Detail Information

Basic Information:


  VIRBase ID:  

HVID00006037

  Virus:  

Human immunodeficiency virus 1 (HIV-1)

  Host:  

Homo sapiens

  Confidence Score:  

0.8847

  Interaction Type:  

Host-Virus interaction

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-223-3p rev
miRBase
Accession/Entrez ID
MIMAT0000280 155908
Organism Homo sapiens Human immunodeficiency virus 1 (HIV-1)
Category miRNA mRNA
Alias - HIV1gp6

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-223-3p
rs1182356657 chrX:66018952    T/C
rs1244940152 chrX:66018956    C/T
rs1437865022 chrX:66018957    C/T
rs1482840597 chrX:66018949    A/G
rs375191439 chrX:66018939    T/C

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-223-3p
Endoplasmic reticulum membrane Cortical tissue     32451872
Exosome Dendritic cells (in vitro differentiated Langerhans cells)|Healthy plasma|Mast cells (HMC-1 cell line)|PCa patient plasma     25267620
Exosome Macrophages     27396686
Exosome B cell line (Raji)|Primary dendritic cells     21505438
Exosome Breast cancer cell lines (HEK-293T|MDA-MB-231|SKBR3)|Macrophages     21939504
Exosome Ovarian follicular fluid     22116803
Exosome Breast milk     22211110
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Human mast cell line (HMC-1)     24009880
Exosome Plasma     24130905
Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326
Exosome Saliva     25376581
Exosome Blood|Breast milk|Mast cells     -
Microvesicle Liver resident stem cells|Mesenchymal stem cells     20668554
Microvesicle Plasma     23077538
Microvesicle Follicular fluid     23666971
Microvesicle Fibroblasts|Mesenchymal stem cells     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID
Function Link  
RNAInter hsa-miR-223-3p
Gemcitabine 60750 Drug interaction    RC00002247
Clopidogrel 60606 Drug interaction    RC00002246
Testosterone 6013 Drug interaction    RC00002242
Cholesterol 5997 Drug interaction    RC00002241
Mitomycin 5746 Drug interaction    RC00002240
RETINOIC ACID, 13-cis- 5538 Drug interaction    RC00002239
Vorinostat 5311 Drug interaction    RC00002252
Genistein 5280961 Drug interaction    RC00002251
Praziquantel 4891 Drug interaction    RC00002238
Tretinoin 444795 Drug interaction    RC00002250
Paclitaxel 36314 Drug interaction    RC00002245
5-Fluorouracil 3385 Drug interaction    RC00002237
Doxorubicin 31703 Drug interaction    RC00002244
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00002236
Chlorzoxazone 2733 Drug interaction    RC00002235
Benzene 241 Drug interaction    RC00002234
Erlotinib 176870 Drug interaction    RC00002249
Methamphetamine 10836 Drug interaction    RC00002243
modified ALLIC BFM 2002 protocol - Drug interaction    RC00002253
Nesiritide - Drug interaction    RC00002254
Trastuzumab - Drug interaction    RC00002255
1,2,6-Tri-O-galloyl-beta-D-glucopyranose - Drug interaction    RC00002256
Interleukin 13 (IL-13) - Drug interaction    RC00002258
Glucocorticoid - Drug interaction    RC00002257
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-223-3p

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-223-3p
Interactor2: rev

Evidence Support:


Strong-Evidence qRT-PCR
Weak-Evidence Microarray
Prediction-Evidence MicroInspector
Support Database ViRBase

References:


PMID 17906637 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line CD4(+) T cells Interactor2 expression Downregulation
Description We have found that the 3'ends of HIV-1 messenger RNAs are targeted by a cluster of cellular miRNAs including miR-28, miR-125b, miR-150, miR-223 and miR-382, which are enriched in resting CD4+ T cells as compared to activated CD4+ T cells. It is known that every spliced or unspliced HIV-1 mRNA, with the exception of Nef-encoding mRNA, contains the 1.2-kb fragment we used (or a portion of it) in its 3'UTR25 . Thus, these cellular miRNAs, which bind the 1.2-kb fragment of the HIV-1 RNA 3'end, can inhibit the translation of almost all HIV-1-encoded proteins-including Tat and Rev, which are key in the transcription and translocation of viral RNA.

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