Basic Information
RNALocate ID: RLID:11000672
RNA Symbol: hsa-miR-16-5p
Localization: Exosome
RNA Information
RNA Name: hsa-miR-16
RNA ID: miRBase:MIMAT0000069
RNA Category: miRNA
Species: Homo sapiens
Sequence:
Localization Information
PubMed ID: 20615901
Tissue/Cell Line: Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)
Method: Microarray|qRT-PCR|RT-PCR

Originally published in Nucleic Acids Res. Wang K, et al, 2010. Reproduced under the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/)
Description: These observations of miRNA distribution demonstrate that the miRNA export system in the cells must somehow be able to target specific miRNAs to specific extracellular structures, but does not exclusively channel specific miRNAs to a given fraction. There are, however, some miRNAs that are found in the supernatant almost to the exclusion of all other fractions (miR-219 in A549 culture medium, Figure 4b, for example). Another significant observation from this data is that even though we showed that the two cell lines studied here export a similar spectrum of miRNAs (Figure 1b) the distributions of miRNAs from the two cell lines demonstrate clear differences, as shown in Figure 4b and c. For example, miR-145 is present at very low levels in HepG2 derived microvesicles (Figure 4c), while the same miRNA is present at significant levels in both A549 derived microvesicles and exosomes (Figure 4b). On the other hand, there are some miRNAs, notably those that are almost uniformly distributed among the fractions, with the same distribution no matter which cell-line is the source. These observations certainly indicate the degree of complexity of this export system that will bear further investigation. Data are collected from Figure 4.
Other Subcellular Localization
RNALocate ID Localization Tissue/Cell line PubMed ID
RLID:01001255 Cytoplasm Nasopharyngeal carcinoma cells 20498841
RLID:01001256 Cytoplasm Cell line (HeLa) 21695135
RLID:01001257 Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa) 24918059
RLID:01001258 Mitochondrion Osteosarcoma cell line (143B) 27396686
RLID:01001259 Mitochondrion Osteosarcoma cell line (143B) 27563705
RLID:01001260 Mitochondrion Cell line (HEK-293|HeLa) 22984580
RLID:01001261 Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa) 24918059
RLID:01001262 Nucleolus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa) 24918059
RLID:01001263 Nucleus GC cell line (MGC-803) 29872807
RLID:01001264 Nucleus Nasopharyngeal carcinoma cells 20498841
RLID:01001265 Nucleus Neural progenitor cells 21363885
RLID:01001266 Polysome Human cervical cancer cell line (HeLa) 25609084
RLID:11000667 Exosome Pooled sera 27278097
RLID:11000668 Exosome EBV- and KSHV-negative Burkitt lymphoma cell line (Bjab)|EBV-infected lymphoblastoid cell line (LCL)|KSHV-infected lymphoma cell lines (BCBL-1|TY-1) 27611973
RLID:11000669 Exosome Plasma 30154547
RLID:11000670 Exosome Glioblastoma cells 19011622
RLID:11000671 Exosome Human embryonic kidney cell line (HEK-293) 20353945
RLID:11000673 Exosome Breast cancer cell line (MCF-7) 20976003
RLID:11000674 Exosome Primary dendritic cells|T cell line (J77) 21505438
RLID:11000675 Exosome Brain tissue 23382797
RLID:11000676 Exosome Plasma 23663360
RLID:11000677 Exosome Human mast cell line (HMC-1) 24009880
RLID:11000678 Exosome Plasma 24130905
RLID:11000679 Exosome Breast cancer cell lines (MCF-7|MDA-MB-231) 24468161
RLID:11000680 Extracellular Vesicle Plasma 28588009
RLID:11000681 Microvesicle Glioblastoma cells 19011622
RLID:11000682 Microvesicle Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549) 20615901
RLID:11000683 Microvesicle Plasma 23077538
RLID:11000684 Microvesicle Seminal plasma 23539611
RLID:11000685 Microvesicle Hepatoma cells 23771658
RLID-D:11000008 Exosome Blood|B lymphoblastoid cells|Breast milk|Colon tissue|Endothelial cells|Epithelial cells|Kidney tissue|Lymphoma tissue|Mast cells|Seminal fluid|Tongue tissue
RLID-D:11000268 Microvesicle Blood|Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine
ncRNA Disease Information
Resource RNA Symbol Disease Link
MNDR hsa-miR-16-5p Alk+ anaplastic large-cell lymphoma MNDR-E-MI-18717
MNDR hsa-miR-16-5p Mantle cell lymphoma MNDR-E-MI-18718
MNDR hsa-miR-16-5p Splenic marginal zone lymphoma MNDR-E-MI-18719
MNDR hsa-miR-16-5p Multiple sclerosis chronic progressive MNDR-E-MI-18720
MNDR hsa-miR-16-5p Oral squamous cell carcinoma MNDR-E-MI-18721
MNDR hsa-miR-16-5p Medulloblastoma MNDR-E-MI-18722
MNDR hsa-miR-16-5p B cell lymphoma of malt type MNDR-E-MI-18723
MNDR hsa-miR-16-5p High-grade serous ovarian carcinoma MNDR-E-MI-18724
MNDR hsa-miR-16-5p Uterine corpus endometrial carcinoma MNDR-E-MI-18725
MNDR hsa-miR-16-5p Lymphoma MNDR-E-MI-18726
MNDR hsa-miR-16-5p Lymphoma non-hodgkin MNDR-E-MI-18727
MNDR hsa-miR-16-5p Estrogen-receptor positive breast cancer MNDR-E-MI-18728
MNDR hsa-miR-16-5p Estrogen-receptor negative breast cancer MNDR-E-MI-18729
MNDR hsa-miR-16-5p Progesterone-receptor positive breast cancer MNDR-E-MI-18730
MNDR hsa-miR-16-5p Progesterone-receptor negative breast cancer MNDR-E-MI-18731
MNDR hsa-miR-16-5p Her2-receptor positive breast cancer MNDR-E-MI-18732
MNDR hsa-miR-16-5p Breast cancer luminal MNDR-E-MI-18733
MNDR hsa-miR-16-5p Niemann-pick disease type c MNDR-E-MI-18734
MNDR hsa-miR-16-5p Prostate cancer MNDR-E-MI-18735
MNDR hsa-miR-16-5p B-cell chronic lymphocytic leukemia MNDR-E-MI-18736
MNDR hsa-miR-16-5p Gastric cancer MNDR-E-MI-18737
MNDR hsa-miR-16-5p Gastric lymphoma MNDR-E-MI-18738
MNDR hsa-miR-16-5p Alzheimer disease MNDR-E-MI-18739
MNDR hsa-miR-16-5p Intracranial aneurysm MNDR-E-MI-18740
MNDR hsa-miR-16-5p Dysautonomia familial MNDR-E-MI-18741
MNDR hsa-miR-16-5p Malaria MNDR-E-MI-18742
MNDR hsa-miR-16-5p Ataxia telangiectasia MNDR-E-MI-18743
MNDR hsa-miR-16-5p Huntington disease MNDR-E-MI-18744
MNDR hsa-miR-16-5p Chorea MNDR-E-MI-18745
MNDR hsa-miR-16-5p Cardiovascular disease MNDR-E-MI-18746
MNDR hsa-miR-16-5p Moyamoya disease MNDR-E-MI-18747
MNDR hsa-miR-16-5p Lung cancer MNDR-E-MI-18748
MNDR hsa-miR-16-5p Down syndrome MNDR-E-MI-18749
MNDR hsa-miR-16-5p Parkinson disease MNDR-E-MI-18750
MNDR hsa-miR-16-5p Niemann-pick disease MNDR-E-MI-18751
MNDR hsa-miR-16-5p Basal-like breast cancer MNDR-E-MI-18752
MNDR hsa-miR-16-5p Cancer MNDR-E-MI-18753
MNDR hsa-miR-16-5p Pituitary neoplasms MNDR-E-MI-18754
MNDR hsa-miR-16-5p Pancreatic cancer MNDR-E-MI-18755
MNDR hsa-miR-16-5p Melanoma MNDR-E-MI-18756
MNDR hsa-miR-16-5p Gaucher disease MNDR-E-MI-18757
MNDR hsa-miR-16-5p Rectum adenocarcinoma MNDR-E-MI-18758
MNDR hsa-miR-16-5p Colon cancer MNDR-E-MI-18759
MNDR hsa-miR-16-5p Ischemic attack transient MNDR-E-MI-18760
MNDR hsa-miR-16-5p Colon adenocarcinoma MNDR-E-MI-18761
MNDR hsa-miR-16-5p Multiple sclerosis MNDR-E-MI-18762
MNDR hsa-miR-16-5p Multiple sclerosis relapsing-remitting MNDR-E-MI-18763
MNDR hsa-miR-16-5p Familial ovarian cancer MNDR-E-MI-18764
MNDR hsa-miR-16-5p Laryngeal carcinoma MNDR-E-MI-18765
MNDR hsa-miR-16-5p Carcinoma ductal breast MNDR-E-MI-18766
MNDR hsa-miR-16-5p Glioblastoma MNDR-E-MI-18767
MNDR hsa-miR-16-5p Astrocytoma MNDR-E-MI-18768
MNDR hsa-miR-16-5p Glioma MNDR-E-MI-18769
MNDR hsa-miR-16-5p Chronic obstructive pulmonary disease MNDR-E-MI-18770
MNDR hsa-miR-16-5p Oligodendroglioma MNDR-E-MI-18771
MNDR hsa-miR-16-5p Chordoma MNDR-E-MI-18772
MNDR hsa-miR-16-5p Amyotrophic lateral sclerosis MNDR-E-MI-18773
MNDR hsa-miR-16-5p Epilepsy temporal lobe MNDR-E-MI-18774
MNDR hsa-miR-16-5p Osteosarcoma MNDR-E-MI-18775
MNDR hsa-miR-16-5p Liposarcoma MNDR-E-MI-18776
MNDR hsa-miR-16-5p Coronary artery disease MNDR-E-MI-18777
MNDR hsa-miR-16-5p Breast carcinoma MNDR-E-MI-18778
MNDR hsa-miR-16-5p Infarction middle cerebral artery MNDR-E-MI-18779
MNDR hsa-miR-16-5p Cerebral infarction MNDR-E-MI-18780
MNDR hsa-miR-16-5p Liver cancer MNDR-E-MI-18781
MNDR hsa-miR-16-5p Cervical adenocarcinoma MNDR-E-MI-18782
MNDR hsa-miR-16-5p Gastric adenocarcinoma MNDR-E-MI-18783
MNDR hsa-miR-16-5p Cervical squamous cell carcinoma MNDR-E-MI-18784
MNDR hsa-miR-16-5p Pituitary adenoma MNDR-E-MI-18785
MNDR hsa-miR-16-5p Lung squamous cell carcinoma MNDR-E-MI-18786
MNDR hsa-miR-16-5p Carcinoma lung non small cell MNDR-E-MI-18787
MNDR hsa-miR-16-5p Adrenocortical cancer MNDR-E-MI-18788
MNDR hsa-miR-16-5p Thyroid carcinoma MNDR-E-MI-18789
MNDR hsa-miR-16-5p Papillary thyroid carcinoma MNDR-E-MI-18790
MNDR hsa-miR-16-5p Ovarian carcinoma MNDR-E-MI-18791
MNDR hsa-miR-16-5p Bladder urothelial carcinoma MNDR-E-MI-18792
MNDR hsa-miR-16-5p Pancreatic adenocarcinoma MNDR-E-MI-18793
MNDR hsa-miR-16-5p Myasthenia gravis autoimmune experimental MNDR-E-MI-18794
MNDR hsa-miR-16-5p Carcinoma renal cell MNDR-E-MI-18795
MNDR hsa-miR-16-5p Kidney renal papillary cell carcinoma MNDR-E-MI-18796
MNDR hsa-miR-16-5p Clear cell renal cell carcinoma MNDR-E-MI-18797
MNDR hsa-miR-16-5p Biliary tract cancer MNDR-E-MI-18798
MNDR hsa-miR-16-5p Cholangiocarcinoma MNDR-E-MI-18799
MNDR hsa-miR-16-5p Esophageal cancer MNDR-E-MI-18800
MNDR hsa-miR-16-5p Lung small cell carcinoma MNDR-E-MI-18801
MNDR hsa-miR-16-5p Head and neck squamous cell carcinoma MNDR-E-MI-18802
MNDR hsa-miR-16-5p Testicular germ cell cancer MNDR-E-MI-18803
MNDR hsa-miR-16-5p Heart failure MNDR-E-MI-18804
MNDR hsa-miR-16-5p Growth hormone-secreting pituitary adenoma MNDR-E-MI-18805
MNDR hsa-miR-16-5p Breast invasive carcinoma MNDR-E-MI-18806
MNDR hsa-miR-16-5p Juvenile rheumatoid arthritis MNDR-E-MI-18807
MNDR hsa-miR-16-5p Hepatocellular carcinoma MNDR-E-MI-18808
MNDR hsa-miR-16-5p Familiar ovarian carcinoma MNDR-E-MI-18809
MNDR hsa-miR-16-5p B-cell lymphoma MNDR-E-MI-18810
MNDR hsa-miR-16-5p Rheumatoid arthritis MNDR-E-MI-18811
MNDR hsa-miR-16-5p T-cell leukemia MNDR-E-MI-18812
MNDR hsa-miR-16-5p Neuroblastoma MNDR-E-MI-18813
MNDR hsa-miR-16-5p Osteoarthritis MNDR-E-MI-18814
MNDR hsa-miR-16-5p Hodgkin lymphoma MNDR-E-MI-18815
MNDR hsa-miR-16-5p Ulcerative colitis MNDR-E-MI-18816
MNDR hsa-miR-16-5p Burkitt lymphoma MNDR-E-MI-18817
MNDR hsa-miR-16-5p Crohn disease MNDR-E-MI-18818
MNDR hsa-miR-16-5p Neuromyelitis optica MNDR-E-MI-18819
MNDR hsa-miR-16-5p Skin cutaneous melanoma MNDR-E-MI-18820
MNDR hsa-miR-16-5p Skin melanoma MNDR-E-MI-18821
MNDR hsa-miR-16-5p Acute myelogenous leukemia MNDR-E-MI-18822
MNDR hsa-miR-16-5p Colorectal cancer MNDR-E-MI-18823
MNDR hsa-miR-16-5p Type 2 diabetes mellitus MNDR-E-MI-18824
MNDR hsa-miR-16-5p Multiple myeloma MNDR-E-MI-18825
MNDR hsa-miR-16-5p Serous ovarian cancer MNDR-E-MI-18826
MNDR hsa-miR-16-5p Ependymoma MNDR-E-MI-18827
MNDR hsa-miR-16-5p Hearing loss noise-induced MNDR-E-MI-18828
MNDR hsa-miR-16-5p Nasopharyngeal cancer MNDR-E-MI-18829
MNDR hsa-miR-16-5p Prostatic neoplasms MNDR-E-MI-18830
MNDR hsa-miR-16-5p Pseudorabies MNDR-E-MI-18831
MNDR hsa-miR-16-5p Sleep deprivation MNDR-E-MI-18832
MNDR hsa-miR-16-5p Hypersomnolence idiopathic MNDR-E-MI-18833
MNDR hsa-miR-16-5p Subarachnoid hemorrhage traumatic MNDR-E-MI-18834
MNDR hsa-miR-16-5p Intracranial hemorrhage hypertensive MNDR-E-MI-18835
MNDR hsa-miR-16-5p Pituitary acth hypersecretion MNDR-E-MI-18836
MNDR hsa-miR-16-5p Stroke lacunar MNDR-E-MI-18837
MNDR hsa-miR-16-5p Breast cancer her3+ negative MNDR-E-MI-18838
RNA Interaction Information
Resource RNA Symbol Species Link RNALocate ID
RNAInter ABCB1 Homo sapiens RR00022775
TOP