Detail Information

Basic Information:


  VIRBase ID:  

HHID00105349

  Virus:  

SARS-CoV-2

  Host:  

Homo sapiens

  Confidence Score:  

0.2494

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-513b-5p:           TNF:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-513b-5p TNF
miRBase
Accession/Entrez ID		 MIMAT0005788 7124
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - DIF//TNF-alpha//TNFA//TNFSF2//TNLG1F

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-513b-5p
rs1024611353 chrX:147199098    T/C
rs1209982442 chrX:147199101    C/T
rs1557095054 chrX:147199096    A/C
rs1557095056 chrX:147199100    A/G
rs1557095060 chrX:147199103    C/G
rs1267843127 chrX:147199110    G/C
rs370968962 chrX:147199108    T/C
rs782747791 chrX:147199107    C/G

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase TNF
chr6:31543363-31543364(+) m6A 5'UTR       -
chr6:31543373-31543374(+) m6A 5'UTR       -
chr6:31543403-31543404(+) m6A 5'UTR       -
chr6:31543416-31543417(+) m6A 5'UTR       -
chr6:31543513-31543514(+) m6A 5'UTR       -
chr6:31545104-31545105(+) m6A CDS       26404942
chr6:31545152-31545153(+) m6A CDS       26404942
chr6:31545323-31545324(+) m6A 3'UTR       26404942
chr6:31545382-31545383(+) m6A 3'UTR       26404942
chr6:31545434-31545435(+) m6A 3'UTR       26404942
chr6:31545447-31545448(+) m6A 3'UTR       26404942
chr6:31545462-31545463(+) m6A 3'UTR       26404942
chr6:31545476-31545477(+) m6A 3'UTR       26404942
chr6:31545537-31545538(+) m6A 3'UTR       26404942
chr6:31545552-31545553(+) m6A 3'UTR       26404942
chr6:31545599-31545600(+) m6A 3'UTR       26404942
chr6:31545636-31545637(+) m6A 3'UTR       26404942
chr6:31545646-31545647(+) m6A 3'UTR       26404942
chr6:31545673-31545674(+) m6A 3'UTR       26404942
chr6:31545706-31545707(+) m6A 3'UTR       26404942
chr6:31545717-31545718(+) m6A 3'UTR       26404942
chr6:31545833-31545834(+) m6A 3'UTR       26404942
chr6:31545851-31545852(+) m6A 3'UTR       26404942
chr6:31545879-31545880(+) m6A 3'UTR       26404942
chr6:31545906-31545907(+) m6A 3'UTR       26404942

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-513b-5p
Exosome B cell line (Raji)|Jurkat-derived T cell line (J77cl20)     21505438
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Extracellular Vesicle Plasma     28588009
Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
TNF
Exosome Blood     -
Polysome HeLa cells     26000482

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-513b-5p
[(1R,2S,6R,7R,9S,12S,13S)-13-(Acetyloxymethyl)-12-hydroxy-9-methyl-5-methylidene-4-oxo-3,14-dioxatricyclo[7.4.1.02,6]tetradecan-7-yl] (Z)-2-(acetyloxymethyl)but-2-enoate 90473692 Drug sensitive
(3R,10S,13S,16S,19R)-16-[(2S)-Butan-2-yl]-10,11,14-trimethyl-3-(2-methylpropyl)-13-propan-2-yl-4-oxa-1,8,11,14,17-pentazabicyclo[17.3.0]docosane-2,5,9,12,15,18-hexone 90471303 Drug sensitive
Clothixamide maleate 76972759 Drug sensitive
Indolo[2,1-b]quinazoline-6,12-dione 73549 Drug sensitive
Jacaranone 73307 Drug sensitive
Piperidinium pentamethylenedithiocarbamate 72508 Drug sensitive
Coptisine chloride 72321 Drug sensitive
Phosphotrienin 6913994 Drug sensitive
Pyrazolo[1,5-b]pyridazine deriv. 40 6539382 Drug resistant
Tributyrin 6050 Drug sensitive
Cisplatin 5702198 Drug sensitive
Liatris laevigata lactone #2 5477810 Drug sensitive
Tetrocarcin A, sodium salt 54724658 Drug sensitive
Antineoplastic-690266 5469577 Drug sensitive
p-Chloranilinum[bis(p-chloraniline)dioxalatoruthenate(III)] 54608061 Drug sensitive
Heliangolide 5384466 Drug sensitive
N-(5-Ethylsulfonyl-2-methoxyphenyl)-5-[3-(2-fluorophenyl)phenyl]-1,3-oxazol-2-amine 5329875 Drug resistant
Pyrimethamine 4993 Drug sensitive
Ammonia; dichloroplatinum; 2-(4-methoxyphenyl)ethanamine 498559 Drug sensitive
Elsinochrome C 495866 Drug sensitive
1,4-Benzoquinone 4650 Drug sensitive
9-beta-D-Xylofuranosyladenine 447916 Drug resistant
Oxyacanthine 442333 Drug sensitive
Methyl 4-[4-(dimethylamino)-5-[4-hydroxy-6-methyl-5-(6-methyl-5-oxooxan-2-yl)oxyoxan-2-yl]oxy-6-methyloxan-2-yl]oxy-2-ethyl-2,5,7,12-tetrahydroxy-6,11-dioxo-3,4-dihydro-1H-tetracene-1-carboxylate 438788 Drug sensitive
Oridonin (thiol adduct OF) 432952 Drug sensitive
10-Hydroxy-5-methoxy-1-(2-methyloxiran-2-yl)-1,2-dihydrofuro[2,3-c]xanthen-6-one 429905 Drug sensitive
Menadione 4055 Drug sensitive
1,2 Benzo-8-(1-hydroxy-2-methylamino propane)-3-phenoxazone 400530 Drug sensitive
Sjg-136 393111 Drug sensitive
Benzo[1,2-b:5,4-b']dithiophene-4,8-dione, 2-acetyl- 388028 Drug sensitive
3-(4-Fluorophenyl)-3-(4-hydroxy-2-methylphenyl)-2-benzofuran-1(3H)-one 387973 Drug resistant
3-(4-Fluorophenyl)-3-(4-acetoxy-2-methylphenyl)phthalide 383342 Drug resistant
19-Hydroxy-8-O-methyltetrangulol 379539 Drug sensitive
7-Chloro-6-(2-fluoroethylamino)quinoline-5,8-dione 379079 Drug sensitive
2-(2-Chloroethoxy)naphthazarin 378770 Drug sensitive
N-(8-Hydroxy-6-methyl-1,4-dioxo-1,4-dihydro-2-naphthalenyl)acetamide 377214 Drug sensitive
5,8-Dihydroxy-2-(4-(2-pyridinyl)-1-piperazinyl)naphthoquinone 376947 Drug sensitive
2-Acetyl-1,2-dihydroellipticine 376328 Drug resistant
1,2-Dimethyl-phenothiazone 369387 Drug sensitive
4-(1-Benzofuran-2-yl)-7-methoxychromen-2-one 364364 Drug resistant
4-Nitro-6-(trifluoromethyl)-2,1,3-benzoselenadiazole 362897 Drug sensitive
Girolline 362388 Drug resistant
Imidazole, 1-(4-chlorophenyl)-4-(4-nitrophenyl)- 355940 Drug resistant
Dolastatin 11 354399 Drug sensitive
Acronycine, 2-nitro 342903 Drug sensitive
8-Trichloromethyldihydroberberine 320713 Drug sensitive
Dichloroallyl lawsone 277767 Drug sensitive
1-(2-Chloroethyl)-3-(2,6-dioxo-3-piperidyl)-1-nitrosourea 26328 Drug sensitive
2'-Deoxy-5-(trifluoromethyl)uridine 253083 Drug sensitive
Dechlorinated rebeccamycin 24203043 Drug sensitive
[4-[(4-Arsonophenyl)methyl]phenyl]arsonic acid 241158 Drug sensitive
9H-Purin-2-amine, 6-[(1-methyl-4-nitro-1H-imidazol-5-yl)thio]-9-(2-methylpropyl)- 239491 Drug sensitive
Methyl 1,6,8,14a-tetrahydroxy-11-[(4-hydroxy-3,5-dimethoxy-6-methyloxan-2-yl)amino]-6a-methoxy-3-methyl-7,9,12,14-tetraoxo-5,6-dihydrobenzo[a]tetracene-2-carboxylate 197261 Drug sensitive
Azaribine 16574 Drug sensitive
Trihexyltetradecylphosphonium tetrafluoroborate 16211343 Drug sensitive
(2Z,9E,13Z,15E)-4',11-Dihydroxy-2,4',9-trimethylspiro[3-aza-1(2,4)-thiazolacyclohexadecaphanene-6,3'-[1,2]dithiolane]-9,13,15-triene-4,5',12-trione 2'-oxide 154730760 Drug sensitive
(10S,13S,16S,19S)-16-Butan-2-yl-10,11,14-trimethyl-3-(oxiran-2-ylmethyl)-13-propan-2-yl-4-oxa-1,8,11,14,17-pentazabicyclo[17.3.0]docosane-2,5,9,12,15,18-hexone 152771884 Drug sensitive
Diphenyltin dichloride 14342 Drug sensitive
Methyl ester prodigiosene 136040158 Drug sensitive
C8, Carbonyl prodigiosine 135540857 Drug sensitive
8-Azahypoxanthine 135410720 Drug sensitive
3-Nitro-benzoic acid (2-hydroxy-benzylidene)-hydrazide 135408681 Drug sensitive
8-Azaguanine 135403646 Drug sensitive
DTIC-Dome 135398738 Drug sensitive
[(1S,2S,3R,4S,7R,9S,10S,12R,15S)-4,12-Diacetyloxy-1-hydroxy-15-[(2R,3S)-2-hydroxy-3-[[(E)-2-methylbut-2-enoyl]amino]-3-phenylpropanoyl]oxy-10,14,17,17-tetramethyl-11-oxo-9-[(3R,4S,5R)-3,4,5-trihydroxyoxan-2-yl]oxy-6-oxatetracyclo[11.3.1.03,10.04,7]heptadec-13-en-2-yl] benzoate 134714918 Drug sensitive
(2R,4R,6S,7S,12S)-6,7,16-Trihydroxy-18-methoxy-12-methyl-3,13-dioxatricyclo[13.4.0.02,4]nonadeca-1(15),9,16,18-tetraene-8,14-dione 131676399 Drug sensitive
Sendanin 12806435 Drug sensitive
Dibutyltin dichloride 12688 Drug sensitive
(1S,3R,7Z,9R,12S,13R,15S)-13-Butan-2-yl-13-hydroxy-3,7,12-trimethyl-10,14,16-trioxatetracyclo[7.5.1.13,6.012,15]hexadeca-5,7-diene-4,11-dione 11972510 Drug sensitive
Acetylenedicarboxamide 10971 Drug sensitive
[(1R,2R,4R,6R,7S,9S,10Z,12R)-10-(Hydroxymethyl)-4-methyl-15-methylidene-14-oxo-5,8,13-trioxatetracyclo[10.3.0.04,6.07,9]pentadec-10-en-2-yl] (Z)-2-(acetyloxymethyl)but-2-enoate 101277368 Drug sensitive
Chimaphilin 101211 Drug sensitive
N,N-Bis(2-chloroethyl)-p-toluidine 100400 Drug sensitive
1,3-diphenyl-4-(3-phenyl-4,5-dihydro-1H-pyrazol-5-yl)-1H-pyrazole - Drug resistant
indole-2,3-dione, 5-methyl-, 3-[(o-nitrophenyl)hydrazone] - Drug resistant
il4(38-37)-pe38kdel - Drug resistant
ovb3-pe - Drug resistant
tgf.alpha.-pe40 - Drug resistant
toxin .delta.53l - Drug resistant
2-[(3,4-dicloro)anilino]-3-phenyl-5,7-diamino quinoxaline - Drug sensitive
2-chloro-3-amino-5,8-dihydoxy-1,4-naphthoquinone - Drug sensitive
4'-deoxy-13',17-dinitro-3',4'-epoxy-vincaleukoblastine - Drug sensitive
4-quinazolone, 7-amino-3-(4-methoxyphenyl)-, hydrate - Drug sensitive
9,10-anthracenedione, 1-[(oxiranylmethyl)amino]- - Drug sensitive
acetamide, n-(2-mercaptoethyl)-, benzoate (6ci, 7ci) - Drug sensitive
b676297k277 3',4'-deoxypsorospermin 3',4'-chlorohydrin - Drug sensitive
benzo[1,2-b:4,5-b']dithiophene-4,8-diol, dipropionate - Drug sensitive
dimethylarsinothious acid, 2,4-pyrimidinediyl ester - Drug sensitive
mercury, tetrakis(acetato)(2,3,4,5-thiophenetetrayl)tetra- - Drug sensitive
naphtho[2,3-d]-1,3-dioxepin-6,11-dione, 4-methyl- - Drug sensitive
naphtho[2,3-d]oxazole-4,9-dione, 2-(1,1-dimethylethyl)- - Drug sensitive
phenol, 4,4'-(5,5'-biisoxazole-3,3'-diyl)bis- - Drug sensitive
[bis(aminomethyl)diethylsilane]dichloroplatinum (ii) - Drug sensitive
7-propanoyltaxol - Drug sensitive
analog of cc-1065 - Drug sensitive
Camptothecin Derivative - Drug sensitive
chlorambucil-spermidine - Drug sensitive
crotoxin cd - Drug sensitive
hymenialdisine - Drug sensitive
methyl 3-farnesylthioacetate - Drug sensitive
mitaplatin - Drug sensitive
potassium[trichloro(isopropylamine)platinum] - Drug sensitive
rh(iii)-amodiaquine - Drug sensitive
Tetraplatin - Drug sensitive
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-513b-5p
Alocrest 60780 Drug interaction    RC00007657
Progesterone 5994 Drug interaction    RC00007656

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-513b-5p
Interactor2: TNF

Evidence Support:


Prediction-Evidence microT//miRanda//miRMap//PicTar//PITA//Targetscan
Support Database ViRBase

References:


PMID 33428154 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line None Interactor2 expression None
Description To explore the regulatory relationship between the 5 key genes, 3 coronavirus-related genes (ACE2, TMPRSS2, BSG), and their target miRNA, we used 6 miRNA target prediction databases to predict the target miRNA of these genes.

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