Detail Information

Basic Information:


  VIRBase ID:  

VHID00276930

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

Interactor Information:


Interactor1 Interactor2
Symbol EBER2 IL6
miRBase
Accession/Entrez ID		 EBER2 3569
Organism Human gammaherpesvirus 4 (Epstein-Barr virus, EPV) Homo sapiens
Category lncRNA mRNA
Alias - BSF-2//BSF2//CDF//HGF//HSF//IFN-beta-2//IFNB2//IL-6

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR IL6
chr7:22770700(+) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase IL6
chr7:22766885-22766886(+) m6A 5'UTR//CDS//exon       -
chr7:22766928-22766929(+) m6A exon//intron       -

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate EBER2
EBV-postitive Burkitt lymphoma-derived cell line (Raji) Cytoplasm     1332043
EBV-postitive Burkitt lymphoma-derived cell line (Raji) Nucleus     1332043
IL6
Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539
Exosome Serum     -
Nucleus HeLa-S3 cells     -
Polysome HeLa cells     26000482

Interaction Network (The top 100 interactions):


Interactor1: EBER2
Interactor2: IL6

Evidence Support:


Strong-Evidence qRT-PCR
Support Database ViRBase

References:


PMID 20399962 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line B cells Interactor2 expression Downregulation
Description Previous studies demonstrated that EBERs (EBER1 and EBER2) play significant roles in various EBV-infected cancer cells. EBERs induce the expression of interleukin(IL)-10 in BL cells, insulin-like growth factor(IGF)-1 in gastric carcinoma and nasopharyngeal carcinoma cells, IL-9 in T cells that act as an autocrine growth factor. It was also reported that EBERs play critical roles in the B cell growth transformation including IL-6 induction by EBER2.

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