Basic Information:

  VIRBase ID:  

HHID00105374

  Virus:  

SARS-CoV-2

  Host:  

Homo sapiens

  Confidence Score:  

0.2494

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-3121-3p:  MIMAT0014983          TNF:  NM_000594     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-3121-3p	TNF
miRBase Accession/Entrez ID	MIMAT0014983	7124
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	DIF//TNF-alpha//TNFA//TNFSF2//TNLG1F

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-3121-3p	rs1006143795 chr1:180438334    T/C rs778817728 chr1:180438323    T/C rs887772082 chr1:180438327    C/T rs911596096 chr1:180438331    G/C

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	TNF	chr6:31543363-31543364(+) m6A 5'UTR       - chr6:31543373-31543374(+) m6A 5'UTR       - chr6:31543403-31543404(+) m6A 5'UTR       - chr6:31543416-31543417(+) m6A 5'UTR       - chr6:31543513-31543514(+) m6A 5'UTR       - chr6:31545104-31545105(+) m6A CDS       26404942 chr6:31545152-31545153(+) m6A CDS       26404942 chr6:31545323-31545324(+) m6A 3'UTR       26404942 chr6:31545382-31545383(+) m6A 3'UTR       26404942 chr6:31545434-31545435(+) m6A 3'UTR       26404942 chr6:31545447-31545448(+) m6A 3'UTR       26404942 chr6:31545462-31545463(+) m6A 3'UTR       26404942 chr6:31545476-31545477(+) m6A 3'UTR       26404942 chr6:31545537-31545538(+) m6A 3'UTR       26404942 chr6:31545552-31545553(+) m6A 3'UTR       26404942 chr6:31545599-31545600(+) m6A 3'UTR       26404942 chr6:31545636-31545637(+) m6A 3'UTR       26404942 chr6:31545646-31545647(+) m6A 3'UTR       26404942 chr6:31545673-31545674(+) m6A 3'UTR       26404942 chr6:31545706-31545707(+) m6A 3'UTR       26404942 chr6:31545717-31545718(+) m6A 3'UTR       26404942 chr6:31545833-31545834(+) m6A 3'UTR       26404942 chr6:31545851-31545852(+) m6A 3'UTR       26404942 chr6:31545879-31545880(+) m6A 3'UTR       26404942 chr6:31545906-31545907(+) m6A 3'UTR       26404942

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-3121-3p	Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Mesenchymal stem cells     -
	TNF	Exosome Blood     - Polysome HeLa cells     26000482

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-3121-3p
Interactor2: TNF

Evidence Support:

Prediction-Evidence	microT//miRanda//miRMap//PicTar//PITA//Targetscan
Support Database	ViRBase

References:

PMID	33428154	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	None	Interactor2 expression	None
Description	To explore the regulatory relationship between the 5 key genes, 3 coronavirus-related genes (ACE2, TMPRSS2, BSG), and their target miRNA, we used 6 miRNA target prediction databases to predict the target miRNA of these genes.