| Detail: | |
| ncRNA Symmbol: | miR-19 |
|---|---|
| ncRNA Category: | miRNA |
| Interaction Gene Symbol: | |
| Death Pathway: | apoptosis |
| Expression Direction of ncRNA: | |
| Species: | Rattus norvegicus |
| Tissue: | gliomas cell |
| PMID: | 25646654 |
| Detail Description: | The results demonstrated that Res inhibited glioma cell proliferation, arrested cell cycle in S?phase and induced apoptosis in?vitro. Res also suppressed intracranial C6 tumor growth in?vivo and prolonged survival in a fraction of the rats bearing intracranial gliomas. Res significantltly downregulated the specific miRs, including miR?21, miR?30a-5p and miR?19, which have been identified as oncomiRs in our previous studies, and altered the expression of their targeting and crucial genes for glioma formation and progression such as p53, PTEN, EGFR, STAT3, COX-2, NF-¦ÊB and PI3K/AKT/mTOR pathway. Therefore, the anti-glioma effect of Res, at least in part, is through the regulation of oncogenic miRNAs. The effect of Res on non-coding RNAs should be studied further. Res is a potential multi-targeting drug for the treatment of gliomas. |
The 'First Node' or 'Second Node' option represents the sub-network of interacting entry with the first or second interaction node,
the 'Both the Nodes' option represents the sub-network of interacting entry with both of interaction nodes.
The 'First Neighbour' represents the sub-network of direct interacting with the center node,
the 'Second Neighbour' represents the sub-network of direct or second step interacting with the center node.
Interaction sub-network based on the two nodes of this interaction may help the researchers represents all interacting partners immediately.
The Detail page: representing the detail information for RNA-RNA/RNA-Protein interaction;
The Binding page: representing the predicted binding sites and/or constants.
The Network page: representing the interaction sub-network of interacting RNA/Protein.