Basic Information:

  VIRBase ID:  

VHID00503762

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          IL6:  NM_001318095     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	IL6
miRBase Accession/Entrez ID	MIMAT0001581	3569
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	BSF-2//BSF2//CDF//HGF//HSF//IFN-beta-2//IFNB2//IL-6

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	IL6	chr7:22770700(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	IL6	chr7:22766885-22766886(+) m6A 5'UTR//CDS//exon       - chr7:22766928-22766929(+) m6A exon//intron       -

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	IL6	Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Serum     - Nucleus HeLa-S3 cells     - Polysome HeLa cells     26000482

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: IL6

Evidence Support:

Strong-Evidence	RISC-IP
Support Database	ViRBase

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.