Basic Information:

  VIRBase ID:  

HHID00105072

  Virus:  

SARS-CoV-2

  Host:  

Homo sapiens

  Confidence Score:  

0.2494

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-16-5p:  MIMAT0000069          TLR3:  NM_003265     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-16-5p	TLR3
miRBase Accession/Entrez ID	MIMAT0000069	7098
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	CD283//IIAE2

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-16-5p	rs1211671197 chr13:50049032    A/G rs372220237 chr13:50049040    G/A rs754694443 chr13:50049039    C/T rs760368482 chr13:50049028    G/A rs1193058159 chr3:160404764    TA/T rs1254426807 chr3:160404754    T/C rs1258560931 chr3:160404770    T/C rs1258574236 chr3:160404762    C/A rs1258574236 chr3:160404762    C/T rs748289135 chr3:160404763    G/A rs756199981 chr3:160404774    C/T rs777900452 chr3:160404775    G/A

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	TLR3	chr4:187001863(+) A-I      intronic chr4:187003336(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	TLR3	chr4:186990367-186990368(+) m6A 5'UTR       24981863 chr4:186997778-186997779(+) m6A CDS       24981863 chr4:187003525-187003526(+) m6A 5'UTR//CDS//exon       24981863 chr4:187003579-187003580(+) m6A 5'UTR//CDS//exon       24981863 chr4:187003649-187003650(+) m6A 5'UTR//CDS//exon       24981863 chr4:187003659-187003660(+) m6A 5'UTR//CDS//exon       24981863 chr4:187003978-187003979(+) m6A CDS//exon       24981863 chr4:187004022-187004023(+) m6A CDS//exon       24284625//24981863 chr4:187004037-187004038(+) m6A CDS//exon       24284625//24981863 chr4:187004177-187004178(+) m6A CDS//exon       24209618//24981863 chr4:187004260-187004261(+) m6A CDS//exon       24284625//24209618//24981863 chr4:187004635-187004636(+) m6A CDS//exon       24981863 chr4:187004686-187004687(+) m6A CDS//exon       24981863 chr4:187004746-187004747(+) m6A CDS//exon       24981863 chr4:187004829-187004830(+) m6A CDS//exon       24284625//24209618//24981863 chr4:187004906-187004907(+) m6A CDS//exon       24284625//24209618//24981863 chr4:187004932-187004933(+) m6A CDS//exon       24284625//24209618//24981863 chr4:187004948-187004949(+) m6A CDS//exon       24284625//24209618//24981863 chr4:187005082-187005083(+) m6A CDS//exon       24284625//24981863 chr4:187005090-187005091(+) m6A CDS//exon       24284625//24981863 chr4:187005095-187005096(+) m6A CDS//exon       24284625//24981863 chr4:187005155-187005156(+) m6A CDS//exon       24284625//24981863 chr4:187005181-187005182(+) m6A CDS//exon       24284625//25456834//24981863 chr4:187005214-187005215(+) m6A CDS//exon       25456834//24981863 chr4:187005236-187005237(+) m6A CDS//exon       25456834//24981863 chr4:187005310-187005311(+) m6A CDS//exon       24981863 chr4:187005888-187005889(+) m6A CDS//exon       24981863 chr4:187005893-187005894(+) m6A CDS//exon       24981863 chr4:187005944-187005945(+) m6A CDS//exon       24981863 chr4:187006013-187006014(+) m6A CDS//exon       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-16-5p	Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytoplasm Cell line (HeLa)     21695135 Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Exosome Pooled sera     27278097 Exosome EBV- and KSHV-negative Burkitt lymphoma cell line (Bjab)|EBV-infected lymphoblastoid cell line (LCL)|KSHV-infected lymphoma cell lines (BCBL-1|TY-1)     27611973 Exosome Plasma     30154547 Exosome Glioblastoma cells     19011622 Exosome Human embryonic kidney cell line (HEK-293)     20353945 Exosome Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901 Exosome Breast cancer cell line (MCF-7)     20976003 Exosome Primary dendritic cells|T cell line (J77)     21505438 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Human mast cell line (HMC-1)     24009880 Exosome Plasma     24130905 Exosome Breast cancer cell lines (MCF-7|MDA-MB-231)     24468161 Exosome Blood|B lymphoblastoid cells|Breast milk|Colon tissue|Endothelial cells|Epithelial cells|Kidney tissue|Lymphoma tissue|Mast cells|Seminal fluid|Tongue tissue     - Extracellular Vesicle Plasma     28588009 Microvesicle Glioblastoma cells     19011622 Microvesicle Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901 Microvesicle Plasma     23077538 Microvesicle Seminal plasma     23539611 Microvesicle Hepatoma cells     23771658 Microvesicle Blood|Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     - Mitochondrion Osteosarcoma cell line (143B)     27396686 Mitochondrion Osteosarcoma cell line (143B)     27563705 Mitochondrion Cell line (HEK-293|HeLa)     22984580 Nucleolus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Nucleus GC cell line (MGC-803)     29872807 Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus Neural progenitor cells     21363885 Polysome Human cervical cancer cell line (HeLa)     25609084
	TLR3	Exosome Blood     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function
ncDR	hsa-miR-16-5p	8-Aminoadenosine 96851 Drug resistant [[4-(3-Aminophenyl)-2-pyridyl]methyleneamino]thiourea 9556427 Drug sensitive Vancide 26 79411 Drug sensitive 1,5-Methano-11H-furo(3,2-g)pyrano(3,2-b)xanthene-3a(4H)-crotonaldehyde, 1,2,5,7-tetrahydro-8-hydroxy-alpha,2,2,11,11-pentamethyl-13-(3-methyl-2-butenyl)-4,7-dioxo-, trans- 78358492 Drug sensitive Crotonoside 65085 Drug sensitive trans-1,2-Bis(propylsulfonyl)ethylene 5904452 Drug sensitive 2,3-Diphenyl-1,4-naphthoquinone 555037 Drug sensitive Artelasticin 5471311 Drug sensitive 5,10-Dimethoxybenzo[g]quinolin-2(1H)-one 54612875 Drug resistant Antineoplastic-651590 54604785 Drug sensitive Aspiculamycin hcl 54600418 Drug resistant Pyrethrosin 5281496 Drug sensitive 8-Hydroxymanzamine A 5270765 Drug sensitive (7S,9S)-7-[(2R,4S,5S,6S)-4-(Dimethylamino)-5-hydroxy-6-methyl-tetrahydropyran-2-yl]oxy-6,9,11-trihydroxy-9-(2-hydroxyacetyl)-4-methoxy-8,10-dihydro-7H-tetracene-5,12-dione 474312 Drug resistant Benzamide riboside 458027 Drug sensitive 1,4-Diamino-5-nitroanthraquinone 4421615 Drug resistant Ditercalinium dimethanesulfonate dimethanesulfonate 435243 Drug sensitive S-(Dimethylarsino)-3-mercapto-1,2-propyl diacetate 406479 Drug sensitive 3-Acetoxymethyl-1-methyl-5-methoxyindole-4,7-dione 404937 Drug resistant 2-[(Phenylamino)methyl]benzene-1,4-diol 403336 Drug sensitive Rogiolol 402519 Drug sensitive (3R,5S)-Fluvastatin(1-) 37888681 Drug resistant 2-Acetyl-1,2-dihydroellipticine 376328 Drug resistant 3,8-Dimethyl-1,2-naphthoquinone 373912 Drug sensitive 11H-Benzo[a]carbazole-1,4-dione, 7,11-dimethyl- 371271 Drug sensitive 10-(2,4-Dichlorophenyl)-3-methylbenzo[g]pteridine-2,4-dione 362038 Drug resistant Helenin 327378 Drug sensitive Mercury, (p-carboxyphenyl)(purin-6-ylthio)- 3246339 Drug sensitive 2-Hydroxy-4-((2,4,6-triamino-5-pyrimidinyl)diazenyl)phenylarsonic acid 272658 Drug sensitive 1H-Benzo[a]carbazole-1,4(11H)-dione, 11-methyl- 261066 Drug sensitive Salarin C 24867082 Drug resistant [(4E,6Z,10Z)-20,22-Dihydroxy-13,14,17-trimethoxy-4,8,10,12,16-pentamethyl-3-oxo-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18(22),19-hexaen-9-yl] carbamate 24199492 Drug sensitive 1-[1-(Diethylamino)propan-2-ylamino]-4-nitrothioxanthen-9-one;chloride 24186469 Drug resistant (S)-2-Amino-3-(hydroxy(nitroso)amino)propanoic acid 136096147 Drug resistant 12-Iminodaunorubicin hcl 135539784 Drug sensitive 5-[(E)-[Amino(methyl)amino]azo]-1H-imidazole-4-carboxamide 135493930 Drug sensitive DTIC-Dome 135398738 Drug sensitive Cladospirone bisepoxide 10316810 Drug sensitive naphthalene-1,2-dione, 4-[(4-bromophenyl)amino]-, 1-oxime - Drug resistant antineoplastic-d655481 - Drug resistant stereoisomer of nsc 672622-t - Drug resistant (2r,3r)-(+)-methyl 3-phenyloxirane-carboxylate - Drug sensitive 1,2-naphthoquinone, 3,7-dimethyl- - Drug sensitive 1h-benzo[a]carbazole-1,4(11h)-dione, 11-phenyl- - Drug sensitive 2,2',5,5'-tetrahydroxy-4,4'-dimethylbiphenyl - Drug sensitive 2h-naphtho[1,2-b]pyran-2-one, 9-hydroxy-4-phenyl- - Drug sensitive benzofurazan, 5-nitro-6-(1-piperidinyl)-, 1-oxide - Drug sensitive cis-difluorobis(1-phenylhexane-1,3-dionato)titanium(iv) - Drug sensitive dichloro(dodeca-2,6,10-triene-1,12-diyl)- ruthenium - Drug sensitive 1-[(2-phenylethoxy)methyl]-5-ethyl-6-(phenylseleno)uracil - Drug sensitive 4-carbo-1-thiazolidine-3-o-gluconyl-.gamma.-lactone - Drug sensitive ambrosin piperidine diadduct di-n-oxide - Drug sensitive cyclo [n-naphthoyl-d-lys-asn-gln-trp-ala-val-d-ala-his-leu] - Drug sensitive

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-16-5p	Curcumin 969516 Drug interaction    RC00000380 Nicotine 89594 Drug interaction    RC00000368 Formaldehyde 712 Drug interaction    RC00000347 Bisphenol A 6623 Drug interaction    RC00000358 Gemcitabine 60750 Drug interaction    RC00000365 Vincristine 5978 Drug interaction    RC00000357 D-Glucose 5793 Drug interaction    RC00000356 Mitomycin 5746 Drug interaction    RC00000355 Temozolomide 5394 Drug interaction    RC00000354 Eloxatine 5310940 Drug interaction    RC00000384 Imatinib 5291 Drug interaction    RC00000353 Morphine 5288826 Drug interaction    RC00000383 Genistein 5280961 Drug interaction    RC00000382 Melphalan 460612 Drug interaction    RC00000379 Decitabine 451668 Drug interaction    RC00000378 Diethylstilbestrol 448537 Drug interaction    RC00000377 Tretinoin 444795 Drug interaction    RC00000375 Trichostatin A 444732 Drug interaction    RC00000374 Carboplatinum 38904 Drug interaction    RC00000364 Bortezomib 387447 Drug interaction    RC00000373 Paclitaxel 36314 Drug interaction    RC00000363 5-Fluorouracil 3385 Drug interaction    RC00000352 Enoxacin 3229 Drug interaction    RC00000351 Doxorubicin 31703 Drug interaction    RC00000362 cis-Diaminedichloroplatinum 2767 Drug interaction    RC00000350 Tamoxifen 2733526 Drug interaction    RC00000381 Verapamil 2520 Drug interaction    RC00000349 Calcium sulfate 24497 Drug interaction    RC00000361 Benzo[a]pyrene 2336 Drug interaction    RC00000348 Nutlin-3 216345 Drug interaction    RC00000372 Polylysine 162282 Drug interaction    RC00000371 Arsenic trioxide 14888 Drug interaction    RC00000360 Docetaxel 148124 Drug interaction    RC00000370 Pemetrexed 135410875 Drug interaction    RC00000376 Vinblastine 13342 Drug interaction    RC00000359 Ginsenoside Rh2 119307 Drug interaction    RC00000369 5-aza-2'-deoxycytidine (5-Aza-CdR) + trichostatin A(TSA) - Drug interaction    RC00000385 Estrogen - Drug interaction    RC00000386 Glucocorticoid - Drug interaction    RC00000387 Marine fungal metabolite 1386A - Drug interaction    RC00000388 Trypaflavine - Drug interaction    RC00000389

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-16-5p
Interactor2: TLR3

Evidence Support:

Prediction-Evidence	microT//miRanda//miRMap//PicTar//PITA//Targetscan
Support Database	ViRBase

References:

PMID	33428154	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	None	Interactor2 expression	None
Description	To explore the regulatory relationship between the 5 key genes, 3 coronavirus-related genes (ACE2, TMPRSS2, BSG), and their target miRNA, we used 6 miRNA target prediction databases to predict the target miRNA of these genes.