Basic Information:

  VIRBase ID:  

HHID00105067

  Virus:  

SARS-CoV-2

  Host:  

Homo sapiens

  Confidence Score:  

0.2500

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-let-7f-5p:  MIMAT0000067          TMPRSS2:  NM_001135099     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-let-7f-5p	TMPRSS2
miRBase Accession/Entrez ID	MIMAT0000067	7113
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	PRSS10

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-let-7f-5p	rs1156338084 chr9:94176368    T/C rs1421386283 chr9:94176365    T/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	TMPRSS2	chr21:42853862(-) A-I      intronic chr21:42853848(-) A-I      intronic chr21:42853888(-) A-I      intronic chr21:42853850(-) A-I      intronic chr21:42853879(-) A-I      intronic chr21:42857482(-) A-I      intronic chr21:42857493(-) A-I      intronic chr21:42857494(-) A-I      intronic chr21:42857532(-) A-I      intronic chr21:42861840(-) A-I      intronic chr21:42863176(-) A-I      intronic chr21:42863181(-) A-I      intronic chr21:42864020(-) A-I      intronic chr21:42857454(-) A-I      intronic chr21:42852821(-) A-I      intronic chr21:42852811(-) A-I      intronic chr21:42868840(-) A-I      intronic chr21:42864037(-) A-I      intronic chr21:42852802(-) A-I      intronic chr21:42852784(-) A-I      intronic chr21:42852783(-) A-I      intronic chr21:42852698(-) A-I      intronic chr21:42868853(-) A-I      intronic chr21:42853773(-) A-I      intronic chr21:42853747(-) A-I      intronic chr21:42852838(-) A-I      intronic chr21:42868879(-) A-I      intronic chr21:42853786(-) A-I      intronic chr21:42853787(-) A-I      intronic chr21:42853866(-) A-I      intronic chr21:42853876(-) A-I      intronic chr21:42853901(-) A-I      intronic chr21:42853902(-) A-I      intronic chr21:42853905(-) A-I      intronic chr21:42853936(-) A-I      intronic chr21:42857436(-) A-I      intronic chr21:42852837(-) A-I      intronic chr21:42852694(-) A-I      intronic chr21:42857467(-) A-I      intronic chr21:42857468(-) A-I      intronic chr21:42857476(-) A-I      intronic chr21:42859902(-) A-I      ncRNA chr21:42859884(-) A-I      ncRNA chr21:42859893(-) A-I      ncRNA chr21:42868835(-) A-I      intronic chr21:42859992(-) A-I      intronic chr21:42855936(-) A-I      intronic chr21:42868944(-) A-I      intronic chr21:42868836(-) A-I      intronic chr21:42852668(-) A-I      intronic chr21:42859993(-) A-I      intronic chr21:42869010(-) A-I      intronic chr21:42863353(-) A-I      intronic chr21:42868900(-) A-I      intronic chr21:42868945(-) A-I      intronic chr21:42852703(-) A-I      intronic chr21:42860827(-) A-I      intronic chr21:42859858(-) A-I      ncRNA chr21:42859831(-) A-I      ncRNA chr21:42859844(-) A-I      ncRNA chr21:42858403(-) A-I      ncRNA

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	TMPRSS2	chr21:42858403(-) A-I intron -    15342557 chr21:42858406(-) A-I intron -    15342557 chr21:42859670(-) A-I intron -    15342557 chr21:42859831(-) A-I intron -    15342557   //15258596 chr21:42859844(-) A-I intron -    15342557   //15258596 chr21:42859858(-) A-I intron -    15342557   //15258596 chr21:42859884(-) A-I intron -    15342557   //15258596 chr21:42859893(-) A-I intron -    15342557   //15258596 chr21:42859902(-) A-I intron -    15342557   //15258596 chr21:42868835(-) A-I intron -    15342557 chr21:42868836(-) A-I intron -    15342557 chr21:42868864(-) A-I intron -    15342557 chr21:42868900(-) A-I intron -    15342557 chr21:42868905(-) A-I intron -    15342557 chr21:42868944(-) A-I intron -    15342557 chr21:42868945(-) A-I intron -    15342557 chr21:42868950(-) A-I intron -    15342557 chr21:42869010(-) A-I intron -    15342557 chr21:42869014(-) A-I intron -    15342557 chr21:42869073(-) A-I intron -    15342557 chr21:42853823(-) A-I intron -    21960545 chr21:42853826(-) A-I intron -    21960545 chr21:42853866(-) A-I intron -    21960545 chr21:42855839(-) A-I intron -    21960545 chr21:42855936(-) A-I intron -    21960545 chr21:42855984(-) A-I intron -    21960545 chr21:42857419(-) A-I intron -    21960545 chr21:42857454(-) A-I intron -    21960545 chr21:42857468(-) A-I intron -    21960545 chr21:42857493(-) A-I intron -    21960545

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	TMPRSS2	chr21:42836773-42836774(-) m6A 3'UTR       25456834

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-let-7f-5p	Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Exosome Human cervical cancer cell line (HeLa)     25760330 Exosome Human milk     28688106 Exosome Hetastatic gastric cancer cell line (AZ-P7a)     20949044 Exosome Breast cancer cell line (MCF-7)     20976003 Exosome Primary dendritic cells|T cell line (J77)     21505438 Exosome Renal cancer cells     21670082 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Human mast cell line (HMC-1)     24009880 Exosome Breast cancer cell lines (MCF-7|MDA-MB-231)     24468161 Exosome Plasma     24937531 Exosome Human esophageal cancer cell line (EC9706)     25184951 Exosome Blood|B lymphoblastoid cells|Breast milk|Colon tissue|Endothelial cells|Epithelial cells|Lymphoma tissue|Mast cells|Seminal fluid|Tongue tissue     - Microvesicle Plasma     23077538 Microvesicle Seminal plasma     23539611 Microvesicle Hepatoma cells     23771658 Microvesicle Blood|Breast cell line|Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     - Mitochondrion Skeletal muscle myoblasts     21637849 Mitochondrion Cell line (HEK-293|HeLa)     22984580 Nucleolus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus Colon adenocarcinoma cells     20864815
	TMPRSS2	Exosome Blood     - Nucleus HCC cell line (HepG2)     - Ribosome Colon cancer cells     24393600

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function
ncDR	hsa-let-7f-5p	3-3'-(1H-Pyrazole-3,5-diyl)bis(1-methyl-1H-indole) 44433919 Drug sensitive Artelastin 399488 Drug resistant Salarin C 24867082 Drug resistant Epilactose 128037 Drug resistant 1H-Indole-3-methanol, 1-[(4-chlorophenyl)methyl]- 11821732 Drug resistant organosulfur compound - Drug resistant

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-let-7f-5p	Formaldehyde 712 Drug interaction    RC00000304 Bisphenol A 6623 Drug interaction    RC00000311 Gemcitabine 60750 Drug interaction    RC00000315 Estradiol 5757 Drug interaction    RC00000310 Imatinib 5291 Drug interaction    RC00000309 Cholecalciferol 5280795 Drug interaction    RC00000319 Decitabine 451668 Drug interaction    RC00000318 Oleic acid 445639 Drug interaction    RC00000317 Docosahexaenoic acid 445580 Drug interaction    RC00000316 Letrozole 3902 Drug interaction    RC00000308 5-Fluorouracil 3385 Drug interaction    RC00000307 Doxorubicin 31703 Drug interaction    RC00000314 cis-Diaminedichloroplatinum 2767 Drug interaction    RC00000306 Verapamil 2520 Drug interaction    RC00000305 Arsenic trioxide 14888 Drug interaction    RC00000313 Hesperidin 10621 Drug interaction    RC00000312 Hydroxamic acid HDACi LAQ824 - Drug interaction    RC00000320

Interaction Network (The top 100 interactions):

Interactor1: hsa-let-7f-5p
Interactor2: TMPRSS2

Evidence Support:

Prediction-Evidence	microT//miRanda//miRBase//miRDB//miRMap//miRWalk//PicTar//PITA//Targetscan
Support Database	ViRBase

References:

[1]PMID	33428154	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	None	Interactor2 expression	None
Description	To explore the regulatory relationship between the 5 key genes, 3 coronavirus-related genes (ACE2, TMPRSS2, BSG), and their target miRNA, we used 6 miRNA target prediction databases to predict the target miRNA of these genes.

[2]PMID	32992681	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	None	Interactor2 expression	None
Description	Table 2 shows a list of novel potential candidate miRNAs against TMPRSS2 gene which were not studied previously.

[3]PMID	33359190	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	None	Interactor2 expression	None
Description	Albeit, list of putative miRNAs (11 miRNAs) retrieved as result from all the three prediction tools is represented in Fig. 2f.

[4]PMID	32814446	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	None	Interactor2 expression	None
Description	Considering the significance of ACE2 and TMPRSS2 in SARS-CoV-2 infection, we also performed a TargetScan (http://www.targetscan.org/vert_72/) search for the miRNAs that could target these two receptors, and the analysis revealed a list of miRNAs such as, hsa-miRNA 200b-3p, hsa-miRNA 200c-3p and miRNA 429 for ACE2, and hsa-let 7c-5p, hsa-miRNA 98-5p, hsa-let 7f-5p, hsa-let 7a-5p, hsa-let 7g-5p, hsa-let 7b-5p, hsa-miRNA 4458, hsa-let 7e-5p, hsa-let 7i-5p, hsa-let 7d-5p, and hsa-miRNA 4500 for TMPRSS2.