Detail: | |
ncRNA Symmbol: | miR-17 |
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ncRNA Category: | miRNA |
Interaction Gene Symbol: | Sqstm1 |
Death Pathway: | autophagy |
Expression Direction of ncRNA: | down |
Species: | Mus musculus |
Tissue: | myeloid progenitors |
PMID: | 21628417 |
Detail Description: | Here, we show that ectopic expression o miR-17, -20,-93 and -106, all AAAGUGC seed-containing miRNAs, increases proliferation, colony outgrowth and replating capacity of myeloid progenitors an results in enhanced P-ERK levels. Quantitative proteomics identified sequestosome 1 (SQSTM1), an ubiquitin-binding protein and regulator of autophagy mediated protein degradation, as a major target for these miRNAs in myeloid progenitors. |
The 'First Node' or 'Second Node' option represents the sub-network of interacting entry with the first or second interaction node,
the 'Both the Nodes' option represents the sub-network of interacting entry with both of interaction nodes.
The 'First Neighbour' represents the sub-network of direct interacting with the center node,
the 'Second Neighbour' represents the sub-network of direct or second step interacting with the center node.
Interaction sub-network based on the two nodes of this interaction may help the researchers represents all interacting partners immediately.
The Detail page: representing the detail information for RNA-RNA/RNA-Protein interaction;
The Binding page: representing the predicted binding sites and/or constants.
The Network page: representing the interaction sub-network of interacting RNA/Protein.