| Detail: | |
| ncRNA Symmbol: | let-7i |
|---|---|
| ncRNA Category: | miRNA |
| Interaction Gene Symbol: | IGF1R |
| Death Pathway: | autophagy |
| Expression Direction of ncRNA: | down |
| Species: | Homo sapiens |
| Tissue: | Jurkat cells |
| PMID: | 25305490 |
| Detail Description: | Overexpression of let-7i inJurkat cells significantly suppressed IGF1R expression, which mimicked the actionof IGF1R siRNA. IGF1R inhibition led to a strinking decrease in phosphorylationof mTOR and Akt, down-regulation of Bcl-2, up-regulation of Bax and cleavage ofcaspase 3 and PARP. Meanwhile, IGF1R inhibition induced autophagy. |
The 'First Node' or 'Second Node' option represents the sub-network of interacting entry with the first or second interaction node,
the 'Both the Nodes' option represents the sub-network of interacting entry with both of interaction nodes.
The 'First Neighbour' represents the sub-network of direct interacting with the center node,
the 'Second Neighbour' represents the sub-network of direct or second step interacting with the center node.
Interaction sub-network based on the two nodes of this interaction may help the researchers represents all interacting partners immediately.
The Detail page: representing the detail information for RNA-RNA/RNA-Protein interaction;
The Binding page: representing the predicted binding sites and/or constants.
The Network page: representing the interaction sub-network of interacting RNA/Protein.