ncRNADetailInformation

Detail Information
Functional analysis

miRNA name

pre-miRNA

family

pre-miRNA Sequence

mature-miRNA

mature sequence

pre-miRNA description

miR-124

MI0000445	MIPF0000021	UGAGGGCCCCUCUGCGUGUUCACAGCGGACCUUGAUUUAAUGUCUAUACAAUUAAGGCACGCGGUGAAUGCCAAGAGAGGCGCCUCC	MIMAT0000422 hsa-miR-124-3p	UAAGGCACGCGGUGAAUGCC	miR-124 was first identified by cloning studies in mouse . Itsexpression was later verified in human embryonic stem cells . Themature sequence shown here represents the most commonly cloned form fromlarge-scale cloning studies . The 5' end of the miRNA may be offsetwith respect to previous annotations.
MI0000445	MIPF0000021	UGAGGGCCCCUCUGCGUGUUCACAGCGGACCUUGAUUUAAUGUCUAUACAAUUAAGGCACGCGGUGAAUGCCAAGAGAGGCGCCUCC	MIMAT0004591 hsa-miR-124-5p	CGUGUUCACAGCGGACCUUGAU	miR-124 was first identified by cloning studies in mouse . Itsexpression was later verified in human embryonic stem cells . Themature sequence shown here represents the most commonly cloned form fromlarge-scale cloning studies . The 5' end of the miRNA may be offsetwith respect to previous annotations.
MI0000445	MIPF0000021	UGAGGGCCCCUCUGCGUGUUCACAGCGGACCUUGAUUUAAUGUCUAUACAAUUAAGGCACGCGGUGAAUGCCAAGAGAGGCGCCUCC	MIMAT0000422 hsa-miR-124-3p	UAAGGCACGCGGUGAAUGCC	miR-124 was first identified by cloning studies in mouse . Itsexpression was later verified in human embryonic stem cells . Themature sequence shown here represents the most commonly cloned form fromlarge-scale cloning studies . The 5' end of the miRNA may be offsetwith respect to previous annotations.
MI0000445	MIPF0000021	UGAGGGCCCCUCUGCGUGUUCACAGCGGACCUUGAUUUAAUGUCUAUACAAUUAAGGCACGCGGUGAAUGCCAAGAGAGGCGCCUCC	MIMAT0004591 hsa-miR-124-5p	CGUGUUCACAGCGGACCUUGAU	miR-124 was first identified by cloning studies in mouse . Itsexpression was later verified in human embryonic stem cells . Themature sequence shown here represents the most commonly cloned form fromlarge-scale cloning studies . The 5' end of the miRNA may be offsetwith respect to previous annotations.
MI0000445	MIPF0000021	UGAGGGCCCCUCUGCGUGUUCACAGCGGACCUUGAUUUAAUGUCUAUACAAUUAAGGCACGCGGUGAAUGCCAAGAGAGGCGCCUCC	MIMAT0000422 hsa-miR-124-3p	UAAGGCACGCGGUGAAUGCC	miR-124 was first identified by cloning studies in mouse . Itsexpression was later verified in human embryonic stem cells . Themature sequence shown here represents the most commonly cloned form fromlarge-scale cloning studies . The 5' end of the miRNA may be offsetwith respect to previous annotations.
MI0000445	MIPF0000021	UGAGGGCCCCUCUGCGUGUUCACAGCGGACCUUGAUUUAAUGUCUAUACAAUUAAGGCACGCGGUGAAUGCCAAGAGAGGCGCCUCC	MIMAT0004591 hsa-miR-124-5p	CGUGUUCACAGCGGACCUUGAU	miR-124 was first identified by cloning studies in mouse . Itsexpression was later verified in human embryonic stem cells . Themature sequence shown here represents the most commonly cloned form fromlarge-scale cloning studies . The 5' end of the miRNA may be offsetwith respect to previous annotations.
MI0000445	MIPF0000021	UGAGGGCCCCUCUGCGUGUUCACAGCGGACCUUGAUUUAAUGUCUAUACAAUUAAGGCACGCGGUGAAUGCCAAGAGAGGCGCCUCC	MIMAT0000422 hsa-miR-124-3p	UAAGGCACGCGGUGAAUGCC	miR-124 was first identified by cloning studies in mouse . Itsexpression was later verified in human embryonic stem cells . Themature sequence shown here represents the most commonly cloned form fromlarge-scale cloning studies . The 5' end of the miRNA may be offsetwith respect to previous annotations.
MI0000445	MIPF0000021	UGAGGGCCCCUCUGCGUGUUCACAGCGGACCUUGAUUUAAUGUCUAUACAAUUAAGGCACGCGGUGAAUGCCAAGAGAGGCGCCUCC	MIMAT0004591 hsa-miR-124-5p	CGUGUUCACAGCGGACCUUGAU	miR-124 was first identified by cloning studies in mouse . Itsexpression was later verified in human embryonic stem cells . Themature sequence shown here represents the most commonly cloned form fromlarge-scale cloning studies . The 5' end of the miRNA may be offsetwith respect to previous annotations.
MI0000445	MIPF0000021	UGAGGGCCCCUCUGCGUGUUCACAGCGGACCUUGAUUUAAUGUCUAUACAAUUAAGGCACGCGGUGAAUGCCAAGAGAGGCGCCUCC	MIMAT0000422 hsa-miR-124-3p	UAAGGCACGCGGUGAAUGCC	miR-124 was first identified by cloning studies in mouse . Itsexpression was later verified in human embryonic stem cells . Themature sequence shown here represents the most commonly cloned form fromlarge-scale cloning studies . The 5' end of the miRNA may be offsetwith respect to previous annotations.
MI0000445	MIPF0000021	UGAGGGCCCCUCUGCGUGUUCACAGCGGACCUUGAUUUAAUGUCUAUACAAUUAAGGCACGCGGUGAAUGCCAAGAGAGGCGCCUCC	MIMAT0004591 hsa-miR-124-5p	CGUGUUCACAGCGGACCUUGAU	miR-124 was first identified by cloning studies in mouse . Itsexpression was later verified in human embryonic stem cells . Themature sequence shown here represents the most commonly cloned form fromlarge-scale cloning studies . The 5' end of the miRNA may be offsetwith respect to previous annotations.
MI0000445	MIPF0000021	UGAGGGCCCCUCUGCGUGUUCACAGCGGACCUUGAUUUAAUGUCUAUACAAUUAAGGCACGCGGUGAAUGCCAAGAGAGGCGCCUCC	MIMAT0000422 hsa-miR-124-3p	UAAGGCACGCGGUGAAUGCC	miR-124 was first identified by cloning studies in mouse . Itsexpression was later verified in human embryonic stem cells . Themature sequence shown here represents the most commonly cloned form fromlarge-scale cloning studies . The 5' end of the miRNA may be offsetwith respect to previous annotations.
MI0000445	MIPF0000021	UGAGGGCCCCUCUGCGUGUUCACAGCGGACCUUGAUUUAAUGUCUAUACAAUUAAGGCACGCGGUGAAUGCCAAGAGAGGCGCCUCC	MIMAT0004591 hsa-miR-124-5p	CGUGUUCACAGCGGACCUUGAU	miR-124 was first identified by cloning studies in mouse . Itsexpression was later verified in human embryonic stem cells . Themature sequence shown here represents the most commonly cloned form fromlarge-scale cloning studies . The 5' end of the miRNA may be offsetwith respect to previous annotations.
MI0000445	MIPF0000021	UGAGGGCCCCUCUGCGUGUUCACAGCGGACCUUGAUUUAAUGUCUAUACAAUUAAGGCACGCGGUGAAUGCCAAGAGAGGCGCCUCC	MIMAT0000422 hsa-miR-124-3p	UAAGGCACGCGGUGAAUGCC	miR-124 was first identified by cloning studies in mouse . Itsexpression was later verified in human embryonic stem cells . Themature sequence shown here represents the most commonly cloned form fromlarge-scale cloning studies . The 5' end of the miRNA may be offsetwith respect to previous annotations.
MI0000445	MIPF0000021	UGAGGGCCCCUCUGCGUGUUCACAGCGGACCUUGAUUUAAUGUCUAUACAAUUAAGGCACGCGGUGAAUGCCAAGAGAGGCGCCUCC	MIMAT0004591 hsa-miR-124-5p	CGUGUUCACAGCGGACCUUGAU	miR-124 was first identified by cloning studies in mouse . Itsexpression was later verified in human embryonic stem cells . Themature sequence shown here represents the most commonly cloned form fromlarge-scale cloning studies . The 5' end of the miRNA may be offsetwith respect to previous annotations.
MI0000445	MIPF0000021	UGAGGGCCCCUCUGCGUGUUCACAGCGGACCUUGAUUUAAUGUCUAUACAAUUAAGGCACGCGGUGAAUGCCAAGAGAGGCGCCUCC	MIMAT0000422 hsa-miR-124-3p	UAAGGCACGCGGUGAAUGCC	miR-124 was first identified by cloning studies in mouse . Itsexpression was later verified in human embryonic stem cells . Themature sequence shown here represents the most commonly cloned form fromlarge-scale cloning studies . The 5' end of the miRNA may be offsetwith respect to previous annotations.

link to database

TargetScanS 6.2 | MicroCosm | microRNA.org | miRNAMap 2.0

Interacted genes from RAID,miRTarBase

CDCP1,DCAF16,RECK,PNPLA2,TUBE1,TGOLN2,KIAA1217,RHBDF1,DNM2,SH2D1B,NRAS,DCC,SLC7A1,MPRIP,CCDC165
more » CDCP1,DCAF16,RECK,PNPLA2,TUBE1,TGOLN2,KIAA1217,RHBDF1,DNM2,SH2D1B,NRAS,DCC,SLC7A1,MPRIP,CCDC165,ANXA11,PSD4,PARN,TMEM179B,ATG4A,MVP,IL7,FHL2,BEX1,TARBP1,NRTN,TRIM37,CLN5,RAB27A,CEPT1,G3BP2,RUFY3,SGSM3,HMGB3,RHOG,FAM122B,LCLAT1,CPNE3,SEC14L3,ZNF420,TLR3,EIF2AK2,LMNB1,FAM133A,TAX1BP3,RELA,DNAH5,SAMSN1,CNN3,PTPN9,VPS4B,HTATIP2,TRIM7,SNX12,TWIST2,NFIX,ACAT2,SLC35F3,HOXA3,SLC25A30,CTHRC1,BACE1,SDC4,EZH2,PPP1R3B,FCHSD2,LRRN1,ACOT11,ANXA5,KANSL2,PTGS1,ZFP36L2,PDLIM7,NID1,NUB1,HEBP2,LLPH,PIM3,PICALM,GPATCH4,FAM129A,F11R,PSG3,TRIM65,PRB2,BTG3,RAB8A,SNRPB,HADHA,CDK4,TSN,PRKAG1,AFAP1L1,NFATC1,PI4K2B,MUC1,C10orf46,RUNX2,CCDC102B,RSAD1,ZNF440,DDX6,FRAS1,ICAM5,ADCY6,C8orf22,TBX2,PTP4A2,GPX7,PLSCR3,C11orf75,ID1,SQRDL,ZNF548,CD151,HSPB7,FGF5,SEC22C,BCL6,BCAP29,CTDSP2,SNAI2,PPIF,SSFA2,KIRREL2,CHMP2B,PTPRJ,ZBTB2,ZNF740,SYNE1,MOV10,C12orf23,TGFB1I1,MEPE,PDAP1,THAP2,LAMB3,CPNE8,TMEM161A,PPAN,RHOA,SLC35G1,PLDN,PALLD,NOL10,ABCG8,HIPK3,PTGES,IFI16,CCL2,C1orf198,C1orf85,TRPS1,ANKS6,CD2AP,KCNS3,SNX16,SUCLG2,TMEM156,PCSK9,FOXF2,PLEKHM2,NSUN2,KIF13A,ZDHHC14,CRLF1,SPATA9,LRIG1,DSEL,NFKBIZ,SLC31A2,TRIM29,TFB2M,DHCR24,B4GALT1,NPLOC4,AIM1,FAM116A,INO80C,FAM171A1,DRG2,GPR161,TOPBP1,RDH10,PACSIN3,HSD17B6,ATP8B3,ANGPTL4,PHF6,APPL2,MSN,CDKN2A,CLMP,CDV3,NBL1,MFAP5,PLXNA2,TMEM104,COL4A1,SERP1,C3orf64,CXCL1,ZNF549,TBXA2R,ALDOB,OGFOD2,DEPDC1,MECP2,EFHD2,CHST14,RCAN1,CCDC99,MCM7,EFNB1,SLC25A36,RAB32,ALDH3B2,GRM1,SS18L2,ABT1,NCAPH2,PDGFC,CCDC71,PXN,KAT2A,CAPRIN1,KLF6,H6PD,INF2,DDX50,RYK,CPM,WRAP53,IVD,LRRC58,SNRPF,LRRC8C,SLC30A7,LCA5L,SULT1B1,METTL7A,HADHB,TRPC1,GOLT1B,LAPTM4A,CYP1B1,KRT33A,RNF144B,MINA,CDCA7,PDSS1,CCDC3,TMEM79,NIP7,KCNK1,MFAP4,CTAGE5,ATP6V0E1,DCTN3,SENP8,ZNF395,BVES,TLN1,RNF141,LIMCH1,SNX7,GREM1,MYO19,SLC46A3,C3orf58,RCC1,RAB31,LRP10,RARG,THOC6,KIAA1199,IL27RA,ORC1,DDX51,RAET1E,NGDN,CDC14B,C6orf89,CKS2,PGGT1B,GPM6B,MVD,C9orf85,ROM1,BICD2,MBD3,ANPEP,PHF17,SURF4,SECTM1,FLG,FBLIM1,ARPC5L,PGM2,CHIC2,MXD4,CDADC1,CPA6,STC2,CENPQ,IPCEF1,STAT3,SP1,PGM1,DNMBP,RFFL,TTC7A,FAM19A2,TFEB,ENDOD1,NLGN4Y,ASCC2,C21orf7,TOM1L1,AP1M2,AVEN,,AATF,IGFBP1,SERTAD4,COL8A2,MSRB3,DCUN1D5,RBM28,PLEKHF2,COL12A1,DDX3X,MTUS2,PDPR,IGFBP4,LPP,STK36,LMNA,ASPN,EIF2S2,SLC38A5,NOC3L,FMNL2,TMEM45A,E2F6,KIF20A,SRSF5,EVI5,ZNF655,CYB5A,POLR2J,AURKA,AR,ALG2,NDE1,ANKRD27,IL11,BTC,ACTR8,GLT25D1,TMEM5,HMOX1,TMED1,GRSF1,ATRIP,ANAPC7,CNP,SCN3A,SLC22A5,ANXA8,RAB38,NID2,IQCK,STX10,PEMT,GAB3,RBM24,ANXA6,PARP14,GMCL1,ADD3,FLI1,AK3,MFSD12,SNAI1,PLEKHA7,CALU,RASSF2,IL6R,PDE3B,WNT5B,AKT3,XBP1,PSME3,MYPN,CYBRD1,GNPDA1,CC2D2A,GIT2,BIRC2,FAM83H,FMOD,DHX33,SHC3,XRCC2,LIN7A,ADCY3,CRB1,SP3,TMEM121,PLEKHA1,ESYT1,PLEKHB1,TIMM13,TTLL3,GNB4,ZCCHC24,SEPT2,NEU4,MDFIC,MAML1,FAM125A,NT5E,ILF2,CORO2A,NSMAF,CDC27,SNAP23,EREG,KIF7,CDC42EP3,TMEM44,DGKA,CCDC68,ERBB2,SEC11A,DUS4L,LYVE1,RPS6KA4,CEBPE,FAR1,C8orf55,SLC9A9,SIRT1,SOS2,MTMR6,DNAJC25,AGXT2L1,TSEN54,RHBDL2,FGF1,SYNC,EIF3B,SLC25A39,RRP15,ACP6,QKI,RBBP9,MLEC,NR3C1,LITAF,TGDS,MKX,POLR3G,LYSMD3,TPD52L2,GOLGA7,TWSG1,SLC22A3,TNFRSF21,EYS,DIEXF,PIAS1,DZIP1,SPIN1,CTGF,NKAP,DPYD,LAMP2,NONO,C5orf4,CDRT4,GALNT7,SLC17A5,ELF4,SKIL,KDSR,DOK7,RBM47,RYR3,NEK9,SLC39A3,KLF2,S100G,SLC1A3,CABP7,SNX18,TP63,UHRF1,METTL11A,ROCK2,PRPS1,EPB41L5,COL4A4,PLEC,GMPR2,SPTA1,TMEM54,ADAMTSL5,GCH1,UMPS,ASPRV1,NT5C1B,TCOF1,GRAMD3,ACADVL,CABLES1,RILPL2,PLA2G4A,IQGAP1,CAST,HFM1,KDM2A,KATNA1,ACTR5,PLEKHA4,GPX4,RFC3,ERF,TCTA,CAMP,GAR1,MST4,PRKCB,KIAA1804,NRG1,TNPO1,BABAM1,SLC13A2,NEDD4,SNTA1,PTRF,PHF7,HTRA3,CSDA,PLEKHG4,SMPDL3A,CSPG4,F13B,GTF3C5,VAMP3,EDN1,PECR,LRRC1,TSR2,TAF1A,GNA12,IL6,STX18,MVK,MOGS,PLOD1,MAPK14,DENND2D,TUBB4A,ZNHIT6,TSPAN6,PEX16,CCDC121,C18orf1,SLC25A16,OCA2,ARMC1,ROR1,EML1,LIMD2,ABHD5,MDK,GATA6,DNAJC1,NUP50,IL8,ATXN2L,ARHGAP29,RPS15,AK2,LRRFIP2,SEC24D,YKT6,TRIP11,CMTM3,DDIT4,CLIC3,APEX2,PODXL,RRAS,HNRNPCL1,TMEM128,LIN7C,PIK3C2A,FECH,SLU7,PPAP2B,CAPN11,WASF2,GFPT2,IMPACT,SMCR7L,BRE,RAB34,KCNK2,LOXL1,BAG5,MAP3K3,GCA,WIPF1,ATP8B2,DISP1,KLHL24,POGLUT1,USH2A,SULT1E1,FRMD6,SPHK1,FAM35A,ADPRH,FAM167A,SLC43A3,MRPS11,,FKBP14,GTF3C6,TPST2,THPO,VIT,PLXNB2,IKBKE,KRT17P2,NFIC,MBD6,SRSF3,L1CAM,HRH1,STOM,PTP4A1,NAA15,CEBPA,RASIP1,FAM105A,SNX9,TMED9,RAPGEF3,IFRD2,NTF4,NFIA,CD2BP2,SYNGR2,ERCC5,TPM1,G3BP1,MMP26,RHOC,IRAK3,CRTC3,TFAP4,CD59,FLII,SAMD10,RNFT1,LHX2,USP38,CPSF4,PRPH,EIF3L,PQLC3,MAPKAPK3,USP10,IL1R1,FGFBP1,EIF3M,CDH2,STX2,FAM65C,CD164,TRIM25,RPRD1B,COL6A2,POLR2L,SPIN3,C19orf21,ELP2,TRPC6,CCDC142,SLC26A4,DUSP2,GNRHR,GAS6,SGPL1,PTPRB,ARHGEF1,C3orf45,PARP9,KANK1,TRIM38,NXN,KDELR2,LDLRAP1,MAGT1,NR4A3,SSNA1,STAT5A,LRRC2,CBR3,DFFB,C11orf67,MAP2K3,KLHL14,CTNNB1,CUX2,SLC44A1,ACAA2,PPRC1,EIF4E,MTPN,RBCK1,MICAL1,SEPT9,SPOCD1,RAD51AP1,CCBL2,EGR2,C1orf122,NECAP2,TRIM4,TNS4,ZNF451,FSTL1,E2F4,AHNAK2,PHF21B,ATOH8,C2orf29,ANO1,RPL23,FPGS,NARG2,SC5DL,MPHOSPH9,CKAP4,FBXL18,HAUS6,MAPK1IP1L,VPS37C,P4HA3,SH3PXD2A,BCCIP,CHST6,ACADL,CTDSPL,TM9SF3,GDA,ITSN2,NCF2,NRF1,FAM175B,GPC1,IGFBP3,FAM35B,PRDM13,SHE,VIM,PSG9,CA5B,INA,MLLT4,PTGS2,STK38,KLF4,MED20,EPGN,CTDSP1,FAM134B,RFX1,C1orf212,TNFRSF25,SGK1,PRRX2,HES1,MTHFSD,CSRP1,ABCF2,C8orf33,RBPJ,DSCAML1,KIF1B,FAM171B,LGR5,GXYLT1,VANGL1,CXXC1,TSC22D3,VAMP8,LDLR,PPP2R1B,MAN2A1,SLC26A2,METAP2,GMCL1P1,PSKH1,HSD17B2,KIAA1967,LRRC4,MYH7B,MAP3K4,C6orf72,TRPV3,NRP1,USP47,LIMD1,JUP,SULF1,S100A2,DPH5,MESDC2,CALR,EMD,VASN,TPST1,DAPK1,DISC1,CSTF3,TPRA1,FXR1,PTTG1IP,NFIB,ASCC3,RHOV,FAM83D,SMPD4,SLC15A4,SMYD3,HS2ST1,POP5,IGFBP7,NUDT19,PLP2,ADCY9,RBPMS,FLOT2,OAF,COL1A1,ZMPSTE24,HELLS,CCNA1,FTSJ1,BEND3,BMPR1A,PLSCR4,B4GALT5,FAM76A,FAM109B,POFUT1,HLA-A,WISP2,RFWD3,FAM63B,CDO1,DRAM1,PTPN11,NME4,DYNC2H1,MAZ,BDKRB1,CTSH,ZWINT,B3GNT2,GABBR2,TPCN2,LIN28A,WTAP,HS1BP3,AIF1L,TIMP3,IGFN1,LARP1,ZBED3,WASF4P,SCAMP2,F3,CNNM2,CERS2,RASSF5,LAS1L,C12orf40,IFIT2,GSN,PLA2G4C,BRWD1,DCAF5,MTCH1,PORCN,CA12,CHSY1,AGTR2,SERPINB2,MED10,EHD2,MFSD1,C7orf30,ELK3,KRT14,HEATR5A,VKORC1,ROBO3,SBNO2,FCF1,FAM65B,TUBB2B,SLC16A1,ARHGAP22,E2F5,PBX1,USP5,ZNF410,MPHOSPH10,CBX2,ECE1,SHPK,PLA2G7,HKDC1,TMTC2,DKC1,ECE2,EVI2A,EIF4EBP1,FNDC4,PTBP3,RPIA,PGRMC2,TRIP12,RASSF1,BMP6,RAB11FIP5,SLITRK4,KANK2,DIS3,FRMD8,SPTY2D1,ELOVL5,SWAP70,CSGALNACT1,PLOD3,AHR,RAB3IL1,LRRC15,RAB2A,ELOVL1,KIF26A,PABPC4,EYA4,EPDR1,NEK6,ARFIP1,CABP1,MOBP,FXN,CDK6,SMARCA2,PIWIL4,RFX2,CDON,ICMT,SLC50A1,KIAA0101,ARHGAP28,SERPINB6,TNFRSF11B,TMEFF2,ARPP21,NTHL1,TUB,UGT1A10,GK5,GLIPR2,SLC39A11,RAVER2,ELF3,SH2B3,TJP2,LOXL4,TUBA3D,TOMM34,PEA15,BDNF,TIMM8B,COL17A1,PNP,CALCRL,CCDC86,RAD51,DEFB118,PPP1R13L,MARCH11,DNM3,PAPSS2,ACTR3,TBX22,MYH9,TUBB6,ANXA8L2,EEA1,ARPC1B,CNKSR3,DACT1,LSM10,MALL,NPM3,TGM1,GPR123,FGFR1,PES1,FSTL3,RBMS1,OSBP,TTC8,FARP1,NNMT,SGMS1,SNX17,ID2,AKT1S1,KCNC4,MBNL1,KRI1,RCC2,ANKS1B,ECI2,ADAM15,MAPK11,FBXO17,CCDC41,GUK1,FBXO18,SLC35A2,NEUROD1,KIAA0930,GNB2L1,GALNT3,TRIB3,ID3,HMGA1,AKAP4,ANAPC4,FAM199X,FHDC1,MMP19,NUFIP2,C1orf150,EMP1,ANKRD42,PCNA,LMAN2L,TXLNA,FOXRED2,CD55,HN1L,LNX2,KIF16B,TSKU,CHRAC1,MSRA,FAM206A,PRKCDBP,CTNND1,MLLT3,FAM89A,ITPRIP,CHCHD7,HSD17B10,FNDC3B,NOSIP,DHRS3,IL18R1,IFI44L,SAMD11,NAT6,GTPBP8,ALDH18A1,AMIGO2,PREB,CHSY3,LAMC1,CARD14,IFIT3,MAPKAPK2,ARAF,ARMCX2,TSC22D4,C14orf178,TPP1,DVL2,TUBA1A,CPOX,HCN2,C4BPB,RAVER1,RXFP1,PTK7,GBP1,PUS1,ZBTB6,LTA4H,CMTM4,PHF19,MAP3K8,RIPK4,JAG2,GGA2,LAMA1,DRD4,GSTK1,TREX2,SLC1A4,KLF9,PRSS50,RIN1,MICAL2,PPARA,CCT3,CAPNS1,SRBD1,CDCA7L,C7orf42,FAM129B,DDX19A,TMEM109,ENAH,SMAD5,ID4,IKBIP,NSUN7,AARS,IQCE,CHRDL1,AKT2,NOL8,HOXC9,AURKB,GNAI3,WBSCR16,AHRR,FAM177A1,NUPR1,TMED10,STT3A,GNG10,ITGB1,SERPINE1,UNC5B,ANAPC5,EGR1,FAM57A,ZHX3,TP53INP1,ADIPOR2,C9orf41,ITGA3,CYR61,SLC16A6,TNFRSF12A,UBE2R2,ANGPTL7,GNAI2,TERF2,SCAF11,ADARB1,QSOX1,POLA1,PGM5,ANO6,PTPN12,NPR1,DCTD,KCNK18,SERTAD2,EFNA1,CDK2,NLRX1,RIBC2,KIAA1704,PHC2,PUS3,SHC1,PRRX1,MRPL49,SERPINH1,TMBIM1,UNC79,UNC5D,CDKN2AIP,VNN2,S1PR5,MKLN1,TMEM43,HMGN4,PTBP1,CCDC11,TYK2,CMTM7,TRAIP,CCDC39,NR3C2,FAM120A,TCF3,DDX3Y,DBNL,SDF2L1,SIX4,CCDC28A,MAD2L2,ZNF483,SLC44A2,MRPS12,SPRY2,C20orf160,C11orf82,RNPEPL1,OASL,ANKS3,HADH,CTNS,AMMECR1,FRMD3,PTH2R,CLTA,HOXC4,ESYT2,TMEM184B,CD86,SLC2A4RG,KIF2C,ADAMTS1,SLC29A1,USP48,SNRPD3,ABHD4,LAMA4,CAV1,CDH12,STK38L,LRRC42,CAPRIN2,ABCC3,C9orf23,DPF2,MCAM,PYCARD,YBX1,BARX1,POLR2B,ALDH9A1,RANBP10,NMNAT1,XKRX,FCHO2,SDCCAG8,DHRS1,CREB3L2,GAS2L1,MORC4,BCL6B,LOC157627,CCT5,TMEM102,SLC38A2,ACSL5,PTBP2,C14orf149,SYNJ2BP,RFT1,TMEM41A,ATAD3A,CYP2U1,ANKRD36B,SH2D3A,POC1B,TOR3A,CDH11,MFSD10,PARP16,DSG2,PTPRZ1,SHMT2,CLDND1,RRAS2,DBT,SYPL1,NASP,GDF10,TEAD1,NR4A1,PHACTR2,GRB2,AGTR1,OSBPL8,ZFYVE26,PAQR3

KEGG pathways enriched for interacted genes

pathway name

pathway description

target genes enrich in pathway

p-value

hsa05200	Pathways in cancer	PIAS1,SOS2,STAT3,PRKCB,LAMA1,RELA,CDKN2A,FGF5,JUP,RASSF5,CTNNB1,CEBPA,CCNA1,ITGA3,FGF1,ARAF,RHOA,STK36,AR,RAD51,IL8,WNT5B,ERBB2,DVL2,COL4A1,PTGS2,BIRC2,COL4A4,CDK2,CDK4,RASSF1,AKT2,FGFR1,CDK6,ITGB1,NRAS,AKT3,LAMB3,GRB2,LAMC1,STAT5A,LAMA4,DAPK1,IL6,DCC,	1.91E-4
hsa04914	Progesterone-mediated oocyte maturation	PDE3B,MAPK11,ADCY9,ADCY6,MAPK14,CDK2,GNAI3,AKT2,CDC27,CCNA1,GNAI2,AKT3,ARAF,ADCY3,MAD2L2,ANAPC7,ANAPC5,ANAPC4,	2.67E-4
hsa05222	Small cell lung cancer	PIAS1,COL4A1,LAMA1,PTGS2,BIRC2,RELA,COL4A4,CDK2,CDK4,AKT2,CDK6,ITGA3,ITGB1,AKT3,LAMB3,LAMC1,LAMA4,	6.22E-4
hsa05223	Non-small cell lung cancer	ERBB2,SOS2,PRKCB,CDKN2A,CDK4,RASSF1,AKT2,RASSF5,CDK6,AKT3,NRAS,GRB2,ARAF,	7.12E-4
hsa05221	Acute myeloid leukemia	SOS2,STAT3,RELA,JUP,AKT2,CEBPA,CCNA1,AKT3,NRAS,GRB2,ARAF,EIF4EBP1,STAT5A,	1.39E-2

hsa00071	Fatty acid metabolism	ACAA2,HADH,HADHB,ALDH9A1,HADHA,ACSL5,ECI2,ACADL,ACAT2,ACADVL,	2.98E-2
hsa04540	Gap junction	SOS2,ADCY9,ADCY6,TUBA1A,PRKCB,TUBB2B,PDGFC,GNAI3,GRM1,TUBB4A,GNAI2,NRAS,ADCY3,GRB2,TUBB6,TUBA3D,	3.26E-2
hsa05130	Pathogenic Escherichia coli infection	TUBB4A,ITGB1,TTLL3,RHOA,TUBA1A,TUBB6,TUBB2B,ARPC5L,ARPC1B,ROCK2,CTNNB1,TUBA3D,	3.88E-2
hsa05220	Chronic myeloid leukemia	SOS2,PTPN11,SHC1,RELA,CDKN2A,SHC3,CDK4,AKT2,CDK6,AKT3,NRAS,ARAF,GRB2,STAT5A,	4.69E-2
hsa04012	ErbB signaling pathway	ERBB2,SOS2,PRKCB,BTC,SHC1,NRG1,SHC3,AKT2,EREG,AKT3,NRAS,ARAF,GRB2,EIF4EBP1,STAT5A,	6.75E-2
hsa04722	Neurotrophin signaling pathway	SOS2,MAPK11,PTPN11,MAPK14,SHC1,IRAK3,MAP3K3,RELA,MAPKAPK2,SHC3,AKT2,AKT3,NRAS,RHOA,GRB2,BDNF,NTF4,RPS6KA4,SH2B3,	6.98E-2
hsa05214	Glioma	CDK6,SOS2,NRAS,AKT3,ARAF,PRKCB,GRB2,SHC1,CDKN2A,CDK4,SHC3,AKT2,	8.51E-2
hsa04670	Leukocyte transendothelial migration	MLLT4,RAPGEF3,MAPK11,PTPN11,MAPK14,NCF2,PRKCB,GNAI3,RASSF5,CTNNB1,MSN,GNAI2,ITGB1,RHOA,CTNND1,PXN,F11R,ROCK2,	9.29E-2
hsa04370	VEGF signaling pathway	MAPKAPK3,MAPK11,PLA2G4A,PRKCB,MAPK14,PTGS2,MAPKAPK2,AKT2,AKT3,NRAS,SPHK1,NFATC1,PXN,	1.22E-1
hsa04510	Focal adhesion	COL6A2,SOS2,LAMA1,PRKCB,SHC1,PDGFC,SHC3,CTNNB1,ITGA3,RHOA,PXN,ROCK2,ERBB2,COL4A1,BIRC2,COL4A4,CAV1,AKT2,ITGB1,AKT3,LAMB3,GRB2,LAMC1,COL1A1,TLN1,LAMA4,	1.22E-1
hsa04530	Tight junction	MLLT4,MYH7B,CSDA,PRKCB,CDK4,GNAI3,TJP2,AKT2,CTNNB1,RRAS,GNAI2,AKT3,NRAS,CNKSR3,RHOA,MYH9,PPP2R1B,RRAS2,F11R,	1.52E-1
hsa00280	Valine, leucine and isoleucine degradation	IVD,ACAA2,HADH,HADHB,ALDH9A1,DBT,HADHA,ACAT2,HSD17B10,	1.85E-1
hsa05215	Prostate cancer	CREB3L2,ERBB2,SOS2,RELA,PDGFC,CDK2,AKT2,FGFR1,CTNNB1,AKT3,NRAS,ARAF,GRB2,AR,	1.93E-1
hsa00062	Fatty acid elongation in mitochondria	ACAA2,HADH,HADHB,HADHA,	1.95E-1
hsa04810	Regulation of actin cytoskeleton	SOS2,TTLL3,GSN,PDGFC,GNA12,FGF5,ENAH,RRAS,ITGA3,FGF1,BDKRB1,ARAF,RHOA,RRAS2,PXN,ROCK2,WASF2,FGFR1,MSN,ITGB1,NRAS,ARHGEF1,IQGAP1,ARPC1B,ARPC5L,MYH9,	2.65E-1
hsa00230	Purine metabolism	AK2,PDE3B,ADCY9,ADCY6,GMPR2,GDA,POLR2J,PAPSS2,NT5C1B,NME4,PRPS1,ADCY3,POLR2B,PNP,POLA1,POLR3G,NT5E,GUK1,POLR2L,NPR1,	2.74E-1
hsa04062	Chemokine signaling pathway	SOS2,ADCY9,ADCY6,STAT3,PRKCB,CXCL1,SHC1,RELA,SHC3,GNB4,CCL2,GNAI3,AKT2,GNG10,DNAJC25,GNAI2,AKT3,NRAS,RHOA,ADCY3,GRB2,PXN,ROCK2,IL8,	3.21E-1
hsa04520	Adherens junction	MLLT4,WASF2,ERBB2,PTPRJ,RHOA,CTNND1,IQGAP1,SNAI2,SNAI1,PTPRB,FGFR1,CTNNB1,	3.48E-1
hsa04350	TGF-beta signaling pathway	BMPR1A,ID1,ID2,E2F5,E2F4,SP1,BMP6,RHOA,SMAD5,ID4,ID3,PPP2R1B,ROCK2,	3.59E-1
hsa04912	GnRH signaling pathway	SOS2,ADCY9,MAPK11,ADCY6,MAPK14,MAP2K3,PLA2G4A,PRKCB,MAP3K3,MAP3K4,GNRHR,NRAS,ADCY3,GRB2,	3.92E-1
hsa00030	Pentose phosphate pathway	PRPS1,PGM1,ALDOB,RPIA,PGM2,H6PD,	4.05E-1
hsa04360	Axon guidance	UNC5B,EFNB1,PLXNB2,PLXNA2,GNAI3,L1CAM,EFNA1,GNAI2,ITGB1,NRAS,ROBO3,RHOA,NRP1,NFATC1,DCC,UNC5D,ROCK2,	4.13E-1
hsa05219	Bladder cancer	ERBB2,NRAS,ARAF,CDKN2A,CDK4,RASSF1,DAPK1,IL8,	4.13E-1
hsa05218	Melanoma	CDK6,NRAS,AKT3,FGF1,ARAF,PDGFC,CDKN2A,CDK4,FGF5,AKT2,FGFR1,	4.67E-1
hsa04110	Cell cycle	CDC14B,MCM7,CDK2,CDKN2A,E2F5,CDK4,E2F4,CDC27,ORC1,CCNA1,CDK6,MAD2L2,ANAPC7,ANAPC5,PCNA,ANAPC4,	6.00E-1
hsa00240	Pyrimidine metabolism	POLR2J,NME4,NT5C1B,DPYD,UMPS,PNP,POLA1,POLR3G,POLR2B,DCTD,NT5E,AK3,POLR2L,	6.35E-1
hsa04666	Fc gamma R-mediated phagocytosis	WASF2,TTLL3,PLA2G4A,PRKCB,DNM3,GSN,DNM2,PPAP2B,AKT2,AKT3,ARPC1B,ARPC5L,SPHK1,	6.35E-1
hsa00590	Arachidonic acid metabolism	LTA4H,PLA2G4A,PTGS2,GPX7,PTGES,PTGS1,GPX4,CBR3,CYP2U1,	6.63E-1
hsa04130	SNARE interactions in vesicular transport	YKT6,STX2,SNAP23,STX18,VAMP3,STX10,VAMP8,	7.09E-1
hsa00600	Sphingolipid metabolism	NEU4,SPHK1,SGPL1,KDSR,PPAP2B,SMPD4,SGMS1,	7.86E-1
hsa00903	Limonene and pinene degradation	NAT6,ALDH9A1,LCLAT1,HADHA,	8.97E-1
hsa04010	MAPK signaling pathway	MAPKAPK3,SOS2,MAPK14,PRKCB,RELA,MAPKAPK2,GNA12,FGF5,RRAS,DUSP2,FGF1,BDNF,NTF4,RRAS2,IL1R1,MAPK11,MAP2K3,PLA2G4A,MAP3K3,MAP3K4,MAP3K8,AKT2,FGFR1,AKT3,NRAS,NR4A1,GRB2,RPS6KA4,	9.38E-1

Gene ontology terms enriched for interacted genes

GO terms

GO terms description

target genes enrich in GO term

p-value

GO:0042127	regulation of cell proliferation	SMARCA2,PEMT,BTG3,CXCL1,CD86,LAMA1,BTC,NRG1,SHC1,HES1,ADAMTS1,RARG,B4GALT1,CCL2,CALCRL,CDCA7,CEBPA,TCF3,ICMT,FGF1,WISP2,TPD52L2,IGFBP3,PNP,SPHK1,PGGT1B,THPO,F3,HOXA3,BCL6,IL8,EFNB1,ERBB2,JAG2,PLA2G4A,PTGS2,PTGS1,ID2,TP63,EDN1,FGFR1,TAX1BP3,DHCR24,IGFBP7,ITGB1,NRAS,NRP1,MVD,LAMC1,ID4,STAT5A,KLF4,SIRT1,IL11,RUNX2,FGFBP1,PBX1,CAPNS1,PTGES,RELA,PDGFC,CDKN2A,CD164,EIF2AK2,CTNNB1,TBX2,EREG,TGFB1I1,GNAI2,BDNF,NFIB,CALR,FXN,BMPR1A,RHOG,IL6R,IL7,QSOX1,CDK2,CDK4,CAV1,GNRHR,E2F4,SERPINE1,CDK6,HMOX1,RBBP9,PRRX1,MXD4,AGTR1,NUPR1,IL6,EPGN,PRRX2,	1.59E-6
GO:0007265	Ras protein signal transduction	MAPKAPK3,SGSM3,WASF2,RHOG,MAPK11,G3BP2,MAPK14,SHC1,MAPKAPK2,GNA12,SHC3,ARHGAP29,RASSF1,DBNL,TAX1BP3,RRAS,DHCR24,NRAS,RHOA,GRB2,ARHGEF1,RRAS2,G3BP1,	5.12E-6
GO:0001568	blood vessel development	ELK3,MAPK14,B4GALT1,PPAP2B,CTNNB1,EREG,FGF1,RBPJ,MMP19,SGPL1,HOXA3,IL8,QKI,WASF2,PTPRJ,CSPG4,ID1,CAV1,ANPEP,EDN1,POFUT1,TNFRSF12A,HMOX1,CYR61,PRRX1,HTATIP2,ANGPTL4,NRP1,MYH9,AGTR2,CTGF,ARHGAP22,COL1A1,LAMA4,NAA15,CDH2,RECK,EPGN,PRRX2,	6.79E-6
GO:0048514	blood vessel morphogenesis	ELK3,MAPK14,B4GALT1,CTNNB1,EREG,RBPJ,FGF1,MMP19,SGPL1,HOXA3,IL8,QKI,WASF2,PTPRJ,CSPG4,ID1,CAV1,ANPEP,EDN1,POFUT1,TNFRSF12A,HMOX1,CYR61,PRRX1,HTATIP2,ANGPTL4,NRP1,MYH9,AGTR2,CTGF,ARHGAP22,NAA15,CDH2,PRRX2,EPGN,	8.92E-6
GO:0008284	positive regulation of cell proliferation	LAMA1,CD86,HES1,SHC1,NRG1,BTC,B4GALT1,CCL2,CALCRL,TCF3,FGF1,ICMT,PNP,SPHK1,PGGT1B,THPO,HOXA3,F3,BCL6,ERBB2,EFNB1,PLA2G4A,PTGS2,TP63,ID2,EDN1,FGFR1,ITGB1,NRAS,MVD,NRP1,LAMC1,ID4,STAT5A,IL11,RUNX2,PBX1,CAPNS1,RELA,PDGFC,TBX2,GNAI2,EREG,CALR,FXN,IL6R,RHOG,BMPR1A,IL7,CDK2,CDK4,CDK6,PRRX1,IL6,PRRX2,EPGN,	8.93E-6

GO:0001944	vasculature development	ELK3,MAPK14,B4GALT1,PPAP2B,CTNNB1,EREG,FGF1,RBPJ,MMP19,SGPL1,HOXA3,IL8,QKI,WASF2,PTPRJ,CSPG4,ID1,CAV1,ANPEP,EDN1,POFUT1,TNFRSF12A,HMOX1,CYR61,PRRX1,HTATIP2,ANGPTL4,NRP1,MYH9,AGTR2,CTGF,ARHGAP22,COL1A1,LAMA4,NAA15,CDH2,RECK,EPGN,PRRX2,	1.20E-5
GO:0042060	wound healing	RAB27A,ANXA8,ELK3,NRG1,CD59,GSN,B4GALT1,KLF6,GNA12,PABPC4,PPARA,EREG,TPM1,C4BPB,IGFBP1,ANXA8L2,F3,ERBB2,ANXA5,PAPSS2,SERPINE1,SERPINB2,MTPN,INA,PLDN,HMOX1,PLSCR4,TIMP3,F13B,IL6,IL11,	4.85E-5
GO:0001525	angiogenesis	ELK3,MAPK14,B4GALT1,CTNNB1,EREG,RBPJ,FGF1,MMP19,IL8,WASF2,CSPG4,ID1,ANPEP,EDN1,POFUT1,TNFRSF12A,HMOX1,CYR61,HTATIP2,NRP1,ANGPTL4,MYH9,ARHGAP22,CTGF,NAA15,EPGN,	6.06E-5
GO:0008361	regulation of cell size	CAPRIN2,NRG1,RARG,CDKN2A,SERTAD2,BDKRB1,IGFBP1,AR,EMP1,SPHK1,ATP6V0E1,CDKN2AIP,ADIPOR2,BCL6,NPR1,SGMS1,FXN,IL7,TP63,CDK4,E2F4,GREM1,EDN1,FGFR1,MTPN,TNFRSF12A,PHF17,NRP1,NUPR1,AKT1S1,AGTR2,NOL8,	8.38E-5
GO:0006631	fatty acid metabolic process	LTA4H,MAPK14,PTGES,ACADL,ACADVL,PPARA,ACAA2,HADH,HADHB,HADHA,ADIPOR2,C5orf4,QKI,ACOT11,RNPEPL1,PLA2G4A,ELOVL5,PTGS2,ACSL5,PTGS1,PLA2G4C,EDN1,PECR,SC5DL,PRKAG1,ABHD5,ECI2,STAT5A,ELOVL1,FAR1,	2.26E-4
GO:0016044	membrane organization	TIMM13,ATP8B3,ZMPSTE24,STX2,RAB34,SERP1,VAMP3,DNM2,NEDD4,LMNA,PDLIM7,VAMP8,PICALM,LDLR,SNAP23,ICAM5,CEBPE,EMD,NPLOC4,GCA,EHD2,PREB,RAB8A,WASF2,RIN1,PACSIN3,TIMM8B,DNM3,SEC24D,CAV1,GNAI3,DBNL,ITSN2,PLSCR3,PLDN,PPIF,DHCR24,LDLRAP1,NRAS,CLTA,PLSCR4,CRB1,EEA1,LRP10,NECAP2,AP1M2,SNX17,MTCH1,	2.43E-4
GO:0001501	skeletal system development	RUNX2,MAPK14,PBX1,TRPS1,CDH11,KIAA1217,PDLIM7,CTNNB1,FHL2,RYK,SIX4,IGFBP3,SMAD5,HOXC4,SGPL1,TCOF1,HOXA3,DSCAML1,JAG2,BMPR1A,MEPE,PTGS2,HOXC9,PLEKHA1,TP63,PAPSS2,CHRDL1,IGFBP4,SP1,COL12A1,TWSG1,TNFRSF11B,EDN1,BMP6,FGFR1,PRRX1,GDF10,SP3,CTGF,COL1A1,SLC26A2,PRRX2,	2.49E-4
GO:0009719	response to endogenous stimulus	VKORC1,ADCY9,PTPN11,ADCY6,PEMT,STAT3,SHC1,PCSK9,SLC25A36,GNB4,CCL2,NR4A3,IGFBP1,EIF4EBP1,ADIPOR2,RCAN1,ERBB2,PLA2G4A,PTGS2,PTGS1,CDO1,AKT2,TNFRSF11B,DNAJC25,IGFBP7,GRB2,COL1A1,STAT5A,TIMP3,DRD4,UGT1A10,PDE3B,EGR2,RELA,AARS,AURKA,CTNNB1,PPARA,GNG10,LDLR,FHL2,ADCY3,AR,GPX4,ATP6V0E1,IL6R,BIRC2,ALDOB,CAV1,HMOX1,IL6,	2.85E-4
GO:0032535	regulation of cellular component size	CAPRIN2,NRG1,GSN,RARG,CDKN2A,SPTA1,SERTAD2,BDKRB1,IGFBP1,AR,EMP1,SPHK1,ATP6V0E1,CDKN2AIP,ADIPOR2,BCL6,NPR1,SGMS1,FXN,IL7,TP63,CDK4,E2F4,GREM1,EDN1,FGFR1,MTPN,TNFRSF12A,PHF17,NRP1,ACTR3,ARPC5L,ARPC1B,NUPR1,AKT1S1,AGTR2,NOL8,	3.08E-4
GO:0010033	response to organic substance	COL6A2,VKORC1,ADCY9,STAT3,PEMT,PTPN11,GCH1,ADCY6,SHC1,PCSK9,SLC25A36,CCL2,GNB4,TJP2,NR4A3,IGFBP1,NEUROD1,EIF4EBP1,ADIPOR2,PGGT1B,THPO,TMEM102,RCAN1,ERBB2,PLA2G4A,PTGS2,NR3C1,PTGS1,ID1,ID2,ANXA5,CDO1,AKT2,TNFRSF11B,HSPB7,DNAJC25,IGFBP7,CYR61,ACTR3,GRB2,COL1A1,STAT5A,TIMP3,DRD4,SERPINH1,UGT1A10,PDE3B,EGR2,EGR1,MAPK14,GSN,RELA,AARS,EIF2AK2,LIN28A,CTNNB1,AURKA,GNG10,PPARA,LDLR,BDKRB1,ADCY3,FHL2,AR,ID3,GPX4,ATP6V0E1,IL1R1,CYP1B1,CREB3L2,IL6R,VPS4B,BIRC2,IRAK3,ALDOB,CAV1,HMOX1,TLR3,IL6,	3.71E-4
GO:0030278	regulation of ossification	RUNX2,IL6R,MEPE,BMPR1A,EGR2,PLA2G4A,PBX1,TWSG1,PDLIM7,BMP6,CTNNB1,CDK6,GDF10,SMAD5,TWIST2,IL6,	4.27E-4
GO:0009611	response to wounding	LYVE1,ELK3,STAT3,CXCL1,NRG1,B4GALT1,KLF6,CCL2,TPM1,IGFBP1,ANXA8L2,TPST1,F3,IL8,F11R,ERBB2,MAP2K3,ANXA5,PAPSS2,SLC1A3,MDK,CDO1,IGFBP4,PLA2G7,PLDN,INA,NRP1,CTGF,TIMP3,F13B,IL11,RAB27A,ANXA8,LTA4H,CD59,GSN,RELA,GNA12,PABPC4,CD55,PPARA,EREG,BDKRB1,C4BPB,ID3,NFKBIZ,ELF3,SGMS1,IL6R,PLA2G4C,SERPINE1,BMP6,SERPINB2,MTPN,HMOX1,TLR3,PLSCR4,NUPR1,IL6,HRH1,	6.45E-4
GO:0001558	regulation of cell growth	CAPRIN2,NRG1,CDKN2A,SERTAD2,BDKRB1,IGFBP1,WISP2,IGFBP3,CDKN2AIP,SPHK1,ADIPOR2,BCL6,NPR1,FXN,IL7,TP63,IGFBP4,GREM1,HTRA3,TNFRSF12A,IGFBP7,CYR61,PHF17,NRP1,AGTR1,AGTR2,CTGF,NOL8,	8.24E-4
GO:0045667	regulation of osteoblast differentiation	RUNX2,IL6R,CDK6,BMPR1A,SMAD5,TWIST2,TWSG1,IL6,CTNNB1,BMP6,PDLIM7,	8.25E-4
GO:0043200	response to amino acid stimulus	PEMT,RELA,ATP6V0E1,CCL2,TIMP3,CDO1,AARS,	8.93E-4
GO:0045596	negative regulation of cell differentiation	EZH2,HMGB3,PBX1,HES1,LIN28A,CTNNB1,PPARA,EREG,TGFB1I1,RHOA,RUFY3,BDNF,USH2A,BCL6,RCAN1,CALR,BMPR1A,TP63,CAV1,TWSG1,CDK6,ITGB1,TLR3,NRP1,ARHGEF1,ID4,STAT5A,KLF4,TWIST2,SIRT1,	9.67E-4
GO:0001101	response to acid	PEMT,GSN,RELA,ATP6V0E1,CCL2,TIMP3,CDO1,AARS,	1.20E-2
GO:0009725	response to hormone stimulus	UGT1A10,PDE3B,ADCY9,EGR2,ADCY6,STAT3,PTPN11,SHC1,PCSK9,RELA,SLC25A36,CCL2,GNB4,NR4A3,AURKA,CTNNB1,PPARA,GNG10,LDLR,FHL2,IGFBP1,ADCY3,AR,GPX4,EIF4EBP1,ADIPOR2,RCAN1,ERBB2,IL6R,PLA2G4A,PTGS2,PTGS1,ALDOB,CDO1,CAV1,TNFRSF11B,AKT2,DNAJC25,HMOX1,IGFBP7,GRB2,COL1A1,STAT5A,TIMP3,IL6,	1.25E-2
GO:0007242	intracellular signaling cascade	KLF9,STAT3,RAB34,CCL2,GNB4,TYK2,CALCRL,STK38,SPHK1,ADIPOR2,RRAS2,RCAN1,RAB8A,WASF2,MAP3K3,MAP3K4,EDN1,DNMBP,DHCR24,RXFP1,NRAS,CARD14,CTGF,STAT5A,G3BP1,DRD4,DAPK1,PIAS1,ZWINT,G3BP2,MAPK14,ATRIP,GNA12,SHC3,BRE,RAB31,GNG10,DUSP2,TGFB1I1,GNAI2,STK38L,BABAM1,ADCY3,FHL2,RHOV,SH2B3,CALR,RAPGEF3,RHOG,MDFIC,AGTR1,AGTR2,NUPR1,IFI16,NFATC1,EPGN,SOS2,ADCY9,PTPN11,ADCY6,CXCL1,PRKCB,SHC1,RARG,ARHGAP29,GRM1,RHOC,FGF1,RHOA,NEUROD1,IL8,ERBB2,DVL2,MAPK11,MAP2K3,NR3C1,TP63,RASSF1,DBNL,FGFR1,EFNA1,TAX1BP3,DNAJC25,GRB2,IQGAP1,RAB38,RPS6KA4,MAPKAPK3,RAB27A,SGSM3,KIAA1804,GSN,SH2D3A,MAPKAPK2,NEDD4,DGKA,RASSF5,AURKA,CTNNB1,NRTN,RRAS,ARAF,AR,PCNA,PIK3C2A,ROCK2,NPR1,ACOT11,RAB2A,RAB32,CAV1,PLA2G4C,CORO2A,HMOX1,DFFB,TLR3,ARHGEF1,TBXA2R,HRH1,CKS2,DEPDC1,	1.28E-2
GO:0045669	positive regulation of osteoblast differentiation	RUNX2,IL6R,BMPR1A,SMAD5,IL6,CTNNB1,BMP6,PDLIM7,	1.57E-2
GO:0010647	positive regulation of cell communication	SLC44A2,PTPN11,ECE1,TSPAN6,RELA,CCL2,NEDD4,L1CAM,GOLT1B,CTNNB1,TGFB1I1,EREG,RHOC,RHOA,CDKN2AIP,F3,SECTM1,BMPR1A,ERBB2,IL6R,MAP3K3,PTGS2,BIRC2,COL4A4,TP63,SLC1A3,CAV1,TWSG1,TRIM38,HMOX1,NRAS,PRRX1,TLR3,IKBKE,LITAF,IL6,NEK6,IL11,EPGN,PRRX2,	1.67E-2
GO:0010243	response to organic nitrogen	VKORC1,PEMT,PLA2G4A,PTGS2,BIRC2,PTGS1,RELA,CCL2,AARS,CDO1,ATP6V0E1,DRD4,TIMP3,	1.70E-2
GO:0051094	positive regulation of developmental process	RUNX2,MAPK14,CD86,NRG1,BTC,RELA,XRCC2,B4GALT1,PLXNB2,GATA6,FNDC3B,PDLIM7,CTNNB1,TGFB1I1,RHOA,NEUROD1,IGFBP3,SMAD5,PNP,BDNF,SPHK1,F3,BMPR1A,IL6R,PLA2G4A,IL7,ID2,BMP6,TNFRSF12A,ANGPTL4,ACTR3,AGTR1,ARHGEF1,STAT5A,IL6,	1.92E-2
GO:0007568	aging	CALR,TERF2,TPRA1,PLA2G4A,GSN,PTGS1,RELA,CDKN2A,TP63,ERCC5,HSD17B10,SERPINE1,TBX2,NRAS,GRB2,GPX4,TIMP3,SIRT1,	2.38E-2
GO:0045597	positive regulation of cell differentiation	RUNX2,MAPK14,CD86,NRG1,BTC,XRCC2,RELA,PLXNB2,GATA6,FNDC3B,PDLIM7,CTNNB1,TGFB1I1,RHOA,IGFBP3,NEUROD1,SMAD5,PNP,BDNF,BMPR1A,IL6R,IL7,ID2,BMP6,TNFRSF12A,ACTR3,AGTR1,ARHGEF1,STAT5A,IL6,	2.39E-2
GO:0022403	cell cycle phase	DCTN3,RCC2,ZWINT,FAM83D,TUBB2B,XRCC2,CDKN2A,KATNA1,SEPT2,RCC1,DNM2,CCDC99,PES1,AURKA,HELLS,EREG,CCNA1,TCF3,ADCY3,MPHOSPH9,POLA1,RAD51,ZNF655,TREX2,CDK2,E2F6,CDK4,E2F4,CDC27,CDK6,ITGB1,AURKB,KIF2C,NEK9,MAD2L2,MYH9,NDE1,ANAPC7,ID4,CD2AP,ANAPC5,NFATC1,ANAPC4,NEK6,HAUS6,CKS2,PIWIL4,	2.53E-2
GO:0007398	ectoderm development	STX2,FLOT2,RELA,CDKN2A,KRT14,AARS,FLG,PLOD1,CTNNB1,PPARA,AHNAK2,EREG,FRAS1,EMP1,ASPRV1,ELF3,SNAI1,BMPR1A,COL17A1,PTGS2,TP63,TGM1,DHCR24,LAMB3,COL1A1,CTGF,KLF4,	2.54E-2
GO:0007264	small GTPase mediated signal transduction	MAPKAPK3,RAB27A,SGSM3,SOS2,G3BP2,MAPK14,SHC1,RAB34,SH2D3A,MAPKAPK2,GNA12,SHC3,ARHGAP29,RAB31,RRAS,RHOC,RHOA,RHOV,RRAS2,RAB8A,RAPGEF3,WASF2,RHOG,RAB2A,MAPK11,RAB32,RASSF1,DBNL,TAX1BP3,DHCR24,HMOX1,NRAS,GRB2,IQGAP1,ARHGEF1,RAB38,G3BP1,	2.65E-2
GO:0051301	cell division	DCTN3,RCC2,CDC14B,STX2,ZWINT,FAM83D,KATNA1,CDKN2A,SEPT2,RCC1,ANXA11,AATF,HELLS,CCNA1,SEPT9,ROCK2,VPS4B,CDK2,TREX2,CDK4,CDK6,AURKB,NEK9,MAD2L2,CABLES1,MYH9,NDE1,EVI5,ANAPC7,CD2AP,ANAPC5,CDCA7L,NEK6,ANAPC4,HAUS6,CKS2,	2.77E-2
GO:0009967	positive regulation of signal transduction	SLC44A2,PTPN11,ECE1,TSPAN6,RELA,NEDD4,L1CAM,GOLT1B,CTNNB1,TGFB1I1,EREG,RHOC,RHOA,CDKN2AIP,F3,SECTM1,BMPR1A,ERBB2,IL6R,MAP3K3,BIRC2,TP63,CAV1,TWSG1,TRIM38,HMOX1,NRAS,PRRX1,TLR3,IKBKE,LITAF,IL6,NEK6,IL11,EPGN,PRRX2,	2.77E-2
GO:0007017	microtubule-based process	DCTN3,ZWINT,DNAH5,TTLL3,TUBA1A,TUBB2B,KATNA1,RCC1,BICD2,CCDC99,CTNNB1,AURKA,TUBB4A,TUBE1,KIF1B,KIF20A,RANBP10,CNP,KIF26A,TREX2,KIF13A,CAV1,DYNC2H1,KIF2C,MYH9,TUBB6,NDE1,KIF16B,KIF7,HAUS6,CKS2,TUBA3D,	2.89E-2
GO:0051325	interphase	CDK2,CDKN2A,E2F6,KATNA1,CDK4,RCC1,DNM2,E2F4,CDK6,ITGB1,TCF3,POLA1,ID4,ANAPC5,ZNF655,NFATC1,ANAPC4,	4.01E-2
GO:0006357	regulation of transcription from RNA polymerase II promoter	SMARCA2,KLF9,CSDA,TFAP4,MECP2,STAT3,HES1,CBX2,RARG,KLF6,NRF1,AHR,SNAI2,BCL6B,KAT2A,NR4A3,CEBPA,TFEB,MED10,TCF3,RHOA,NEUROD1,UHRF1,SKIL,MAML1,BCL6,ID1,TP63,ID2,ID4,STAT5A,KLF4,TWIST2,SIRT1,IL11,TEAD1,RUNX2,EGR2,EGR1,MAPK14,PBX1,RELA,GATA6,NEDD4,AATF,ERF,TARBP1,CTNNB1,PPARA,TBX2,ELP2,FHL2,SIX4,AR,ID3,SMAD5,NFIC,NFIB,MED20,CALR,E2F6,E2F4,SP1,MBD3,BMP6,HMOX1,BRWD1,MXD4,HTATIP2,NR4A1,LITAF,IL6,ELF4,	4.15E-2
GO:0019221	cytokine-mediated signaling pathway	IL6R,STAT3,IRAK3,RELA,KLF6,PLP2,CCL2,CEBPA,EREG,PYCARD,STAT5A,IL1R1,IL6,	4.26E-2
GO:0001889	liver development	CEBPA,ERBB2,ICMT,SP3,MAN2A1,HES1,PCSK9,RELA,GATA6,SP1,CTNNB1,	4.34E-2
GO:0022402	cell cycle process	DCTN3,RCC1,CCDC99,TUBE1,TCF3,MPHOSPH9,PSME3,RAD51,C11orf82,IL8,RASSF1,DHCR24,ITGB1,AURKB,TP53INP1,KIF2C,NDE1,ANAPC7,ID4,ANAPC5,CD2AP,ANAPC4,PIWIL4,RCC2,SGSM3,ZWINT,FAM83D,TUBB2B,XRCC2,CDKN2A,KATNA1,SEPT2,DNM2,PES1,CTNNB1,AURKA,HELLS,CCNA1,EREG,ADCY3,GAS2L1,POLA1,ZNF655,CALR,TREX2,CDK2,E2F6,CDK4,E2F4,UHMK1,CDC27,CDK6,NEK9,MAD2L2,MYH9,NFATC1,NEK6,HAUS6,CKS2,	4.45E-2
GO:0030155	regulation of cell adhesion	ERBB2,PDE3B,JAG2,LAMA1,GSN,NRG1,CDKN2A,CD164,L1CAM,CDK6,CYR61,TPM1,FGF1,NID1,COL1A1,STAT5A,LAMA4,PODXL,BCL6,IL8,	4.77E-2
GO:0007599	hemostasis	RAB27A,ANXA8,CD59,GNA12,PAPSS2,ANXA5,PABPC4,FLI1,SERPINE1,PLDN,C4BPB,PLSCR4,ANXA8L2,F13B,F3,IL6,IL11,	4.84E-2
GO:0022613	ribonucleoprotein complex biogenesis	SNRPB,ZNHIT6,SNRPF,SRSF5,SNRPD3,TSR2,CDKN2A,FCF1,NIP7,DKC1,RPS15,PES1,GAR1,AATF,DDX51,NPM3,MPHOSPH10,FTSJ1,DIS3,SCAF11,SLU7,TFB2M,MINA,MBNL1,	5.73E-2
GO:0007584	response to nutrient	UGT1A10,PEMT,PLA2G4A,GSN,PTGS2,RARG,RELA,HSD17B2,CCL2,CAV1,STC2,TNFRSF11B,GNAI2,HMOX1,IGFBP7,MUC1,COL1A1,KLF4,ADIPOR2,TIMP3,	6.04E-2
GO:0007049	cell cycle	DCTN3,RCC1,AHR,CCDC99,TUBE1,TCF3,SPIN1,MPHOSPH9,PSME3,UHRF1,PTP4A1,RAD51,C11orf82,IL8,JAG2,MAP3K8,RASSF1,WTAP,DHCR24,AURKB,ITGB1,TP53INP1,KIF2C,APPL2,CABLES1,BCCIP,NDE1,ID4,ANAPC7,ANAPC5,CD2AP,ANAPC4,PIWIL4,RCC2,SGSM3,ZWINT,FAM83D,TUBB2B,XRCC2,CDKN2A,KATNA1,SEPT2,DNM2,PES1,CTNNB1,AURKA,HELLS,CCNA1,EREG,ADCY3,GAS2L1,POLA1,NASP,ZNF655,SEPT9,RASSF2,CALR,TERF2,VPS4B,MCM7,CDK2,TREX2,E2F6,CDK4,E2F4,UHMK1,CDC27,CDK6,NEK9,MAD2L2,MYH9,EVI5,NFATC1,NEK6,HAUS6,CKS2,	6.33E-2
GO:0000087	M phase of mitotic cell cycle	RCC2,DCTN3,ZWINT,FAM83D,TUBB2B,KATNA1,RCC1,SEPT2,CCDC99,PES1,AURKA,HELLS,CCNA1,MPHOSPH9,CDK2,TREX2,CDC27,AURKB,KIF2C,NEK9,MAD2L2,NDE1,ANAPC7,CD2AP,ANAPC5,NEK6,ANAPC4,HAUS6,	6.48E-2
GO:0050878	regulation of body fluid levels	RAB27A,ANXA8,CD59,GNA12,ANXA5,PAPSS2,PABPC4,FLI1,SERPINE1,EDN1,PLDN,C4BPB,PLSCR4,ANXA8L2,F3,F13B,IL6,IL11,TRPC1,NPR1,	6.52E-2
GO:0007596	blood coagulation	RAB27A,ANXA8,CD59,GNA12,PAPSS2,ANXA5,PABPC4,SERPINE1,PLDN,C4BPB,PLSCR4,ANXA8L2,F13B,F3,IL6,IL11,	6.70E-2
GO:0050817	coagulation	RAB27A,ANXA8,CD59,GNA12,PAPSS2,ANXA5,PABPC4,SERPINE1,PLDN,C4BPB,PLSCR4,ANXA8L2,F13B,F3,IL6,IL11,	6.70E-2
GO:0008283	cell proliferation	GAS6,IFRD2,PEMT,COL8A2,CXCL1,CD86,NRG1,FGF5,PES1,TRAIP,ERF,CTNNB1,HELLS,GNAI2,EREG,OCA2,AR,UHRF1,EMP1,POLA1,NASP,THPO,PCNA,ZFP36L2,RAPGEF3,ERBB2,MCM7,CDV3,TP63,DKC1,IGFBP4,CDC27,HMOX1,KIF2C,CYR61,APPL2,ARHGEF1,C2orf29,NDE1,TXLNA,EVI5,ID4,CSGALNACT1,PDAP1,IFI16,CKS2,ELF4,	6.70E-2
GO:0051329	interphase of mitotic cell cycle	CDK2,CDKN2A,E2F6,KATNA1,RCC1,CDK4,DNM2,E2F4,CDK6,ITGB1,TCF3,POLA1,ID4,ANAPC5,NFATC1,ANAPC4,	7.33E-2
GO:0008544	epidermis development	COL17A1,PTGS2,FLOT2,RELA,CDKN2A,TP63,AARS,KRT14,FLG,PLOD1,PPARA,TGM1,AHNAK2,DHCR24,EREG,FRAS1,LAMB3,EMP1,CTGF,COL1A1,KLF4,ASPRV1,ELF3,SNAI1,	7.46E-2
GO:0007018	microtubule-based movement	DNAH5,TUBA1A,TUBB2B,KIF26A,KIF13A,BICD2,DYNC2H1,TUBB4A,TUBE1,KIF2C,TUBB6,NDE1,KIF16B,KIF20A,KIF1B,KIF7,TUBA3D,	7.52E-2
GO:0033273	response to vitamin	IGFBP7,PEMT,PLA2G4A,PTGS2,GSN,RELA,RARG,MUC1,HSD17B2,KLF4,CCL2,TIMP3,	7.54E-2
GO:0010627	regulation of protein kinase cascade	SLC44A2,KIAA1804,TSPAN6,RELA,NEDD4,GRM1,GOLT1B,CTNNB1,RHOC,RHOA,F3,HIPK3,SECTM1,ERBB2,IL6R,MDFIC,BIRC2,MAP3K3,CAV1,DBNL,EDN1,AKT2,TRIM38,HMOX1,TLR3,IKBKE,LITAF,IL6,NEK6,IL11,	7.87E-2
GO:0006928	cell motion	LYVE1,DNAH5,UNC5B,STAT3,LAMA1,B4GALT1,CCL2,CTHRC1,TPM1,SGPL1,IL8,WASF2,ERBB2,EFNB1,VNN2,LHX2,PTGS2,ID1,PLXNA2,TNFRSF12A,PARP9,ITGB1,ROBO3,ACTR3,NRP1,ARPC1B,LAMC1,NDE1,CTGF,CD2AP,CDH2,B3GNT2,EGR2,MAPK14,KATNA1,PPAP2B,L1CAM,NRTN,SIX4,BDNF,PODXL,IL6R,S100A2,AKAP4,VIM,MSN,MYH9,TLN1,DCC,IL6,	7.95E-2
GO:0007569	cell aging	TBX2,TERF2,NRAS,CDKN2A,TP63,HSD17B10,SIRT1,SERPINE1,	8.41E-2
GO:0031667	response to nutrient levels	UGT1A10,PEMT,GSN,RELA,PCSK9,RARG,CCL2,STC2,PPARA,GNAI2,MUC1,ADIPOR2,SLC22A3,PLA2G4A,PTGS2,HSD17B2,ALDOB,CAV1,TNFRSF11B,IGFBP7,HMOX1,COL1A1,KLF4,TIMP3,SIRT1,	8.70E-2
GO:0051347	positive regulation of transferase activity	KIAA1804,ADCY9,ADCY6,WRAP53,PTPN11,NRG1,SHC1,PDGFC,GRM1,DGKA,GNAI2,EREG,BDKRB1,ADCY3,SPHK1,ERBB2,FXN,MDFIC,MAP2K3,MAP3K4,DBNL,EDN1,EFNA1,PRKAG1,TLR3,SDC4,CARD14,DRD4,EPGN,	8.71E-2
GO:0007067	mitosis	RCC2,DCTN3,FAM83D,ZWINT,TUBB2B,KATNA1,RCC1,SEPT2,CCDC99,PES1,AURKA,HELLS,CCNA1,CDK2,TREX2,CDC27,AURKB,KIF2C,NEK9,MAD2L2,NDE1,ANAPC7,CD2AP,ANAPC5,NEK6,ANAPC4,HAUS6,	9.55E-2
GO:0000280	nuclear division	RCC2,DCTN3,FAM83D,ZWINT,TUBB2B,KATNA1,RCC1,SEPT2,CCDC99,PES1,AURKA,HELLS,CCNA1,CDK2,TREX2,CDC27,AURKB,KIF2C,NEK9,MAD2L2,NDE1,ANAPC7,CD2AP,ANAPC5,NEK6,ANAPC4,HAUS6,	9.55E-2
GO:0010740	positive regulation of protein kinase cascade	SLC44A2,IL6R,ERBB2,TSPAN6,BIRC2,MAP3K3,RELA,NEDD4,GOLT1B,CTNNB1,TRIM38,HMOX1,RHOC,TLR3,RHOA,IKBKE,LITAF,F3,NEK6,IL6,SECTM1,IL11,	9.62E-2
GO:0051726	regulation of cell cycle	ZWINT,BTG3,PTPN11,MAPK14,BTC,ATRIP,CDKN2A,RCC1,PES1,BRE,AATF,EREG,TCF3,BABAM1,ID3,SPHK1,ZNF655,PGGT1B,BCL6,ROCK2,CALR,PIM3,PTGS2,SRSF5,CDK2,ID2,CDK4,EDN1,CDK6,ITGB1,MAD2L2,CABLES1,BCCIP,STAT5A,NEK6,CKS2,EPGN,	9.82E-2

KEGG pathways and Gene Ontology terms enriched for the interacted genes of ncRNA from RAID and miRTarBase.

disease name	related genes	p-value