Detail Information

Basic Information:


  VIRBase ID:  

HVID00009299

  Virus:  

SARS-CoV-2 (NC_045512.2)

  Host:  

Homo sapiens

  Confidence Score:  

0.1828

  Interaction Type:  

Host-Virus interaction

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-361-5p ORF1ab
miRBase
Accession/Entrez ID		 MIMAT0000703 43740578
Organism Homo sapiens SARS-CoV-2 (NC_045512.2)
Category miRNA mRNA
Alias - GU280_gp01

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-361-5p
rs1201941835 chrX:85903694    T/C
rs1341659793 chrX:85903684    C/A
rs1430235395 chrX:85903683    A/AC

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-361-5p
Cytoplasm Nasopharyngeal carcinoma cells     20498841
Cytoplasm Neural progenitor cells     21363885
Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Exosome Serum     18589210
Exosome Breast cancer cell line (MCF-7)     20976003
Exosome Primary dendritic cells|T cell line (J77)     21505438
Exosome Renal cancer cells     21670082
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Human mast cell line (HMC-1)     24009880
Exosome Serum     25349172
Exosome Blood|Kidney tissue     -
Extracellular vesicle HEK-293T cells     22849433
Microvesicle Seminal plasma     23539611
Microvesicle Blood|Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     -
Mitochondrion Cell line (HEK-293|HeLa)     22984580
Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Nucleus Nasopharyngeal carcinoma cells     20498841

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-361-5p
7-Epi-10-deacetylbaccatin III 9872117 Drug sensitive
Pharmakon1600-01503602 60148415 Drug sensitive
Ayanin 5280682 Drug resistant
Rogiolol 402519 Drug sensitive
2-Acetyl-1,2-dihydroellipticine 376328 Drug resistant
Jasplakinolide epoxide C 372550 Drug sensitive
Antineoplastic-642316 369949 Drug sensitive
Gold;(2S,3R,4S,5R,6R)-3,4,5-triacetyloxy-6-(acetyloxymethyl)oxane-2-thiolate;triethylphosphanium 138402869 Drug sensitive
Dibutyltin dichloride 12688 Drug sensitive
Capri Blue 102162 Drug sensitive
6-aryl alkyl fluoro quinolone derivative - Drug resistant
antineoplastic-d655481 - Drug resistant
2-[(3,4-dicloro)anilino]-3-phenyl-5,7-diamino quinoxaline - Drug sensitive
4-[3-(3,4-dihydro-1H-isoquinolin-2-yl)prop-1-en-2-yl]-N-pyrazin-2-ylbenzamide - Drug sensitive
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-361-5p
Formaldehyde 712 Drug interaction    RC00004017
Gemcitabine 60750 Drug interaction    RC00004022
Eloxatine 5310940 Drug interaction    RC00004027
Diethylstilbestrol 448537 Drug interaction    RC00004025
Paclitaxel 36314 Drug interaction    RC00004021
5-Fluorouracil 3385 Drug interaction    RC00004019
Doxorubicin 31703 Drug interaction    RC00004020
Tamoxifen 2733526 Drug interaction    RC00004026
Verapamil 2520 Drug interaction    RC00004018
N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719 Drug interaction    RC00004028
Docetaxel 148124 Drug interaction    RC00004024
Methotrexate 126941 Drug interaction    RC00004023
Glucocorticoid - Drug interaction    RC00004031
platinum-based doublet chemotherapy - Drug interaction    RC00004029
1,2,6-Tri-O-galloyl-beta-D-glucopyranose - Drug interaction    RC00004030
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-361-5p
N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719       26456124
Resource Symbol Drug Name PubChem ID
RNAactDrug hsa-miR-361-5p
Topotecan       60700
Palbociclib       5330286

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-361-5p
Interactor2: ORF1ab

Evidence Support:


Prediction-Evidence miRanda
Support Database ViRBase

References:


[1]PMID 33251388 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line None Interactor2 expression None
Description Among the 2654 human mature miRNAs, 444 miRNAs were identified with direct binding site on different positions along with the coronavirus 2 reference genome (Table S1).
[2]PMID 33173539 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line None Interactor2 expression None
Description We identified 1,018 miRNAs to target SARS-CoV-2 genes, among which 98 miRNAs are predicted to target SARS-CoV-2 genes uniquely when compared with other viruses studied here (Supplementary Table S6).

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