ncRNADetailInformation

Detail Information
Functional analysis

miRNA name

pre-miRNA

family

pre-miRNA Sequence

mature-miRNA

mature sequence

pre-miRNA description

miR-181

MI0000289	MIPF0000007	UGAGUUUUGAGGUUGCUUCAGUGAACAUUCAACGCUGUCGGUGAGUUUGGAAUUAAAAUCAAAACCAUCGACCGUUGAUUGUACCCUAUGGCUAACCAUCAUCUACUCCA	MIMAT0000256 hsa-miR-181a-5p	AACAUUCAACGCUGUCGGUGAGU
MI0000683	MIPF0000007	CUGAUGGCUGCACUCAACAUUCAUUGCUGUCGGUGGGUUUGAGUCUGAAUCAACUCACUGAUCAAUGAAUGCAAACUGCGGACCAAACA	MIMAT0000257 hsa-miR-181b-5p	AACAUUCAUUGCUGUCGGUGGGU	This human miRNA was predicted by computational methods using conservationwith mouse and Fugu rubripes sequences . Expression of the excised miRhas been validated in zebrafish, and the ends mapped by cloning. Itsexpression was later verified in human BC-1 cells . There are twopredicted hairpin precursor sequences in the human genome; mir-181b-1(MIR:MI0000270) is found on chromosome 1 , and mir-181b-2(MIR:MI0000683) on chromosome 9 . The mature sequence shown hererepresents the most commonly cloned form from large-scale cloning studies.
MI0000271	MIPF0000007	CGGAAAAUUUGCCAAGGGUUUGGGGGAACAUUCAACCUGUCGGUGAGUUUGGGCAGCUCAGGCAAACCAUCGACCGUUGAGUGGACCCUGAGGCCUGGAAUUGCCAUCCU	MIMAT0000258 hsa-miR-181c-5p	AACAUUCAACCUGUCGGUGAGU	This human miRNA was predicted by computational methods using conservationwith mouse and Fugu rubripes sequences . Expression of the excised miRhas been validated in zebrafish, and the ends mapped by cloning. Landgrafet al. confirm the expression of miR-181c in human .
	MIPF0001858		MIMAT000027
MI0000289	MIPF0000007	UGAGUUUUGAGGUUGCUUCAGUGAACAUUCAACGCUGUCGGUGAGUUUGGAAUUAAAAUCAAAACCAUCGACCGUUGAUUGUACCCUAUGGCUAACCAUCAUCUACUCCA	MIMAT0000256 hsa-miR-181a-5p	AACAUUCAACGCUGUCGGUGAGU
MI0000683	MIPF0000007	CUGAUGGCUGCACUCAACAUUCAUUGCUGUCGGUGGGUUUGAGUCUGAAUCAACUCACUGAUCAAUGAAUGCAAACUGCGGACCAAACA	MIMAT0000257 hsa-miR-181b-5p	AACAUUCAUUGCUGUCGGUGGGU	This human miRNA was predicted by computational methods using conservationwith mouse and Fugu rubripes sequences . Expression of the excised miRhas been validated in zebrafish, and the ends mapped by cloning. Itsexpression was later verified in human BC-1 cells . There are twopredicted hairpin precursor sequences in the human genome; mir-181b-1(MIR:MI0000270) is found on chromosome 1 , and mir-181b-2(MIR:MI0000683) on chromosome 9 . The mature sequence shown hererepresents the most commonly cloned form from large-scale cloning studies.
MI0000271	MIPF0000007	CGGAAAAUUUGCCAAGGGUUUGGGGGAACAUUCAACCUGUCGGUGAGUUUGGGCAGCUCAGGCAAACCAUCGACCGUUGAGUGGACCCUGAGGCCUGGAAUUGCCAUCCU	MIMAT0000258 hsa-miR-181c-5p	AACAUUCAACCUGUCGGUGAGU	This human miRNA was predicted by computational methods using conservationwith mouse and Fugu rubripes sequences . Expression of the excised miRhas been validated in zebrafish, and the ends mapped by cloning. Landgrafet al. confirm the expression of miR-181c in human .
	MIPF0001858		MIMAT000027

link to database

TargetScanS 6.2 | MicroCosm | microRNA.org | miRNAMap 2.0

Interacted genes from RAID,miRTarBase

ZFHX3,C17orf63,TEAD4,DIDO1,CCDC165,MED14,KLHDC5,KAT2B,ZNF25,CHRFAM7A,PABPC1,UCHL1,GATAD2B,EIF4E2,EP300
more » ZFHX3,C17orf63,TEAD4,DIDO1,CCDC165,MED14,KLHDC5,KAT2B,ZNF25,CHRFAM7A,PABPC1,UCHL1,GATAD2B,EIF4E2,EP300,LCLAT1,RNF187,SLCO2A1,HSP90AB1,ZNF445,TGIF2,PLAG1,HUWE1,UBB,ZFP36L2,FKBP7,TAF15,KIAA1462,MGRN1,HOOK3,RALA,FBXO28,WNT16,FKBP10,USP28,ZNF652,PPP1R9A,ANKRD1,GANAB,SNAI2,MRPS23,BMPR2,OR11A1,GCNT1,RPRD1A,PGAM1,PRR4,TAF5L,H3F3B,C1orf109,GADD45G,RNF34,NFYB,EIF5A,RBMX,NEK3,ZBTB4,TMEM48,FSIP1,ASB13,LRRC17,CBX7,FAM47B,MECP2,FAM5B,AFTPH,ACOT12,SIK2,LRRN3,C2orf69,KLF6,ATM,ZNF763,ZNF526,MAP3K10,BTBD3,SRPK2,ATP6V0E1,SCD,DUSP5,C5orf34,S100A1,TMEM14A,STAG2,PDHX,ARHGAP35,TIAL1,TUSC1,TGFBR1,SEC24C,RPS12,HRAS,TMED7,DDX27,HEY2,TGFBR3,TNIP1,DDX3X,ARF6,HIST1H1E,TMEM45A,DNAJC7,KBTBD3,NDE1,PHPT1,RASSF6,CLUAP1,UBR7,NID2,HIPK2,CST5,PTPLAD1,TCF21,COL27A1,FAM160A2,DDHD1,FRA10AC1,MTMR12,KIAA1524,CCDC6,TRIM2,NLK,HDAC6,LAMA3,CHL1,IFNGR1,METAP1,GPR83,ZNF562,ILF2,C10orf35,NR2F1,PGD,IDS,H1F0,CYLD,MAP2K1,RNF2,CTC1,SIRT1,ND2,PTPN22,RPS8,MOB1B,EPHA5,LYSMD3,TMED4,ATP8A1,PLCL2,TGFBRAP1,NR6A1,C17orf100,NOTCH2,BAG2,FBXO33,ZNF558,NRBP1,BPTF,NUDT12,MEPCE,CDKN1B,TAAR6,PUM1,TCL1A,ZEB2,WNT2,CFI,PRDX3,SLC37A3,OCA2,GATA6,ROPN1L,BRMS1L,DDIT4,OTUD1,TMPRSS11A,BCL2,FBXO34,YOD1,C20orf173,TMEM189,RPL18A,TAB2,HIST1H3D,PRLR,GPR78,UGT3A1,PWP2,CCNG1,NPM2,AP1M1,MOB1A,SRRM2,MGAT5,ISCA1,KIAA0100,USP10,NUPL1,LFNG,DSCR8,PFKFB2,PRAP1,GIGYF1,RPS7,ATP6,USP24,LMCD1,DNAJB11,ENO1,KPNA2,WNT3A,TBX4,FBXO11,TM9SF3,UBA2,TMEM64,MRPS14,PTGS2,GRIA2,LBR,HERC3,MGMT,E2F1,XPO6,SIX6,IL2,VSNL1,PROX1,TRRAP,RPS14,NRP1,SLC7A11,BCL2L11,C20orf43,ZNF350,KCTD3,LPGAT1,RAP1GAP2,ARID1A,CAT,DUSP6,CD46,KIT,XRCC6,C8A,PTPN11,MAZ,SMCHD1,GSTM2,FOS,TIMP3,PLXDC2,OFCC1,EIF3C,PITPNB,PLA2G4C,PHOX2A,KLRC4,IQCG,SRSF7,ZNF503,KLHL15,FAT1,DCST1,MTOR,FXYD6,SMG1,NOL4,RASSF1,H2AFY,FBL,COPS2,MTMR3,XIAP,EYA4,ZNF148,TSHR,SH3BGRL,AKAP12,MCL1,GPR137B,KIAA0101,ZBTB20,GAB1,HMGB1,TUB,PCDHB8,MYO1C,C14orf126,ARL6IP6,ANKRD13C,NKX3-2,ATF7IP2,FGFR1,TAF2,FUS,INO80B,KRI1,NOTCH4,NRD1,ARID3B,HMGB2,LGALSL,ZXDC,BRCA1,TMEM192,RLF,IGF1R,KRAS,MMP25,ARHGAP12,SCAP,ZNF594,OTX2,SLC35B4,KPNB1,KLHL7,BORA,ZNF747,ENAH,CDX2,GNAI3,RTEL1-TNFRSF6B,RPL14,DHRS4,PBX2,INCENP,GPRIN3,HSD17B3,PRRC2B,MOB3B,THOC3,PTEN,SPRY2,NOTCH1,CXorf1,AMMECR1,ZNF12,HNRNPAB,NANOG,TMEM132B,ATG10,ITGB1BP3,BPGM,HIST2H4B,FCHO2,ZNF35,ZNF426,C1QTNF9,KCTD2,PTPRZ1,HSPA13,PROSC,RQCD1

KEGG pathways enriched for interacted genes

pathway name

pathway description

target genes enrich in pathway

p-value

hsa05200	Pathways in cancer	HRAS,PTEN,WNT3A,E2F1,BCL2,CCDC6,RALA,PTGS2,EP300,MAP2K1,KIT,KRAS,CDKN1B,XIAP,WNT2,HSP90AB1,RASSF1,LAMA3,WNT16,MTOR,FGFR1,IGF1R,FOS,TGFBR1,	6.36E-7
hsa05215	Prostate cancer	IGF1R,HRAS,PTEN,E2F1,BCL2,EP300,MAP2K1,KRAS,CDKN1B,HSP90AB1,FGFR1,MTOR,	3.71E-6
hsa04916	Melanogenesis	HRAS,WNT3A,EP300,MAP2K1,KIT,KRAS,WNT2,GNAI3,WNT16,	1.56E-2
hsa04320	Dorso-ventral axis formation	NOTCH4,NOTCH2,MAP2K1,NOTCH1,KRAS,	2.10E-2
hsa05214	Glioma	IGF1R,HRAS,PTEN,E2F1,MAP2K1,KRAS,MTOR,	2.67E-2

hsa04330	Notch signaling pathway	LFNG,NOTCH4,NOTCH2,KAT2B,EP300,NOTCH1,	3.75E-2
hsa05218	Melanoma	IGF1R,HRAS,PTEN,E2F1,MAP2K1,KRAS,FGFR1,	4.87E-2
hsa05220	Chronic myeloid leukemia	HRAS,E2F1,PTPN11,MAP2K1,KRAS,CDKN1B,TGFBR1,	6.37E-2
hsa05222	Small cell lung cancer	PTEN,E2F1,BCL2,PTGS2,CDKN1B,XIAP,LAMA3,	1.09E-1
hsa05219	Bladder cancer	HRAS,E2F1,MAP2K1,KRAS,RASSF1,	1.39E-1
hsa04730	Long-term depression	IGF1R,HRAS,MAP2K1,GRIA2,KRAS,GNAI3,	1.86E-1
hsa05211	Renal cell carcinoma	HRAS,GAB1,PTPN11,EP300,MAP2K1,KRAS,	1.97E-1
hsa05216	Thyroid cancer	HRAS,CCDC6,MAP2K1,KRAS,	2.62E-1
hsa04520	Adherens junction	IGF1R,NLK,EP300,SNAI2,TGFBR1,FGFR1,	2.85E-1
hsa05223	Non-small cell lung cancer	HRAS,E2F1,MAP2K1,KRAS,RASSF1,	3.20E-1
hsa05210	Colorectal cancer	IGF1R,BCL2,MAP2K1,KRAS,FOS,TGFBR1,	3.94E-1
hsa05221	Acute myeloid leukemia	HRAS,MAP2K1,KIT,KRAS,MTOR,	4.02E-1
hsa04012	ErbB signaling pathway	HRAS,GAB1,MAP2K1,KRAS,CDKN1B,MTOR,	4.48E-1
hsa04720	Long-term potentiation	HRAS,EP300,MAP2K1,GRIA2,KRAS,	6.53E-1
hsa04010	MAPK signaling pathway	HRAS,NLK,GADD45G,MAP2K1,TAB2,KRAS,FOS,DUSP5,TGFBR1,DUSP6,FGFR1,	7.50E-1
hsa05212	Pancreatic cancer	E2F1,RALA,MAP2K1,KRAS,TGFBR1,	7.71E-1

Gene ontology terms enriched for interacted genes

GO terms

GO terms description

target genes enrich in GO term

p-value

GO:0045449	regulation of transcription	NOTCH4,E2F1,ZNF25,RLF,MECP2,NR2F1,HMGB2,NOTCH2,ZNF652,ZNF148,HMGB1,NOTCH1,KLF6,TAF2,ZNF350,CDX2,MED14,CAT,SNAI2,RPS14,ANKRD1,SCAP,NR6A1,TGIF2,ZNF426,LMCD1,TBX4,MAZ,PLAG1,ZNF562,NKX3-2,ZNF35,TGFBRAP1,BRCA1,MAP2K1,MAP3K10,UBB,ZNF763,TIAL1,HNRNPAB,ZNF526,PHOX2A,ARHGAP35,ZNF503,ENO1,ARID3B,TRRAP,SIRT1,TEAD4,COPS2,PBX2,ILF2,EP300,EYA4,KRAS,TMEM189,GATA6,ZNF747,SIX6,CDKN1B,ZBTB4,RNF2,RQCD1,HIPK2,OTX2,TCF21,NFYB,HDAC6,ZXDC,ARID1A,TGFBR3,GATAD2B,TGFBR1,IL2,ATF7IP2,NLK,KAT2B,PROX1,ZNF558,TAF5L,S100A1,ZNF594,HEY2,ZEB2,CBX7,ZFHX3,BRMS1L,NANOG,PRDX3,ZNF445,ZBTB20,ZNF12,XRCC6,BPTF,FOS,	3.02E-9
GO:0016481	negative regulation of transcription	COPS2,E2F1,HMGB2,NR2F1,MECP2,ZNF148,HMGB1,ZNF350,CDX2,CDKN1B,RPS14,SNAI2,NR6A1,RNF2,HIPK2,TCF21,LMCD1,BRCA1,PROX1,MAP3K10,S100A1,HEY2,ZEB2,ZFHX3,HNRNPAB,ARHGAP35,ENO1,BPTF,SIRT1,	2.32E-7
GO:0010557	positive regulation of macromolecule biosynthetic process	TEAD4,HRAS,PBX2,NOTCH4,E2F1,HMGB2,ILF2,ZNF148,EP300,NOTCH1,KLF6,TAF2,GATA6,MED14,CDX2,SCAP,MTOR,IGF1R,HIPK2,NPM2,TCF21,NFYB,HDAC6,ZXDC,ARID1A,TGFBR1,IL2,BRCA1,PROX1,UBB,HNRNPAB,EIF5A,XRCC6,BPTF,FOS,	4.95E-7
GO:0051252	regulation of RNA metabolic process	ZNF25,E2F1,NOTCH4,MECP2,HMGB2,NR2F1,NOTCH2,HMGB1,ZNF148,NOTCH1,TAF2,KLF6,ZNF350,CDX2,MED14,SNAI2,RPS14,ANKRD1,NR6A1,SCAP,TGIF2,ZNF426,LMCD1,TBX4,ZNF562,NKX3-2,ZFP36L2,ZNF35,BRCA1,MAP2K1,ZNF763,TIAL1,HNRNPAB,PHOX2A,ENO1,PABPC1,SIRT1,TEAD4,PBX2,ILF2,EP300,TMEM189,GATA6,ZNF747,CDKN1B,SIX6,RNF2,HIPK2,OTX2,TCF21,HDAC6,NFYB,ARID1A,GATAD2B,IL2,KAT2B,PROX1,ZNF558,S100A1,ZEB2,HEY2,ZFHX3,NANOG,ZNF445,ZNF12,XRCC6,FOS,BPTF,	6.12E-7
GO:0009891	positive regulation of biosynthetic process	TEAD4,HRAS,PBX2,NOTCH4,E2F1,HMGB2,ILF2,ZNF148,EP300,NOTCH1,KLF6,TAF2,GATA6,MED14,CDX2,SCAP,MTOR,IGF1R,HIPK2,NPM2,TCF21,NFYB,HDAC6,ZXDC,ARID1A,TGFBR1,IL2,BRCA1,PROX1,UBB,HSP90AB1,HNRNPAB,EIF5A,XRCC6,BPTF,FOS,	6.99E-7

GO:0010604	positive regulation of macromolecule metabolic process	TEAD4,HRAS,PBX2,NOTCH4,E2F1,HMGB2,ILF2,ZNF148,EP300,NOTCH1,TAF2,KLF6,GATA6,MED14,CDX2,NRD1,SCAP,MTOR,IGF1R,HIPK2,NPM2,TCF21,HDAC6,NFYB,ZXDC,ARID1A,TGFBR1,IL2,BMPR2,BCL2,ATG10,BRCA1,MAP2K1,PROX1,KIT,UBB,HNRNPAB,EIF5A,XRCC6,BPTF,FOS,	7.38E-7
GO:0051173	positive regulation of nitrogen compound metabolic process	TEAD4,HRAS,PBX2,E2F1,NOTCH4,HMGB2,ILF2,ZNF148,EP300,NOTCH1,KLF6,TAF2,GATA6,MED14,CDX2,SCAP,IGF1R,HIPK2,NPM2,TCF21,NFYB,ZXDC,ARID1A,TGFBR1,IL2,BRCA1,MAP2K1,PROX1,UBB,HSP90AB1,HNRNPAB,XRCC6,BPTF,FOS,	1.02E-6
GO:0006355	regulation of transcription, DNA-dependent	ZNF25,E2F1,NOTCH4,MECP2,HMGB2,NR2F1,NOTCH2,HMGB1,ZNF148,NOTCH1,TAF2,KLF6,ZNF350,MED14,CDX2,SNAI2,RPS14,ANKRD1,NR6A1,SCAP,TGIF2,ZNF426,LMCD1,TBX4,ZNF562,NKX3-2,ZNF35,BRCA1,MAP2K1,ZNF763,TIAL1,HNRNPAB,PHOX2A,ENO1,SIRT1,TEAD4,PBX2,ILF2,EP300,TMEM189,GATA6,ZNF747,CDKN1B,SIX6,RNF2,HIPK2,OTX2,TCF21,HDAC6,NFYB,ARID1A,GATAD2B,IL2,KAT2B,PROX1,ZNF558,S100A1,ZEB2,HEY2,ZFHX3,NANOG,ZNF445,ZNF12,XRCC6,FOS,BPTF,	1.26E-6
GO:0031328	positive regulation of cellular biosynthetic process	TEAD4,HRAS,PBX2,NOTCH4,E2F1,HMGB2,ILF2,ZNF148,EP300,NOTCH1,KLF6,TAF2,GATA6,MED14,CDX2,SCAP,MTOR,IGF1R,HIPK2,NPM2,TCF21,NFYB,ZXDC,ARID1A,TGFBR1,IL2,BRCA1,PROX1,UBB,HSP90AB1,HNRNPAB,EIF5A,XRCC6,BPTF,FOS,	1.40E-6
GO:0045935	positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	TEAD4,HRAS,PBX2,E2F1,NOTCH4,HMGB2,ILF2,ZNF148,EP300,NOTCH1,KLF6,TAF2,GATA6,MED14,CDX2,SCAP,IGF1R,HIPK2,NPM2,TCF21,NFYB,ZXDC,ARID1A,TGFBR1,IL2,BRCA1,MAP2K1,PROX1,UBB,HNRNPAB,XRCC6,BPTF,FOS,	1.48E-6
GO:0010629	negative regulation of gene expression	COPS2,E2F1,HMGB2,NR2F1,MECP2,ZNF148,HMGB1,ZNF350,CDX2,CDKN1B,RPS14,SNAI2,NR6A1,RNF2,HIPK2,TCF21,LMCD1,BRCA1,PROX1,MAP3K10,S100A1,HEY2,ZEB2,ZFHX3,HNRNPAB,ARHGAP35,ENO1,BPTF,SIRT1,	1.50E-6
GO:0006357	regulation of transcription from RNA polymerase II promoter	TEAD4,PBX2,E2F1,HMGB2,NR2F1,MECP2,HMGB1,ZNF148,EP300,NOTCH1,KLF6,TAF2,GATA6,MED14,CDX2,SNAI2,RPS14,SCAP,NR6A1,ANKRD1,RNF2,HIPK2,LMCD1,IL2,BRCA1,MAP2K1,PROX1,S100A1,HEY2,ZFHX3,TIAL1,ENO1,XRCC6,BPTF,FOS,SIRT1,	1.94E-6
GO:0045934	negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	COPS2,E2F1,HMGB2,NR2F1,MECP2,ZNF148,HMGB1,ZNF350,CDX2,CDKN1B,RPS14,SNAI2,NR6A1,RNF2,HIPK2,TCF21,LMCD1,BRCA1,PROX1,MAP3K10,S100A1,HEY2,ZEB2,ZFHX3,HNRNPAB,ARHGAP35,ENO1,BPTF,SIRT1,	2.03E-6
GO:0051172	negative regulation of nitrogen compound metabolic process	COPS2,E2F1,HMGB2,NR2F1,MECP2,ZNF148,HMGB1,ZNF350,CDX2,CDKN1B,RPS14,SNAI2,NR6A1,RNF2,HIPK2,TCF21,LMCD1,BRCA1,PROX1,MAP3K10,S100A1,HEY2,ZEB2,ZFHX3,HNRNPAB,ARHGAP35,ENO1,BPTF,SIRT1,	2.67E-6
GO:0051254	positive regulation of RNA metabolic process	TEAD4,E2F1,NOTCH4,PBX2,HMGB2,ILF2,ZNF148,EP300,NOTCH1,KLF6,TAF2,GATA6,MED14,CDX2,SCAP,HIPK2,TCF21,NFYB,ARID1A,IL2,BRCA1,PROX1,MAP2K1,HNRNPAB,XRCC6,BPTF,FOS,	6.03E-6
GO:0009890	negative regulation of biosynthetic process	COPS2,E2F1,HMGB2,NR2F1,MECP2,ZNF148,HMGB1,ZNF350,CDKN1B,CDX2,RPS14,SNAI2,NR6A1,SCAP,RNF2,HIPK2,TCF21,LMCD1,BRCA1,PROX1,MAP3K10,S100A1,HEY2,ZEB2,ZFHX3,HNRNPAB,ARHGAP35,ENO1,BPTF,SIRT1,	6.13E-6
GO:0010558	negative regulation of macromolecule biosynthetic process	COPS2,E2F1,HMGB2,NR2F1,MECP2,ZNF148,HMGB1,ZNF350,CDX2,CDKN1B,RPS14,SNAI2,NR6A1,RNF2,HIPK2,TCF21,LMCD1,BRCA1,PROX1,MAP3K10,S100A1,HEY2,ZEB2,ZFHX3,HNRNPAB,ARHGAP35,ENO1,BPTF,SIRT1,	7.24E-6
GO:0010628	positive regulation of gene expression	TEAD4,PBX2,E2F1,NOTCH4,HMGB2,ILF2,ZNF148,EP300,NOTCH1,KLF6,TAF2,GATA6,MED14,CDX2,SCAP,HIPK2,TCF21,NFYB,ZXDC,ARID1A,TGFBR1,IL2,BRCA1,PROX1,KIT,UBB,HNRNPAB,XRCC6,BPTF,FOS,	8.09E-6
GO:0031327	negative regulation of cellular biosynthetic process	COPS2,E2F1,HMGB2,NR2F1,MECP2,ZNF148,HMGB1,ZNF350,CDX2,CDKN1B,RPS14,SNAI2,NR6A1,RNF2,HIPK2,TCF21,LMCD1,BRCA1,PROX1,MAP3K10,S100A1,HEY2,ZEB2,ZFHX3,HNRNPAB,ARHGAP35,ENO1,BPTF,SIRT1,	1.14E-5
GO:0035295	tube development	BMPR2,WNT3A,NOTCH4,BCL2,SPRY2,EP300,NOTCH1,PROX1,GATA6,WNT2,ZEB2,NRP1,TCF21,ARHGAP35,TBX4,BCL2L11,TGFBR1,	1.15E-5
GO:0045941	positive regulation of transcription	TEAD4,E2F1,NOTCH4,PBX2,HMGB2,ILF2,ZNF148,EP300,NOTCH1,KLF6,TAF2,GATA6,MED14,CDX2,SCAP,HIPK2,TCF21,NFYB,ZXDC,ARID1A,TGFBR1,IL2,BRCA1,PROX1,UBB,HNRNPAB,XRCC6,BPTF,FOS,	1.28E-5
GO:0045892	negative regulation of transcription, DNA-dependent	E2F1,NR2F1,MECP2,ZNF148,HMGB1,PROX1,CDX2,CDKN1B,RPS14,SNAI2,S100A1,NR6A1,HEY2,ZFHX3,RNF2,HIPK2,HNRNPAB,TCF21,LMCD1,ENO1,BPTF,SIRT1,	1.33E-5
GO:0043549	regulation of kinase activity	PTEN,PTPN11,SPRY2,PRLR,PTPLAD1,CHRFAM7A,MAP2K1,MAP3K10,KIT,KRAS,CDKN1B,ZEB2,MTOR,GAB1,GADD45G,PFKFB2,PRDX3,CCNG1,TGFBR1,LRRN3,DUSP6,IL2,	1.39E-5
GO:0045893	positive regulation of transcription, DNA-dependent	TEAD4,E2F1,NOTCH4,PBX2,HMGB2,ILF2,ZNF148,EP300,NOTCH1,KLF6,TAF2,GATA6,MED14,CDX2,SCAP,HIPK2,TCF21,NFYB,ARID1A,IL2,BRCA1,PROX1,HNRNPAB,XRCC6,BPTF,FOS,	1.54E-5
GO:0010605	negative regulation of macromolecule metabolic process	COPS2,E2F1,HMGB2,NR2F1,MECP2,ZNF148,HMGB1,ZNF350,CDKN1B,CDX2,SNAI2,RPS14,NR6A1,RNF2,HIPK2,TCF21,HDAC6,LMCD1,IL2,BRCA1,PROX1,MAP3K10,UBB,HSP90AB1,S100A1,HEY2,ZEB2,ZFHX3,HNRNPAB,ARHGAP35,ENO1,TIMP3,BPTF,SIRT1,	1.63E-5
GO:0051253	negative regulation of RNA metabolic process	E2F1,NR2F1,MECP2,ZNF148,HMGB1,PROX1,CDX2,CDKN1B,RPS14,SNAI2,S100A1,NR6A1,HEY2,ZFHX3,RNF2,HIPK2,HNRNPAB,TCF21,LMCD1,ENO1,BPTF,SIRT1,	1.71E-5
GO:0006350	transcription	E2F1,ZNF25,NOTCH4,RLF,MECP2,NR2F1,NOTCH2,ZNF652,ZNF148,NOTCH1,KLF6,TAF2,ZNF350,CDX2,MED14,SNAI2,NR6A1,TGIF2,ZNF426,TBX4,MAZ,PLAG1,ZNF562,NKX3-2,ZNF35,ZNF763,ZNF526,PHOX2A,ARHGAP35,ZNF503,ARID3B,ENO1,TRRAP,SIRT1,DIDO1,TEAD4,COPS2,PBX2,ILF2,EP300,EYA4,GATA6,ZBTB4,RNF2,RQCD1,HIPK2,TCF21,NFYB,HDAC6,ZXDC,ARID1A,GATAD2B,ATF7IP2,BMPR2,NLK,KAT2B,PROX1,ZNF558,TAF5L,ZNF594,HEY2,ZEB2,CBX7,ZFHX3,BRMS1L,NANOG,ZNF445,ZBTB20,ZNF12,BPTF,	2.57E-5
GO:0051338	regulation of transferase activity	PTEN,PTPN11,SPRY2,PRLR,PTPLAD1,CHRFAM7A,MAP2K1,MAP3K10,KIT,KRAS,CDKN1B,ZEB2,MTOR,GAB1,GADD45G,PFKFB2,PRDX3,CCNG1,TGFBR1,LRRN3,DUSP6,IL2,	2.58E-5
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	E2F1,MECP2,NR2F1,ZNF148,HMGB1,PROX1,CDX2,SNAI2,RPS14,S100A1,NR6A1,HEY2,ZFHX3,RNF2,HIPK2,LMCD1,ENO1,BPTF,	3.30E-5
GO:0006793	phosphorus metabolic process	PTPN11,SIK2,PRLR,PTPLAD1,NEK3,WNT2,MTOR,IGF1R,ND2,HIPK2,PTPRZ1,PHPT1,PTPN22,MOB1B,ATP6V0E1,TGFBR3,NRBP1,DUSP5,TGFBR1,DUSP6,MTMR3,BMPR2,PTEN,SRPK2,BCL2,NLK,EPHA5,CHRFAM7A,MAP2K1,MAP3K10,MTMR12,KIT,FGFR1,ATP6,GAB1,GADD45G,ATM,SMG1,LRRN3,	8.16E-5
GO:0006796	phosphate metabolic process	PTPN11,SIK2,PRLR,PTPLAD1,NEK3,WNT2,MTOR,IGF1R,ND2,HIPK2,PTPRZ1,PHPT1,PTPN22,MOB1B,ATP6V0E1,TGFBR3,NRBP1,DUSP5,TGFBR1,DUSP6,MTMR3,BMPR2,PTEN,SRPK2,BCL2,NLK,EPHA5,CHRFAM7A,MAP2K1,MAP3K10,MTMR12,KIT,FGFR1,ATP6,GAB1,GADD45G,ATM,SMG1,LRRN3,	8.16E-5
GO:0007568	aging	HRAS,PTEN,BCL2,NOTCH4,PHOX2A,KRAS,FOS,TIMP3,TGFBR1,SIRT1,SCAP,	8.27E-5
GO:0042325	regulation of phosphorylation	BMPR2,PTEN,BCL2,PTPN11,SPRY2,PRLR,PTPLAD1,CHRFAM7A,MAP2K1,MAP3K10,KIT,KRAS,CDKN1B,ZEB2,MTOR,GAB1,GADD45G,PFKFB2,PRDX3,CCNG1,TGFBR1,LRRN3,DUSP6,IL2,	8.57E-5
GO:0045859	regulation of protein kinase activity	PTEN,PTPN11,SPRY2,PRLR,PTPLAD1,CHRFAM7A,MAP2K1,MAP3K10,KIT,KRAS,CDKN1B,ZEB2,MTOR,GAB1,GADD45G,CCNG1,TGFBR1,LRRN3,DUSP6,IL2,	8.72E-5
GO:0032583	regulation of gene-specific transcription	HMGB2,HNRNPAB,PROX1,NOTCH1,TAF2,XRCC6,GATA6,CDKN1B,BPTF,SIRT1,HEY2,SCAP,	9.33E-5
GO:0006325	chromatin organization	HMGB2,KAT2B,EP300,EYA4,HMGB1,H1F0,TAF5L,H2AFY,HIST1H1E,CBX7,HUWE1,H3F3B,RNF2,HIST1H3D,NPM2,HDAC6,ARID1A,BPTF,TRRAP,HIST2H4B,SIRT1,	9.90E-5
GO:0008284	positive regulation of cell proliferation	HRAS,NOTCH4,BCL2,PTGS2,CHRFAM7A,NOTCH1,PROX1,KIT,KRAS,CDX2,CDKN1B,HEY2,MTOR,FGFR1,TSHR,IGF1R,HIPK2,NRP1,EIF5A,PRDX3,TGFBR1,IL2,	1.19E-4
GO:0043069	negative regulation of programmed cell death	HRAS,PTEN,BCL2,PRLR,NOTCH2,HMGB1,NOTCH1,KIT,KRAS,XIAP,UBB,CAT,MCL1,IGF1R,HIPK2,PRDX3,ATM,TGFBR1,NKX3-2,IL2,	1.46E-4
GO:0043405	regulation of MAP kinase activity	SPRY2,GAB1,PTPN11,PTPLAD1,CHRFAM7A,MAP2K1,MAP3K10,KIT,KRAS,LRRN3,DUSP6,ZEB2,	1.47E-4
GO:0060548	negative regulation of cell death	HRAS,PTEN,BCL2,PRLR,NOTCH2,HMGB1,NOTCH1,KIT,KRAS,XIAP,UBB,CAT,MCL1,IGF1R,HIPK2,PRDX3,ATM,TGFBR1,NKX3-2,IL2,	1.53E-4
GO:0051174	regulation of phosphorus metabolic process	BMPR2,PTEN,BCL2,PTPN11,SPRY2,PRLR,PTPLAD1,CHRFAM7A,MAP2K1,MAP3K10,KIT,KRAS,CDKN1B,ZEB2,MTOR,GAB1,GADD45G,PFKFB2,PRDX3,CCNG1,TGFBR1,LRRN3,DUSP6,IL2,	1.55E-4
GO:0019220	regulation of phosphate metabolic process	BMPR2,PTEN,BCL2,PTPN11,SPRY2,PRLR,PTPLAD1,CHRFAM7A,MAP2K1,MAP3K10,KIT,KRAS,CDKN1B,ZEB2,MTOR,GAB1,GADD45G,PFKFB2,PRDX3,CCNG1,TGFBR1,LRRN3,DUSP6,IL2,	1.55E-4
GO:0044087	regulation of cellular component biogenesis	PTEN,RALA,HMGB1,PROX1,HDAC6,KIT,CDKN1B,ARF6,UBB,WNT2,TGFBR1,MTOR,	1.56E-4
GO:0002520	immune system development	BPGM,WNT3A,NOTCH4,BCL2,NOTCH2,KLF6,KIT,RPS14,TSHR,PTPN22,PRDX3,TGFBR3,XRCC6,BCL2L11,TGFBR1,NKX3-2,IL2,	1.76E-4
GO:0030324	lung development	BMPR2,SPRY2,TCF21,EP300,PROX1,NOTCH1,TBX4,GATA6,WNT2,TGFBR1,	1.87E-4
GO:0007243	protein kinase cascade	SRPK2,NOTCH4,NLK,PTPN11,SIK2,PRLR,PTPLAD1,CHRFAM7A,TMED7,MAP2K1,MAP3K10,KIT,FGFR1,IGF1R,GAB1,GADD45G,TGFBR3,TGFBR1,LRRN3,DUSP6,	2.15E-4
GO:0043406	positive regulation of MAP kinase activity	GAB1,PTPN11,PTPLAD1,CHRFAM7A,MAP2K1,MAP3K10,KIT,KRAS,LRRN3,ZEB2,	2.34E-4
GO:0030323	respiratory tube development	BMPR2,SPRY2,TCF21,EP300,PROX1,NOTCH1,TBX4,GATA6,WNT2,TGFBR1,	2.34E-4
GO:0009719	response to endogenous stimulus	PTEN,BCL2,HMGB2,PTPN11,SIK2,KAT2B,BRCA1,EP300,PTGS2,MAP2K1,KRAS,WNT2,MTOR,IGF1R,GAB1,HDAC6,ATP6V0E1,TGFBR3,TIMP3,FOS,TGFBR1,	2.47E-4
GO:0033674	positive regulation of kinase activity	PTPN11,PRLR,PTPLAD1,CHRFAM7A,MAP2K1,MAP3K10,KRAS,KIT,ZEB2,GAB1,GADD45G,PFKFB2,TGFBR1,LRRN3,IL2,	2.79E-4
GO:0048534	hemopoietic or lymphoid organ development	BPGM,WNT3A,NOTCH4,BCL2,NOTCH2,KLF6,KIT,RPS14,TSHR,PTPN22,PRDX3,TGFBR3,BCL2L11,TGFBR1,NKX3-2,IL2,	2.95E-4
GO:0018205	peptidyl-lysine modification	KAT2B,EIF5A,EP300,HDAC6,SIRT1,	3.27E-4
GO:0046777	protein amino acid autophosphorylation	IGF1R,NLK,MOB1B,MAP3K10,KIT,SMG1,WNT2,TGFBR1,MTOR,	3.35E-4
GO:0043066	negative regulation of apoptosis	HRAS,PTEN,BCL2,PRLR,NOTCH2,HMGB1,NOTCH1,KRAS,XIAP,UBB,CAT,MCL1,IGF1R,HIPK2,PRDX3,ATM,TGFBR1,NKX3-2,IL2,	3.57E-4
GO:0060541	respiratory system development	BMPR2,SPRY2,TCF21,EP300,PROX1,NOTCH1,TBX4,GATA6,WNT2,TGFBR1,	3.60E-4
GO:0007389	pattern specification process	BMPR2,WNT3A,NOTCH4,PBX2,NOTCH2,EP300,NOTCH1,CDX2,ZEB2,RNF2,HIPK2,LFNG,NRP1,ATM,TGFBR1,NKX3-2,	3.91E-4
GO:0043193	positive regulation of gene-specific transcription	HMGB2,HNRNPAB,PROX1,NOTCH1,TAF2,XRCC6,GATA6,BPTF,SCAP,	3.93E-4
GO:0051276	chromosome organization	HMGB2,KAT2B,HMGB1,EP300,EYA4,SMCHD1,H1F0,TAF5L,H2AFY,HIST1H1E,CBX7,HUWE1,H3F3B,RNF2,HIST1H3D,NPM2,HDAC6,ARID1A,XRCC6,BPTF,TRRAP,HIST2H4B,SIRT1,	3.98E-4
GO:0051347	positive regulation of transferase activity	PTPN11,PRLR,PTPLAD1,CHRFAM7A,MAP2K1,MAP3K10,KRAS,KIT,ZEB2,GAB1,GADD45G,PFKFB2,TGFBR1,LRRN3,IL2,	4.17E-4
GO:0010647	positive regulation of cell communication	HRAS,PTPN11,NOTCH2,PTGS2,TMED7,GRIA2,KRAS,KIT,TMEM189,UBB,CAT,ZEB2,MTOR,HIPK2,HDAC6,TAB2,TGFBR1,IL2,	4.30E-4
GO:0006266	DNA ligation	MGMT,HMGB2,HMGB1,XRCC6,	4.36E-4
GO:0051153	regulation of striated muscle cell differentiation	ZFHX3,BCL2,PROX1,NOTCH1,ITGB1BP3,UBB,	4.37E-4
GO:0006468	protein amino acid phosphorylation	SIK2,PTPN11,PRLR,PTPLAD1,NEK3,WNT2,MTOR,IGF1R,HIPK2,MOB1B,TGFBR3,NRBP1,TGFBR1,BMPR2,SRPK2,BCL2,EPHA5,NLK,MAP2K1,CHRFAM7A,MAP3K10,KIT,FGFR1,GAB1,GADD45G,ATM,SMG1,LRRN3,	5.35E-4
GO:0009725	response to hormone stimulus	PTEN,BCL2,HMGB2,PTPN11,SIK2,KAT2B,BRCA1,EP300,PTGS2,MAP2K1,KRAS,WNT2,MTOR,IGF1R,GAB1,TGFBR3,FOS,TIMP3,TGFBR1,	5.43E-4
GO:0033554	cellular response to stress	PTPN11,HMGB2,EYA4,HMGB1,PTPLAD1,XIAP,CAT,SCAP,MGMT,HIPK2,HDAC6,BMPR2,BCL2,BRCA1,ATG10,MAP3K10,GAB1,GADD45G,PRDX3,ATM,ZNF12,XRCC6,FOS,SMG1,SIRT1,	5.78E-4
GO:0007167	enzyme linked receptor protein signaling pathway	BMPR2,PTEN,EPHA5,NLK,PTPN11,SIK2,GIGYF1,PRLR,TGFBRAP1,KIT,FGFR1,IGF1R,HIPK2,GAB1,NRP1,TGFBR3,FOS,TGFBR1,	6.65E-4
GO:0045860	positive regulation of protein kinase activity	PTPN11,PRLR,PTPLAD1,MAP2K1,CHRFAM7A,MAP3K10,KRAS,KIT,ZEB2,GAB1,GADD45G,TGFBR1,LRRN3,IL2,	6.71E-4
GO:0016310	phosphorylation	PTPN11,SIK2,PRLR,PTPLAD1,NEK3,WNT2,MTOR,IGF1R,ND2,HIPK2,MOB1B,ATP6V0E1,TGFBR3,NRBP1,TGFBR1,BMPR2,SRPK2,BCL2,EPHA5,NLK,CHRFAM7A,MAP2K1,MAP3K10,KIT,FGFR1,ATP6,GAB1,GADD45G,ATM,SMG1,LRRN3,	9.22E-4
GO:0044093	positive regulation of molecular function	PTPN11,PRLR,EP300,PTPLAD1,KRAS,TMEM189,CAT,TSHR,HIPK2,NPM2,PFKFB2,TGFBR3,TGFBR1,IL2,BCL2,MAP2K1,CHRFAM7A,MAP3K10,KIT,UBB,ZEB2,GAB1,GADD45G,PRDX3,LRRN3,	9.39E-4
GO:0030163	protein catabolic process	TMEM189,YOD1,USP24,XIAP,MTOR,KLHL15,RNF2,USP10,MGRN1,HDAC6,CYLD,USP28,UBA2,UBR7,ASB13,BRCA1,ATG10,FBXO34,RNF34,UBB,FBXO28,FBXO11,HUWE1,UCHL1,HERC3,FBXO33,	9.58E-4
GO:0008361	regulation of cell size	BCL2,NOTCH2,EP300,CDKN1B,FGFR1,MTOR,NRP1,ATP6V0E1,TGFBR3,ENO1,CCNG1,TGFBR1,IL2,	1.07E-2
GO:0051147	regulation of muscle cell differentiation	ZFHX3,BCL2,PROX1,NOTCH1,ITGB1BP3,UBB,	1.11E-2
GO:0035239	tube morphogenesis	WNT3A,BCL2,NOTCH4,SPRY2,NRP1,TCF21,NOTCH1,ARHGAP35,BCL2L11,ZEB2,	1.16E-2
GO:0043067	regulation of programmed cell death	HRAS,PRLR,NOTCH2,HMGB1,NOTCH1,KRAS,XIAP,CDKN1B,CAT,MGMT,IGF1R,HIPK2,HDAC6,BCL2L11,TGFBR1,NKX3-2,IL2,PTEN,BCL2,PTGS2,BRCA1,MAP3K10,KIT,UBB,MCL1,TIAL1,EIF5A,PRDX3,ATM,TIMP3,SIRT1,	1.17E-2
GO:0080135	regulation of cellular response to stress	HIPK2,GAB1,BRCA1,PTPLAD1,MAP3K10,TMEM189,ZEB2,SIRT1,MTOR,	1.21E-2
GO:0010941	regulation of cell death	HRAS,PRLR,NOTCH2,HMGB1,NOTCH1,KRAS,XIAP,CDKN1B,CAT,MGMT,IGF1R,HIPK2,HDAC6,BCL2L11,TGFBR1,NKX3-2,IL2,PTEN,BCL2,PTGS2,BRCA1,MAP3K10,KIT,UBB,MCL1,TIAL1,EIF5A,PRDX3,ATM,TIMP3,SIRT1,	1.24E-2
GO:0051603	proteolysis involved in cellular protein catabolic process	YOD1,USP24,TMEM189,XIAP,KLHL15,RNF2,USP10,MGRN1,HDAC6,CYLD,USP28,UBA2,UBR7,ASB13,BRCA1,ATG10,FBXO34,RNF34,UBB,FBXO28,FBXO11,HUWE1,UCHL1,HERC3,FBXO33,	1.30E-2
GO:0044257	cellular protein catabolic process	YOD1,USP24,TMEM189,XIAP,KLHL15,RNF2,USP10,MGRN1,HDAC6,CYLD,USP28,UBA2,UBR7,ASB13,BRCA1,ATG10,FBXO34,RNF34,UBB,FBXO28,FBXO11,HUWE1,UCHL1,HERC3,FBXO33,	1.38E-2
GO:0016049	cell growth	BCL2,NOTCH2,TGFBR3,ATP6V0E1,CCNG1,FGFR1,MTOR,	1.48E-2
GO:0042127	regulation of cell proliferation	HRAS,NOTCH4,NOTCH2,NOTCH1,KRAS,CDKN1B,CDX2,WNT2,MTOR,TSHR,IGF1R,HIPK2,TGFBR3,TGFBR1,IL2,BMPR2,PTEN,BCL2,KAT2B,PTGS2,BRCA1,CHRFAM7A,PROX1,KIT,HEY2,FGFR1,NRP1,EIF5A,PRDX3,SIRT1,	1.48E-2
GO:0000904	cell morphogenesis involved in differentiation	WNT3A,NOTCH4,BCL2,PTPN11,NOTCH1,PROX1,UBB,IGF1R,UCHL1,PTPRZ1,OTX2,HNRNPAB,NRP1,TGFBR3,	1.52E-2
GO:0048742	regulation of skeletal muscle fiber development	ZFHX3,BCL2,NOTCH1,ITGB1BP3,UBB,	1.52E-2
GO:0043632	modification-dependent macromolecule catabolic process	USP28,UBA2,UBR7,FBXO34,ATG10,BRCA1,ASB13,RNF34,TMEM189,YOD1,USP24,XIAP,UBB,FBXO28,FBXO11,HUWE1,KLHL15,RNF2,UCHL1,HERC3,USP10,MGRN1,CYLD,FBXO33,	1.59E-2
GO:0019941	modification-dependent protein catabolic process	USP28,UBA2,UBR7,FBXO34,ATG10,BRCA1,ASB13,RNF34,TMEM189,YOD1,USP24,XIAP,UBB,FBXO28,FBXO11,HUWE1,KLHL15,RNF2,UCHL1,HERC3,USP10,MGRN1,CYLD,FBXO33,	1.59E-2
GO:0035020	regulation of Rac protein signal transduction	HRAS,KRAS,ARF6,MTOR,	1.61E-2
GO:0045596	negative regulation of cell differentiation	NOTCH4,NOTCH2,NOTCH1,KIT,ITGB1BP3,CDX2,TCL1A,ZFHX3,NRP1,TGFBR3,HIST2H4B,TGFBR1,SIRT1,	1.61E-2
GO:0032268	regulation of cellular protein metabolic process	BMPR2,BCL2,ATG10,BRCA1,EP300,PTPLAD1,MAP3K10,UBB,HSP90AB1,NRD1,ZEB2,MTOR,METAP1,EIF4E2,GAB1,PUM1,EIF5A,HDAC6,TIMP3,TGFBR1,IL2,	1.77E-2
GO:0044265	cellular macromolecule catabolic process	TMEM189,YOD1,USP24,XIAP,KLHL15,RNF2,USP10,MGRN1,HDAC6,CYLD,ZFP36L2,USP28,UBA2,UBR7,FBXO34,ATG10,ASB13,BRCA1,RNF34,UBB,FBXO28,FBXO11,HUWE1,UCHL1,HERC3,ATM,FBXO33,SMG1,	1.88E-2
GO:0048545	response to steroid hormone stimulus	PTEN,BCL2,HMGB2,PTGS2,BRCA1,EP300,MAP2K1,KRAS,FOS,TIMP3,WNT2,TGFBR1,	1.96E-2
GO:0042981	regulation of apoptosis	HRAS,PRLR,NOTCH2,HMGB1,NOTCH1,KRAS,XIAP,CDKN1B,CAT,MGMT,IGF1R,HIPK2,HDAC6,BCL2L11,TGFBR1,NKX3-2,IL2,PTEN,BCL2,PTGS2,BRCA1,MAP3K10,UBB,MCL1,TIAL1,EIF5A,PRDX3,ATM,TIMP3,SIRT1,	2.04E-2
GO:0051270	regulation of cell motion	IGF1R,PTEN,BCL2,GAB1,NRP1,HDAC6,MAP2K1,TGFBR3,KIT,CDKN1B,TGFBR1,LAMA3,	2.05E-2
GO:0045165	cell fate commitment	TEAD4,WNT3A,BCL2,NOTCH4,SPRY2,NOTCH2,PROX1,NOTCH1,TGFBR1,MCL1,	2.18E-2
GO:0009952	anterior/posterior pattern formation	BMPR2,RNF2,WNT3A,HIPK2,LFNG,EP300,ATM,NOTCH1,TGFBR1,ZEB2,	2.29E-2
GO:0009057	macromolecule catabolic process	TMEM189,YOD1,USP24,XIAP,MTOR,KLHL15,RNF2,USP10,MGRN1,HDAC6,CYLD,ZFP36L2,USP28,UBA2,UBR7,FBXO34,ATG10,ASB13,BRCA1,RNF34,UBB,FBXO28,FBXO11,HUWE1,UCHL1,HERC3,ATM,FBXO33,SMG1,	2.68E-2
GO:0048641	regulation of skeletal muscle tissue development	ZFHX3,BCL2,NOTCH1,ITGB1BP3,UBB,	2.69E-2
GO:0003006	reproductive developmental process	BCL2,HMGB2,PTGS2,KIT,HSD17B3,MTOR,IGF1R,RQCD1,LFNG,NPM2,TCF21,OCA2,BCL2L11,SIRT1,	2.85E-2
GO:0034728	nucleosome organization	H3F3B,HMGB2,HIST1H3D,H1F0,H2AFY,ARID1A,HIST2H4B,HIST1H1E,	2.90E-2
GO:0009967	positive regulation of signal transduction	HRAS,PTPN11,NOTCH2,TMED7,KRAS,KIT,TMEM189,CAT,ZEB2,MTOR,HIPK2,HDAC6,TAB2,TGFBR1,IL2,	2.99E-2
GO:0043388	positive regulation of DNA binding	HIPK2,PRDX3,EP300,TGFBR3,KRAS,TMEM189,CAT,	3.00E-2
GO:0010551	regulation of specific transcription from RNA polymerase II promoter	HMGB2,NOTCH1,TAF2,XRCC6,GATA6,SIRT1,HEY2,SCAP,	3.08E-2
GO:0051101	regulation of DNA binding	HIPK2,PRDX3,EP300,PROX1,TGFBR3,KRAS,TMEM189,CAT,SIRT1,	3.34E-2
GO:0030097	hemopoiesis	BPGM,WNT3A,NOTCH4,BCL2,NOTCH2,KLF6,KIT,RPS14,TSHR,PRDX3,PTPN22,TGFBR3,IL2,	3.36E-2
GO:0016202	regulation of striated muscle tissue development	ZFHX3,BCL2,NOTCH1,ITGB1BP3,UBB,HEY2,	3.41E-2
GO:0010033	response to organic substance	PTPN11,SIK2,HMGB2,EP300,TAF2,KRAS,WNT2,MTOR,IGF1R,PFKFB2,HDAC6,ATP6V0E1,TGFBR3,TGFBR1,PTEN,BCL2,KAT2B,PTGS2,BRCA1,CHRFAM7A,MAP2K1,HSP90AB1,MCL1,GAB1,PRDX3,FOS,TIMP3,	3.47E-2
GO:0012501	programmed cell death	HRAS,PTEN,E2F1,BAG2,BCL2,BRCA1,EP300,KIT,RNF34,KRAS,GATA6,ARF6,XIAP,CDKN1B,UBB,DDIT4,MCL1,HIPK2,TIAL1,GADD45G,ATM,BCL2L11,SIRT1,DIDO1,	3.50E-2
GO:0048634	regulation of muscle development	ZFHX3,BCL2,NOTCH1,ITGB1BP3,UBB,HEY2,	3.72E-2
GO:0032535	regulation of cellular component size	BCL2,NOTCH2,EP300,CDKN1B,ARF6,FGFR1,MTOR,NRP1,ATP6V0E1,TGFBR3,ENO1,CCNG1,TGFBR1,IL2,	3.80E-2
GO:0048729	tissue morphogenesis	BMPR2,WNT3A,BCL2,NOTCH2,TCF21,PROX1,NOTCH1,TGFBR3,ARHGAP35,TBX4,ZEB2,	3.87E-2
GO:0051098	regulation of binding	HIPK2,BCL2,PRDX3,EP300,PROX1,TGFBR3,KRAS,TMEM189,CAT,SIRT1,	4.16E-2
GO:0016568	chromatin modification	KAT2B,EP300,EYA4,TAF5L,H2AFY,CBX7,HUWE1,RNF2,NPM2,HDAC6,ARID1A,TRRAP,BPTF,SIRT1,	4.19E-2
GO:0016311	dephosphorylation	PTEN,PTPRZ1,BCL2,PTPN11,PHPT1,PTPN22,MTMR12,DUSP5,DUSP6,MTMR3,	4.34E-2
GO:0040007	growth	BCL2,PTPN11,NOTCH2,PTGS2,NOTCH1,TGFBR3,ATP6V0E1,TIMP3,CCNG1,FGFR1,MTOR,	4.36E-2
GO:0001889	liver development	EP300,PROX1,NOTCH1,TGFBR3,GATA6,ARF6,	4.39E-2
GO:0000165	MAPKKK cascade	GAB1,PTPN11,GADD45G,PTPLAD1,CHRFAM7A,MAP2K1,MAP3K10,TGFBR1,LRRN3,DUSP6,FGFR1,	4.53E-2
GO:0051094	positive regulation of developmental process	BMPR2,BCL2,CHRFAM7A,NOTCH1,PROX1,MAP2K1,KIT,GATA6,CDX2,HEY2,TGIF2,ZFHX3,XRCC6,IL2,	4.73E-2
GO:0051090	regulation of transcription factor activity	PRDX3,EP300,PROX1,TGFBR3,KRAS,TMEM189,CAT,SIRT1,	5.11E-2
GO:0051099	positive regulation of binding	HIPK2,PRDX3,EP300,TGFBR3,KRAS,TMEM189,CAT,	5.14E-2
GO:0010627	regulation of protein kinase cascade	PTEN,TMED7,PTPLAD1,MAP3K10,TMEM189,CAT,ZEB2,MTOR,HIPK2,GAB1,TAB2,TGFBR1,IL2,	5.15E-2
GO:0031334	positive regulation of protein complex assembly	HDAC6,CDKN1B,ARF6,WNT2,MTOR,	5.39E-2
GO:0060491	regulation of cell projection assembly	RALA,KIT,TGFBR1,MTOR,	5.46E-2
GO:0018107	peptidyl-threonine phosphorylation	BCL2,NLK,TGFBR1,MTOR,	5.46E-2
GO:0070647	protein modification by small protein conjugation or removal	HUWE1,RNF2,UCHL1,ATG10,BRCA1,HDAC6,TMEM189,TRRAP,UBB,FBXO11,	5.56E-2
GO:0045662	negative regulation of myoblast differentiation	ZFHX3,NOTCH1,ITGB1BP3,	5.89E-2
GO:0010552	positive regulation of specific transcription from RNA polymerase II promoter	HMGB2,NOTCH1,TAF2,XRCC6,GATA6,SCAP,	6.01E-2
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	BMPR2,IGF1R,PTEN,EPHA5,SIK2,GAB1,GIGYF1,PTPN11,NRP1,PRLR,KIT,FGFR1,	6.37E-2
GO:0031175	neuron projection development	WNT3A,PTEN,BCL2,PTPN11,NOTCH1,MAP2K1,UBB,FGFR1,IGF1R,UCHL1,PTPRZ1,OTX2,NRP1,	6.41E-2
GO:0048732	gland development	IGF1R,WNT3A,BCL2,NOTCH4,PRLR,TCF21,WNT2,BCL2L11,TGFBR1,	6.46E-2
GO:0008219	cell death	HRAS,E2F1,BAG2,EP300,KRAS,GATA6,CDKN1B,XIAP,ARF6,HIPK2,BCL2L11,FUS,PTEN,BCL2,BRCA1,KIT,RNF34,UBB,DDIT4,MCL1,TIAL1,GADD45G,ATM,C8A,SIRT1,DIDO1,	6.48E-2
GO:0000902	cell morphogenesis	WNT3A,NOTCH4,BCL2,PTPN11,NOTCH1,PROX1,MAP2K1,UBB,IGF1R,UCHL1,PTPRZ1,OTX2,HNRNPAB,NRP1,NDE1,TGFBR3,	6.48E-2
GO:0000187	activation of MAPK activity	GAB1,PTPN11,PTPLAD1,CHRFAM7A,MAP2K1,MAP3K10,LRRN3,	6.55E-2
GO:0034621	cellular macromolecular complex subunit organization	XPO6,SRPK2,KPNB1,HMGB2,PRLR,H1F0,H2AFY,RPS14,WNT2,HIST1H1E,H3F3B,HIST1H3D,ARID1A,MAZ,HIST2H4B,TMEM48,	6.64E-2
GO:0016265	death	HRAS,E2F1,BAG2,EP300,KRAS,GATA6,CDKN1B,XIAP,ARF6,HIPK2,BCL2L11,FUS,PTEN,BCL2,BRCA1,KIT,RNF34,UBB,DDIT4,MCL1,TIAL1,GADD45G,ATM,C8A,SIRT1,DIDO1,	7.02E-2
GO:0003002	regionalization	BMPR2,RNF2,WNT3A,HIPK2,PBX2,LFNG,EP300,ATM,NOTCH1,TGFBR1,ZEB2,	7.25E-2
GO:0006334	nucleosome assembly	H3F3B,HMGB2,HIST1H3D,H1F0,H2AFY,HIST2H4B,HIST1H1E,	7.35E-2
GO:0051091	positive regulation of transcription factor activity	PRDX3,EP300,TGFBR3,KRAS,TMEM189,CAT,	7.46E-2
GO:0048103	somatic stem cell division	WNT3A,NOTCH1,KIT,	8.13E-2
GO:0018210	peptidyl-threonine modification	BCL2,NLK,TGFBR1,MTOR,	8.51E-2
GO:0031497	chromatin assembly	H3F3B,HMGB2,HIST1H3D,H1F0,H2AFY,HIST2H4B,HIST1H1E,	8.68E-2
GO:0030879	mammary gland development	IGF1R,WNT3A,NOTCH4,PRLR,WNT2,BCL2L11,	9.14E-2
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	TEAD4,E2F1,PBX2,HMGB2,ZNF148,EP300,NOTCH1,KLF6,TAF2,GATA6,MED14,SCAP,HIPK2,XRCC6,FOS,IL2,	9.18E-2
GO:0060284	regulation of cell development	ZFHX3,TGIF2,BCL2,NRP1,PROX1,NOTCH1,TGFBR3,ITGB1BP3,KIT,XRCC6,UBB,	9.46E-2
GO:0051092	positive regulation of NF-kappaB transcription factor activity	PRDX3,TGFBR3,KRAS,TMEM189,CAT,	9.49E-2

KEGG pathways and Gene Ontology terms enriched for the interacted genes of ncRNA from RAID and miRTarBase.

disease name	related genes	p-value