KEGG pathways enriched for interacted genes |
pathway name | pathway description | target genes enrich in pathway | p-value |
|
hsa05212
|
Pancreatic cancer |
CCND1,CDK6,CHUK,VEGFA,RAF1,CDK4,E2F3,CDC42, |
5.67E-9 |
hsa04110
|
Cell cycle |
CCND1,CDK6,CHEK1,CDK4,WEE1,CCNE1,E2F3,CCND3, |
2.72E-7 |
hsa05222
|
Small cell lung cancer |
CCND1,CDK6,BCL2,CHUK,CDK4,CCNE1,E2F3, |
5.46E-7 |
hsa05200
|
Pathways in cancer |
CCND1,CDK6,BCL2,CHUK,VEGFA,RAF1,CDK4,CCNE1,E2F3,CDC42, |
1.54E-6 |
hsa04115
|
p53 signaling pathway |
CCND1,CDK6,CHEK1,CDK4,CCNE1,CCND3, |
4.89E-6 |
|
hsa05220
|
Chronic myeloid leukemia |
CCND1,CDK6,CHUK,RAF1,CDK4,E2F3, |
7.95E-6 |
hsa05219
|
Bladder cancer |
CCND1,VEGFA,RAF1,CDK4,E2F3, |
1.77E-5 |
hsa05215
|
Prostate cancer |
CCND1,BCL2,CHUK,RAF1,CCNE1,E2F3, |
1.84E-5 |
hsa05223
|
Non-small cell lung cancer |
CCND1,CDK6,RAF1,CDK4,E2F3, |
4.85E-5 |
hsa05214
|
Glioma |
CCND1,CDK6,RAF1,CDK4,E2F3, |
8.93E-5 |
hsa05218
|
Melanoma |
CCND1,CDK6,RAF1,CDK4,E2F3, |
1.42E-4 |
hsa04510
|
Focal adhesion |
CCND1,BCL2,VEGFA,RAF1,CDC42,CCND3, |
8.75E-4 |
hsa04062
|
Chemokine signaling pathway |
CCL4,CHUK,RAF1,CDC42,JAK2, |
5.40E-2 |
hsa04660
|
T cell receptor signaling pathway |
CHUK,RAF1,CDK4,CDC42, |
8.16E-2 |
hsa05221
|
Acute myeloid leukemia |
CCND1,CHUK,RAF1, |
2.12E-1 |
hsa05211
|
Renal cell carcinoma |
VEGFA,RAF1,CDC42, |
3.02E-1 |
hsa04370
|
VEGF signaling pathway |
VEGFA,RAF1,CDC42, |
3.43E-1 |
hsa05210
|
Colorectal cancer |
CCND1,BCL2,RAF1, |
4.22E-1 |
hsa04722
|
Neurotrophin signaling pathway |
BCL2,RAF1,CDC42, |
8.42E-1 |
|
|
|
|
|
|
Gene ontology terms enriched for interacted genes |
GO terms | GO terms description | target genes enrich in GO term | p-value |
|
GO:0051325
|
interphase |
CCND1,CDK6,BCL2,LATS2,CHEK1,CDK4,KRT7,CCNE1, |
1.85E-8 |
GO:0051329
|
interphase of mitotic cell cycle |
CCND1,CDK6,BCL2,LATS2,CHEK1,CDK4,CCNE1, |
4.47E-7 |
GO:0008406
|
gonad development |
CCND1,BCL2,BCL2L2,VEGFA,BCL2L11,CCNE1,SIRT1, |
7.35E-7 |
GO:0007049
|
cell cycle |
CCND1,BCL2,LATS2,CHEK1,WEE1,CDK4,KRT7,NOLC1,E2F3,CDK6,ARL2,CCNE1,CCND3, |
1.08E-6 |
GO:0048608
|
reproductive structure development |
CCND1,BCL2,BCL2L2,VEGFA,BCL2L11,CCNE1,SIRT1, |
1.46E-6 |
|
GO:0045137
|
development of primary sexual characteristics |
CCND1,BCL2,BCL2L2,VEGFA,BCL2L11,CCNE1,SIRT1, |
1.53E-6 |
GO:0006468
|
protein amino acid phosphorylation |
CCND1,CDK6,CAMKV,BCL2,CHUK,RAF1,LATS2,SPTBN1,CHEK1,CDK4,WEE1,JAK2, |
1.82E-6 |
GO:0022403
|
cell cycle phase |
CCND1,CDK6,BCL2,LATS2,CHEK1,CDK4,WEE1,KRT7,NOLC1,CCNE1, |
2.02E-6 |
GO:0007548
|
sex differentiation |
CCND1,BCL2,BCL2L2,VEGFA,BCL2L11,CCNE1,SIRT1, |
4.21E-6 |
GO:0000278
|
mitotic cell cycle |
CCND1,CDK6,BCL2,LATS2,CHEK1,CDK4,WEE1,NOLC1,CCNE1, |
8.50E-6 |
GO:0042127
|
regulation of cell proliferation |
CCND1,RUNX2,CDK6,BCL2,VEGFA,CHEK1,CDK4,AGER,SKI,E2F3,SIRT1,JAK2, |
8.98E-6 |
GO:0016310
|
phosphorylation |
CCND1,CDK6,CAMKV,BCL2,CHUK,RAF1,LATS2,SPTBN1,CHEK1,CDK4,WEE1,JAK2, |
1.04E-5 |
GO:0051301
|
cell division |
CCND1,CDK6,LATS2,CDK4,WEE1,CCNE1,CDC42,CCND3, |
1.84E-5 |
GO:0008284
|
positive regulation of cell proliferation |
CCND1,RUNX2,CDK6,BCL2,VEGFA,CDK4,AGER,E2F3,JAK2, |
1.92E-5 |
GO:0000082
|
G1/S transition of mitotic cell cycle |
CCND1,BCL2,LATS2,CDK4,CCNE1, |
1.94E-5 |
GO:0022402
|
cell cycle process |
CCND1,CDK6,BCL2,LATS2,CHEK1,CDK4,WEE1,KRT7,NOLC1,CCNE1, |
2.49E-5 |
GO:0051726
|
regulation of cell cycle |
CCND1,CDK6,BCL2,LATS2,CHEK1,CDK4,CDC42,CCND3, |
3.86E-5 |
GO:0006793
|
phosphorus metabolic process |
CCND1,CDK6,CAMKV,BCL2,CHUK,RAF1,LATS2,SPTBN1,CHEK1,CDK4,WEE1,JAK2, |
6.48E-5 |
GO:0006796
|
phosphate metabolic process |
CCND1,CDK6,CAMKV,BCL2,CHUK,RAF1,LATS2,SPTBN1,CHEK1,CDK4,WEE1,JAK2, |
6.48E-5 |
GO:0048534
|
hemopoietic or lymphoid organ development |
CDK6,BCL2,CHUK,VEGFA,BCL2L11,CDC42,JAK2, |
9.11E-5 |
GO:0003006
|
reproductive developmental process |
CCND1,BCL2,BCL2L2,VEGFA,BCL2L11,CCNE1,SIRT1, |
9.50E-5 |
GO:0002520
|
immune system development |
CDK6,BCL2,CHUK,VEGFA,BCL2L11,CDC42,JAK2, |
1.26E-4 |
GO:0008584
|
male gonad development |
CCND1,BCL2,BCL2L2,BCL2L11, |
4.44E-4 |
GO:0048511
|
rhythmic process |
BCL2,VEGFA,CDK4,CCNE1,SIRT1, |
4.86E-4 |
GO:0000079
|
regulation of cyclin-dependent protein kinase activity |
CCND1,LATS2,CHEK1,CCND3, |
4.96E-4 |
GO:0030097
|
hemopoiesis |
CDK6,BCL2,CHUK,VEGFA,CDC42,JAK2, |
5.49E-4 |
GO:0010604
|
positive regulation of macromolecule metabolic process |
CCND1,RUNX2,BCL2,VEGFA,CDK4,CCNE1,E2F3,CAND1,CCND3,JAK2, |
5.94E-4 |
GO:0022602
|
ovulation cycle process |
BCL2,VEGFA,CCNE1,SIRT1, |
7.44E-4 |
GO:0008585
|
female gonad development |
BCL2,VEGFA,CCNE1,SIRT1, |
8.17E-4 |
GO:0046546
|
development of primary male sexual characteristics |
CCND1,BCL2,BCL2L2,BCL2L11, |
8.55E-4 |
GO:0042698
|
ovulation cycle |
BCL2,VEGFA,CCNE1,SIRT1, |
9.34E-4 |
GO:0051412
|
response to corticosterone stimulus |
CCND1,BCL2,CCNE1, |
9.47E-4 |
GO:0031099
|
regeneration |
CCND1,BCL2,CCNE1,JAK2, |
1.01E-2 |
GO:0046545
|
development of primary female sexual characteristics |
BCL2,VEGFA,CCNE1,SIRT1, |
1.01E-2 |
GO:0046660
|
female sex differentiation |
BCL2,VEGFA,CCNE1,SIRT1, |
1.01E-2 |
GO:0046661
|
male sex differentiation |
CCND1,BCL2,BCL2L2,BCL2L11, |
1.19E-2 |
GO:0030278
|
regulation of ossification |
RUNX2,CDK6,BCL2,SKI, |
1.45E-2 |
GO:0051385
|
response to mineralocorticoid stimulus |
CCND1,BCL2,CCNE1, |
1.48E-2 |
GO:0042325
|
regulation of phosphorylation |
CCND1,BCL2,LATS2,CHEK1,CDC42,CCND3,JAK2, |
2.00E-2 |
GO:0001934
|
positive regulation of protein amino acid phosphorylation |
CCND1,BCL2,CCND3,JAK2, |
2.11E-2 |
GO:0032268
|
regulation of cellular protein metabolic process |
CCND1,BCL2,EIF2C1,CDK4,KRT7,CCND3,JAK2, |
2.18E-2 |
GO:0030099
|
myeloid cell differentiation |
CHUK,VEGFA,CDC42,JAK2, |
2.40E-2 |
GO:0019220
|
regulation of phosphate metabolic process |
CCND1,BCL2,LATS2,CHEK1,CDC42,CCND3,JAK2, |
2.45E-2 |
GO:0051174
|
regulation of phosphorus metabolic process |
CCND1,BCL2,LATS2,CHEK1,CDC42,CCND3,JAK2, |
2.45E-2 |
GO:0048609
|
reproductive process in a multicellular organism |
BCL2,BCL2L2,VEGFA,CHEK1,BCL2L11,CCNE1,SIRT1, |
2.50E-2 |
GO:0032504
|
multicellular organism reproduction |
BCL2,BCL2L2,VEGFA,CHEK1,BCL2L11,CCNE1,SIRT1, |
2.50E-2 |
GO:0042327
|
positive regulation of phosphorylation |
CCND1,BCL2,CCND3,JAK2, |
2.70E-2 |
GO:0040017
|
positive regulation of locomotion |
BCL2,VEGFA,AGER,JAK2, |
2.78E-2 |
GO:0045937
|
positive regulation of phosphate metabolic process |
CCND1,BCL2,CCND3,JAK2, |
2.95E-2 |
GO:0010562
|
positive regulation of phosphorus metabolic process |
CCND1,BCL2,CCND3,JAK2, |
2.95E-2 |
GO:0010608
|
posttranscriptional regulation of gene expression |
BCL2,VEGFA,EIF2C1,CDK4,KRT7, |
3.08E-2 |
GO:0043549
|
regulation of kinase activity |
CCND1,LATS2,CHEK1,CDC42,CCND3,JAK2, |
3.42E-2 |
GO:0051338
|
regulation of transferase activity |
CCND1,LATS2,CHEK1,CDC42,CCND3,JAK2, |
4.08E-2 |
GO:0032270
|
positive regulation of cellular protein metabolic process |
CCND1,BCL2,CDK4,CCND3,JAK2, |
4.39E-2 |
GO:0051247
|
positive regulation of protein metabolic process |
CCND1,BCL2,CDK4,CCND3,JAK2, |
5.10E-2 |
GO:0033197
|
response to vitamin E |
CCND1,CCNE1, |
5.75E-2 |
GO:0001541
|
ovarian follicle development |
BCL2,VEGFA,CCNE1, |
6.18E-2 |
GO:0045667
|
regulation of osteoblast differentiation |
RUNX2,CDK6,SKI, |
6.78E-2 |
GO:0007242
|
intracellular signaling cascade |
CCND1,CHUK,RAF1,LATS2,CHEK1,AGER,ARL2,CCNE1,CDC42,JAK2, |
8.16E-2 |
GO:0051098
|
regulation of binding |
BCL2,SKI,SIRT1,JAK2, |
9.62E-2 |
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