Detail Information

Basic Information:


  VIRBase ID:  

VHID00517852

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:           TRIM59:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hcmv-miR-US25-1-5p TRIM59
miRBase
Accession/Entrez ID		 MIMAT0001581 286827
Organism Human herpesvirus 5 strain AD169 Homo sapiens
Category miRNA mRNA
Alias - IFT80L//MRF1//RNF104//TRIM57//TSBF1

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR TRIM59
chr3:160161625(-) A-I      intronic
chr3:160163877(-) A-I      intronic
chr3:160153071(-) A-I      3'UTR
chr3:160161618(-) A-I      intronic
chr3:160161642(-) A-I      intronic
chr3:160161605(-) A-I      intronic
chr3:160160758(-) A-I      intronic
chr3:160163046(-) A-I      intronic
chr3:160154393(-) A-I      3'UTR
chr3:160163204(-) A-I      intronic
chr3:160163691(-) A-I      intronic
chr3:160163318(-) A-I      intronic
chr3:160153110(-) A-I      3'UTR
chr3:160154419(-) A-I      3'UTR
chr3:160154937(-) A-I      3'UTR
chr3:160153124(-) A-I      3'UTR
chr3:160153026(-) A-I      3'UTR
chr3:160153164(-) A-I      3'UTR
chr3:160153038(-) A-I      3'UTR
chr3:160153138(-) A-I      3'UTR
chr3:160153166(-) A-I      3'UTR
chr3:160153032(-) A-I      3'UTR
chr3:160154314(-) A-I      3'UTR
chr3:160155016(-) A-I      3'UTR
chr3:160160207(-) A-I      intronic
chr3:160163203(-) A-I      intronic
chr3:160163871(-) A-I      intronic
chr3:160163164(-) A-I      intronic
chr3:160163800(-) A-I      intronic
chr3:160161525(-) A-I      intronic
chr3:160163479(-) A-I      intronic
chr3:160163662(-) A-I      intronic
chr3:160161623(-) A-I      intronic
chr3:160163690(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED TRIM59
chr3:160154332(-) T-C exon 3'UTR    22484847
chr3:160154360(-) C-T exon 3'UTR    22484847
chr3:160154937(-) A-G exon 3'UTR    22484847
chr3:160154941(-) T-C exon 3'UTR    22484847
chr3:160154955(-) A-G exon 3'UTR    22484847
chr3:160161592(-) A-G intron -    22484847
chr3:160161623(-) A-G intron -    22484847
chr3:160161635(-) T-C intron -    22484847
chr3:160163121(-) A-G intron -    22484847
chr3:160163204(-) A-G intron -    22484847
chr3:160163479(-) A-G intron -    22484847
chr3:160163540(-) A-C intron -    22484847
chr3:160163870(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase TRIM59
chr3:160150879-160150880(-) m6A 3'UTR       27773535
chr3:160150973-160150974(-) m6A 3'UTR       27773535
chr3:160151433-160151434(-) m6A 3'UTR       24981863//27773535//22608085
chr3:160151465-160151466(-) m6A 3'UTR       24981863//27773535//22608085
chr3:160151495-160151496(-) m6A 3'UTR       24981863//27773535//22575960//22608085
chr3:160152260-160152261(-) m6A 3'UTR       27773535
chr3:160152292-160152293(-) m6A 3'UTR       27773535
chr3:160152554-160152555(-) m6A 3'UTR       27773535
chr3:160152615-160152616(-) m6A 3'UTR       27773535
chr3:160152638-160152639(-) m6A 3'UTR       27773535
chr3:160152664-160152665(-) m6A 3'UTR       27773535
chr3:160155979-160155980(-) m6A CDS//intron       25456834//24981863//27773535//22608085
chr3:160156086-160156087(-) m6A CDS       24209618//24981863//28052920//27773535//22608085
chr3:160156097-160156098(-) m6A CDS       24209618//24981863//28052920//27773535//22608085
chr3:160156170-160156171(-) m6A CDS       24209618//24981863//28052920//27773535//22608085
chr3:160156176-160156177(-) m6A CDS       24209618//24981863//28052920//27773535//22608085
chr3:160156380-160156381(-) m6A CDS       24209618//24981863//27773535//22608085
chr3:160156464-160156465(-) m6A CDS       24209618//25456834//24981863//27773535//27371828//22608085
chr3:160156499-160156500(-) m6A CDS       24209618//25456834//24981863//27773535//27371828//22608085
chr3:160156521-160156522(-) m6A CDS       24209618//25456834//24981863//27773535//27371828//22608085
chr3:160156530-160156531(-) m6A CDS       24209618//25456834//24981863//27773535//27371828//22608085
chr3:160156543-160156544(-) m6A CDS       24209618//25456834//24981863//27773535//27371828//22608085
chr3:160156674-160156675(-) m6A CDS       24209618//24981863//27773535//22608085
chr3:160156702-160156703(-) m6A CDS       24209618//24981863//27773535//22608085
chr3:160156827-160156828(-) m6A CDS       24209618//24981863//27773535//22608085
chr3:160156864-160156865(-) m6A CDS       24209618//24981863//27773535//22608085
chr3:160165540-160165541(-) m6A 5'UTR//intron       24981863//22608085
chr3:160166529-160166530(-) m6A 5'UTR//CDS//intron       24209618//24981863//22608085
chr3:160166659-160166660(-) m6A 5'UTR//intron       24981863
chr3:160166693-160166694(-) m6A 5'UTR//intron       24981863
chr3:160167589-160167590(-) m6A 5'UTR//intron       24981863

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate TRIM59
Chromatin K562 cells     -
Cytoplasm Nasopharyngeal carcinoma cells     20498841
Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Nucleoplasm K562 cells     -
Nucleus Nasopharyngeal carcinoma cells     20498841
Nucleus HeLa-S3 cells     -
Ribosome-free cytosol Colon cancer cells     24393600

Interaction Network (The top 100 interactions):


Interactor1: hcmv-miR-US25-1-5p
Interactor2: TRIM59

Evidence Support:


Strong-Evidence RISC-IP
Support Database ViRBase

References:


PMID 20585629 Target region 5'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line HEK293 cells Interactor2 expression None
Description Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.

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