ncRNADetailInformation

Detail Information
Functional analysis

miRNA name

pre-miRNA

family

pre-miRNA Sequence

mature-miRNA

mature sequence

pre-miRNA description

miR-17-5p

MI0000687	MIPF0000001	GUCAGAAUAAUGUCAAAGUGCUUACAGUGCAGGUAGUGAUGUGUGCAUCUACUGCAGUGAGGGCACUUGUAGCAUUAUGCUGAC	MIMAT0000649 mmu-miR-17-5p	CAAAGUGCUUACAGUGCAGGUAG	Mouse mir-17 is predicted based on homology to a cloned miR from human(MIR:MI0000071) [1,2]. miRNAs derived from the 5' and 3' arms ofthe human mir-17 precursor have been reported. Landgraf et al. show thatthe 5' product is the predominant one . The mature sequence shown hererepresents the most commonly cloned form from large-scale cloning studies.
MI0000687	MIPF0000001	GUCAGAAUAAUGUCAAAGUGCUUACAGUGCAGGUAGUGAUGUGUGCAUCUACUGCAGUGAGGGCACUUGUAGCAUUAUGCUGAC	MIMAT0000649 mmu-miR-17-5p	CAAAGUGCUUACAGUGCAGGUAG	Mouse mir-17 is predicted based on homology to a cloned miR from human(MIR:MI0000071) [1,2]. miRNAs derived from the 5' and 3' arms ofthe human mir-17 precursor have been reported. Landgraf et al. show thatthe 5' product is the predominant one . The mature sequence shown hererepresents the most commonly cloned form from large-scale cloning studies.
MI0000687	MIPF0000001	GUCAGAAUAAUGUCAAAGUGCUUACAGUGCAGGUAGUGAUGUGUGCAUCUACUGCAGUGAGGGCACUUGUAGCAUUAUGCUGAC	MIMAT0000649 mmu-miR-17-5p	CAAAGUGCUUACAGUGCAGGUAG	Mouse mir-17 is predicted based on homology to a cloned miR from human(MIR:MI0000071) [1,2]. miRNAs derived from the 5' and 3' arms ofthe human mir-17 precursor have been reported. Landgraf et al. show thatthe 5' product is the predominant one . The mature sequence shown hererepresents the most commonly cloned form from large-scale cloning studies.

link to database

TargetScanS 6.2 | MicroCosm | microRNA.org | miRNAMap 2.0

Interacted genes from RAID,miRTarBase

Cend1,Gramd1a,Sdccag3,Sox8,Ogfod1,Zfp367,Scp2,Wnk1,Cadm2,Acap2,Skil,Hsd17b10,Tnks,Dhx36,March6
more » Cend1,Gramd1a,Sdccag3,Sox8,Ogfod1,Zfp367,Scp2,Wnk1,Cadm2,Acap2,Skil,Hsd17b10,Tnks,Dhx36,March6,Scn8a,Rsf1,Nfia,Cpeb3,Pabpc5,Eef2k,Lnp,Rogdi,Tmcc1,Aff4,Elovl6,Ppp3r1,Nbea,Mrc1,Sall3,Tmem64,Cbx2,Ftsjd2,Syt1,App,Zhx3,Gng4,Dmd,Map4k2,Dpysl5,Kbtbd8,Ppap2b,Lrp11,Etnk1,Tmx4,Npat,Tor1aip2,1700052N19Rik,Rb1,Ankhd1,Ubxn2a,Alkbh5,Itm2c,Dcbld2,Plxna2,Lmbrd1,Abca1,Scn2a1,Gpatch8,Ift88,Nr1d2,Kif21a,Qser1,Ttc14,Ugcg,Rora,Mylip,Fam134c,Ranbp2,Lrrc55,2810055G20Rik,Rbl2,Yipf6,Lrrn3,Ildr2,Fam134a,Reep1,Mcm7,Celf2,Aldh6a1,Pik3r4,Mtap1a,Ccdc88a,Ankrd9,A930001N09Rik,Amot,Acvr1b,Fam120c,Polr3k,Xpc,Aspscr1,Ythdf3,Zic2,Adcyap1r1,Ptprj,Mapre3,Bmp2k,Zfp704,Dhcr24,Ep300,Bmp4,C630004H02Rik,4930506M07Rik,Odz4,Dgkd,Atf2,Tspan9,Dpysl2,Rasa1,Gtf2h2,D630045J12Rik,Tceb3,Slc17a7,Trim2,Gas7,Ezh1,Cdh2,Col4a2,Robo2,Zfp217,Spag9,Kdelr2,Rabgap1l,Sez6l,Ppp2r2c,Lcorl,Tfe3,Mycbp,Pfn2,Gabbr2,Zfp62,Zmat3,Klraq1,Slc36a1,Rev3l,Cav1,Fam63b,Ralgds,Mtap2,Pcf11,Oprl1,Brwd1,Nf1,Spast,Cdc42se2,Taok1,Capn2,Nrip1,Nfe2l2,Epb4.1l5,Map3k5,Rasal1,Zfp597,Arhgef9,Med17,Cyld,Camta1,Mtap7d2,Dnm1l,Cd164,Dip2a,Kif5c,Wfs1,Cyth1,Bcl2l11,Tgfa,Ptprg,Hdac8,Nipa2,A330021E22Rik,Pank1,Lsamp,Phlpp1,Adam17,Xrn1,Gpm6b,Eml1,Extl2,Sh3d19,Zfp84,Ap3d1,Nptx1,Socs6,Rab30,Pvr,Gabrb3,Macf1,C1qa,B3galt2,Ppp6c,Plagl2,Tbc1d12,Brms1l,Trip12,Fbxo9,Ski,Appl2,Serpinb9,Dync1li2,Tex2,Rapgefl1,Ankrd29,Slc24a2,Dio2,Fcho2,Napb,2610109H07Rik,Tnfrsf21,Cpeb4,1600012H06Rik,Casc4,Luc7l3,Mgll,Neurod1,Chl1,Pcdhac1,Fchsd2,St6galnac5,Rab12,Ankrd17,Jub,Wdr82,Cpe,Pappa,Slc1a4,Rcan3,Pum1,Stxbp5,D15Ertd621e,Whsc1l1,Klhl20,Prune2,Slc7a14,Shh,Anp32a,Rundc3b,Foxp1,Mtap4,Kpnb1,Zfp652,Klhl2,Limch1,Cdc7,Fat2,Serinc1,Syt11,Frmpd4,Nefh,Lpp,Celsr2,Pten,Atxn3,4931406C07Rik,Adam19,Ttc9,Scn3b,Yy1,Nsg2,Grb10,Rnf220,F3,Nudcd3,Itgb8,Cxcl12,Rap1gds1,Smoc2,Gpr63,Rgma,En2,Gxylt1,Mlxip,Lrrc3,Mcl1,Igfbp7,Ptpn11,Islr2,D4Wsu53e,Rdx,Rab33b,Zeb2,Fam117b,Ubr3,Papolg,Taok2,Slc35f3,Klhdc5,Msl1,Entpd7,Stat3,Znfx1,Rab11fip4,Ppig,Polq,Otud4,Usp3,Nudt18,March8,Rassf4,Mapk14,Cnot6l,Camk2n1,Lrch1,Pim3,8430410K20Rik,Akt3,Scn1a,Srcin1,Flnb,Insm1,1810013D10Rik,Slc10a7,Heg1,2510009E07Rik,Slc7a2,Ubtf,Rsrc2,Zdhhc16,Gcap14,Gabra1,Ncam1,5730494N06Rik,Ryr2,Kif5a,Pgrmc2,Erbb4,M6pr,Klf9,Anubl1,Rasgef1a,Fn1,Rnf213,N4bp2l2,Cdkn1a,Zfp317,Klf10,Adam10,Slc44a5,Kras,Nt5dc3,Tbc1d8b,Cds1,Eps15,C2cd4c,Aifm1,Sepp1,Igsf3,Tmod2,Myo10,Sema3c,Cald1,Epha7,Tmed8,Fam49b,March9,Trp53inp1,Zfhx3,Fbxo21,Arap2,B4galnt1,Cops2,Aplp2,Ficd,Megf9,Pbrm1,Btg2,Rnf103,Extl3,Mga,Dnmt3a,Sh3bgrl,Necab1,6030458C11Rik,Wdr37,Scara5,Tnrc6b,Cacna2d1,Derl2,Tomm34

KEGG pathways enriched for interacted genes

pathway name

pathway description

target genes enrich in pathway

p-value

mmu04360	Axon guidance	Dpysl2,Dpysl5,Rasa1,Kras,Robo2,Sema3c,Plxna2,Cxcl12,Epha7,Ppp3r1,	5.23E-4
mmu05212	Pancreatic cancer	Tgfa,Stat3,Acvr1b,Rb1,Kras,Ralgds,Akt3,	1.73E-2
mmu04010	MAPK signaling pathway	Cacna2d1,Kras,Flnb,Nf1,Acvr1b,Map4k2,Rasa1,Map3k5,Mapk14,Taok1,Atf2,Akt3,Ppp3r1,	2.62E-2
mmu05200	Pathways in cancer	Ralgds,Kras,Shh,Bmp4,Col4a2,Ep300,Stat3,Tgfa,Acvr1b,Rb1,Pten,Akt3,Cdkn1a,Fn1,	4.83E-2
mmu05215	Prostate cancer	Tgfa,Ep300,Rb1,Kras,Pten,Akt3,Cdkn1a,	5.32E-2

Gene ontology terms enriched for interacted genes

GO terms

GO terms description

target genes enrich in GO term

p-value

GO:0030182	neuron differentiation	Rora,Chl1,Dpysl5,Ptpn11,Shh,Kif5c,App,Bmp4,En2,Btg2,Stat3,Gas7,Mtap2,Sall3,Robo2,4930506M07Rik,2610109H07Rik,Pten,Cxcl12,Epha7,C630004H02Rik,Dmd,	4.80E-5
GO:0030030	cell projection organization	Chl1,Dpysl5,Ptpn11,Shh,Kif5c,App,Ccdc88a,Gas7,Mtap2,Ift88,Robo2,Jub,4930506M07Rik,2610109H07Rik,Pten,Cxcl12,Epha7,Rdx,Dmd,	7.03E-5
GO:0031175	neuron projection development	Chl1,Dpysl5,Ptpn11,Shh,Kif5c,App,Gas7,Mtap2,Robo2,2610109H07Rik,4930506M07Rik,Pten,Epha7,Cxcl12,Dmd,	1.18E-4
GO:0006928	cell motion	Chl1,Dpysl5,Shh,Pvr,Kif5c,App,Adam17,Plxna2,Ccdc88a,Zeb2,Macf1,Cdh2,Robo2,Jub,Sema3c,2610109H07Rik,Pten,Cxcl12,Epha7,Amot,	1.39E-4
GO:0051338	regulation of transferase activity	Ptpn11,Cav1,Aplp2,App,Spag9,Ccdc88a,Nf1,Zeb2,Tgfa,Dgkd,Rb1,Serinc1,Map3k5,Cdkn1a,	1.74E-4

GO:0048858	cell projection morphogenesis	Chl1,Dpysl5,Ptpn11,Shh,Kif5c,App,Gas7,Ift88,Robo2,2610109H07Rik,4930506M07Rik,Epha7,Cxcl12,Dmd,	2.02E-4
GO:0048812	neuron projection morphogenesis	Chl1,Dpysl5,Ptpn11,Shh,Kif5c,App,Gas7,Robo2,2610109H07Rik,4930506M07Rik,Epha7,Cxcl12,Dmd,	2.07E-4
GO:0007517	muscle organ development	Cav1,Shh,Zfhx3,App,Flnb,Nf1,Scn8a,Ep300,Foxp1,Cd164,Mapk14,Pten,Dmd,	2.07E-4
GO:0048666	neuron development	Chl1,Dpysl5,Ptpn11,Shh,Kif5c,App,En2,Gas7,Mtap2,Sall3,Robo2,4930506M07Rik,2610109H07Rik,Pten,Epha7,Cxcl12,Dmd,	2.47E-4
GO:0032990	cell part morphogenesis	Chl1,Dpysl5,Ptpn11,Shh,Kif5c,App,Gas7,Ift88,Robo2,2610109H07Rik,4930506M07Rik,Epha7,Cxcl12,Dmd,	3.23E-4
GO:0045859	regulation of protein kinase activity	Ptpn11,Cav1,Aplp2,App,Spag9,Ccdc88a,Zeb2,Nf1,Tgfa,Dgkd,Rb1,Map3k5,Cdkn1a,	3.45E-4
GO:0000902	cell morphogenesis	Chl1,Dpysl5,Ptpn11,Shh,Kif5c,App,Gas7,Macf1,Mapk14,Ift88,Robo2,2610109H07Rik,4930506M07Rik,Epha7,Cxcl12,Ppp3r1,Dmd,	4.58E-4
GO:0043549	regulation of kinase activity	Ptpn11,Cav1,Aplp2,App,Spag9,Ccdc88a,Zeb2,Nf1,Tgfa,Dgkd,Rb1,Map3k5,Cdkn1a,	4.61E-4
GO:0007519	skeletal muscle tissue development	Ep300,Foxp1,Cav1,Mapk14,Flnb,App,Nf1,Dmd,	5.53E-4
GO:0048514	blood vessel morphogenesis	Cav1,Shh,Bmp4,Ptprj,Nf1,Tgfa,Rasa1,Mapk14,Cdh2,Sema3c,Cxcl12,Pten,Amot,	6.02E-4
GO:0060538	skeletal muscle organ development	Ep300,Foxp1,Cav1,Mapk14,Flnb,App,Nf1,Dmd,	6.54E-4
GO:0007411	axon guidance	Chl1,Dpysl5,Shh,Kif5c,Robo2,App,2610109H07Rik,Cxcl12,Epha7,	7.36E-4
GO:0014706	striated muscle tissue development	Ep300,Foxp1,Cav1,Shh,Mapk14,Flnb,App,Nf1,Pten,Dmd,	9.72E-4
GO:0001568	blood vessel development	Cav1,Shh,Bmp4,Ppap2b,Ptprj,Nf1,Tgfa,Rasa1,Mapk14,Cdh2,Sema3c,Cxcl12,Pten,Amot,	1.20E-2
GO:0007162	negative regulation of cell adhesion	Rasa1,Adam10,Nf1,Pten,Srcin1,	1.38E-2
GO:0001944	vasculature development	Cav1,Shh,Bmp4,Ppap2b,Ptprj,Nf1,Tgfa,Rasa1,Mapk14,Cdh2,Sema3c,Cxcl12,Pten,Amot,	1.50E-2
GO:0007409	axonogenesis	Chl1,Dpysl5,Ptpn11,Shh,Kif5c,Robo2,App,2610109H07Rik,4930506M07Rik,Cxcl12,Epha7,	1.55E-2
GO:0060537	muscle tissue development	Ep300,Foxp1,Cav1,Shh,Mapk14,Flnb,App,Nf1,Pten,Dmd,	1.57E-2
GO:0007507	heart development	Shh,Adam19,Bmp4,Ptprj,Nf1,Pbrm1,Ep300,Foxp1,Ift88,Erbb4,Sema3c,Pten,Ppp3r1,	1.69E-2
GO:0032989	cellular component morphogenesis	Chl1,Dpysl5,Ptpn11,Shh,Kif5c,App,Gas7,Macf1,Mapk14,Ift88,Robo2,2610109H07Rik,4930506M07Rik,Epha7,Cxcl12,Ppp3r1,Dmd,	1.78E-2
GO:0042325	regulation of phosphorylation	Ptpn11,Cav1,Aplp2,App,Bmp4,Spag9,Ccdc88a,Nf1,Zeb2,Tgfa,Dgkd,Rb1,Map3k5,Cdkn1a,Rgma,	2.00E-2
GO:0051056	regulation of small GTPase mediated signal transduction	Ralgds,Kras,Rasgef1a,Nf1,Rasa1,Tbc1d8b,Arhgef9,Rabgap1l,Cyth1,Acap2,Arap2,Rasal1,Tbc1d12,	2.04E-2
GO:0018210	peptidyl-threonine modification	Acvr1b,Tnks,Mtap2,Akt3,	2.40E-2
GO:0018107	peptidyl-threonine phosphorylation	Acvr1b,Tnks,Mtap2,Akt3,	2.40E-2
GO:0006357	regulation of transcription from RNA polymerase II promoter	Rora,Zfhx3,Shh,App,Bmp4,Ski,Zfp367,Neurod1,Nfia,Plagl2,Tceb3,Stat3,Ep300,Rb1,Med17,Foxp1,Skil,Mapk14,Nrip1,Tfe3,Cbx2,Brwd1,Dnmt3a,Sox8,	2.79E-2
GO:0051174	regulation of phosphorus metabolic process	Ptpn11,Cav1,Aplp2,App,Bmp4,Spag9,Ccdc88a,Nf1,Zeb2,Tgfa,Dgkd,Rb1,Map3k5,Cdkn1a,Rgma,	2.82E-2
GO:0019220	regulation of phosphate metabolic process	Ptpn11,Cav1,Aplp2,App,Bmp4,Spag9,Ccdc88a,Nf1,Zeb2,Tgfa,Dgkd,Rb1,Map3k5,Cdkn1a,Rgma,	2.82E-2
GO:0045449	regulation of transcription	Hdac8,Anp32a,Mycbp,Bmp4,Zfp367,Neurod1,Klf9,Zeb2,Brms1l,Zfp317,Plagl2,Atxn3,Lcorl,Yy1,Rbl2,Nrip1,Atf2,Polr3k,Gtf2h2,Zhx3,Ubtf,Zfhx3,Zfp84,App,Nfe2l2,Ski,Nfia,Btg2,Tceb3,Rb1,Skil,Mapk14,Sall3,Camta1,Mapre3,Tfe3,Ezh1,Mga,Cbx2,Celsr2,Sox8,Rora,Klf10,Nr1d2,Ep300,Mcm7,Zfp652,Whsc1l1,Foxp1,Aff4,Brwd1,Dnmt3a,Dmd,Shh,Znfx1,En2,Cops2,Stat3,Zfp62,Npat,Pbrm1,Med17,Mlxip,	2.92E-2
GO:0042592	homeostatic process	Scara5,Aspscr1,Aifm1,Scn1a,Socs6,Ptpn11,Cav1,Bcl2l11,Tmx4,Aplp2,App,Bmp4,Neurod1,Ryr2,Slc24a2,Nf1,Xrn1,Ildr2,Stat3,Rb1,Skil,4930506M07Rik,Dmd,	3.05E-2
GO:0000904	cell morphogenesis involved in differentiation	Chl1,Dpysl5,Ptpn11,Shh,Kif5c,Robo2,App,2610109H07Rik,4930506M07Rik,Cxcl12,Epha7,Ppp3r1,	3.46E-2
GO:0048667	cell morphogenesis involved in neuron differentiation	Chl1,Dpysl5,Ptpn11,Shh,Kif5c,Robo2,App,2610109H07Rik,4930506M07Rik,Cxcl12,Epha7,	3.48E-2
GO:0045995	regulation of embryonic development	Shh,Bmp4,Nfe2l2,Amot,	4.29E-2
GO:0001953	negative regulation of cell-matrix adhesion	Rasa1,Nf1,Pten,	5.59E-2
GO:0043405	regulation of MAP kinase activity	Tgfa,Ptpn11,Map3k5,Cav1,Spag9,Nf1,Zeb2,	6.49E-2
GO:0010812	negative regulation of cell-substrate adhesion	Rasa1,Nf1,Pten,	7.73E-2
GO:0060428	lung epithelium development	Shh,Bmp4,Ppp3r1,	7.73E-2
GO:0033500	carbohydrate homeostasis	Stat3,Aspscr1,Socs6,Ptpn11,Neurod1,	7.94E-2
GO:0042593	glucose homeostasis	Stat3,Aspscr1,Socs6,Ptpn11,Neurod1,	7.94E-2
GO:0016477	cell migration	Chl1,Shh,Pvr,Cdh2,Sema3c,Jub,Ccdc88a,Plxna2,Pten,Zeb2,Cxcl12,Amot,	8.62E-2
GO:0006350	transcription	Hdac8,Anp32a,Mycbp,Zfp367,Neurod1,Klf9,Zeb2,Zfp317,Brms1l,Atxn3,Lcorl,Yy1,Rbl2,Nrip1,Atf2,Polr3k,Gtf2h2,Zhx3,Ubtf,Zfhx3,Zfp84,Nfe2l2,Nfia,Btg2,Tceb3,Rb1,Sall3,Camta1,Tfe3,Ezh1,Cbx2,Mga,Sox8,Rora,Klf10,Nr1d2,Zfp652,Mcm7,Whsc1l1,Foxp1,Aff4,Brwd1,Dnmt3a,Papolg,Npat,Pbrm1,Zfp62,Stat3,Med17,Mlxip,	9.73E-2

KEGG pathways and Gene Ontology terms enriched for the interacted genes of ncRNA from RAID and miRTarBase.

disease name	related genes	p-value