Basic information:

Untranslated mRNA: Sponge mRNA

Related IDs	cncRNA ID	CNC_M_001586
	Name	FOXO1
	Gene ID	2308
Location	Coordinate(Strand)	13:40555667-40666641(-)
Locus Sequence
Organism	Homo sapiens

Evidence support:

  

In vivo/vitro assay	In vitro assay
Low-throughput method	Transfection assay;Western blotting;qRT-PCR;Luciferase assay;Wound healing assay;Transwell migration assay;Adhesion assay;Immunofluorescence assay
High-throughput method	/
Tissue/Cell	MCF-7 cell;MDA-MB-231 cell;MDA-MB-453 cell;SKBR3 cell;MCF-10A cell
Description of experimental evidence	The mRNA was detected by transfection assay, western blotting, qRT-PCR, luciferase assay, wound healing assay, transwell migration assay, Adhesion assay, Immunofluorescence assay in MCF-7 cell, MDA-MB-231 cell, MDA-MB-453 cell, SKBR3 cell, MCF-10A cell, which can repress the metastases of breast cancer cells by binding miR-139-5p, acting as a decoy for E-cadherin-targeting microRNAs.

Orthologues:

  

Chimpanzee	ENSPTRG00000005806
Mouse	ENSMUSG00000044167
Drosophila	/
Zebrafish	ENSDARG00000061549   ENSDARG00000099555

References:

  

PMID	25017439
Description	FOXO1 3'UTR functions as a ceRNA in repressing the metastases of breast cancer cells via regulating miRNA activity.

Related Subcelluar Localization:

  

Subcelluar Localization	RLID	Link to RNALocate
membrane	RLID00066059	Link to RNALocate
nucleus	RLID00066060	Link to RNALocate
nucleus	RLID00066061	Link to RNALocate
exosome	RLID00066062	Link to RNALocate
Cytosol	RLID00006862	Link to RNALocate
Ribosome	RLID00006863	Link to RNALocate

Related Diseases:

  

OMIM Phenotype	Phenotype MIM number	Link to OMIM
Rhabdomyosarcoma, alveolar	OMIM:268220	Link to OMIM

Related Interactions:

  

  

   Notes: You can browse the related interactions in RNAinter by click the above link (since the interaction entries are too much to show here).