Detail Information

Basic Information:


  VIRBase ID:  

HHID00105309

  Virus:  

SARS-CoV-2

  Host:  

Homo sapiens

  Confidence Score:  

0.2494

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-149-3p:           TLR3:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-149-3p TLR3
miRBase
Accession/Entrez ID		 MIMAT0004609 7098
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - CD283//IIAE2

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-149-3p
rs1010751133 chr2:240456073    G/A
rs1010751133 chr2:240456073    G/C
rs1010751133 chr2:240456073    G/T
rs1165267714 chr2:240456066    G/T
rs1248860515 chr2:240456074    T/C
rs1283632093 chr2:240456072    T/C
rs1284461395 chr2:240456075    G/T
rs1299093493 chr2:240456069    G/A
rs1320221915 chr2:240456076    C/G
rs1358442678 chr2:240456067    G/T
rs1399133005 chr2:240456068    G/T
rs1445917433 chr2:240456071    C/A
rs1445917433 chr2:240456071    C/T
rs963649591 chr2:240456070    G/A
rs963649591 chr2:240456070    G/T
rs1405842421 chr2:240456062    G/A
rs1412989618 chr2:240456061    G/C
rs1412989618 chr2:240456061    G/T
rs747327479 chr2:240456058    G/C

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR TLR3
chr4:187001863(+) A-I      intronic
chr4:187003336(+) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase TLR3
chr4:186990367-186990368(+) m6A 5'UTR       24981863
chr4:186997778-186997779(+) m6A CDS       24981863
chr4:187003525-187003526(+) m6A 5'UTR//CDS//exon       24981863
chr4:187003579-187003580(+) m6A 5'UTR//CDS//exon       24981863
chr4:187003649-187003650(+) m6A 5'UTR//CDS//exon       24981863
chr4:187003659-187003660(+) m6A 5'UTR//CDS//exon       24981863
chr4:187003978-187003979(+) m6A CDS//exon       24981863
chr4:187004022-187004023(+) m6A CDS//exon       24284625//24981863
chr4:187004037-187004038(+) m6A CDS//exon       24284625//24981863
chr4:187004177-187004178(+) m6A CDS//exon       24209618//24981863
chr4:187004260-187004261(+) m6A CDS//exon       24284625//24209618//24981863
chr4:187004635-187004636(+) m6A CDS//exon       24981863
chr4:187004686-187004687(+) m6A CDS//exon       24981863
chr4:187004746-187004747(+) m6A CDS//exon       24981863
chr4:187004829-187004830(+) m6A CDS//exon       24284625//24209618//24981863
chr4:187004906-187004907(+) m6A CDS//exon       24284625//24209618//24981863
chr4:187004932-187004933(+) m6A CDS//exon       24284625//24209618//24981863
chr4:187004948-187004949(+) m6A CDS//exon       24284625//24209618//24981863
chr4:187005082-187005083(+) m6A CDS//exon       24284625//24981863
chr4:187005090-187005091(+) m6A CDS//exon       24284625//24981863
chr4:187005095-187005096(+) m6A CDS//exon       24284625//24981863
chr4:187005155-187005156(+) m6A CDS//exon       24284625//24981863
chr4:187005181-187005182(+) m6A CDS//exon       24284625//25456834//24981863
chr4:187005214-187005215(+) m6A CDS//exon       25456834//24981863
chr4:187005236-187005237(+) m6A CDS//exon       25456834//24981863
chr4:187005310-187005311(+) m6A CDS//exon       24981863
chr4:187005888-187005889(+) m6A CDS//exon       24981863
chr4:187005893-187005894(+) m6A CDS//exon       24981863
chr4:187005944-187005945(+) m6A CDS//exon       24981863
chr4:187006013-187006014(+) m6A CDS//exon       24981863

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-149-3p
Exosome Breast cancer cell line (MCF-7)     20976003
Exosome B cell line (Raji)|Jurkat-derived T cell line (J77cl20)     21505438
Exosome Plasma     23663360
Exosome K562 cells     24460325
Exosome Breast cancer cell lines (MCF-7|MDA-MB-231)     24468161
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Seminal plasma     23539611
Microvesicle Fibroblasts|Mesenchymal stem cells     -
Mitochondrion Cell line (HEK-293)     22984580
TLR3
Exosome Blood     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-149-3p
Ethyl phenylpropiolate 91516 Drug resistant
Clothixamide maleate 76972759 Drug resistant
Phosphotrienin 6913994 Drug resistant
Sulbentine 67686 Drug resistant
Tacacoside A2 6712615 Drug resistant
1,3,8-Trihydroxy-6-methoxyanthracene-9,10-dione 636723 Drug resistant
Primaquine phosphate 6135 Drug resistant
6-[2-[(2-Methylsulfonylethylamino)methyl]-1,3-thiazol-4-yl]-N-[4-[[3-(trifluoromethyl)phenyl]methoxy]phenyl]quinazolin-4-amine;hydrochloride 57395317 Drug sensitive
Thiopyrimidine-CH3 5473238 Drug resistant
Tetrocarcin A, sodium salt 54724658 Drug resistant
p-Chloranilinum[bis(p-chloraniline)dioxalatoruthenate(III)] 54608061 Drug resistant
Cyclosporin A 5284373 Drug resistant
9-beta-D-Xylofuranosyladenine 447916 Drug sensitive
Oxyacanthine 442333 Drug resistant
10-Hydroxy-5-methoxy-1-(2-methyloxiran-2-yl)-1,2-dihydrofuro[2,3-c]xanthen-6-one 429905 Drug resistant
S-(Diisopropylarsino)-3-mercapto-1,2-propanediol 406478 Drug resistant
Aminopyrimidine-CH3 406278 Drug resistant
Fagaronine chloride 40304 Drug sensitive
11-Hydroxyusambarine Chlorhydrate 401426 Drug resistant
5'-Formyl-2,5-bis(2'-selenyl)-N-methylpyrrol 394652 Drug sensitive
3-(4-Fluorophenyl)-3-(4-hydroxy-2-methylphenyl)-2-benzofuran-1(3H)-one 387973 Drug sensitive
3,8-Dimethyl-1,2-naphthoquinone 373912 Drug resistant
4-(1-Benzofuran-2-yl)-7-methoxychromen-2-one 364364 Drug sensitive
4-Nitro-6-(trifluoromethyl)-2,1,3-benzoselenadiazole 362897 Drug resistant
Imidazole, 1-(4-chlorophenyl)-4-(4-nitrophenyl)- 355940 Drug sensitive
Acronycine, 2-nitro 342903 Drug resistant
Clomifene citrate 3033832 Drug resistant
N-[(4R)-4-[(3R,5R,7R,8R,9S,10S,12S,13R,14S,17R)-3,7,12-Tris(3-aminopropoxy)-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentyl]octan-1-amine 24205348 Drug resistant
4,5-Bis(4-methoxyphenyl)-1,5-dihydroimidazol-2-one 231112 Drug resistant
4-[5-(2-Amino-pyrimidin-4-yl)-4-(4-fluoro-phenyl)-imidazol-1-yl]-cyclohexanol 22464120 Drug sensitive
4-Chloro-5-phenoxy-3H-1,2-dithiole-3-thione 16766044 Drug resistant
Cysteine, S-[(4-aminocarbonyl-1H-imidazol-5-yl)azo]- 135493928 Drug resistant
DTIC-Dome 135398738 Drug resistant
(2R,4R,6S,7S,12S)-6,7,16-Trihydroxy-18-methoxy-12-methyl-3,13-dioxatricyclo[13.4.0.02,4]nonadeca-1(15),9,16,18-tetraene-8,14-dione 131676399 Drug resistant
Acetylenedicarboxamide 10971 Drug resistant
(S)-Morpholin-3-ylmethyl (4-((1-(3-fluorobenzyl)-1H-indazol-5-yl)amino)-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl)carbamate 10437018 Drug sensitive
Selumetinib 10127622 Drug resistant
(1R,6S,11aS,13S,14aR)-1,13-dihydroxy-6-vinyl-1,6,7,8,9,11a,12,13,14,14a-decahydro-4H-cyclopenta[f]oxacyclotridecin-4-one - Drug resistant
(E)-2-(2-(benzo[d][1,3]dioxol-5-yl)vinyl)-5-(3-methyl-1H-pyrazol-5-yl)-1,3,4-oxadiazole - Drug resistant
(E)-8-(4-chlorobenzylidene)-4-(4-chlorophenyl)-3,4,5,6,7,8-hexahydroquinazolin-2-amine - Drug resistant
1,1'-biphenyl, 4,4'bis(thiomethyl)- - Drug resistant
2,3,4-tri-o-acetyl-1-s-dimethylarsino-1-thio- a -d-xylose - Drug resistant
4(1h)-quinazolinone, 2-(2-chlorophenyl)-2,3-dihydro- - Drug resistant
4-[3-(3,4-dihydro-1H-isoquinolin-2-yl)prop-1-en-2-yl]-N-pyrazin-2-ylbenzamide - Drug resistant
5,6-dimethyl-9-oxo-9h-xanthene-4-acetic acid, sodium salt - Drug resistant
b676297k277 3',4'-deoxypsorospermin 3',4'-chlorohydrin - Drug resistant
benzo[1,2-b:4,5-b']dithiophene-4,8-diol, dipropionate - Drug resistant
benzo[b]naphtho[2,3-d]furan-6,11-dione, 4-chloro-3-hydroxy - Drug resistant
dimethylarsinothious acid, 2,4-pyrimidinediyl ester - Drug resistant
pyrimidine, 2,4,5-trichloro-6-ethyl- - Drug resistant
pyrimidine, 2,4,5-trichloro-6-isopropyl- - Drug resistant
7-ethyl-9-methoxy-5-ethoxycamptothecin - Drug resistant
b705009k098 - Drug resistant
crambescidin 800 trihydrochloride - Drug resistant
somatostatin analog in diacetic form mw=1067.2 - Drug resistant
1,3-diphenyl-4-(3-phenyl-4,5-dihydro-1H-pyrazol-5-yl)-1H-pyrazole - Drug sensitive
6-phenyl-6h-indeno[1,2-c]isoquinoline-5,11-dione - Drug sensitive
indole-2,3-dione, 5-methyl-, 3-[(o-nitrophenyl)hydrazone] - Drug sensitive
antineoplastic-d655481 - Drug sensitive
geldanamycin dimethylglycinate - Drug sensitive
organosulfur compound - Drug sensitive
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-149-3p
5-Fluorouracil 3385 Drug interaction    RC00006967
Celecoxib 2662 Drug interaction    RC00006966
Trastuzumab - Drug interaction    RC00006968
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-149-3p
Platinum 23939       25872328

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-149-3p
Interactor2: TLR3

Evidence Support:


Prediction-Evidence microT//miRanda//miRMap//PicTar//PITA//Targetscan
Support Database ViRBase

References:


PMID 33428154 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line None Interactor2 expression None
Description To explore the regulatory relationship between the 5 key genes, 3 coronavirus-related genes (ACE2, TMPRSS2, BSG), and their target miRNA, we used 6 miRNA target prediction databases to predict the target miRNA of these genes.

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