Basic Information
| RNALocate ID: | RLID:02000602 |
| RNA Symbol: | MEG3 |
| Localization: | Nucleus |
RNA Information
| RNA Name: | MEG3 |
| RNA ID: | NCBI:55384|Ensembl:ENSG00000214548 |
| RNA Category: | lncRNA |
| Species: | Homo sapiens |
| Alias: | FP504|GTL2|LINC00023|NCRNA00023|PRO0518|PRO2160|onco-lncRNA-83|prebp1 |
Localization Information
| PubMed ID: | 31107149 |
| Tissue/Cell Line: | HeLa cells |
| Method: | RNA FISH |
|
RNA-FISH showing nuclear localization of MEG3 and subcellular localization of ANCR after transient transfection. Originally published in RNA Biol. Azam S, et al, 2019. Reproduced under the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) |
|
| Description: | MEG3 and ANCR reporter transcripts were detected in both cytoplasm and nucleus, with apparent enrichment of MEG3 in the nucleus and enrichment of ANCR in the cytoplasm (Figure 1C). The localization of these transcripts were further assayed using RNA-FISH, MEG3 reporter transcripts were observed dominantly in the nucleus, compared to a more even distribution in the cytoplasm and nucleus for ANCR reporter transcripts (Figure 1D). |
Other Subcellular Localization
| RNALocate ID | Localization | Tissue/Cell line | PubMed ID |
| RLID:02000599 | Cytoplasm | Hepatoma cells | 21625215 |
| RLID:02000600 | Endoplasmic reticulum | Human myelogenous leukemia cell line (K-562) | 21613539 |
| RLID:02000601 | Nucleus | Cell line (BT-549) | 26205790 |
| RLID:02000603 | Nucleus | Cell lines (GM12878|HeLaS3|HepG2)|Human umbilical vein endothelial cells | 22955988 |
| RLID:02000604 | Nucleus | Lung fibroblasts | 25630241 |
| RLID:02001151 | Cytoplasm | Human lens epithelial cells (SRA01/04) | 32841649 |
| RLID:02001152 | Nucleus | Human lens epithelial cells (SRA01/04) | 32841649 |
| RLID-D:12005230 | Exosome | Serum |
ncRNA Disease Information
| Resource | RNA Symbol | Disease | Link |
| MNDR | MEG3 | Phaeochromocytoma | MNDR-E-LNC-17886 |
| MNDR | MEG3 | Renal fibrosis | MNDR-E-LNC-17887 |
| MNDR | MEG3 | Tongue squamous cell carcinoma | MNDR-E-LNC-17888 |
| MNDR | MEG3 | Oral squamous cell carcinoma | MNDR-E-LNC-17889 |
| MNDR | MEG3 | Myelodysplastic syndrome | MNDR-E-LNC-17890 |
| MNDR | MEG3 | Prostate cancer | MNDR-E-LNC-17891 |
| MNDR | MEG3 | Hirschsprung disease | MNDR-E-LNC-17892 |
| MNDR | MEG3 | Gastric cancer | MNDR-E-LNC-17893 |
| MNDR | MEG3 | Pre-eclampsia | MNDR-E-LNC-17894 |
| MNDR | MEG3 | Bladder cancer | MNDR-E-LNC-17895 |
| MNDR | MEG3 | Huntington disease | MNDR-E-LNC-17896 |
| MNDR | MEG3 | Cardiovascular disease | MNDR-E-LNC-17897 |
| MNDR | MEG3 | Lung cancer | MNDR-E-LNC-17898 |
| MNDR | MEG3 | Endometrial cancer | MNDR-E-LNC-17899 |
| MNDR | MEG3 | Metabolic syndrome | MNDR-E-LNC-17900 |
| MNDR | MEG3 | Breast cancer | MNDR-E-LNC-17901 |
| MNDR | MEG3 | Cancer | MNDR-E-LNC-17902 |
| MNDR | MEG3 | Ventricular septal defect | MNDR-E-LNC-17903 |
| MNDR | MEG3 | Thyroid cancer | MNDR-E-LNC-17904 |
| MNDR | MEG3 | Clinical nonfunctioning pituitary adenoma | MNDR-E-LNC-17905 |
| MNDR | MEG3 | Pancreatic cancer | MNDR-E-LNC-17906 |
| MNDR | MEG3 | Pancreatic endocrine carcinoma | MNDR-E-LNC-17907 |
| MNDR | MEG3 | Pancreatic neuroendocrine tumor | MNDR-E-LNC-17908 |
| MNDR | MEG3 | Melanoma | MNDR-E-LNC-17909 |
| MNDR | MEG3 | Atherosclerosis | MNDR-E-LNC-17910 |
| MNDR | MEG3 | Vulva squamous cell carcinoma | MNDR-E-LNC-17911 |
| MNDR | MEG3 | Epithelial ovarian cancer | MNDR-E-LNC-17912 |
| MNDR | MEG3 | Nephroblastoma | MNDR-E-LNC-17913 |
| MNDR | MEG3 | Colon cancer | MNDR-E-LNC-17914 |
| MNDR | MEG3 | Ovarian cancer | MNDR-E-LNC-17915 |
| MNDR | MEG3 | Hemangioma | MNDR-E-LNC-17916 |
| MNDR | MEG3 | Kidney cancer | MNDR-E-LNC-17917 |
| MNDR | MEG3 | Carcinoma endometrial | MNDR-E-LNC-17918 |
| MNDR | MEG3 | Laryngeal squamous cell cancer | MNDR-E-LNC-17919 |
| MNDR | MEG3 | Glioblastoma | MNDR-E-LNC-17920 |
| MNDR | MEG3 | Glioma | MNDR-E-LNC-17921 |
| MNDR | MEG3 | Chronic obstructive pulmonary disease | MNDR-E-LNC-17922 |
| MNDR | MEG3 | Gallbladder cancer | MNDR-E-LNC-17923 |
| MNDR | MEG3 | Embryonal rhabdomyosarcoma | MNDR-E-LNC-17924 |
| MNDR | MEG3 | Osteosarcoma | MNDR-E-LNC-17925 |
| MNDR | MEG3 | Pancreatic ductal adenocarcinoma | MNDR-E-LNC-17926 |
| MNDR | MEG3 | Meningioma | MNDR-E-LNC-17927 |
| MNDR | MEG3 | Liver cancer | MNDR-E-LNC-17928 |
| MNDR | MEG3 | Choriocarcinoma | MNDR-E-LNC-17929 |
| MNDR | MEG3 | Gastric adenocarcinoma | MNDR-E-LNC-17930 |
| MNDR | MEG3 | Esophagus squamous cell carcinoma | MNDR-E-LNC-17931 |
| MNDR | MEG3 | Non-functioning pituitary adenoma | MNDR-E-LNC-17932 |
| MNDR | MEG3 | Lung squamous cell carcinoma | MNDR-E-LNC-17933 |
| MNDR | MEG3 | Carcinoma lung non-small-cell | MNDR-E-LNC-17934 |
| MNDR | MEG3 | Lung adenocarcinoma | MNDR-E-LNC-17935 |
| MNDR | MEG3 | Thyroid carcinoma | MNDR-E-LNC-17936 |
| MNDR | MEG3 | Papillary thyroid cancer | MNDR-E-LNC-17937 |
| MNDR | MEG3 | Bladder urothelial carcinoma | MNDR-E-LNC-17938 |
| MNDR | MEG3 | Valvulopathy | MNDR-E-LNC-17939 |
| MNDR | MEG3 | Liver disease | MNDR-E-LNC-17940 |
| MNDR | MEG3 | Cervical cancer | MNDR-E-LNC-17941 |
| MNDR | MEG3 | Renal cell carcinoma | MNDR-E-LNC-17942 |
| MNDR | MEG3 | Clear cell renal cell carcinoma | MNDR-E-LNC-17943 |
| MNDR | MEG3 | Cholangiocarcinoma | MNDR-E-LNC-17944 |
| MNDR | MEG3 | Myelofibrosis | MNDR-E-LNC-17945 |
| MNDR | MEG3 | Esophageal cancer | MNDR-E-LNC-17946 |
| MNDR | MEG3 | Liver cirrhosis | MNDR-E-LNC-17947 |
| MNDR | MEG3 | Head and neck squamous cell carcinoma | MNDR-E-LNC-17948 |
| MNDR | MEG3 | Testicular germ cell cancer | MNDR-E-LNC-17949 |
| MNDR | MEG3 | Functionless pituitary adenoma | MNDR-E-LNC-17950 |
| MNDR | MEG3 | Gastric cardia adenocarcinoma | MNDR-E-LNC-17951 |
| MNDR | MEG3 | Hypoxia-induced pulmonary hypertension | MNDR-E-LNC-17952 |
| MNDR | MEG3 | Pulmonary hypertension | MNDR-E-LNC-17953 |
| MNDR | MEG3 | Cerebrovascular disease | MNDR-E-LNC-17954 |
| MNDR | MEG3 | Hepatocellular carcinoma | MNDR-E-LNC-17955 |
| MNDR | MEG3 | Cervical carcinoma | MNDR-E-LNC-17956 |
| MNDR | MEG3 | Intraductal papillary mucinous neoplasms of the pancreas | MNDR-E-LNC-17957 |
| MNDR | MEG3 | Retinoblastoma | MNDR-E-LNC-17958 |
| MNDR | MEG3 | Neuroblastoma | MNDR-E-LNC-17959 |
| MNDR | MEG3 | Osteoarthritis | MNDR-E-LNC-17960 |
| MNDR | MEG3 | Chronic myeloid leukemia | MNDR-E-LNC-17961 |
| MNDR | MEG3 | Immune thrombocytopenia | MNDR-E-LNC-17962 |
| MNDR | MEG3 | Acute myeloid leukemia | MNDR-E-LNC-17963 |
| MNDR | MEG3 | Colorectal cancer | MNDR-E-LNC-17964 |
| MNDR | MEG3 | Nasopharyngeal carcinoma | MNDR-E-LNC-17965 |
| MNDR | MEG3 | Nasopharynx carcinoma | MNDR-E-LNC-17966 |
| MNDR | MEG3 | Diabetes mellitus | MNDR-E-LNC-17967 |
| MNDR | MEG3 | Multiple myeloma | MNDR-E-LNC-17968 |
| MNDR | MEG3 | Type 1 diabetes mellitus | MNDR-E-LNC-17969 |
| MNDR | MEG3 | Heroin dependence | MNDR-E-LNC-17970 |
| MNDR | MEG3 | Ovarian epithelial cancer | MNDR-E-LNC-17971 |
| MNDR | MEG3 | Esophageal squamous cell cancer | MNDR-E-LNC-17972 |
| MNDR | MEG3 | Uterine cervical neoplasms | MNDR-E-LNC-17973 |
| MNDR | MEG3 | Liver fibrosis | MNDR-E-LNC-17974 |
| MNDR | MEG3 | Nasopharyngeal cancer | MNDR-E-LNC-17975 |
| MNDR | MEG3 | Prostate | MNDR-E-LNC-17976 |
| MNDR | MEG3 | Purpura thrombocytopenic | MNDR-E-LNC-17977 |
| MNDR | MEG3 | Stroke | MNDR-E-LNC-17978 |
| MNDR | MEG3 | T-cell lymphoblastic lymphoma | MNDR-E-LNC-17979 |
| MNDR | MEG3 | Liver ischemia/reperfusion(i/r)injury | MNDR-E-LNC-17980 |
| MNDR | MEG3 | Spiral artery remodeling | MNDR-E-LNC-17981 |
RNA Interaction Information
| Resource | RNA Symbol | Species | Link | RNALocate ID |
| RNAInter | ABCB1 | Homo sapiens | RR00022756 |
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