Detail Information

Basic Information:


  VIRBase ID:  

HVID00001815

  Virus:  

Hepacivirus C (HCV)

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Host-Virus interaction

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-122-5p HCV mRNA
miRBase
Accession/Entrez ID		 MIMAT0000421 HCV mRNA
Organism Homo sapiens Hepacivirus C (HCV)
Category miRNA mRNA
Alias - -

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-122-5p
rs1258166649 chr18:58451088    T/C
rs1426570658 chr18:58451093    T/A

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-122-5p
Cytoplasm Huh-7 cells|Sorafenib-resistant Huh-7 cells (Huh-7-DR)     29253196
Cytoplasm Huh-7 cells     29486652
Cytoplasm Nasopharyngeal carcinoma cells     20498841
Endoplasmic reticulum Huh-7 cells     26304123
Exosome Breast cancer cell lines (MCF10A|MDA-MB-231)     25621950
Exosome B cell line (Raji)     21505438
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Human mast cell line (HMC-1)     24009880
Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326
Exosome Blood|Chronic lymphocytic leukemia cells     -
Microvesicle Plasma     23077538
Microvesicle Seminal plasma     23539611
Microvesicle Blood|Fibroblasts|Mesenchymal stem cells|Urine     -
Mitochondrion Cell line (HEK-293|HeLa)     22984580
Nucleus Adjacent noncancerous tissue|HCC tissue|Huh-7 cells|Sorafenib-resistant Huh-7 cells (Huh-7-DR)     29253196
Nucleus Nasopharyngeal carcinoma cells     20498841
Polysome Human cervical cancer cell line (HeLa)     25609084

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-122-5p
Interactor2: HCV mRNA

Evidence Support:


Strong-Evidence Northern blot
Support Database VIRmiRNA//VmiReg

References:


[1]PMID 21821155 Target region 5'UTR
Source VIRmiRNA Interactor1 expression None
Tissue or cell line Hepatocytes cells Interactor2 expression None
Description Earlier studies noted specific changes in miRNA expression patterns in HCC as compared with adjacent normal liver tumor tissues, or liver cirrhosis that correlated with the disease outcome[57,58], [59,60](Table 1).
[2]PMID 16141076 Target region 5'UTR
Source VIRmiRNA//VmiReg Interactor1 expression None
Tissue or cell line Huh7 cells//NNeo/C-5B cells Interactor2 expression None
Description A genetic interaction between miR-122 and the 5'noncoding region of the viral genome was revealed by mutational analyses of the predicted microRNA binding site and ectopic expression of miR-122 molecules containing compensatory mutations.

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