Detail Information

Basic Information:


  VIRBase ID:  

HVID00008721

  Virus:  

SARS coronavirus Tor2

  Host:  

Homo sapiens

  Confidence Score:  

0.1828

  Interaction Type:  

Host-Virus interaction

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-320a-5p ORF1ab
miRBase
Accession/Entrez ID		 MIMAT0037311 1489680
Organism Homo sapiens SARS coronavirus Tor2
Category miRNA mRNA
Alias - sarsp1

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-320a-5p
rs1178430716 chr8:22245014    C/A
rs1178430716 chr8:22245014    C/T
rs1222383224 chr8:22245020    A/C
rs1302873200 chr8:22245028    C/T
rs751837733 chr8:22245017    G/A
rs751837733 chr8:22245017    G/T
rs759553956 chr8:22245018    G/A
rs762775040 chr8:22245011    G/A
rs762775040 chr8:22245011    G/C
rs766581008 chr8:22245016    G/A
rs767640621 chr8:22245019    A/G
rs773034756 chr8:22245010    A/G
rs773281428 chr8:22245008    G/A
rs773281428 chr8:22245008    G/C
rs371890344 chr8:22245023    G/A
rs371890344 chr8:22245023    G/C
rs375622631 chr8:22245027    G/A
rs566154595 chr8:22245021    G/A
rs566154595 chr8:22245021    G/C
rs764559789 chr8:22245026    G/A

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-320a-5p
Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Exosome Human cervical cancer cell line (HeLa)     25760330
Exosome Pooled sera     27278097
Exosome Breast cancer cell line (MCF-7)     20976003
Exosome Ovarian follicular fluid     22116803
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Serum     25135963
Exosome Human esophageal cancer cell line (EC9706)     25184951
Exosome Colon cancer cell line (LIM1863)     25330373
Exosome Cerebrospinal fluid     25420022
Microvesicle Plasma     23077538
Microvesicle Seminal plasma     23539611
Microvesicle Serum     24797360
Mitochondrion HEK-293 cells|HeLa cells     27396686
Mitochondrion HEK-293 cells|HeLa cells     27563705
Mitochondrion Skeletal muscle myoblasts     21637849
Mitochondrion Cell line (HEK-293|HeLa)     22984580
Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-320a-5p
Interactor2: ORF1ab

Evidence Support:


Prediction-Evidence miRTarP
Support Database ViRBase

References:


PMID 33173539 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line None Interactor2 expression None
Description Interestingly, we observed that 717 miRNAs targeting SARS-CoV-2 genes are common with those targeting SARS-CoV genes, possibly due to high genome similarity (Xu et al., 2020; Zhang and Holmes, 2020, p. 2) (Supplementary Table S7).

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