Detail Information

Basic Information:


  VIRBase ID:  

HVID00009686

  Virus:  

SARS-CoV-2 (NC_045512.2)

  Host:  

Homo sapiens

  Confidence Score:  

0.1828

  Interaction Type:  

Host-Virus interaction

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-1976 ORF1ab
miRBase
Accession/Entrez ID		 MIMAT0009451 43740578
Organism Homo sapiens SARS-CoV-2 (NC_045512.2)
Category miRNA mRNA
Alias - GU280_gp01

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-1976
rs1173366847 chr1:26554586    C/T
rs1208235584 chr1:26554592    G/A
rs985342579 chr1:26554590    C/T
rs1478358767 chr1:26554578    C/T
rs765589931 chr1:26554577    C/G
rs972150493 chr1:26554576    T/C

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-1976
Cytoplasm Cell line (HeLa)     21695135
Exosome Breast cancer cell lines (MCF-7|MDA-MB-231)     24468161
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
Mitochondrion Skeletal muscle cells     27563705

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-1976
Gemcitabine 60750 Drug interaction    RC00007973
5-Fluorouracil 3385 Drug interaction    RC00007972
Resource Symbol Drug Name PubChem ID
RNAactDrug hsa-miR-1976
Panobinostat       6918837
Paclitaxel       36314

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-1976
Interactor2: ORF1ab

Evidence Support:


Prediction-Evidence miRanda
Support Database ViRBase

References:


[1]PMID 33251388 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line None Interactor2 expression None
Description Among the 2654 human mature miRNAs, 444 miRNAs were identified with direct binding site on different positions along with the coronavirus 2 reference genome (Table S1).
[2]PMID 33173539 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line None Interactor2 expression None
Description We identified 1,018 miRNAs to target SARS-CoV-2 genes, among which 98 miRNAs are predicted to target SARS-CoV-2 genes uniquely when compared with other viruses studied here (Supplementary Table S6).

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