Basic Information:

  VIRBase ID:  

VHID00501990

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7903

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          CAPN1:  NR_040008     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	CAPN1
miRBase Accession/Entrez ID	MIMAT0001581	823
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	CANP//CANP1//CANPL1//muCANP//muCL//SPG76

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	CAPN1	chr11:64959543(+) A-I      intronic chr11:64959552(+) A-I      intronic chr11:64959553(+) A-I      intronic chr11:64965205(+) A-I      intronic chr11:64965219(+) A-I      intronic chr11:64959579(+) A-I      intronic chr11:64956553(+) A-I      intronic chr11:64965206(+) A-I      intronic chr11:64965681(+) A-I      intronic chr11:64959523(+) A-I      intronic chr11:64959527(+) A-I      intronic chr11:64967726(+) A-I      intronic chr11:64959542(+) A-I      intronic chr11:64967916(+) A-I      intronic chr11:64962751(+) A-I      intronic chr11:64959033(+) A-I      intronic chr11:64967919(+) A-I      intronic chr11:64965172(+) A-I      intronic chr11:64967981(+) A-I      intronic chr11:64969935(+) A-I      intronic chr11:64961272(+) A-I      intronic chr11:64955243(+) A-I      intronic chr11:64960278(+) A-I      intronic chr11:64970017(+) A-I      intronic chr11:64965228(+) A-I      intronic chr11:64960908(+) A-I      intronic chr11:64970018(+) A-I      intronic chr11:64965238(+) A-I      intronic chr11:64965244(+) A-I      intronic chr11:64970761(+) A-I      intronic chr11:64965265(+) A-I      intronic chr11:64965202(+) A-I      intronic chr11:64961513(+) A-I      intronic chr11:64960928(+) A-I      intronic chr11:64959611(+) A-I      intronic chr11:64965846(+) A-I      intronic chr11:64965193(+) A-I      intronic chr11:64959559(+) A-I      intronic chr11:64958301(+) A-I      intronic chr11:64959626(+) A-I      intronic chr11:64960939(+) A-I      intronic chr11:64965251(+) A-I      intronic chr11:64974770(+) A-I      intronic chr11:64961337(+) A-I      intronic chr11:64961326(+) A-I      intronic chr11:64962680(+) A-I      intronic chr11:64965280(+) A-I      intronic chr11:64960985(+) A-I      intronic chr11:64965162(+) A-I      intronic chr11:64965304(+) A-I      intronic chr11:64960979(+) A-I      intronic chr11:64967600(+) A-I      intronic chr11:64965274(+) A-I      intronic chr11:64959547(+) A-I      intronic chr11:64967633(+) A-I      intronic chr11:64967660(+) A-I      intronic chr11:64956624(+) A-I      intronic chr11:64958929(+) A-I      intronic chr11:64958919(+) A-I      intronic chr11:64967780(+) A-I      intronic chr11:64965086(+) A-I      intronic chr11:64958381(+) A-I      intronic chr11:64968181(+) A-I      intronic chr11:64962650(+) A-I      intronic chr11:64958367(+) A-I      intronic chr11:64965279(+) A-I      intronic chr11:64956621(+) A-I      intronic chr11:64975226(+) A-I      intronic chr11:64956594(+) A-I      intronic chr11:64961622(+) A-I      intronic chr11:64961563(+) A-I      intronic chr11:64958930(+) A-I      intronic chr11:64962617(+) A-I      intronic chr11:64961569(+) A-I      intronic chr11:64961533(+) A-I      intronic chr11:64961668(+) A-I      intronic chr11:64959567(+) A-I      intronic chr11:64965102(+) A-I      intronic chr11:64962752(+) A-I      intronic chr11:64960929(+) A-I      intronic chr11:64961282(+) A-I      intronic chr11:64968545(+) A-I      intronic chr11:64959591(+) A-I      intronic chr11:64965309(+) A-I      intronic chr11:64961619(+) A-I      intronic chr11:64961537(+) A-I      intronic chr11:64965724(+) A-I      intronic chr11:64974788(+) A-I      intronic chr11:64959577(+) A-I      intronic chr11:64975305(+) A-I      intronic chr11:64961204(+) A-I      intronic chr11:64956595(+) A-I      intronic chr11:64965171(+) A-I      intronic chr11:64961048(+) A-I      intronic chr11:64974745(+) A-I      intronic chr11:64965198(+) A-I      intronic chr11:64959585(+) A-I      intronic chr11:64975264(+) A-I      intronic chr11:64967590(+) A-I      intronic chr11:64965801(+) A-I      intronic chr11:64961469(+) A-I      intronic chr11:64965211(+) A-I      intronic chr11:64959540(+) A-I      intronic chr11:64960969(+) A-I      intronic chr11:64959651(+) A-I      intronic chr11:64965891(+) A-I      intronic chr11:64969433(+) A-I      intronic chr11:64961578(+) A-I      intronic chr11:64965823(+) A-I      intronic chr11:64966264(+) A-I      intronic chr11:64958927(+) A-I      intronic chr11:64965885(+) A-I      intronic chr11:64961519(+) A-I      intronic chr11:64965151(+) A-I      intronic chr11:64966486(+) A-I      intronic chr11:64961559(+) A-I      intronic chr11:64961327(+) A-I      intronic chr11:64959599(+) A-I      intronic chr11:64960933(+) A-I      intronic chr11:64958364(+) A-I      intronic chr11:64967650(+) A-I      intronic chr11:64961001(+) A-I      intronic chr11:64958349(+) A-I      intronic chr11:64974735(+) A-I      intronic chr11:64962760(+) A-I      intronic chr11:64965781(+) A-I      intronic chr11:64958313(+) A-I      intronic chr11:64965257(+) A-I      intronic chr11:64974851(+) A-I      intronic chr11:64959645(+) A-I      intronic chr11:64961562(+) A-I      intronic chr11:64958323(+) A-I      intronic chr11:64959575(+) A-I      intronic chr11:64958924(+) A-I      intronic chr11:64965239(+) A-I      intronic chr11:64967944(+) A-I      intronic chr11:64961639(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	CAPN1	chr11:64959575(+) A-G intron -    22484847 chr11:64959577(+) A-G intron -    22484847 chr11:64959591(+) A-G intron -    22484847 chr11:64961469(+) A-G intron -    22484847 chr11:64961563(+) A-G intron -    22484847 chr11:64962751(+) A-G intron -    22484847 chr11:64962760(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	CAPN1	chr11:64948689-64948690(+) m6A 5'UTR//intron       27773536 chr11:64949177-64949178(+) m6A 5'UTR//intron       24981863 chr11:64949248-64949249(+) m6A 5'UTR//intron       24981863 chr11:64949274-64949275(+) m6A 5'UTR//exon//intron       24284625//25456834//24981863 chr11:64949452-64949453(+) m6A 5'UTR//exon//intron       25456834//24981863 chr11:64949469-64949470(+) m6A 5'UTR//exon//intron       25456834//24981863 chr11:64949970-64949971(+) m6A 5'UTR//intron       25456834 chr11:64950022-64950023(+) m6A 5'UTR//intron       25456834 chr11:64950058-64950059(+) m6A 5'UTR//intron       25456834 chr11:64950362-64950363(+) Y CDS//exon//intron       26075521 chr11:64955429-64955430(+) m6A 3'UTR//CDS//exon       24209618 chr11:64955468-64955469(+) m6A 3'UTR//CDS//exon       24209618 chr11:64955718-64955719(+) m6A exon//intron       24209618 chr11:64955733-64955734(+) m6A exon//intron       24209618 chr11:64955752-64955753(+) m6A exon//intron       24209618 chr11:64955801-64955802(+) m6A exon//intron       24209618 chr11:64955815-64955816(+) m6A exon//intron       24209618 chr11:64955828-64955829(+) m6A exon//intron       - chr11:64955898-64955899(+) m6A CDS//exon       - chr11:64955907-64955908(+) m6A CDS//exon       - chr11:64955922-64955923(+) m6A CDS//exon       - chr11:64956070-64956071(+) m6A CDS//exon       - chr11:64956135-64956136(+) m6A CDS//exon       - chr11:64956151-64956152(+) m6A CDS//exon       - chr11:64956208-64956209(+) m6A CDS//exon       - chr11:64970851-64970852(+) m6A exon//intron       - chr11:64972168-64972169(+) m6A CDS//exon       - chr11:64972222-64972223(+) m6A CDS//exon       - chr11:64973952-64973953(+) Y CDS//exon       26075521 chr11:64975556-64975557(+) m6A CDS//exon       - chr11:64975705-64975706(+) m6A CDS//exon       - chr11:64978764-64978765(+) m6A 3'UTR//exon       24284625//24209618//24981863 chr11:64978934-64978935(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr11:64978976-64978977(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr11:64979038-64979039(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr11:64979130-64979131(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//22608085 chr11:64979137-64979138(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//22608085 chr11:64979356-64979357(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//27773535//22608085 chr11:64979367-64979368(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//27773535//22608085 chr11:64979441-64979442(+) m6A 3'UTR//exon       24284625//25456834//24981863//27773535//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	CAPN1	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol K562 cells     - Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HeLa-S3 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: CAPN1

Evidence Support:

Strong-Evidence	RISC-IP
Prediction-Evidence	miRanda//RNAHybrid
Support Database	ViRBase//VmiReg

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase//VmiReg	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.