Basic Information:
VIRBase ID: HVID00001841
Virus: Hepacivirus C (Hepatitis C virus JFH-1,HCV)
Host: Homo sapiens
Confidence Score: 0.8808
Interaction Type: Host-Virus interaction
Interactor Information:
Interactor1
Interactor2
Symbol
hsa-miR-122-5p
HCV RNA
miRBase Accession/Entrez ID
MIMAT0000421
HCV RNA
Organism
Homo sapiens
Hepacivirus C (Hepatitis C virus JFH-1,HCV)
Category
miRNA
unassigned RNA
Alias
-
-
ncRNA SNP information:
Resource
Symbol
SNP ID
SNP Position
Ref/Alt
miRNASNP-v3
hsa-miR-122-5p
RNA Localization:
Resource
Symbol
Subcellular Localization
Tissue or Cell Line
PMID
RNALocate
hsa-miR-122-5p
Interaction Network (The top 100 interactions) :
Interactor1: hsa-miR-122-5p
Interactor2: HCV RNA
Evidence Support:
Strong-Evidence
Dual luciferase reporter assay//Stem-loop qRT-PCR
Support Database
ViRBase
References:
PMID
29973597
Target region
5'UTR
Source
ViRBase
Interactor1 expression
Upregulation
Tissue or cell line
Human Hep3B hepatoma cells
Interactor2 expression
Upregulation
Description
These data further corroborate our central hypothesis that miR-122 binding to the HCV 5′ UTR stimulates translation by suppressing unfavorable alternative secondary structure interfering with IRES activity.