
GO:0031327	negative regulation of cellular biosynthetic process	KLF11,TCF7L1,SMAD3,HDAC4,ZFPM2,PDCD4,ZEB2,SIRT1,ZEB1,CTNNB1,SMAD2,	3.81E-6
GO:0045597	positive regulation of cell differentiation	BCL2,MAPK14,SMAD3,DLX5,BAD,GATA6,CTNNB1,SMAD2,	4.21E-6
GO:0009890	negative regulation of biosynthetic process	KLF11,TCF7L1,SMAD3,HDAC4,ZFPM2,PDCD4,ZEB2,SIRT1,ZEB1,CTNNB1,SMAD2,	4.61E-6
GO:0006357	regulation of transcription from RNA polymerase II promoter	YAP1,MAPK14,KLF11,TCF7L1,SMAD3,HDAC4,GATA6,ZFPM2,SIRT1,ZEB1,CTNNB1,SMAD2,	5.51E-6
GO:0045892	negative regulation of transcription, DNA-dependent	KLF11,TCF7L1,SMAD3,HDAC4,ZFPM2,SIRT1,ZEB1,CTNNB1,SMAD2,	7.82E-6
GO:0045893	positive regulation of transcription, DNA-dependent	YAP1,MAPK14,TCF7L1,SMAD3,HDAC4,GATA6,ZFPM2,ZEB1,CTNNB1,SMAD2,	8.05E-6
GO:0051254	positive regulation of RNA metabolic process	YAP1,MAPK14,TCF7L1,SMAD3,HDAC4,GATA6,ZFPM2,ZEB1,CTNNB1,SMAD2,	8.62E-6
GO:0051253	negative regulation of RNA metabolic process	KLF11,TCF7L1,SMAD3,HDAC4,ZFPM2,SIRT1,ZEB1,CTNNB1,SMAD2,	8.84E-6
GO:0045935	positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	YAP1,MAPK14,TCF7L1,SHC1,SMAD3,HDAC4,GATA6,ZFPM2,ZEB1,CTNNB1,SMAD2,	9.79E-6
GO:0051173	positive regulation of nitrogen compound metabolic process	YAP1,MAPK14,TCF7L1,SHC1,SMAD3,HDAC4,GATA6,ZFPM2,ZEB1,CTNNB1,SMAD2,	1.29E-5
GO:0048729	tissue morphogenesis	BCL2,TCF7L1,SMAD3,PCDH8,ZEB2,CTNNB1,SMAD2,	1.34E-5
GO:0048598	embryonic morphogenesis	HOXB5,SMAD3,PCDH8,DLX5,ZEB2,ZEB1,CTNNB1,SMAD2,	2.83E-5
GO:0045941	positive regulation of transcription	YAP1,MAPK14,TCF7L1,SMAD3,HDAC4,GATA6,ZFPM2,ZEB1,CTNNB1,SMAD2,	3.06E-5
GO:0010628	positive regulation of gene expression	YAP1,MAPK14,TCF7L1,SMAD3,HDAC4,GATA6,ZFPM2,ZEB1,CTNNB1,SMAD2,	3.86E-5
GO:0032583	regulation of gene-specific transcription	SMAD3,HDAC4,GATA6,SIRT1,CTNNB1,SMAD2,	4.40E-5
GO:0043009	chordate embryonic development	HOXB5,PCDH8,KEAP1,GATA6,ZFPM2,ZEB2,ZEB1,SMAD2,	4.58E-5
GO:0009792	embryonic development ending in birth or egg hatching	HOXB5,PCDH8,KEAP1,GATA6,ZFPM2,ZEB2,ZEB1,SMAD2,	4.85E-5
GO:0060429	epithelium development	BCL2,HOXB5,PCDH8,DLX5,GATA6,ZEB2,CTNNB1,	4.97E-5
GO:0006915	apoptosis	BCL2,ELMO2,KLF11,SMAD3,BAD,GATA6,PDCD4,SIRT1,THBS1,CTNNB1,	5.10E-5
GO:0009952	anterior/posterior pattern formation	TCF7L1,HOXB5,PCDH8,ZEB2,CTNNB1,SMAD2,	5.43E-5
GO:0012501	programmed cell death	BCL2,ELMO2,KLF11,SMAD3,BAD,GATA6,PDCD4,SIRT1,THBS1,CTNNB1,	5.72E-5
GO:0008285	negative regulation of cell proliferation	BCL2,BAP1,KLF11,SMAD3,HDAC4,ZEB1,THBS1,SMAD2,	7.93E-5
GO:0006355	regulation of transcription, DNA-dependent	YAP1,MAPK14,TCF7L1,HOXB5,HDAC4,DLX5,GATA6,ZEB2,CTNNB1,KLF11,SMAD3,ZFPM2,TRAPPC2P1,ZEB1,SIRT1,SMAD2,	8.74E-5
GO:0051252	regulation of RNA metabolic process	YAP1,MAPK14,TCF7L1,HOXB5,HDAC4,DLX5,GATA6,ZEB2,CTNNB1,KLF11,SMAD3,ZFPM2,TRAPPC2P1,ZEB1,SIRT1,SMAD2,	1.13E-4
GO:0007389	pattern specification process	TCF7L1,HOXB5,PCDH8,ZEB2,ZEB1,CTNNB1,SMAD2,	1.22E-4
GO:0043193	positive regulation of gene-specific transcription	SMAD3,HDAC4,GATA6,CTNNB1,SMAD2,	1.22E-4
GO:0010551	regulation of specific transcription from RNA polymerase II promoter	SMAD3,HDAC4,GATA6,SIRT1,CTNNB1,	1.64E-4
GO:0008219	cell death	BCL2,ELMO2,KLF11,SMAD3,BAD,GATA6,PDCD4,SIRT1,THBS1,CTNNB1,	1.98E-4
GO:0017015	regulation of transforming growth factor beta receptor signaling pathway	SMAD3,ZEB1,THBS1,SMAD2,	2.03E-4
GO:0016265	death	BCL2,ELMO2,KLF11,SMAD3,BAD,GATA6,PDCD4,SIRT1,THBS1,CTNNB1,	2.09E-4
GO:0003002	regionalization	TCF7L1,HOXB5,PCDH8,ZEB2,CTNNB1,SMAD2,	2.70E-4
GO:0035295	tube development	BCL2,GATA6,ZFPM2,ZEB2,CTNNB1,SMAD2,	4.49E-4
GO:0045449	regulation of transcription	YAP1,MAPK14,TCF7L1,HOXB5,HDAC4,KEAP1,DLX5,GATA6,ZEB2,PDCD4,CTNNB1,KLF11,SMAD3,ZFPM2,TRAPPC2P1,ZEB1,SIRT1,SMAD2,	6.07E-4
GO:0010552	positive regulation of specific transcription from RNA polymerase II promoter	SMAD3,HDAC4,GATA6,CTNNB1,	6.27E-4
GO:0000578	embryonic axis specification	TCF7L1,CTNNB1,SMAD2,	8.73E-4
GO:0051098	regulation of binding	BCL2,SMAD3,HDAC4,SIRT1,SMAD2,	1.04E-2
GO:0010033	response to organic substance	BCL2,MAPK14,SHC1,TFRC,SMAD3,HDAC4,THBS1,CTNNB1,SMAD2,	1.05E-2
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	KLF11,SMAD3,HDAC4,ZFPM2,ZEB1,CTNNB1,	1.06E-2
GO:0030278	regulation of ossification	BCL2,SMAD3,DLX5,CTNNB1,	1.56E-2
GO:0007049	cell cycle	SEPT7,CCNE2,BCL2,ERBB2IP,PSMD2,SMAD3,THBS1,CTNNB1,RASSF2,	1.68E-2
GO:0008633	activation of pro-apoptotic gene products	BCL2,SMAD3,BAD,	1.89E-2
GO:0046649	lymphocyte activation	VCAM1,BCL2,SMAD3,HDAC4,CTNNB1,	2.74E-2
GO:0019220	regulation of phosphate metabolic process	CCNE2,BCL2,SHC1,SMAD3,PDCD4,ZEB2,THBS1,	2.80E-2
GO:0051174	regulation of phosphorus metabolic process	CCNE2,BCL2,SHC1,SMAD3,PDCD4,ZEB2,THBS1,	2.80E-2
GO:0001952	regulation of cell-matrix adhesion	BCL2,SMAD3,THBS1,	2.85E-2
GO:0030324	lung development	GATA6,ZFPM2,CTNNB1,SMAD2,	3.08E-2
GO:0002009	morphogenesis of an epithelium	BCL2,PCDH8,ZEB2,CTNNB1,	3.26E-2
GO:0030323	respiratory tube development	GATA6,ZFPM2,CTNNB1,SMAD2,	3.35E-2
GO:0030098	lymphocyte differentiation	VCAM1,BCL2,HDAC4,CTNNB1,	3.45E-2
GO:0009798	axis specification	TCF7L1,CTNNB1,SMAD2,	3.51E-2
GO:0045596	negative regulation of cell differentiation	SMAD3,HDAC4,SIRT1,ZEB1,CTNNB1,	3.68E-2
GO:0060541	respiratory system development	GATA6,ZFPM2,CTNNB1,SMAD2,	3.94E-2
GO:0009880	embryonic pattern specification	TCF7L1,CTNNB1,SMAD2,	3.99E-2
GO:0007568	aging	BCL2,TFRC,PDCD4,SIRT1,	4.15E-2
GO:0007569	cell aging	BCL2,PDCD4,SIRT1,	4.24E-2
GO:0045321	leukocyte activation	VCAM1,BCL2,SMAD3,HDAC4,CTNNB1,	5.50E-2
GO:0048332	mesoderm morphogenesis	TCF7L1,SMAD3,SMAD2,	5.60E-2
GO:0006350	transcription	TCF7L1,HOXB5,HDAC4,GATA6,KEAP1,ZEB2,CTNNB1,KLF11,SMAD3,ZFPM2,TRAPPC2P1,ZEB1,SIRT1,SMAD2,	5.76E-2
GO:0051147	regulation of muscle cell differentiation	BCL2,HDAC4,ZEB1,	5.89E-2
GO:0001704	formation of primary germ layer	SMAD3,CTNNB1,SMAD2,	6.19E-2
GO:0010038	response to metal ion	BCL2,TFRC,THBS1,CTNNB1,	6.47E-2
GO:0002521	leukocyte differentiation	VCAM1,BCL2,HDAC4,CTNNB1,	6.75E-2
GO:0044093	positive regulation of molecular function	BCL2,PSMD2,SHC1,SMAD3,HDAC4,ZEB2,THBS1,	7.04E-2
GO:0045667	regulation of osteoblast differentiation	SMAD3,DLX5,CTNNB1,	7.13E-2
GO:0001666	response to hypoxia	BCL2,TFRC,SMAD3,THBS1,	7.18E-2
GO:0042306	regulation of protein import into nucleus	G3BP2,SMAD3,SIRT1,	7.45E-2
GO:0032880	regulation of protein localization	BCL2,G3BP2,SMAD3,SIRT1,	7.79E-2
GO:0010810	regulation of cell-substrate adhesion	BCL2,SMAD3,THBS1,	8.12E-2
GO:0070482	response to oxygen levels	BCL2,TFRC,SMAD3,THBS1,	8.26E-2
GO:0043405	regulation of MAP kinase activity	SHC1,PDCD4,ZEB2,THBS1,	8.26E-2
GO:0030183	B cell differentiation	VCAM1,BCL2,HDAC4,	8.82E-2
GO:0035282	segmentation	TCF7L1,PCDH8,ZEB2,	8.82E-2
GO:0016202	regulation of striated muscle tissue development	BCL2,SMAD3,HDAC4,	9.54E-2
GO:0014031	mesenchymal cell development	BCL2,ZEB2,CTNNB1,	9.91E-2
GO:0048762	mesenchymal cell differentiation	BCL2,ZEB2,CTNNB1,	9.91E-2
GO:0048634	regulation of muscle development	BCL2,SMAD3,HDAC4,	9.91E-2
GO:0001775	cell activation	VCAM1,BCL2,SMAD3,HDAC4,CTNNB1,	9.94E-2

KEGG pathways and Gene Ontology terms enriched for the interacted genes of ncRNA from RAID and miRTarBase.

disease name	related genes	p-value