miR-196b is predicted based on sequence homology to miR-196a . Yektaet al. report that miR-196 miRNAs are expressed from HOX gene clusters inmammals, and that HOX genes in these clusters are targets of miR-196.Indeed, HOXB8 mRNA was shown to be a natural target for miR-196-directedcleavage through a perfectly complementary miR-target site. Other HOXgenes have imperfect miR-196 complementary sites indicative of regulationby translational repression . The mature sequence shown hererepresents the most commonly cloned form from large-scale cloning studies.
miR-196b is predicted based on sequence homology to miR-196a . Yektaet al. report that miR-196 miRNAs are expressed from HOX gene clusters inmammals, and that HOX genes in these clusters are targets of miR-196.Indeed, HOXB8 mRNA was shown to be a natural target for miR-196-directedcleavage through a perfectly complementary miR-target site. Other HOXgenes have imperfect miR-196 complementary sites indicative of regulationby translational repression . The mature sequence shown hererepresents the most commonly cloned form from large-scale cloning studies.