Detail Information

Basic Information:


  VIRBase ID:  

HVID00006005

  Virus:  

Human immunodeficiency virus (HIV)

  Host:  

Homo sapiens

  Confidence Score:  

0.9512

  Interaction Type:  

Host-Virus interaction

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-186-3p HRB
miRBase
Accession/Entrez ID		 MIMAT0004612 HRB
Organism Homo sapiens Human immunodeficiency virus (HIV)
Category miRNA mRNA
Alias - -

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-186-3p
rs1241044041 chr1:71067653    C/T
rs1318830037 chr1:71067663    C/A
rs1318830037 chr1:71067663    C/T
rs771255877 chr1:71067645    A/C
rs776722712 chr1:71067655    C/T
rs934513177 chr1:71067651    T/C
rs1292420312 chr1:71067659    T/A

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-186-3p
Exosome Breast milk     22211110
Exosome Plasma     23663360
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Mesenchymal stem cells     -

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-186-3p
Interactor2: HRB

Evidence Support:


Strong-Evidence Luciferase reporter assay//RT-qPCR
Weak-Evidence Deep sequencing
Prediction-Evidence TargetRank//Targetscan
Support Database ViRBase

References:


PMID 30682089 Target region 3'UTR
Source ViRBase Interactor1 expression Upregulation
Tissue or cell line Jurkat cells//MCF7 cells//SupT1 cells Interactor2 expression None
Description Our results demonstrate the down-regulation of all three genes: Dicer1 by miR-210 and by miR-222 (52% and 41%, respectively); HRB by miR-222 and by miR-186 (39% and 17%, respectively); and HIV-EP2 by miR-210 and by miR-186 (29% and 21%, respectively) (Fig 4B).

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