ncRNADetailInformation

Detail Information
Functional analysis

miRNA name

pre-miRNA

family

pre-miRNA Sequence

mature-miRNA

mature sequence

pre-miRNA description

let-7a

MI0000062	MIPF0000002	GGGUGAGGUAGUAGGUUGUAUAGUUUGGGGCUCUGCCCUGCUAUGGGAUAACUAUACAAUCUACUGUCUUUCCU	MIMAT0000062 hsa-let-7a-5p	UGAGGUAGUAGGUUGUAUAGUU	let-7a-3p cloned in has a 1 nt 3' extension (U), which is incompatiblewith the genome sequence.
MI0000062	MIPF0000002	GGGUGAGGUAGUAGGUUGUAUAGUUUGGGGCUCUGCCCUGCUAUGGGAUAACUAUACAAUCUACUGUCUUUCCU	MIMAT0004481 hsa-let-7a-3p	CUAUACAAUCUACUGUCUUUC	let-7a-3p cloned in has a 1 nt 3' extension (U), which is incompatiblewith the genome sequence.
MI0000061	MIPF0000002	AGGUUGAGGUAGUAGGUUGUAUAGUUUAGAAUUACAUCAAGGGAGAUAACUGUACAGCCUCCUAGCUUUCCU	MIMAT0010195 hsa-let-7a-2-3p	CUGUACAGCCUCCUAGCUUUCC
MI0000062	MIPF0000002	GGGUGAGGUAGUAGGUUGUAUAGUUUGGGGCUCUGCCCUGCUAUGGGAUAACUAUACAAUCUACUGUCUUUCCU	MIMAT0000062 hsa-let-7a-5p	UGAGGUAGUAGGUUGUAUAGUU	let-7a-3p cloned in has a 1 nt 3' extension (U), which is incompatiblewith the genome sequence.
MI0000062	MIPF0000002	GGGUGAGGUAGUAGGUUGUAUAGUUUGGGGCUCUGCCCUGCUAUGGGAUAACUAUACAAUCUACUGUCUUUCCU	MIMAT0004481 hsa-let-7a-3p	CUAUACAAUCUACUGUCUUUC	let-7a-3p cloned in has a 1 nt 3' extension (U), which is incompatiblewith the genome sequence.
MI0000061	MIPF0000002	AGGUUGAGGUAGUAGGUUGUAUAGUUUAGAAUUACAUCAAGGGAGAUAACUGUACAGCCUCCUAGCUUUCCU	MIMAT0010195 hsa-let-7a-2-3p	CUGUACAGCCUCCUAGCUUUCC
MI0000062	MIPF0000002	GGGUGAGGUAGUAGGUUGUAUAGUUUGGGGCUCUGCCCUGCUAUGGGAUAACUAUACAAUCUACUGUCUUUCCU	MIMAT0000062 hsa-let-7a-5p	UGAGGUAGUAGGUUGUAUAGUU	let-7a-3p cloned in has a 1 nt 3' extension (U), which is incompatiblewith the genome sequence.
MI0000062	MIPF0000002	GGGUGAGGUAGUAGGUUGUAUAGUUUGGGGCUCUGCCCUGCUAUGGGAUAACUAUACAAUCUACUGUCUUUCCU	MIMAT0004481 hsa-let-7a-3p	CUAUACAAUCUACUGUCUUUC	let-7a-3p cloned in has a 1 nt 3' extension (U), which is incompatiblewith the genome sequence.
MI0000061	MIPF0000002	AGGUUGAGGUAGUAGGUUGUAUAGUUUAGAAUUACAUCAAGGGAGAUAACUGUACAGCCUCCUAGCUUUCCU	MIMAT0010195 hsa-let-7a-2-3p	CUGUACAGCCUCCUAGCUUUCC
MI0000062	MIPF0000002	GGGUGAGGUAGUAGGUUGUAUAGUUUGGGGCUCUGCCCUGCUAUGGGAUAACUAUACAAUCUACUGUCUUUCCU	MIMAT0000062 hsa-let-7a-5p	UGAGGUAGUAGGUUGUAUAGUU	let-7a-3p cloned in has a 1 nt 3' extension (U), which is incompatiblewith the genome sequence.
MI0000062	MIPF0000002	GGGUGAGGUAGUAGGUUGUAUAGUUUGGGGCUCUGCCCUGCUAUGGGAUAACUAUACAAUCUACUGUCUUUCCU	MIMAT0004481 hsa-let-7a-3p	CUAUACAAUCUACUGUCUUUC	let-7a-3p cloned in has a 1 nt 3' extension (U), which is incompatiblewith the genome sequence.
MI0000061	MIPF0000002	AGGUUGAGGUAGUAGGUUGUAUAGUUUAGAAUUACAUCAAGGGAGAUAACUGUACAGCCUCCUAGCUUUCCU	MIMAT0010195 hsa-let-7a-2-3p	CUGUACAGCCUCCUAGCUUUCC
MI0000062	MIPF0000002	GGGUGAGGUAGUAGGUUGUAUAGUUUGGGGCUCUGCCCUGCUAUGGGAUAACUAUACAAUCUACUGUCUUUCCU	MIMAT0000062 hsa-let-7a-5p	UGAGGUAGUAGGUUGUAUAGUU	let-7a-3p cloned in has a 1 nt 3' extension (U), which is incompatiblewith the genome sequence.
MI0000062	MIPF0000002	GGGUGAGGUAGUAGGUUGUAUAGUUUGGGGCUCUGCCCUGCUAUGGGAUAACUAUACAAUCUACUGUCUUUCCU	MIMAT0004481 hsa-let-7a-3p	CUAUACAAUCUACUGUCUUUC	let-7a-3p cloned in has a 1 nt 3' extension (U), which is incompatiblewith the genome sequence.
MI0000061	MIPF0000002	AGGUUGAGGUAGUAGGUUGUAUAGUUUAGAAUUACAUCAAGGGAGAUAACUGUACAGCCUCCUAGCUUUCCU	MIMAT0010195 hsa-let-7a-2-3p	CUGUACAGCCUCCUAGCUUUCC
MI0000062	MIPF0000002	GGGUGAGGUAGUAGGUUGUAUAGUUUGGGGCUCUGCCCUGCUAUGGGAUAACUAUACAAUCUACUGUCUUUCCU	MIMAT0000062 hsa-let-7a-5p	UGAGGUAGUAGGUUGUAUAGUU	let-7a-3p cloned in has a 1 nt 3' extension (U), which is incompatiblewith the genome sequence.
MI0000062	MIPF0000002	GGGUGAGGUAGUAGGUUGUAUAGUUUGGGGCUCUGCCCUGCUAUGGGAUAACUAUACAAUCUACUGUCUUUCCU	MIMAT0004481 hsa-let-7a-3p	CUAUACAAUCUACUGUCUUUC	let-7a-3p cloned in has a 1 nt 3' extension (U), which is incompatiblewith the genome sequence.
MI0000061	MIPF0000002	AGGUUGAGGUAGUAGGUUGUAUAGUUUAGAAUUACAUCAAGGGAGAUAACUGUACAGCCUCCUAGCUUUCCU	MIMAT0010195 hsa-let-7a-2-3p	CUGUACAGCCUCCUAGCUUUCC
MI0000062	MIPF0000002	GGGUGAGGUAGUAGGUUGUAUAGUUUGGGGCUCUGCCCUGCUAUGGGAUAACUAUACAAUCUACUGUCUUUCCU	MIMAT0000062 hsa-let-7a-5p	UGAGGUAGUAGGUUGUAUAGUU	let-7a-3p cloned in has a 1 nt 3' extension (U), which is incompatiblewith the genome sequence.
MI0000062	MIPF0000002	GGGUGAGGUAGUAGGUUGUAUAGUUUGGGGCUCUGCCCUGCUAUGGGAUAACUAUACAAUCUACUGUCUUUCCU	MIMAT0004481 hsa-let-7a-3p	CUAUACAAUCUACUGUCUUUC	let-7a-3p cloned in has a 1 nt 3' extension (U), which is incompatiblewith the genome sequence.
MI0000061	MIPF0000002	AGGUUGAGGUAGUAGGUUGUAUAGUUUAGAAUUACAUCAAGGGAGAUAACUGUACAGCCUCCUAGCUUUCCU	MIMAT0010195 hsa-let-7a-2-3p	CUGUACAGCCUCCUAGCUUUCC
MI0000062	MIPF0000002	GGGUGAGGUAGUAGGUUGUAUAGUUUGGGGCUCUGCCCUGCUAUGGGAUAACUAUACAAUCUACUGUCUUUCCU	MIMAT0000062 hsa-let-7a-5p	UGAGGUAGUAGGUUGUAUAGUU	let-7a-3p cloned in has a 1 nt 3' extension (U), which is incompatiblewith the genome sequence.
MI0000062	MIPF0000002	GGGUGAGGUAGUAGGUUGUAUAGUUUGGGGCUCUGCCCUGCUAUGGGAUAACUAUACAAUCUACUGUCUUUCCU	MIMAT0004481 hsa-let-7a-3p	CUAUACAAUCUACUGUCUUUC	let-7a-3p cloned in has a 1 nt 3' extension (U), which is incompatiblewith the genome sequence.
MI0000061	MIPF0000002	AGGUUGAGGUAGUAGGUUGUAUAGUUUAGAAUUACAUCAAGGGAGAUAACUGUACAGCCUCCUAGCUUUCCU	MIMAT0010195 hsa-let-7a-2-3p	CUGUACAGCCUCCUAGCUUUCC
MI0000062	MIPF0000002	GGGUGAGGUAGUAGGUUGUAUAGUUUGGGGCUCUGCCCUGCUAUGGGAUAACUAUACAAUCUACUGUCUUUCCU	MIMAT0000062 hsa-let-7a-5p	UGAGGUAGUAGGUUGUAUAGUU	let-7a-3p cloned in has a 1 nt 3' extension (U), which is incompatiblewith the genome sequence.
MI0000062	MIPF0000002	GGGUGAGGUAGUAGGUUGUAUAGUUUGGGGCUCUGCCCUGCUAUGGGAUAACUAUACAAUCUACUGUCUUUCCU	MIMAT0004481 hsa-let-7a-3p	CUAUACAAUCUACUGUCUUUC	let-7a-3p cloned in has a 1 nt 3' extension (U), which is incompatiblewith the genome sequence.
MI0000061	MIPF0000002	AGGUUGAGGUAGUAGGUUGUAUAGUUUAGAAUUACAUCAAGGGAGAUAACUGUACAGCCUCCUAGCUUUCCU	MIMAT0010195 hsa-let-7a-2-3p	CUGUACAGCCUCCUAGCUUUCC
MI0000062	MIPF0000002	GGGUGAGGUAGUAGGUUGUAUAGUUUGGGGCUCUGCCCUGCUAUGGGAUAACUAUACAAUCUACUGUCUUUCCU	MIMAT0000062 hsa-let-7a-5p	UGAGGUAGUAGGUUGUAUAGUU	let-7a-3p cloned in has a 1 nt 3' extension (U), which is incompatiblewith the genome sequence.
MI0000062	MIPF0000002	GGGUGAGGUAGUAGGUUGUAUAGUUUGGGGCUCUGCCCUGCUAUGGGAUAACUAUACAAUCUACUGUCUUUCCU	MIMAT0004481 hsa-let-7a-3p	CUAUACAAUCUACUGUCUUUC	let-7a-3p cloned in has a 1 nt 3' extension (U), which is incompatiblewith the genome sequence.
MI0000061	MIPF0000002	AGGUUGAGGUAGUAGGUUGUAUAGUUUAGAAUUACAUCAAGGGAGAUAACUGUACAGCCUCCUAGCUUUCCU	MIMAT0010195 hsa-let-7a-2-3p	CUGUACAGCCUCCUAGCUUUCC
MI0000062	MIPF0000002	GGGUGAGGUAGUAGGUUGUAUAGUUUGGGGCUCUGCCCUGCUAUGGGAUAACUAUACAAUCUACUGUCUUUCCU	MIMAT0000062 hsa-let-7a-5p	UGAGGUAGUAGGUUGUAUAGUU	let-7a-3p cloned in has a 1 nt 3' extension (U), which is incompatiblewith the genome sequence.
MI0000062	MIPF0000002	GGGUGAGGUAGUAGGUUGUAUAGUUUGGGGCUCUGCCCUGCUAUGGGAUAACUAUACAAUCUACUGUCUUUCCU	MIMAT0000062 hsa-let-7a-5p	UGAGGUAGUAGGUUGUAUAGUU	let-7a-3p cloned in has a 1 nt 3' extension (U), which is incompatiblewith the genome sequence.
MI0000062	MIPF0000002	GGGUGAGGUAGUAGGUUGUAUAGUUUGGGGCUCUGCCCUGCUAUGGGAUAACUAUACAAUCUACUGUCUUUCCU	MIMAT0000062 hsa-let-7a-5p	UGAGGUAGUAGGUUGUAUAGUU	let-7a-3p cloned in has a 1 nt 3' extension (U), which is incompatiblewith the genome sequence.

link to database

TargetScanS 6.2 | MicroCosm | microRNA.org | miRNAMap 2.0

Interacted genes from RAID,miRTarBase

PTP4A1,HIST2H2BE,WDR6,FOXJ3,PAQR5,GTF2I,NRAS,PTGES2,CARHSP1,C7orf60,BACH1,KRASP1,TRIO,DHX9,ANGEL2
more » PTP4A1,HIST2H2BE,WDR6,FOXJ3,PAQR5,GTF2I,NRAS,PTGES2,CARHSP1,C7orf60,BACH1,KRASP1,TRIO,DHX9,ANGEL2,SIK1,WIPI2,NUPL1,FKBP8,BCAT1,REPS1,KIAA1147,SNRPC,INTS12,MEIS1,FAM171A2,HDAC5,RPS4X,METTL6,HMGA2,CD276,EZH2,PCIF1,HUWE1,ZNF260,GCN1L1,PDE4DIP,ZC3H18,MRS2,PIK3R1,JPH4,NCBP1,ATP6,CDKN1A,GLUL,SRSF2,ITGB3,DSC3,PNRC1,TTC22,SESN1,ITM2B,CRYBG3,SYNPR,ERN1,ZCCHC9,C1GALT1,GP5,ZNF746,VGLL4,ARMC8,TTC26,MYO9A,CCNB2,RAD21,TRAF7,ATP6V1B2,TMEM64,RPS13,UHRF2,BMPR1B,UNK,EIF2C2,ALDH7A1,NKIRAS2,ATP2B1,SMARCAD1,SMPDL3B,E2F1,RBMXL1,IGF2,FAM54B,CD2AP,KIAA1274,FBXW2,TAF5L,RPL9,BNIP3L,SLC35C1,ZMYM3,RPL35A,TRRAP,HIST1H1D,NDUFAF3,BTF3,EWSR1,SLC35A4,VAV2,CNBP,AKAP17A,TMEM165,MTUS1,DPH5,THBS1,MYC,BCL2L11,CCND2,ZNF780A,RPS24,GORASP2,PHF6,HMGN2,ASCC3,TMX2,BIRC6,UBOX5,CASP8,ILKAP,ACVR1B,SETD7,CAMK2D,TSPAN3,NEU3,WWP2,NME4,DYNC2H1,LIN28A,ADSL,ZNF609,CDC34,ZNF644,DEGS1,LARP1,IVD,EIF3C,ND1,UBE2Q1,HIST2H2BF,AIDA,HSF2,JAZF1,SESN2,ARRDC3,BAZ1B,SMG7,EEF2,FAM105B,CAND2,ZNF629,MTHFD1,NUDT4,SYVN1,HOXA6,PSMA2,SPATS2,IARS,SOCS1,C12orf62,SPTBN1,CS,CIRH1A,GPM6B,trim71,SEL1L3,COX1,KIAA2026,SP1,KDM6B,AMPD2,TMEM39A,TRIM33,ZNF555,HRAS,TMED7,TRIM5,HAS2,SNX6,C2orf56,USP14,CDK6,E2F2,COX2,MRPS2,LMNA,RAVER2,RPS10,OPRM1,CYP2R1,GPN1,DDX18,APP,ARL6IP6,CCND1,ATP2A2,GADD45GIP1,CLPB,NID2,C11orf57,ZNF264,FAM13C,ATG4C,PHTF2,MAPK11,MAP3K1,LILRB4,CFL2,ARID3B,HMGA1,FOXA1,IPO7,CSNK2A1,NEFM,CNTRL,UBAP2L,SF3A1,CD55,BAZ2A,LHFPL2,ACTB,ZFP36L1,MIB1,KPNA6,PREB,GCFC1,KRAS,NFATC2IP,G2E3,H1F0,NF2,RBFOX2,RPL30,PPP2R2A,GGPS1,ND2,RPSA,RANBP2,RAVER1,WDR46,LTA4H,CTDP1,TRIM71,CCR7,QKI,PEX14,SNX2,RAB13,FNDC3A,UBA6,TCERG1,BSDC1,RPS3A,RPS15A,RPL4,MIPOL1,KRTAP19-1,lin-41,SLC20A1,CDC25B,ORAI2,DNAJC6,CASP9,EIF2C4,COPZ1,ANKRD17,UPP2,HOXB4,UHRF1,AOC2,ANO6,FAS,RIOK3,ND5,BPTF,EGR3,NIPBL,MEPCE,NAA35,NPC1,DHX57,VDR,NOLC1,KCTD1,POU3F2,NOTCH1,SETD4,GTF3C5,IL6,AMMECR1,DICER1,HOXC4,S100PBP,EXPH5,CASP3,SKA3,PLOD1,BCOR,RBM6,NFKB1,C9orf37,NDUFS2,RRM2,TAF9B,LRRC42,ATXN2L,NR1I2,KIAA0284,PIGN,NPTX1,MED13L,LRRC37A2,MCM3AP,FNIP1,BCL2,ACAD8,UBE3C,TUSC2,PRDM1,TMEM241,B4GALNT3,EGFR,UBAP2,C2CD4A,HNRPDL,GBF1,FARSA,F2R,TAF5,GTF3C1,SFSWAP,LIX1L,HNRNPUL1,BUD13,BTBD1,TAB2,EIF2C1,MPL,HIST1H4D,CDC7,SHMT2,NUDT5,MRPL15,SENP7,SAMD4B,ASPM,CCNG1,TARS

KEGG pathways enriched for interacted genes

pathway name

pathway description

target genes enrich in pathway

p-value

hsa04115	p53 signaling pathway	CCND1,CASP9,CASP8,SESN1,RRM2,CDKN1A,CASP3,FAS,CDK6,CCNB2,SESN2,CCND2,CCNG1,THBS1,	1.03E-8
hsa05219	Bladder cancer	CCND1,HRAS,E2F1,NRAS,EGFR,KRAS,CDKN1A,MYC,THBS1,E2F2,	7.72E-7
hsa05215	Prostate cancer	CCND1,CASP9,HRAS,BCL2,E2F1,EGFR,KRAS,CDKN1A,E2F2,IGF2,NRAS,NFKB1,PIK3R1,	2.08E-6
hsa05220	Chronic myeloid leukemia	CCND1,HRAS,CDK6,E2F1,NRAS,ACVR1B,KRAS,NFKB1,CDKN1A,PIK3R1,MYC,E2F2,	2.43E-6
hsa05214	Glioma	CCND1,HRAS,CDK6,E2F1,NRAS,CAMK2D,EGFR,KRAS,CDKN1A,PIK3R1,E2F2,	3.41E-6

hsa05223	Non-small cell lung cancer	CCND1,CASP9,HRAS,CDK6,E2F1,NRAS,EGFR,KRAS,PIK3R1,E2F2,	7.10E-6
hsa03010	Ribosome	RPS24,RPS15A,RPL9,RPL4,RPS10,RPS3A,RPSA,RPS4X,RPL35A,RPS13,RPL30,	6.34E-5
hsa05218	Melanoma	CCND1,HRAS,CDK6,E2F1,NRAS,EGFR,KRAS,CDKN1A,PIK3R1,E2F2,	6.88E-5
hsa05212	Pancreatic cancer	CCND1,CASP9,CDK6,E2F1,EGFR,ACVR1B,KRAS,NFKB1,PIK3R1,E2F2,	7.70E-5
hsa05213	Endometrial cancer	CCND1,CASP9,HRAS,NRAS,EGFR,KRAS,PIK3R1,MYC,	3.11E-4
hsa04110	Cell cycle	CCND1,CDC25B,CDK6,E2F1,CCNB2,CDC7,CCND2,RAD21,CDKN1A,MYC,E2F2,	1.23E-2
hsa05210	Colorectal cancer	CCND1,CASP9,BCL2,EGFR,ACVR1B,KRAS,PIK3R1,CASP3,MYC,	1.25E-2
hsa05222	Small cell lung cancer	CCND1,CASP9,CDK6,E2F1,BCL2,NFKB1,PIK3R1,MYC,E2F2,	1.25E-2
hsa05200	Pathways in cancer	CCND1,CASP9,HRAS,CASP8,E2F1,BCL2,EGFR,ACVR1B,KRAS,CDKN1A,CASP3,E2F2,CDK6,FAS,NRAS,NFKB1,PIK3R1,IL6,MYC,	1.54E-2
hsa04120	Ubiquitin mediated proteolysis	HUWE1,CDC34,WWP2,MAP3K1,UBA6,BIRC6,SYVN1,SOCS1,UBOX5,UBE3C,UBE2Q1,	2.46E-2
hsa05221	Acute myeloid leukemia	CCND1,HRAS,NRAS,KRAS,NFKB1,PIK3R1,MYC,	3.38E-2
hsa05216	Thyroid cancer	CCND1,HRAS,NRAS,KRAS,MYC,	5.90E-2
hsa04012	ErbB signaling pathway	HRAS,NRAS,CAMK2D,EGFR,KRAS,CDKN1A,PIK3R1,MYC,	6.49E-2
hsa05010	Alzheimer's disease	ATP6,CASP9,FAS,CASP8,ERN1,COX2,COX1,NDUFS2,CASP3,APP,ATP2A2,	8.45E-2
hsa04722	Neurotrophin signaling pathway	HRAS,MAPK11,NRAS,BCL2,MAP3K1,CAMK2D,KRAS,NFKB1,PIK3R1,	1.35E-1
hsa05012	Parkinson's disease	ATP6,CASP9,ND2,ND1,COX2,COX1,ND5,NDUFS2,CASP3,	1.61E-1
hsa04210	Apoptosis	CASP9,FAS,CASP8,BCL2,NFKB1,PIK3R1,CASP3,	2.32E-1
hsa05416	Viral myocarditis	CCND1,CASP9,CASP8,ACTB,CASP3,CD55,	3.43E-1
hsa04912	GnRH signaling pathway	HRAS,MAPK11,NRAS,MAP3K1,CAMK2D,EGFR,KRAS,	3.86E-1
hsa04010	MAPK signaling pathway	HRAS,MAPK11,MAP3K1,EGFR,ACVR1B,KRAS,CASP3,CDC25B,FAS,NRAS,TAB2,NFKB1,MYC,	3.92E-1
hsa04662	B cell receptor signaling pathway	HRAS,NRAS,VAV2,KRAS,NFKB1,PIK3R1,	4.20E-1
hsa04370	VEGF signaling pathway	CASP9,HRAS,MAPK11,NRAS,KRAS,PIK3R1,	4.20E-1
hsa04620	Toll-like receptor signaling pathway	CASP8,MAPK11,TMED7,TAB2,NFKB1,IL6,PIK3R1,	4.37E-1
hsa05014	Amyotrophic lateral sclerosis (ALS)	CASP9,MAPK11,BCL2,NEFM,CASP3,	4.55E-1
hsa04810	Regulation of actin cytoskeleton	HRAS,IGF2,NRAS,VAV2,F2R,EGFR,KRAS,ITGB3,ACTB,PIK3R1,CFL2,	4.74E-1
hsa00190	Oxidative phosphorylation	ATP6,ND2,ND1,COX2,COX1,ND5,NDUFS2,ATP6V1B2,	4.79E-1
hsa04664	Fc epsilon RI signaling pathway	HRAS,MAPK11,NRAS,VAV2,KRAS,PIK3R1,	4.84E-1
hsa04660	T cell receptor signaling pathway	HRAS,MAPK11,NRAS,VAV2,KRAS,NFKB1,PIK3R1,	5.73E-1
hsa03022	Basal transcription factors	TAF9B,TAF5,TAF5L,GTF2I,	5.90E-1
hsa04914	Progesterone-mediated oocyte maturation	CDC25B,IGF2,CCNB2,MAPK11,KRAS,PIK3R1,	6.81E-1
hsa04510	Focal adhesion	CCND1,HRAS,BCL2,VAV2,EGFR,CCND2,ITGB3,ACTB,PIK3R1,THBS1,	7.08E-1
hsa04621	NOD-like receptor signaling pathway	CASP8,MAPK11,TAB2,NFKB1,IL6,	7.30E-1
hsa05120	Epithelial cell signaling in Helicobacter pylori infection	MAPK11,EGFR,NFKB1,ATP6V1B2,CASP3,	9.51E-1

Gene ontology terms enriched for interacted genes

GO terms

GO terms description

target genes enrich in GO term

p-value

GO:0044265	cellular macromolecule catabolic process	CASP8,TRIM33,BTBD1,UBA6,USP14,MIB1,UHRF2,SMG7,SOCS1,UBE2Q1,LIN28A,PSMA2,SENP7,FBXW2,UHRF1,UBE3C,ZFP36L1,WWP2,MAP3K1,EIF2C1,NCBP1,SYVN1,EIF2C4,UBOX5,TRIM5,CASP3,RANBP2,HUWE1,CDC34,G2E3,ATG4C,BIRC6,CD2AP,CAND2,NFKB1,MYC,TRAF7,	4.70E-7
GO:0007049	cell cycle	E2F1,EGFR,CDC7,HMGA2,UHRF2,CDKN1A,NOLC1,PSMA2,GADD45GIP1,UHRF1,PTP4A1,RAD21,ASPM,CCND1,SKA3,BCL2,ERN1,CNTRL,CAMK2D,ACVR1B,SESN1,WDR6,E2F2,APP,CDC34,CDK6,CDC25B,CCNB2,NIPBL,SESN2,SIK1,CCND2,CD2AP,BCAT1,CCNG1,TUSC2,THBS1,MYC,	8.46E-7
GO:0051329	interphase of mitotic cell cycle	CCND1,BCL2,E2F1,CAMK2D,EGFR,ACVR1B,CDC7,CDKN1A,APP,CDC34,CDK6,CCND2,BCAT1,	1.03E-6
GO:0051325	interphase	CCND1,BCL2,E2F1,CAMK2D,EGFR,ACVR1B,CDC7,CDKN1A,APP,CDC34,CDK6,CCND2,BCAT1,	1.40E-6
GO:0000082	G1/S transition of mitotic cell cycle	CCND1,CDC34,BCL2,CAMK2D,EGFR,ACVR1B,CDC7,CCND2,BCAT1,CDKN1A,	1.55E-6

GO:0000278	mitotic cell cycle	CCND1,SKA3,E2F1,BCL2,EGFR,CAMK2D,ACVR1B,CDC7,HMGA2,CDKN1A,NOLC1,PSMA2,APP,CDC34,CDK6,CDC25B,CCNB2,NIPBL,CCND2,CD2AP,RAD21,BCAT1,CCNG1,ASPM,	1.65E-6
GO:0010605	negative regulation of macromolecule metabolic process	TRIM33,BCOR,E2F1,HOXB4,EIF2C2,JAZF1,FOXA1,RPS13,SOCS1,BNIP3L,LIN28A,CD276,PSMA2,HDAC5,TAF9B,IGF2,BAZ2A,VDR,DICER1,SNX6,KDM6B,NR1I2,WWP2,PRDM1,EIF2C1,RBFOX2,PEX14,ITGB3,EIF2C4,SIK1,NF2,NFKB1,BPTF,IL6,MYC,THBS1,	1.71E-6
GO:0045449	regulation of transcription	EZH2,BTF3,ZNF644,AKAP17A,E2F1,EIF2C2,BACH1,F2R,NOTCH1,PNRC1,IGF2,SNX6,SMARCAD1,UHRF1,KDM6B,MEIS1,PTGES2,HMGN2,ACAD8,HOXA6,PRDM1,FOXJ3,MAP3K1,EIF2C1,RBFOX2,NFATC2IP,HSF2,TCERG1,VGLL4,ZNF629,TAF5,CAND2,ARID3B,NFKB1,TRRAP,CNBP,MYC,TRAF7,POU3F2,PHF6,EWSR1,ASCC3,BCOR,TRIM33,HOXB4,HNRPDL,KRAS,HMGA2,JAZF1,FOXA1,HNRNPUL1,ZNF746,LIN28A,HDAC5,TAF9B,RQCD1,ZNF555,BAZ2A,VDR,HOXC4,GCFC1,CARHSP1,PREB,NR1I2,PHTF2,SFSWAP,ZNF780A,ZNF264,ERN1,ACVR1B,MED13L,TAF5L,PEX14,HMGA1,SETD7,SP1,ZNF260,E2F2,EGR3,APP,SIK1,BPTF,BAZ1B,GTF2I,IL6,	2.31E-6
GO:0009057	macromolecule catabolic process	CASP8,TRIM33,BTBD1,UBA6,USP14,MIB1,UHRF2,SMG7,SOCS1,UBE2Q1,LIN28A,PSMA2,SENP7,FBXW2,UHRF1,UBE3C,ZFP36L1,WWP2,MAP3K1,EIF2C1,NCBP1,SYVN1,EIF2C4,UBOX5,TRIM5,CASP3,RANBP2,HUWE1,CDC34,G2E3,ATG4C,BIRC6,CD2AP,CAND2,NFKB1,MYC,TRAF7,	2.63E-6
GO:0022402	cell cycle process	E2F1,EGFR,CDC7,HMGA2,CDKN1A,NOLC1,PSMA2,RAD21,ASPM,CCND1,SKA3,BCL2,ERN1,CAMK2D,ACVR1B,SESN1,WDR6,APP,CDC34,CDK6,CDC25B,CCNB2,NIPBL,SESN2,CCND2,CD2AP,BCAT1,CCNG1,THBS1,MYC,	3.48E-6
GO:0006414	translational elongation	RPS24,RPS15A,RPL9,RPL4,EEF2,RPS10,RPS3A,RPSA,RPS4X,RPL35A,RPS13,RPL30,	5.68E-6
GO:0010629	negative regulation of gene expression	BCOR,TRIM33,E2F1,HOXB4,EIF2C2,JAZF1,FOXA1,BNIP3L,LIN28A,HDAC5,TAF9B,BAZ2A,VDR,DICER1,SNX6,KDM6B,NR1I2,WWP2,PRDM1,EIF2C1,RBFOX2,PEX14,EIF2C4,SIK1,BPTF,NFKB1,MYC,	1.05E-5
GO:0051603	proteolysis involved in cellular protein catabolic process	CASP8,TRIM33,BTBD1,UBA6,MIB1,USP14,UHRF2,SOCS1,UBE2Q1,PSMA2,SENP7,FBXW2,UHRF1,UBE3C,WWP2,MAP3K1,SYVN1,UBOX5,TRIM5,RANBP2,HUWE1,CDC34,G2E3,ATG4C,BIRC6,CD2AP,CAND2,NFKB1,TRAF7,	3.01E-5
GO:0044257	cellular protein catabolic process	CASP8,TRIM33,BTBD1,UBA6,MIB1,USP14,UHRF2,SOCS1,UBE2Q1,PSMA2,SENP7,FBXW2,UHRF1,UBE3C,WWP2,MAP3K1,SYVN1,UBOX5,TRIM5,RANBP2,HUWE1,CDC34,G2E3,ATG4C,BIRC6,CD2AP,CAND2,NFKB1,TRAF7,	3.27E-5
GO:0022403	cell cycle phase	CCND1,SKA3,E2F1,BCL2,EGFR,CAMK2D,ACVR1B,CDC7,HMGA2,CDKN1A,NOLC1,APP,CDC34,CDK6,CDC25B,CCNB2,NIPBL,CCND2,CD2AP,RAD21,BCAT1,CCNG1,ASPM,	3.29E-5
GO:0008284	positive regulation of cell proliferation	CCND1,HRAS,BCL2,F2R,EGFR,CAMK2D,NOTCH1,CDC7,KRAS,CDKN1A,CD276,CDK6,IGF2,CDC25B,RPS15A,NRAS,BIRC6,CCND2,RPS4X,IL6,CNBP,MYC,POU3F2,	3.29E-5
GO:0051726	regulation of cell cycle	CCND1,E2F1,BCL2,EGFR,CAMK2D,CDC7,UHRF2,CDKN1A,CASP3,E2F2,APP,CDK6,RPS15A,IGF2,ILKAP,SIK1,CCND2,TRRAP,CCNG1,MYC,	4.13E-5
GO:0006412	translation	EIF2C2,RPL4,RPL9,EEF2,EGFR,EIF3C,RPS10,RPS3A,MRPS2,RPS13,RPL35A,IARS,RPL30,RPS24,FARSA,TARS,RPS15A,MRPL15,RPSA,RPS4X,	4.13E-5
GO:0012501	programmed cell death	CASP9,CASP8,HRAS,E2F1,F2R,KRAS,FKBP8,BNIP3L,TAF9B,RAD21,BCL2L11,BCL2,ERN1,MAP3K1,ITM2B,CASP3,E2F2,APP,FAS,G2E3,VAV2,NRAS,BIRC6,NFKB1,IL6,TRIO,MYC,THBS1,TRAF7,	4.15E-5
GO:0006350	transcription	EZH2,BTF3,ZNF644,E2F1,EIF2C2,BACH1,NOTCH1,PNRC1,UHRF1,MEIS1,ACAD8,HOXA6,PRDM1,FOXJ3,EIF2C1,HSF2,TCERG1,VGLL4,ZNF629,TAF5,CAND2,ARID3B,NFKB1,TRRAP,CNBP,MYC,TRAF7,POU3F2,PHF6,EWSR1,ASCC3,BCOR,TRIM33,HOXB4,HNRPDL,HMGA2,JAZF1,FOXA1,HNRNPUL1,ZNF746,GTF3C1,TAF9B,HDAC5,RQCD1,ZNF555,BAZ2A,VDR,GCFC1,HOXC4,PREB,NR1I2,PHTF2,GTF3C5,SFSWAP,ZNF780A,ZNF264,ERN1,MED13L,TAF5L,HMGA1,SP1,SETD7,ZNF260,E2F2,EGR3,BAZ1B,BPTF,GTF2I,	5.49E-5
GO:0030163	protein catabolic process	CASP8,TRIM33,BTBD1,UBA6,MIB1,USP14,UHRF2,SOCS1,UBE2Q1,PSMA2,SENP7,FBXW2,UHRF1,UBE3C,WWP2,MAP3K1,SYVN1,UBOX5,TRIM5,RANBP2,HUWE1,CDC34,G2E3,ATG4C,BIRC6,CD2AP,CAND2,NFKB1,TRAF7,	5.64E-5
GO:0032446	protein modification by small protein conjugation	HUWE1,SENP7,CDC34,WWP2,G2E3,TRIM33,MAP3K1,MIB1,UHRF2,UBOX5,UBE3C,TRAF7,	7.15E-5
GO:0006325	chromatin organization	EZH2,HIST2H2BE,BCOR,H1F0,TAF5L,HMGA2,HMGA1,SETD7,HIST1H1D,HDAC5,HUWE1,BAZ2A,HIST1H4D,HIST2H2BF,TAF5,SMARCAD1,KDM6B,BAZ1B,BPTF,TRRAP,HMGN2,	8.10E-5
GO:0006915	apoptosis	CASP9,CASP8,HRAS,E2F1,F2R,KRAS,FKBP8,BNIP3L,RAD21,BCL2L11,BCL2,ERN1,MAP3K1,ITM2B,CASP3,E2F2,APP,FAS,G2E3,VAV2,NRAS,BIRC6,NFKB1,IL6,TRIO,MYC,THBS1,TRAF7,	8.24E-5
GO:0009890	negative regulation of biosynthetic process	TRIM33,BCOR,E2F1,HOXB4,EIF2C2,JAZF1,FOXA1,CD276,HDAC5,TAF9B,IGF2,BAZ2A,VDR,SNX6,KDM6B,NR1I2,PRDM1,EIF2C1,RBFOX2,PEX14,ITGB3,EIF2C4,NF2,SIK1,BPTF,NFKB1,IL6,	9.27E-5
GO:0070647	protein modification by small protein conjugation or removal	WWP2,TRIM33,MAP3K1,MIB1,UHRF2,UBOX5,HUWE1,SENP7,CDC34,G2E3,TRRAP,UBE3C,TRAF7,	9.41E-5
GO:0010608	posttranscriptional regulation of gene expression	QKI,GCN1L1,ZFP36L1,BCL2,EIF2C2,EIF2C1,NCBP1,EIF2C4,DHX9,LIN28A,APP,DICER1,RPS4X,IL6,THBS1,	9.45E-5
GO:0019941	modification-dependent protein catabolic process	TRIM33,BTBD1,UBA6,MIB1,USP14,SOCS1,UHRF2,UBE2Q1,PSMA2,SENP7,FBXW2,UHRF1,UBE3C,WWP2,MAP3K1,SYVN1,UBOX5,TRIM5,RANBP2,HUWE1,CDC34,G2E3,ATG4C,BIRC6,CD2AP,CAND2,TRAF7,	9.54E-5
GO:0043632	modification-dependent macromolecule catabolic process	TRIM33,BTBD1,UBA6,MIB1,USP14,SOCS1,UHRF2,UBE2Q1,PSMA2,SENP7,FBXW2,UHRF1,UBE3C,WWP2,MAP3K1,SYVN1,UBOX5,TRIM5,RANBP2,HUWE1,CDC34,G2E3,ATG4C,BIRC6,CD2AP,CAND2,TRAF7,	9.54E-5
GO:0043066	negative regulation of apoptosis	HRAS,BCL2,F2R,EGFR,NOTCH1,KRAS,SYVN1,CDKN1A,BNIP3L,CASP3,TAF9B,FAS,G2E3,IGF2,NRAS,BIRC6,NFKB1,IL6,THBS1,MYC,	1.01E-4
GO:0010558	negative regulation of macromolecule biosynthetic process	TRIM33,BCOR,E2F1,HOXB4,EIF2C2,JAZF1,FOXA1,CD276,HDAC5,TAF9B,BAZ2A,VDR,SNX6,KDM6B,NR1I2,PRDM1,EIF2C1,RBFOX2,PEX14,ITGB3,EIF2C4,NF2,SIK1,BPTF,NFKB1,IL6,	1.13E-4
GO:0043069	negative regulation of programmed cell death	HRAS,BCL2,F2R,EGFR,NOTCH1,KRAS,SYVN1,CDKN1A,BNIP3L,CASP3,TAF9B,FAS,G2E3,IGF2,NRAS,BIRC6,NFKB1,IL6,THBS1,MYC,	1.20E-4
GO:0060548	negative regulation of cell death	HRAS,BCL2,F2R,EGFR,NOTCH1,KRAS,SYVN1,CDKN1A,BNIP3L,CASP3,TAF9B,FAS,G2E3,IGF2,NRAS,BIRC6,NFKB1,IL6,THBS1,MYC,	1.26E-4
GO:0016567	protein ubiquitination	HUWE1,CDC34,WWP2,G2E3,TRIM33,MAP3K1,MIB1,UHRF2,UBOX5,UBE3C,TRAF7,	1.41E-4
GO:0040029	regulation of gene expression, epigenetic	HDAC5,IGF2,BAZ2A,EIF2C2,DICER1,EIF2C1,HMGA1,EIF2C4,LIN28A,	1.52E-4
GO:0031327	negative regulation of cellular biosynthetic process	TRIM33,BCOR,E2F1,HOXB4,EIF2C2,JAZF1,FOXA1,CD276,HDAC5,TAF9B,IGF2,BAZ2A,VDR,SNX6,KDM6B,NR1I2,PRDM1,EIF2C1,RBFOX2,PEX14,EIF2C4,NF2,SIK1,BPTF,NFKB1,IL6,	1.67E-4
GO:0042981	regulation of apoptosis	CASP9,CASP8,HRAS,F2R,EGFR,NOTCH1,KRAS,RPS3A,CDKN1A,BNIP3L,TAF9B,IGF2,VDR,BCL2L11,BCL2,ERN1,MAP3K1,ACVR1B,ITM2B,SYVN1,CASP3,APP,G2E3,FAS,NRAS,VAV2,BIRC6,NFKB1,TRIO,IL6,MYC,THBS1,TRAF7,	1.69E-4
GO:0043067	regulation of programmed cell death	CASP9,CASP8,HRAS,F2R,EGFR,NOTCH1,KRAS,RPS3A,CDKN1A,BNIP3L,TAF9B,IGF2,VDR,BCL2L11,BCL2,ERN1,MAP3K1,ACVR1B,ITM2B,SYVN1,CASP3,APP,G2E3,FAS,NRAS,VAV2,BIRC6,NFKB1,TRIO,IL6,MYC,THBS1,TRAF7,	2.05E-4
GO:0010941	regulation of cell death	CASP9,CASP8,HRAS,F2R,EGFR,NOTCH1,KRAS,RPS3A,CDKN1A,BNIP3L,TAF9B,IGF2,VDR,BCL2L11,BCL2,ERN1,MAP3K1,ACVR1B,ITM2B,SYVN1,CASP3,APP,G2E3,FAS,NRAS,VAV2,BIRC6,NFKB1,TRIO,IL6,MYC,THBS1,TRAF7,	2.17E-4
GO:0008219	cell death	CASP9,CASP8,HRAS,E2F1,F2R,KRAS,FKBP8,BNIP3L,TAF9B,IGF2,RAD21,BCL2L11,BCL2,ERN1,MAP3K1,ITM2B,CASP3,E2F2,APP,G2E3,FAS,VAV2,NRAS,BIRC6,NFKB1,IL6,TRIO,MYC,THBS1,TRAF7,	2.77E-4
GO:0016265	death	CASP9,CASP8,HRAS,E2F1,F2R,KRAS,FKBP8,BNIP3L,TAF9B,IGF2,RAD21,BCL2L11,BCL2,ERN1,MAP3K1,ITM2B,CASP3,E2F2,APP,G2E3,FAS,VAV2,NRAS,BIRC6,NFKB1,IL6,TRIO,MYC,THBS1,TRAF7,	3.06E-4
GO:0035195	gene silencing by miRNA	EIF2C2,DICER1,EIF2C1,EIF2C4,LIN28A,	3.09E-4
GO:0032583	regulation of gene-specific transcription	TAF9B,HDAC5,IGF2,BCOR,MAP3K1,VDR,NOTCH1,PEX14,NFKB1,BPTF,IL6,	3.73E-4
GO:0065003	macromolecular complex assembly	HRAS,CASP8,IPO7,H1F0,SF3A1,RRM2,ADSL,HIST1H1D,TAF9B,HIST1H4D,DICER1,SMARCAD1,HIST2H2BE,SFSWAP,MAP3K1,NCBP1,PEX14,HMGA1,TRIM5,E2F2,FAS,NDUFAF3,HIST2H2BF,TAF5,CD2AP,SNRPC,GTF2I,MYC,	4.10E-4
GO:0006417	regulation of translation	QKI,GCN1L1,ZFP36L1,EIF2C2,NCBP1,EIF2C1,RPS4X,EIF2C4,IL6,THBS1,APP,	4.45E-4
GO:0042127	regulation of cell proliferation	HRAS,F2R,EGFR,NOTCH1,CDC7,KRAS,CDKN1A,CD276,RPS15A,IGF2,OPRM1,VDR,CCND1,BCL2,CAMK2D,RBFOX2,SESN1,WDR6,CASP3,CDK6,CDC25B,NRAS,NF2,BIRC6,CCND2,RPS4X,IL6,CNBP,MYC,THBS1,POU3F2,	5.64E-4
GO:0032268	regulation of cellular protein metabolic process	QKI,CCND1,GCN1L1,ZFP36L1,BCL2,EIF2C2,MAP3K1,EGFR,EIF2C1,NCBP1,ITGB3,SOCS1,EIF2C4,PSMA2,APP,IGF2,NF2,CCND2,RPS4X,NFKB1,IL6,THBS1,	6.13E-4
GO:0030334	regulation of cell migration	HDAC5,IGF2,BCL2,MAP3K1,F2R,EGFR,NF2,PTP4A1,ITGB3,IL6,PIK3R1,THBS1,	6.20E-4
GO:0001776	leukocyte homeostasis	FAS,CCNB2,BCL2,BCL2L11,IL6,CASP3,	7.16E-4
GO:0016441	posttranscriptional gene silencing	EIF2C2,DICER1,EIF2C1,EIF2C4,LIN28A,	7.30E-4
GO:0043029	T cell homeostasis	FAS,CCNB2,BCL2,BCL2L11,CASP3,	7.30E-4
GO:0035194	posttranscriptional gene silencing by RNA	EIF2C2,DICER1,EIF2C1,EIF2C4,LIN28A,	7.30E-4
GO:0051174	regulation of phosphorus metabolic process	CCND1,BCL2,ERN1,F2R,MAP3K1,EGFR,KRAS,SMG7,SOCS1,CDKN1A,CASP3,APP,IGF2,CDC25B,VAV2,SNX6,NF2,CCND2,CCNG1,IL6,THBS1,TRAF7,	8.12E-4
GO:0019220	regulation of phosphate metabolic process	CCND1,BCL2,ERN1,F2R,MAP3K1,EGFR,KRAS,SMG7,SOCS1,CDKN1A,CASP3,APP,IGF2,CDC25B,VAV2,SNX6,NF2,CCND2,CCNG1,IL6,THBS1,TRAF7,	8.12E-4
GO:0051276	chromosome organization	EZH2,HIST2H2BE,BCOR,H1F0,TAF5L,HMGA2,HMGA1,SETD7,HIST1H1D,HDAC5,HUWE1,BAZ2A,HIST1H4D,NIPBL,HIST2H2BF,TAF5,SMARCAD1,KDM6B,BAZ1B,BPTF,TRRAP,HMGN2,	8.12E-4
GO:0042775	mitochondrial ATP synthesis coupled electron transport	ATP6,ND2,ND1,COX2,COX1,ND5,NDUFS2,	8.73E-4
GO:0016458	gene silencing	HDAC5,BAZ2A,EIF2C2,DICER1,EIF2C1,EIF2C4,LIN28A,	8.73E-4
GO:0042773	ATP synthesis coupled electron transport	ATP6,ND2,ND1,COX2,COX1,ND5,NDUFS2,	8.73E-4
GO:0008633	activation of pro-apoptotic gene products	FAS,CASP8,BCL2,BCL2L11,MYC,	8.78E-4
GO:0048872	homeostasis of number of cells	RPS24,FAS,CCNB2,BCL2,F2R,BCL2L11,SP1,IL6,CASP3,	9.08E-4
GO:0043549	regulation of kinase activity	CCND1,ERN1,F2R,MAP3K1,EGFR,KRAS,CDKN1A,CASP3,APP,CDC25B,IGF2,VAV2,SNX6,NF2,CCND2,CCNG1,THBS1,TRAF7,	9.14E-4
GO:0051301	cell division	CCND1,SKA3,HOXB4,CNTRL,NOTCH1,CDC7,HMGA2,CDK6,CDC25B,CCNB2,CD2AP,CCND2,RAD21,CCNG1,ASPM,POU3F2,	9.43E-4
GO:0043933	macromolecular complex subunit organization	HRAS,CASP8,IPO7,H1F0,SF3A1,RRM2,ADSL,HIST1H1D,TAF9B,HIST1H4D,DICER1,SMARCAD1,HIST2H2BE,SFSWAP,MAP3K1,NCBP1,PEX14,HMGA1,TRIM5,E2F2,FAS,NDUFAF3,HIST2H2BF,TAF5,CD2AP,SNRPC,GTF2I,MYC,	1.10E-2
GO:0006793	phosphorus metabolic process	CSNK2A1,F2R,EGFR,CDC7,ND5,PPP2R2A,ND2,ND1,COX2,COX1,PTP4A1,CCND1,BMPR1B,BCL2,MAPK11,ERN1,MAP3K1,CAMK2D,ACVR1B,SPTBN1,NDUFS2,APP,ATP6,CDK6,CDC25B,ILKAP,CTDP1,SIK1,BAZ1B,RIOK3,SLC20A1,ATP6V1B2,TRIO,PIK3R1,THBS1,	1.12E-2
GO:0006796	phosphate metabolic process	CSNK2A1,F2R,EGFR,CDC7,ND5,PPP2R2A,ND2,ND1,COX2,COX1,PTP4A1,CCND1,BMPR1B,BCL2,MAPK11,ERN1,MAP3K1,CAMK2D,ACVR1B,SPTBN1,NDUFS2,APP,ATP6,CDK6,CDC25B,ILKAP,CTDP1,SIK1,BAZ1B,RIOK3,SLC20A1,ATP6V1B2,TRIO,PIK3R1,THBS1,	1.12E-2
GO:0042325	regulation of phosphorylation	CCND1,BCL2,ERN1,F2R,MAP3K1,EGFR,KRAS,SOCS1,CDKN1A,CASP3,APP,IGF2,CDC25B,VAV2,SNX6,NF2,CCND2,CCNG1,IL6,THBS1,TRAF7,	1.20E-2
GO:0051338	regulation of transferase activity	CCND1,ERN1,F2R,MAP3K1,EGFR,KRAS,CDKN1A,CASP3,APP,CDC25B,IGF2,VAV2,SNX6,NF2,CCND2,CCNG1,THBS1,TRAF7,	1.43E-2
GO:0032768	regulation of monooxygenase activity	IGF2,VDR,EGFR,KRAS,NFKB1,	1.44E-2
GO:0000209	protein polyubiquitination	HUWE1,G2E3,MAP3K1,UBOX5,UBE3C,	1.68E-2
GO:0045859	regulation of protein kinase activity	CCND1,ERN1,F2R,MAP3K1,EGFR,KRAS,CDKN1A,CASP3,APP,CDC25B,IGF2,SNX6,NF2,CCND2,CCNG1,THBS1,TRAF7,	1.68E-2
GO:0051252	regulation of RNA metabolic process	EZH2,AKAP17A,E2F1,BACH1,F2R,NOTCH1,RPS13,IGF2,UHRF1,MEIS1,KDM6B,HMGN2,ZFP36L1,HOXA6,PRDM1,FOXJ3,MAP3K1,NCBP1,DHX9,NFATC2IP,HSF2,NFKB1,CNBP,MYC,POU3F2,EWSR1,BCOR,HOXB4,HMGA2,FOXA1,JAZF1,ZNF746,LIN28A,TAF9B,HDAC5,ZNF555,BAZ2A,VDR,CARHSP1,GCFC1,HOXC4,NR1I2,PREB,ZNF780A,ZNF264,MED13L,PEX14,HMGA1,SP1,SETD7,E2F2,APP,SIK1,BPTF,IL6,	1.75E-2
GO:0040012	regulation of locomotion	HDAC5,IGF2,BCL2,MAP3K1,F2R,EGFR,NF2,PTP4A1,ITGB3,IL6,PIK3R1,THBS1,	1.75E-2
GO:0022904	respiratory electron transport chain	ATP6,ND2,ND1,COX2,COX1,ND5,NDUFS2,	1.76E-2
GO:0051270	regulation of cell motion	HDAC5,IGF2,BCL2,MAP3K1,F2R,EGFR,NF2,PTP4A1,ITGB3,IL6,PIK3R1,THBS1,	1.82E-2
GO:0009416	response to light stimulus	CCND1,CASP9,HRAS,NRAS,BCL2,EGFR,KRAS,CDKN1A,CASP3,APP,	1.88E-2
GO:0001952	regulation of cell-matrix adhesion	CDK6,BCL2,NF2,PIK3R1,THBS1,	1.94E-2
GO:0030335	positive regulation of cell migration	IGF2,BCL2,F2R,EGFR,PTP4A1,IL6,PIK3R1,THBS1,	2.08E-2
GO:0002260	lymphocyte homeostasis	FAS,CCNB2,BCL2,BCL2L11,CASP3,	2.23E-2
GO:0035022	positive regulation of Rac protein signal transduction	HRAS,NRAS,KRAS,	2.35E-2
GO:0032582	negative regulation of gene-specific transcription	TAF9B,HDAC5,BCOR,VDR,PEX14,NFKB1,	2.67E-2
GO:0043065	positive regulation of apoptosis	CASP9,CASP8,BCL2,ERN1,MAP3K1,ACVR1B,NOTCH1,ITM2B,RPS3A,CDKN1A,BNIP3L,CASP3,APP,FAS,VAV2,VDR,BCL2L11,TRIO,MYC,	2.73E-2
GO:0043068	positive regulation of programmed cell death	CASP9,CASP8,BCL2,ERN1,MAP3K1,ACVR1B,NOTCH1,ITM2B,RPS3A,CDKN1A,BNIP3L,CASP3,APP,FAS,VAV2,VDR,BCL2L11,TRIO,MYC,	2.93E-2
GO:0016310	phosphorylation	CSNK2A1,F2R,EGFR,CDC7,ND5,ND2,ND1,COX2,COX1,CCND1,BCL2,MAPK11,BMPR1B,ERN1,MAP3K1,CAMK2D,ACVR1B,SPTBN1,NDUFS2,APP,ATP6,CDK6,SIK1,BAZ1B,RIOK3,ATP6V1B2,TRIO,PIK3R1,THBS1,	3.00E-2
GO:0010942	positive regulation of cell death	CASP9,CASP8,BCL2,ERN1,MAP3K1,ACVR1B,NOTCH1,ITM2B,RPS3A,CDKN1A,BNIP3L,CASP3,APP,FAS,VAV2,VDR,BCL2L11,TRIO,MYC,	3.09E-2
GO:0016071	mRNA metabolic process	QKI,ZFP36L1,AKAP17A,SFSWAP,EIF2C2,ERN1,EIF2C1,NCBP1,SF3A1,RBFOX2,SMG7,EIF2C4,DHX9,HNRNPUL1,APP,SNRPC,SRSF2,	3.38E-2
GO:0045333	cellular respiration	ATP6,ND2,ND1,CS,COX2,COX1,ND5,NDUFS2,	3.38E-2
GO:0045934	negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	PRDM1,E2F1,BCOR,TRIM33,HOXB4,RBFOX2,PEX14,FOXA1,JAZF1,RPS13,HDAC5,TAF9B,BAZ2A,VDR,SNX6,NF2,SIK1,KDM6B,BPTF,NFKB1,NR1I2,	3.58E-2
GO:0006119	oxidative phosphorylation	ATP6,ND2,ND1,COX2,COX1,ND5,NDUFS2,ATP6V1B2,	3.58E-2
GO:0040017	positive regulation of locomotion	IGF2,BCL2,F2R,EGFR,PTP4A1,IL6,PIK3R1,THBS1,	3.58E-2
GO:0051272	positive regulation of cell motion	IGF2,BCL2,F2R,EGFR,PTP4A1,IL6,PIK3R1,THBS1,	3.58E-2
GO:0007346	regulation of mitotic cell cycle	CCND1,IGF2,BCL2,ILKAP,CAMK2D,EGFR,SIK1,TRRAP,MYC,APP,	3.62E-2
GO:0006123	mitochondrial electron transport, cytochrome c to oxygen	ATP6,COX2,COX1,	3.86E-2
GO:0045974	regulation of translation, ncRNA-mediated	EIF2C2,EIF2C1,EIF2C4,	3.86E-2
GO:0035278	gene silencing by miRNA, negative regulation of translation	EIF2C2,EIF2C1,EIF2C4,	3.86E-2
GO:0040033	negative regulation of translation, ncRNA-mediated	EIF2C2,EIF2C1,EIF2C4,	3.86E-2
GO:0031047	gene silencing by RNA	EIF2C2,DICER1,EIF2C1,EIF2C4,LIN28A,	4.13E-2
GO:0051172	negative regulation of nitrogen compound metabolic process	PRDM1,E2F1,BCOR,TRIM33,HOXB4,RBFOX2,PEX14,FOXA1,JAZF1,RPS13,HDAC5,TAF9B,BAZ2A,VDR,SNX6,NF2,SIK1,KDM6B,BPTF,NFKB1,NR1I2,	4.16E-2
GO:0000079	regulation of cyclin-dependent protein kinase activity	CCND1,EGFR,CCND2,CDKN1A,CCNG1,CASP3,	4.48E-2
GO:0006917	induction of apoptosis	CASP8,ERN1,ACVR1B,ITM2B,RPS3A,CDKN1A,BNIP3L,CASP3,APP,FAS,VAV2,VDR,BCL2L11,TRIO,MYC,	5.36E-2
GO:0016481	negative regulation of transcription	PRDM1,E2F1,BCOR,TRIM33,HOXB4,RBFOX2,PEX14,FOXA1,JAZF1,TAF9B,HDAC5,BAZ2A,VDR,SNX6,SIK1,KDM6B,BPTF,NFKB1,NR1I2,	5.39E-2
GO:0012502	induction of programmed cell death	CASP8,ERN1,ACVR1B,ITM2B,RPS3A,CDKN1A,BNIP3L,CASP3,APP,FAS,VAV2,VDR,BCL2L11,TRIO,MYC,	5.52E-2
GO:0045787	positive regulation of cell cycle	CCND1,IGF2,RPS15A,EGFR,CCND2,APP,	5.65E-2
GO:0031054	pre-microRNA processing	EIF2C2,DICER1,LIN28A,	5.72E-2
GO:0048536	spleen development	FAS,BCL2,HOXB4,BCL2L11,	6.13E-2
GO:0009411	response to UV	CCND1,CASP9,BCL2,EGFR,CDKN1A,CASP3,	6.54E-2
GO:0051253	negative regulation of RNA metabolic process	PRDM1,E2F1,BCOR,HOXB4,PEX14,FOXA1,JAZF1,RPS13,TAF9B,HDAC5,BAZ2A,VDR,SIK1,KDM6B,NFKB1,BPTF,	6.62E-2
GO:0009967	positive regulation of signal transduction	CASP8,HRAS,F2R,ACVR1B,TMED7,KRAS,FKBP8,IGF2,NRAS,TAB2,SLC20A1,IL6,THBS1,TRAF7,	6.81E-2
GO:0010647	positive regulation of cell communication	HRAS,CASP8,F2R,EGFR,ACVR1B,TMED7,KRAS,FKBP8,IGF2,NRAS,TAB2,SLC20A1,IL6,THBS1,TRAF7,	6.83E-2
GO:0051385	response to mineralocorticoid stimulus	CCND1,BCL2,KRAS,CDKN1A,	7.11E-2
GO:0033674	positive regulation of kinase activity	CCND1,CDC25B,IGF2,VAV2,ERN1,MAP3K1,F2R,EGFR,CCND2,KRAS,THBS1,TRAF7,	7.11E-2
GO:0009314	response to radiation	CCND1,CASP9,HRAS,NRAS,BCL2,EGFR,KRAS,CDKN1A,CASP3,MYC,APP,	7.30E-2
GO:0006396	RNA processing	QKI,SFSWAP,AKAP17A,RBM6,EIF2C2,ERN1,HNRPDL,NCBP1,SF3A1,RBFOX2,RPL35A,DHX9,HNRNPUL1,NOLC1,LIN28A,APP,RPS24,INTS12,DICER1,SNRPC,SRSF2,	7.34E-2
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	PRDM1,BCOR,E2F1,HOXB4,FOXA1,JAZF1,TAF9B,HDAC5,VDR,SIK1,KDM6B,NFKB1,BPTF,	7.66E-2
GO:0006355	regulation of transcription, DNA-dependent	EZH2,AKAP17A,E2F1,BACH1,F2R,NOTCH1,IGF2,UHRF1,MEIS1,KDM6B,HMGN2,HOXA6,PRDM1,FOXJ3,MAP3K1,NFATC2IP,HSF2,NFKB1,CNBP,MYC,POU3F2,BCOR,EWSR1,HOXB4,FOXA1,JAZF1,HMGA2,ZNF746,LIN28A,TAF9B,HDAC5,BAZ2A,ZNF555,VDR,CARHSP1,GCFC1,HOXC4,NR1I2,PREB,ZNF780A,ZNF264,MED13L,PEX14,HMGA1,SP1,SETD7,E2F2,APP,SIK1,BPTF,IL6,	7.80E-2
GO:0048103	somatic stem cell division	HOXB4,NOTCH1,ASPM,	7.91E-2
GO:0051341	regulation of oxidoreductase activity	IGF2,VDR,EGFR,KRAS,NFKB1,	8.27E-2
GO:0010553	negative regulation of specific transcription from RNA polymerase II promoter	TAF9B,HDAC5,BCOR,VDR,NFKB1,	9.02E-2
GO:0051347	positive regulation of transferase activity	CCND1,CDC25B,IGF2,VAV2,ERN1,MAP3K1,F2R,EGFR,CCND2,KRAS,THBS1,TRAF7,	9.36E-2
GO:0016568	chromatin modification	EZH2,BCOR,TAF5L,SETD7,HUWE1,HDAC5,BAZ2A,TAF5,SMARCAD1,KDM6B,TRRAP,BPTF,BAZ1B,	9.58E-2
GO:0006401	RNA catabolic process	ZFP36L1,NCBP1,EIF2C1,SMG7,EIF2C4,LIN28A,	9.80E-2

KEGG pathways and Gene Ontology terms enriched for the interacted genes of ncRNA from RAID and miRTarBase.

disease name	related genes	p-value