Basic Information:

  VIRBase ID:  

HHID00105029

  Virus:  

SARS-CoV-2

  Host:  

Homo sapiens

  Confidence Score:  

0.1828

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      LNCSRLR:  NR_146297          IL6:  NM_001318095     

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Interactor Information:

	Interactor1	Interactor2
Symbol	LNCSRLR	IL6
miRBase Accession/Entrez ID	109729161	3569
Organism	Homo sapiens	Homo sapiens
Category	lncRNA	mRNA
Alias	lncRNA-SRLR	BSF-2//BSF2//CDF//HGF//HSF//IFN-beta-2//IFNB2//IL-6

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt	PMID
LincSNP 3.0	LNCSRLR	rs13087364 chr3:146066485 C/T         19448189

RNA Editing:

Resource	Symbol	Editing Position
Lncediting	LNCSRLR	chr3: 145784463     chr3: 145784458     chr3: 145784438

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	IL6	chr7:22770700(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	IL6	chr7:22766885-22766886(+) m6A 5'UTR//CDS//exon       - chr7:22766928-22766929(+) m6A exon//intron       -

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	LNCSRLR	Exosome Blood     -
	IL6	Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Serum     - Nucleus HeLa-S3 cells     - Polysome HeLa cells     26000482

Interaction Network (The top 100 interactions):

Interactor1: LNCSRLR
Interactor2: IL6

Evidence Support:

Prediction-Evidence	LncRNA2Target
Support Database	ViRBase

References:

PMID	33520952	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	None	Interactor2 expression	None
Description	We identified a total of 24 cytokine-lncRNA relationships using LncRNA2Target (Table 2). The most significant lncRNAs associated with COVID-19 cytokine storm cytokines, accompanied by lncRNA target prediction analysis using average ndG values.