Detail Information

Basic Information:


  VIRBase ID:  

VHID00501188

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:           MEG3:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hcmv-miR-US25-1-5p MEG3
miRBase
Accession/Entrez ID		 MIMAT0001581 55384
Organism Human herpesvirus 5 strain AD169 Homo sapiens
Category miRNA lncRNA
Alias - FP504//GTL2//LINC00023//NCRNA00023//onco-lncRNA-83//prebp1//PRO0518//PRO2160

RNA Editing:


Resource Symbol Editing Position
Lncediting MEG3
    chr14: 101319315
    chr14: 101319442
    chr14: 101312645
    chr14: 101312647
    chr14: 101317814
    chr14: 101318742
    chr14: 101317779
    chr14: 101317798
    chr14: 101316955
    chr14: 101316953
    chr14: 101316952
    chr14: 101316222
    chr14: 101316958
    chr14: 101317570
    chr14: 101317841
    chr14: 101318040
    chr14: 101318393
Resource Symbol Editing Position Change Genetic Region
RADAR MEG3
chr14:101312645(+) A-I      ncRNA
chr14:101312647(+) A-I      ncRNA
chr14:101320975(+) A-I      intronic
chr14:101316952(+) A-I      intronic
chr14:101317570(+) A-I      intronic
chr14:101317779(+) A-I      intronic
chr14:101317798(+) A-I      intronic
chr14:101316953(+) A-I      intronic
chr14:101320992(+) A-I      intronic
chr14:101318393(+) A-I      intronic
chr14:101319315(+) A-I      intronic
chr14:101316955(+) A-I      intronic
chr14:101316958(+) A-I      intronic
chr14:101317814(+) A-I      intronic
chr14:101317841(+) A-I      intronic
chr14:101318040(+) A-I      intronic
chr14:101319442(+) A-I      intronic
chr14:101320973(+) A-I      intronic
chr14:101316222(+) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED MEG3
chr14:101312645(+) A-I intron -    19478186
chr14:101312647(+) A-I intron -    19478186
chr14:101318040(+) A-I intron -    19478186
chr14:101323109(+) A-I intron -    19478186

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase MEG3
chr14:101293768-101293769(+) m6A exon//intron       -
chr14:101293779-101293780(+) m6A exon//intron       -
chr14:101295437-101295438(+) m6A exon       24981863
chr14:101295462-101295463(+) m6A exon       24981863
chr14:101295468-101295469(+) m6A exon       24981863
chr14:101295500-101295501(+) m6A exon       24981863
chr14:101295506-101295507(+) m6A exon       24981863
chr14:101298366-101298367(+) m6A exon//intron       24981863
chr14:101298413-101298414(+) m6A exon//intron       24981863
chr14:101298434-101298435(+) m6A exon//intron       24981863
chr14:101298440-101298441(+) m6A exon//intron       24981863
chr14:101298449-101298450(+) m6A exon//intron       24981863
chr14:101298473-101298474(+) m6A exon//intron       24981863
chr14:101298501-101298502(+) m6A exon//intron       24981863
chr14:101312217-101312218(+) m6A exon//intron       -
chr14:101312286-101312287(+) m6A exon//intron       -
chr14:101312392-101312393(+) m6A exon//intron       -
chr14:101312419-101312420(+) m6A exon//intron       -
chr14:101312425-101312426(+) m6A exon//intron       -
chr14:101312499-101312500(+) m6A exon//intron       -
chr14:101312523-101312524(+) m6A exon//intron       -
chr14:101315936-101315937(+) m6A exon//intron       24981863
chr14:101315969-101315970(+) m6A exon//intron       24981863
chr14:101326624-101326625(+) m6A exon//intron       -
chr14:101326641-101326642(+) m6A exon//intron       -
chr14:101327044-101327045(+) m6A exon//intron       25456834//24981863
chr14:101327068-101327069(+) m6A exon//intron       25456834//24981863
chr14:101327077-101327078(+) m6A exon//intron       25456834//24981863
chr14:101327085-101327086(+) m6A exon       25456834//24981863
chr14:101327092-101327093(+) m6A exon       25456834//24981863
chr14:101327117-101327118(+) m6A exon       25456834//24981863
chr14:101327158-101327159(+) m6A exon       25456834//24981863
chr14:101327171-101327172(+) m6A exon       25456834//24981863
chr14:101327192-101327193(+) m6A exon       25456834//24981863

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate MEG3
Cytoplasm Hepatoma cells     21625215
Cytoplasm Human lens epithelial cells (SRA01/04)     32841649
Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539
Exosome Serum     -
Nucleus Cell line (BT-549)     26205790
Nucleus HeLa cells     31107149
Nucleus Cell lines (GM12878|HeLaS3|HepG2)|Human umbilical vein endothelial cells     22955988
Nucleus Lung fibroblasts     25630241
Nucleus Human lens epithelial cells (SRA01/04)     32841649

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR MEG3
cis-Diaminedichloroplatinum 2767 Drug sensitive
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter MEG3
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00000012
Resource Symbol Drug Name PubChem ID
RNAactDrug MEG3
6-Amino-N-[3-[4-(4-morpholinyl)pyrido[3',2':4,5]furo[3,2-d]pyrimidin-2-yl]phenyl]-3-pyridinecarboxamide       9956222
6-((2-((4-(2,4-Dichlorophenyl)-5-(4-methyl-1H-imidazol-2-yl)pyrimidin-2-yl)amino)ethyl)amino)nicotinonitrile       9956119
Benzamide, N-[4-[2-ethyl-4-(3-methylphenyl)-5-thiazolyl]-2-pyridinyl]-       9952773
5-(5-(7-(Trifluoromethyl)quinolin-4-ylthio)pentyloxy)-2-(morpholinomethyl)-4H-pyran-4-one dihydrochloride       9938202
Tivozanib       9911830
5-(4-Fluorophenyl)-2-ureidothiophene-3-carboxamide       9903786
5Z-7-Oxozeaenol       9863776
2-(4-(Benzo[d][1,3]dioxol-5-yl)-2-tert-butyl-1H-imidazol-5-yl)-6-methylpyridine       9858940
N-[(2R)-2,3-Dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzamide       9826528
9H-Purine, 6-(ethylthio)-9-beta-D-ribofuranosyl-(8CI)(9CI)       95846
6-Benzylthioinosine       95263
Benzethonium chloride       8478
3,6-Acridinediamine, 2,7,9-trimethyl-, monohydrochloride       72769
N-(3-Methylphenyl)-4-pyridin-4-yl-1,3-thiazol-2-amine       704473
(S)-N-Hydroxy-4-(3-methyl-2-phenylbutanamido)benzamide       6918848
Belinostat       6918638
2-(2-Chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide       6918454
Temsirolimus       6918289
Daporinad       6914657
N-(5-(4-Chloro-3-(N-(2-hydroxyethyl)sulfamoyl)phenyl)-4-methylthiazol-2-yl)acetamide       6852167
Tanespimycin       6505803
Ispinesib mesylate       6450816
Axitinib       6450551
Pelitinib       6445562
4-(N-Hydroxyacetamido)stilbene       6433723
Cytarabine       6253
Primaquine phosphate       6135
3-(2-Phenyl-5-pyridin-4-yl-1H-imidazol-4-yl)phenol;hydrochloride       57399804
5-[2-[4-(Aminomethyl)phenyl]-5-pyridin-4-yl-1H-imidazol-4-yl]-2-chlorophenol;hydrochloride       57399803
Phyllanthastatin 1       5477587
Viridenomycin       54686463
2-(1-Benzyl-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxamido)acetic acid       54685215
Lfm-a13       54676905
Mito-tempol       54613387
Permethyl deriv. of cristatic acid       5458762
Rubremetinium chloride       5351504
N-[4-[(4-Ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-4-methyl-3-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)benzamide       53340664
Palbociclib       5330286
N-[4-[(4-Ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-3-[(E)-2-(4-methoxy-1H-pyrrolo[2,3-b]pyridin-5-yl)ethenyl]-4-methylbenzamide       53302361
Bosutinib       5328940
Vorinostat       5311
Isotretinoin       5282379
2-Morpholino-6-(thianthren-1-yl)-4H-pyran-4-one       5278396
Bis(2-hydroxy-1-naphthyl) disulfide       521106
6-Chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide       5113032
Tubastatin A       49850262
2-(2-Amino-3-methoxyphenyl)-4H-1-benzopyran-4-one       4713
2-[(4s)-6-(4-Chlorophenyl)-8-Methoxy-1-Methyl-4h-[1,2,4]triazolo[4,3-A][1,4]benzodiazepin-4-Yl]-N-Ethylacetamide       46943432
3-(4-(4-(2-(3-((Dimethylamino)methyl)phenyl)-1H-pyrrolo[2,3-b]pyridin-4-yl)-1-ethyl-1H-pyrazol-3-yl)phenyl)-1,1-dimethylurea       46885626
N-(6,6-Dimethyl-5-(1-methylpiperidine-4-carbonyl)-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazol-3-yl)-3-methylbutanamide       46191454
N-(2,2,2-Trifluoroethyl)-N-{4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl}benzenesulfonamide       447912
Tretinoin       444795
Dabrafenib       44462760
4-[1-(4-Aminomethyl-phenyl)-1H-imidazo[4,5-c]pyridin-2-yl]-furazan-3-ylamine       44397453
Refametinib       44182295
Foretinib       42642645
Benzofurazan, 4-(4-methyl-1-piperazinyl)-7-nitro-, 3-oxide       42640
Vemurafenib       42611257
1,6-Bis[4-(4-aminophenoxy)phenyl]diamantane       397904
1-(2-(Hydroxymethyl)-1,3-dioxolan-4-yl)cytosine       381525
2-Chloro-3-(3-(N-morpholino)propylamino)-naphthazarine       379081
3,5-Dimethyl-1-nitroso-2,6-diphenyl-4-piperidinone       362605
3,4-Dihydroxynaphthalene-2-carboxylic acid       356138
5-Fluorouracil       3385
Cetalkonium chloride       31202
[5-[2,4-Bis((3S)-3-methylmorpholin-4-yl)pyrido[2,3-d]pyrimidin-7-yl]-2-methoxyphenyl]methanol       25262965
2-(4-Methyl-1,4-diazepan-1-yl)-N-((5-methylpyrazin-2-yl)methyl)-5-oxo-5H-benzo[4,5]thiazolo[3,2-a][1,8]naphthyridine-6-carboxamide       25257557
Cabozantinib       25102847
Navitoclax       24978538
Tert-Butyl (4-(3-((7-(hydroxyamino)-7-oxoheptyl)carbamoyl)isoxazol-5-yl)phenyl)carbamate       24951314
Ponatinib       24826799
Vismodegib       24776445
4-(6,6-Dimethyl-4-oxo-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-((1r,4r)-4-hydroxycyclohexylamino)benzamide       24772860
Arylidene-4-chloro       24202977
(2-Methoxy-9,10-dihydrophenanthren-3-yl)methyl-dimethyl-(phenylsulfanylmethyl)azanium;bromide       24200489
Arenaemycin E       24199350
Thalphenine chloride       24197663
Vincaleukoblastine       241903
N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide       24180719
Olaparib       23725625
Tricinolone acetophenonide       235856
Aristolochic acid       2236
6-Chloro-2-methoxy-9-[(5-piperidinopentyl)amino]acridine       219600
7-(alpha-Anilino-P-nitrobenzyl)-8-quinolinol       219565
Nutlin-3       216345
Lenalidomide       216326
Kinetin riboside       20345
4-Methyl-3-(1-methyl-6-(pyridin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-ylamino)-N-(3-(trifluoromethyl)phenyl)benzamide       16747388
Gsk-690693       16725726
Fedratinib       16722836
1-(Tert-Butyl)-3-(2-((4-(diethylamino)butyl)amino)-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl)urea       1401
N-[5-[5-[4-[2-(Dimethylamino)ethoxy]phenyl]-2-pyridin-4-ylfuran-3-yl]-2,3-dihydroinden-1-ylidene]hydroxylamine;hydrochloride       136207967
4-[(5z)-5-(1-Nitroso-2,3-Dihydro-5h-Inden-5-Ylidene)-2-(Piperidin-4-Yl)-3,5-Dihydro-4h-Imidazol-4-Ylidene]-1,4-Dihydropyridine       136026031
(Z)-3-((3-((Dimethylamino)methyl)phenylamino)(phenyl)methylene)-N,N-dimethyl-2-oxoindoline-6-carboxamide       135659062
Talazoparib       135565082
N,N-Dimethyl-2-[4-[4-(1-nitroso-2,3-dihydroinden-5-ylidene)-5-(1H-pyridin-4-ylidene)-1H-imidazol-2-yl]phenoxy]ethanamine       135564599
(E)-5-(2-(4-(2-(Dimethylamino)ethoxy)phenyl)-5-(pyridin-4-yl)-1H-imidazol-4-yl)-2,3-dihydro-1H-inden-1-one oxime       135421339
Osi-027       135398516
Dovitinib       135398510
Methotrexate       126941
Lestaurtinib       126565
Dactolisib       11977753
Clofarabine       119182
BAY 61-3606 dihydrochloride       11784504
N-[3-[[5-Bromo-4-[[2-(1H-imidazol-5-YL)ethyl]amino]-2-pyrimidinyl]amino]phenyl]-1-pyrrolidinecarboxamide       11754511
Trametinib       11707110
4-[2-(2-Chloro-4-fluoroanilino)-5-methyl-4-pyrimidinyl]-N-[(1S)-1-(3-chlorophenyl)-2-hydroxyethyl]-1H-pyrrole-2-carboxamide       11634725
Benzamide, 4-((1R)-1-aminoethyl)-N-1H-pyrrolo(2,3-b)pyridin-4-yl-, hydrochloride (1:1)       11507964
5-(2-Phenylpyrazolo[1,5-A]pyridin-3-YL)-1H-pyrazolo[3,4-C]pyridazin-3-amine       11493598
Linifanib       11485656
Nvp-aew541       11476171
N-(6-Fluoro-1H-indazol-5-yl)-6-methyl-2-oxo-4-[4-(trifluoromethyl)phenyl]-3,4-dihydro-1H-pyridine-5-carboxamide       11373846
8-(4-Dibenzothienyl)-2-(4-morpholinyl)-4H-1-benzopyran-4-one       11327430
Amuvatinib       11282283
(S)-5-(3-Fluorophenyl)-N-(piperidin-3-yl)-3-ureidothiophene-2-carboxamide       11152667
7-Ethyl-10-hydroxycamptothecin       104842
VX-702       10341154
Afatinib       10184653
Selumetinib       10127622
N-(3-{[5-Iodo-4-({3-[(Thiophen-2-Ylcarbonyl)amino]propyl}amino)pyrimidin-2-Yl]amino}phenyl)pyrrolidine-1-Carboxamide       10077147
Masitinib       10074640
25-Dihydrosaframycin A       100180
1,4-dimethoxy-7-azaisoindole[2,1-a]quinoxalin-6(5h)-one       -
1-bromo-2-bromomethyl-o-carborane       -
;4-fluoro-N-(3-(4-(6-(4-hydroxyphenyl)imidazo[2,1-b]thia...       -
5,6-ethylenediquino[3,2-b       -
8,8'-(3,3'-dimethoxybenzyl)-8-hydroxy-butyrolacton       -
b 80568       -
bis-.mu.-propionatodiaquatetrabromorhenium(ii)       -
Cisplatin       -
formamide, n-[4-(3,3-dimethyl-1-triazenyl)phenyl]-       -
Genentech Cpd 10       -
g-tpp       -
JW-7-24-1       -
KIN001-236       -
KIN001-244       -
KIN001-260       -
KIN001-266       -
KIN001-270       -
MPS-1-IN-1       -
NPK76-II-72-1       -
Nutlin-3a (-)       -
propanedinitrile, [(3,5-dibromo-2-ethoxyphenyl)methylene]-       -
purino[7,8-a]quinazoline-5,9,11-trione, 6,8,10-trimethyl-       -
QL-X-138       -
QL-XI-92       -
riboprine(usan)       -
SB52334       -
THZ-2-102-1       -
TL-1-85       -
TL-2-105       -
triacetyl 13,14,15-isocrambescidin 800 hydrochloride       -
VNLG/124       -
WZ3105       -
XMD14-99       -
XMD15-27       -

Interaction Network (The top 100 interactions):


Interactor1: hcmv-miR-US25-1-5p
Interactor2: MEG3

Evidence Support:


Strong-Evidence RISC-IP
Support Database ViRBase

References:


PMID 20585629 Target region 5'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line HEK293 cells Interactor2 expression None
Description Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.

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