Detail Information

Basic Information:


  VIRBase ID:  

HVID00008997

  Virus:  

SARS-CoV-2 (MT344963.1)

  Host:  

Homo sapiens

  Confidence Score:  

0.2202

  Interaction Type:  

Host-Virus interaction

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-122-5p ORF7b
miRBase
Accession/Entrez ID		 MIMAT0000421 ORF7b
Organism Homo sapiens SARS-CoV-2 (MT344963.1)
Category miRNA mRNA
Alias -

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-122-5p
rs1258166649 chr18:58451088    T/C
rs1426570658 chr18:58451093    T/A

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-122-5p
Cytoplasm Huh-7 cells|Sorafenib-resistant Huh-7 cells (Huh-7-DR)     29253196
Cytoplasm Huh-7 cells     29486652
Cytoplasm Nasopharyngeal carcinoma cells     20498841
Endoplasmic reticulum Huh-7 cells     26304123
Exosome Breast cancer cell lines (MCF10A|MDA-MB-231)     25621950
Exosome B cell line (Raji)     21505438
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Human mast cell line (HMC-1)     24009880
Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326
Exosome Blood|Chronic lymphocytic leukemia cells     -
Microvesicle Plasma     23077538
Microvesicle Seminal plasma     23539611
Microvesicle Blood|Fibroblasts|Mesenchymal stem cells|Urine     -
Mitochondrion Cell line (HEK-293|HeLa)     22984580
Nucleus Adjacent noncancerous tissue|HCC tissue|Huh-7 cells|Sorafenib-resistant Huh-7 cells (Huh-7-DR)     29253196
Nucleus Nasopharyngeal carcinoma cells     20498841
Polysome Human cervical cancer cell line (HeLa)     25609084

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-122-5p
Interactor2: ORF7b

Evidence Support:


Prediction-Evidence miRanda//miRTarP
Support Database ViRBase

References:


PMID 33801496 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line None Interactor2 expression None
Description Additionally, if targets are selected by both tools in at least two strains of SARS-CoV-2, we only considered them as potential targets of miRNA on SARS-CoV-2 (Table S2). In Table 1, we present the list of miRNAs meeting all these criteria.

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