Basic Information
| RNALocate ID: | RLID:11003794 |
| RNA Symbol: | hsa-miR-186-3p |
| Localization: | Exosome |
RNA Information
| RNA Name: | hsa-miR-186-3p |
| RNA ID: | miRBase:MIMAT0004612 |
| RNA Category: | miRNA |
| Species: | Homo sapiens |
Localization Information
| PubMed ID: | 22211110 |
| Tissue/Cell Line: | Breast milk |
| Method: | Next-generation RNA sequencing |
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The expression profile of selected miRNAs in breast milk exosomes. Originally published in Int J Biol Sci. Zhou Q, et al, 2012. Reproduced under the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) |
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| Description: | Distribution and characterization of miRNAs in breast milk exosomes. (A) Distribution of pre-miRNAs. Out of 1,424 pre-miRNAs deposited in miRBase 17.0 (blue circle), 87 (6.11%) pre-miRNAs have been designated as immune-related pre-miRNAs based on annotation in the Pathway Central database (SABiosciences, MD, USA). Immune-related pre-miRNAs (59 of 452, 13.05%) are enriched in breast milk exosomes (red circle). χ2 test: Number of immune-related miRNAs and others detected in breast milk exosomes compared with the total entries in miRBase 17.0. (B) Top ten most highly expressed unique miRNAs. Plot of the unique miRNAs (starting from the miRNA with the highest counts, x-axis) versus their cumulative % of the total counts from 602 unique miRNAs detected in breast milk exosomes for each small RNA library. Values are means ± s.d. The dashed horizontal line at 62.3% represents the level of the top ten unique miRNAs and the % of individual miRNAs is marked by the gray line. (C-E) The expression profile of selected miRNAs in breast milk exosomes. (C) 59 immune-related pre-miRNAs; (D) miR-17-92 cluster and paralogous clusters, and (E) ten well-characterized tissue-specific pre-miRNAs. Data are collected from Figure 2. |
Other Subcellular Localization
| RNALocate ID | Localization | Tissue/Cell line | PubMed ID |
| RLID:11003795 | Exosome | Plasma | 23663360 |
| RLID-D:11000642 | Microvesicle | Mesenchymal stem cells | |
| RLID-D:11001517 | Exosome | Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine |
ncRNA Disease Information
| Resource | RNA Symbol | Disease | Link |
| MNDR | hsa-miR-186-3p | Oral squamous cell carcinoma | MNDR-E-MI-21136 |
| MNDR | hsa-miR-186-3p | Medulloblastoma | MNDR-E-MI-21137 |
| MNDR | hsa-miR-186-3p | Lymphoma | MNDR-E-MI-21138 |
| MNDR | hsa-miR-186-3p | Estrogen-receptor negative breast cancer | MNDR-E-MI-21139 |
| MNDR | hsa-miR-186-3p | Her2-receptor positive breast cancer | MNDR-E-MI-21140 |
| MNDR | hsa-miR-186-3p | Gastric cancer | MNDR-E-MI-21141 |
| MNDR | hsa-miR-186-3p | Lung cancer | MNDR-E-MI-21142 |
| MNDR | hsa-miR-186-3p | Parkinson disease | MNDR-E-MI-21143 |
| MNDR | hsa-miR-186-3p | Basal-like breast cancer | MNDR-E-MI-21144 |
| MNDR | hsa-miR-186-3p | Pancreatic cancer | MNDR-E-MI-21145 |
| MNDR | hsa-miR-186-3p | Familial ovarian cancer | MNDR-E-MI-21146 |
| MNDR | hsa-miR-186-3p | Lung adenocarcinoma | MNDR-E-MI-21147 |
| MNDR | hsa-miR-186-3p | Hepatocellular carcinoma | MNDR-E-MI-21148 |
| MNDR | hsa-miR-186-3p | Familiar ovarian carcinoma | MNDR-E-MI-21149 |
| MNDR | hsa-miR-186-3p | Colorectal cancer | MNDR-E-MI-21150 |
| MNDR | hsa-miR-186-3p | Nasopharynx carcinoma | MNDR-E-MI-21151 |
| MNDR | hsa-miR-186-3p | Nasopharyngeal cancer | MNDR-E-MI-21152 |
| MNDR | hsa-miR-186-3p | Intracranial hemorrhage hypertensive | MNDR-E-MI-21153 |
RNA Interaction Information
| Resource | RNA Symbol | Species | Link | RNALocate ID |
| RNAInter | CASP10 | Homo sapiens | RR02079879 |
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